LOCUS       NM_001271544            3161 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus solute carrier family 4, sodium bicarbonate
            cotransporter, member 9 (Slc4a9), transcript variant 1, mRNA.
ACCESSION   NM_001271544
VERSION     NM_001271544.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3161)
  AUTHORS   Vitzthum,H., Meyer-Schwesinger,C. and Ehmke,H.
  TITLE     Novel functions of the anion exchanger AE4 (SLC4A9)
  JOURNAL   Pflugers Arch 476 (4), 555-564 (2024)
   PUBMED   38195948
  REMARK    GeneRIF: Novel functions of the anion exchanger AE4 (SLC4A9).
            Review article
REFERENCE   2  (bases 1 to 3161)
  AUTHORS   Vitzthum,H., Koch,M., Eckermann,L., Svendsen,S.L., Berg,P.,
            Hubner,C.A., Wagner,C.A., Leipziger,J., Meyer-Schwesinger,C. and
            Ehmke,H.
  TITLE     The AE4 transporter mediates kidney acid-base sensing
  JOURNAL   Nat Commun 14 (1), 3051 (2023)
   PUBMED   37236964
  REMARK    GeneRIF: The AE4 transporter mediates kidney acid-base sensing.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3161)
  AUTHORS   Pena-Munzenmayer,G., Kondo,Y., Salinas,C., Sarmiento,J., Brauchi,S.
            and Catalan,M.A.
  TITLE     Activation of the Ae4 (Slc4a9) cation-driven Cl-/HCO3- exchanger by
            the cAMP-dependent protein kinase in salivary gland acinar cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 321 (6), G628-G638 (2021)
   PUBMED   34585968
  REMARK    GeneRIF: Activation of the Ae4 (Slc4a9) cation-driven Cl(-)/HCO3(-)
            exchanger by the cAMP-dependent protein kinase in salivary gland
            acinar cells.
REFERENCE   4  (bases 1 to 3161)
  AUTHORS   Honda,K., Kim,S.H., Kelly,M.C., Burns,J.C., Constance,L., Li,X.,
            Zhou,F., Hoa,M., Kelley,M.W., Wangemann,P., Morell,R.J. and
            Griffith,A.J.
  TITLE     Molecular architecture underlying fluid absorption by the
            developing inner ear
  JOURNAL   Elife 6, e26851 (2017)
   PUBMED   28994389
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3161)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   6  (bases 1 to 3161)
  AUTHORS   Stehberger,P.A., Shmukler,B.E., Stuart-Tilley,A.K., Peters,L.L.,
            Alper,S.L. and Wagner,C.A.
  TITLE     Distal renal tubular acidosis in mice lacking the AE1 (band3)
            Cl-/HCO3- exchanger (slc4a1)
  JOURNAL   J Am Soc Nephrol 18 (5), 1408-1418 (2007)
   PUBMED   17409310
REFERENCE   7  (bases 1 to 3161)
  AUTHORS   Simpson,J.E., Schweinfest,C.W., Shull,G.E., Gawenis,L.R.,
            Walker,N.M., Boyle,K.T., Soleimani,M. and Clarke,L.L.
  TITLE     PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3-
            exchanger in the upper villous epithelium of the murine duodenum
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 292 (4), G1079-G1088 (2007)
   PUBMED   17170027
REFERENCE   8  (bases 1 to 3161)
  AUTHORS   Kurth,I., Hentschke,M., Hentschke,S., Borgmeyer,U., Gal,A. and
            Hubner,C.A.
  TITLE     The forkhead transcription factor Foxi1 directly activates the AE4
            promoter
  JOURNAL   Biochem J 393 (Pt 1), 277-283 (2006)
   PUBMED   16159312
  REMARK    GeneRIF: The AE4 promoter is identified as a direct target of
            Foxi1.
REFERENCE   9  (bases 1 to 3161)
  AUTHORS   Praetorius,J., Nejsum,L.N. and Nielsen,S.
  TITLE     A SCL4A10 gene product maps selectively to the basolateral plasma
            membrane of choroid plexus epithelial cells
  JOURNAL   Am J Physiol Cell Physiol 286 (3), C601-C610 (2004)
   PUBMED   14592810
REFERENCE   10 (bases 1 to 3161)
  AUTHORS   Ko,S.B., Luo,X., Hager,H., Rojek,A., Choi,J.Y., Licht,C.,
            Suzuki,M., Muallem,S., Nielsen,S. and Ishibashi,K.
  TITLE     AE4 is a DIDS-sensitive Cl(-)/HCO(-)(3) exchanger in the
            basolateral membrane of the renal CCD and the SMG duct
  JOURNAL   Am J Physiol Cell Physiol 283 (4), C1206-C1218 (2002)
   PUBMED   12225984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142545.1, AK085269.1 and AK085424.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1761              AK142545.1         3-1763
            1762-2931           AK085269.1         1546-2715
            2932-3149           AK085424.1         2937-3154
            3150-3161           AK085269.1         2934-2945
FEATURES             Location/Qualifiers
     source          1..3161
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..3161
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /note="solute carrier family 4, sodium bicarbonate
                     cotransporter, member 9"
                     /db_xref="GeneID:240215"
                     /db_xref="MGI:MGI:2443384"
     exon            1..253
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2894
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /note="isoform 1 is encoded by transcript variant 1; anion
                     exchanger 4; solute carrier family 4 member 9; anion
                     exchange protein 4"
                     /codon_start=1
                     /product="anion exchange protein 4 isoform 1"
                     /protein_id="NP_001258473.1"
                     /db_xref="CCDS:CCDS89223.1"
                     /db_xref="GeneID:240215"
                     /db_xref="MGI:MGI:2443384"
                     /translation="MKLPGQGDFESSDAHENAHSEEPDSGLGPGPGLNGPSGIDIGES
                     QVSKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQ
                     KLRSLLAEGIVLLDCQAQSLLELVEQVVSGESLSPELRGQLQALLLQRPQHHIQTMGI
                     RPCRESNAFRKASRDEDAPLKHQNPLRQKLPAGAEAAAVLAGELGFLEQPLGAFVRLR
                     NPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLP
                     DLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQHKRFPSKLQEVTSLSRQSAALA
                     EDKHHHGPHTPIPELQRTGRLFGGLIQDVRRKACWYTSDFLDALHPQCFSAVFYIYLA
                     TVTNAITFGGLLGDATEGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFER
                     LLFSFSRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLI
                     FIYDAMGKMLNLIRAYPIQRPGSSAYGCFCQYPGTGGNTSEWTSAKLKDTEDILSVPG
                     LVNASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFP
                     SVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPW
                     WLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSAL
                     GLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLA
                     PVLKFIPMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHL
                     FTAIQLACLGLLWVVKSTPAAIVFPLMLLGLVAIRKALEWVFSPQELLWLDELMPEEE
                     ETIPENRSEPEHLFSGNDSEDSELMYQPKAPEINISVN"
     exon            254..414
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            415..528
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            529..578
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            579..736
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            737..824
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            825..979
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1096
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1271
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1405
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1668
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1727
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1913
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2027
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2189
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2368
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2441
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2510
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2684
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2840
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2933
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3161
                     /gene="Slc4a9"
                     /gene_synonym="AE 4; AE4; D630003B07; D630024F24Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacagctcc caggatttgt gcaagtcttt ccaggatgaa gctgccaggg cagggggatt
       61 ttgaaagctc tgatgctcat gaaaatgctc actcagagga accggacagt ggcctaggcc
      121 ctggccctgg ccttaatgga ccctcaggca tagacattgg ggaatctcag gtgtctaagg
      181 accctctgct cttcattcaa ctaaatgagc tgctgggttg gccccaggca ctagagtggc
      241 gagagacagg caggtggctg ctgttcgagg aaaagctaga catgggcgcg ggccggtgga
      301 gtgctcccca tgtgcctacc ctggaactcc ccagcctcca gaagcttcga agtctgttgg
      361 ccgagggcat tgtcctgcta gactgtcagg ctcagagcct cctggagctt gtggagcagg
      421 tagtcagtgg ggagtcactg agcccagaac tgagaggaca gcttcaggcc ttgctcctgc
      481 agagacccca gcaccacatc cagaccatgg gcatcaggcc ctgcagagag tccaatgctt
      541 tcagaaaggc ttctcgtgat gaggacgccc cactgaagca ccagaaccct ttgagacaga
      601 agctgcccgc tggagctgag gcagcggcag tgttggcagg agagctgggc ttcctggaac
      661 agccactagg ggccttcgta agactgcgga atcctatagt gctggagcct cttacagaga
      721 tgatcttgcc cagcagattt ttctgcctcc tcttgggtcc tcccaccctg ggaaggagct
      781 accatgagat gggacgggca gctgctgtcc tcctcagtga cccgcaattc cagtggtcag
      841 ttcgtcgggc aagccatctt cctgaccttc tggcagctct ggatgccttc ctgcaggagg
      901 tgacagctct acccccgggc cggtgggacc ggacagcccg gattccccca cccaaatacc
      961 taccatctca gcacaaaaga ttcccctcga aactgcagga ggtcaccagc ctctcccgac
     1021 agagtgctgc cctagcagaa gacaagcacc atcacggacc gcacacaccc atcccagaat
     1081 tgcaaaggac aggcaggctc tttgggggtc ttattcagga cgtgcgccgg aaggcatgtt
     1141 ggtacaccag tgatttcctg gatgccctac acccccagtg tttctcagct gtgttctaca
     1201 tttacctggc cacagtcaca aacgccatca cttttggggg tcttctggga gatgccactg
     1261 aaggtgccca gggagtgctg gagagtttcc tgggcacagc ggtggctgga gctgccttct
     1321 gcctgatggc aggccagccc ctcactatcc ttagcagcac agggccagtg ctggtatttg
     1381 agcgcctact cttctctttt agcagagatt acagcctgga ttatctgccc ttccgcctat
     1441 gggtcggcat ctgggtgacc gcattttgcc tggcactggt ggctacggag gccagcttgc
     1501 tggtgcgcta cttcaccaga ttcacagagg aaggattctg tgccctcatc agcctcatct
     1561 tcatctatga tgccatgggg aagatgctga atttgatccg tgcctatcca atccaaaggc
     1621 cagggtcttc tgcctatggt tgcttctgtc aatacccagg cacaggagga aacacgtctg
     1681 aatggacgag tgcaaagctc aaagacacag aggacatctt aagtgtgcca ggtctagtca
     1741 atgcttcctt cctgcctcca cctgagtgca tccggcaagg aggtcaccct ctcggcccca
     1801 gctgtcacac ggtgccagac atcgccttct tctcccttct cctcttcttt acttctttcc
     1861 tttgtgccat tgctctcaag cacataaaga acagccgctt cttcccctct gtggtgcgca
     1921 aggtgttggg cgacttttcc tcagtcctgg ccatcctgct gggctgtggc cttgacacct
     1981 tcctgggcct agccacaccg aagctcttgg tgcccacaga attcaagcct acactctctg
     2041 ggcgtggctg gctggtgtct ccttttggag ctaacccctg gtggctgagt gtggccgctg
     2101 ccttgcccgc tctactgctg tcaatcctta tcttcatgga ccagcagatc acggcagtca
     2161 tcctcaaccg tgcagaatac agactgcaga agggagctgg cttccacctg gacctcttct
     2221 gtgtggctgt tttgatgctg ttcacatcgg cacttgggct gccatggtac gtctcagcca
     2281 ctgtcatctc cttggcccac atagacagtc ttcggagaga gagcaaagcc tgcatccctg
     2341 gagaagcccc caatttcctg ggcatcaggg aacagaggct gacgggcttg gtggtgttcg
     2401 tccttacagg tgtctccatc ttcctggcac ctgtgctcaa gttcatcccg atgcccgtgc
     2461 tctacggcat cttcctgtac atgggggtag ccgcgctcag cagcatccag ttcgtgaaga
     2521 gagtgcagct attgttgatg ccaaggaaac atcagccaga catgctgctc ctgcggcatg
     2581 tgcctctgag cagagttcac ctcttcacag ccatccagct tgcctgccta ggtctgcttt
     2641 gggtagtcaa gtctacccct gcagccattg tcttcccact catgttactg ggcctggtgg
     2701 ccatccggaa ggcactggag tgggtcttct caccacagga actcctctgg ctggatgagc
     2761 tgatgccaga ggaggaggag accatccccg agaacaggtc cgagccagag cacttgttca
     2821 gtggaaatga cagtgaagat tcagaactga tgtatcagcc caaggctcca gaaatcaaca
     2881 tctctgtgaa ttagctggcg tcacagtgtg gagacctcag gaaacagaca caggtaccag
     2941 agagatggtt cagcagtcac gagtacttgc agctctgatg cccagaggat ctaagcatga
     3001 tgcccagcat ctatgtggca gcttatcacc ctccctaact ccagttccat gggatccagc
     3061 gccctctgct agctttcttg agcaccaggc atgcacaaag tacccttaaa tacatctggg
     3121 caaaataatc atatacataa agtaaaaata aataaatctt t
//
