LOCUS       NM_001360504            7777 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus solute carrier family 4, sodium bicarbonate
            cotransporter, member 7 (Slc4a7), transcript variant 1, mRNA.
ACCESSION   NM_001360504 XM_006518000
VERSION     NM_001360504.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7777)
  AUTHORS   Jiang,M., Salari,A., Stock,C., Nikolovska,K., Boedtkjer,E.,
            Amiri,M. and Seidler,U.E.
  TITLE     The electroneutral Na+-HCO3- cotransporter NBCn1 (SLC4A7) modulates
            colonic enterocyte pHi, proliferation, and migration
  JOURNAL   Am J Physiol Cell Physiol 326 (6), C1625-C1636 (2024)
   PUBMED   38646790
  REMARK    GeneRIF: The electroneutral Na[+]-HCO3[-] cotransporter NBCn1
            (SLC4A7) modulates colonic enterocyte pHi, proliferation, and
            migration.
REFERENCE   2  (bases 1 to 7777)
  AUTHORS   Choi,I., Beedholm,K., Dam,V.S., Bae,S.H., Noble,D.J.,
            Garraway,S.M., Aalkjaer,C. and Boedtkjer,E.
  TITLE     Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor
            activity and hearing in mice
  JOURNAL   Behav Brain Res 401, 113065 (2021)
   PUBMED   33321164
  REMARK    GeneRIF: Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects
            locomotor activity and hearing in mice.
REFERENCE   3  (bases 1 to 7777)
  AUTHORS   Schank,J.R., Lee,S., Gonzalez-Islas,C.E., Nennig,S.E.,
            Fulenwider,H.D., Chang,J., Li,J.M., Kim,Y., Jeffers,L.A., Chung,J.,
            Lee,J.K., Jin,Z., Aalkjaer,C., Boedtkjer,E. and Choi,I.
  TITLE     Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate
            Transporter NBCn1
  JOURNAL   Sci Rep 10 (1), 11017 (2020)
   PUBMED   32620847
  REMARK    GeneRIF: Increased Alcohol Consumption in Mice Lacking Sodium
            Bicarbonate Transporter NBCn1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7777)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7777)
  AUTHORS   Park,H.J., Gonzalez-Islas,C.E., Kang,Y., Li,J.M. and Choi,I.
  TITLE     Deletion of the Na/HCO3 Transporter NBCn1 Protects Hippocampal
            Neurons from NMDA-induced Seizures and Neurotoxicity in Mice
  JOURNAL   Sci Rep 9 (1), 15981 (2019)
   PUBMED   31690738
  REMARK    GeneRIF: Deletion of the Na/HCO3 Transporter NBCn1 Protects
            Hippocampal Neurons from NMDA-induced Seizures and Neurotoxicity in
            Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7777)
  AUTHORS   Praetorius,J., Nejsum,L.N. and Nielsen,S.
  TITLE     A SCL4A10 gene product maps selectively to the basolateral plasma
            membrane of choroid plexus epithelial cells
  JOURNAL   Am J Physiol Cell Physiol 286 (3), C601-C610 (2004)
   PUBMED   14592810
REFERENCE   7  (bases 1 to 7777)
  AUTHORS   Bok,D., Galbraith,G., Lopez,I., Woodruff,M., Nusinowitz,S.,
            BeltrandelRio,H., Huang,W., Zhao,S., Geske,R., Montgomery,C., Van
            Sligtenhorst,I., Friddle,C., Platt,K., Sparks,M.J., Pushkin,A.,
            Abuladze,N., Ishiyama,A., Dukkipati,R., Liu,W. and Kurtz,I.
  TITLE     Blindness and auditory impairment caused by loss of the sodium
            bicarbonate cotransporter NBC3
  JOURNAL   Nat Genet 34 (3), 313-319 (2003)
   PUBMED   12808454
REFERENCE   8  (bases 1 to 7777)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 7777)
  AUTHORS   Park,M., Ko,S.B., Choi,J.Y., Muallem,G., Thomas,P.J., Pushkin,A.,
            Lee,M.S., Kim,J.Y., Lee,M.G., Muallem,S. and Kurtz,I.
  TITLE     The cystic fibrosis transmembrane conductance regulator interacts
            with and regulates the activity of the HCO3- salvage transporter
            human Na+-HCO3- cotransport isoform 3
  JOURNAL   J Biol Chem 277 (52), 50503-50509 (2002)
   PUBMED   12403779
REFERENCE   10 (bases 1 to 7777)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153567.1, JX254910.1, CD541823.1, CO430686.1, AC129580.14 and
            BP761907.1.
            
            On Feb 6, 2018 this sequence version replaced XM_006518000.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JX254910.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AK153567.1         2-55
            55-4124             JX254910.1         1-4070
            4125-4424           CD541823.1         231-530
            4425-4921           CO430686.1         222-718
            4922-7100           AC129580.14        99505-101683
            7101-7777           BP761907.1         1-677               c
FEATURES             Location/Qualifiers
     source          1..7777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 7.08 cM"
     gene            1..7777
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /note="solute carrier family 4, sodium bicarbonate
                     cotransporter, member 7"
                     /db_xref="GeneID:218756"
                     /db_xref="MGI:MGI:2443878"
     exon            1..256
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..3973
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium bicarbonate cotransporter 3; Na-bicarbonate
                     cotransporter; sodium bicarbonate cotransporter NBCn1-B;
                     sodium bicarbonate cotransporter NBCn1-c; sodium
                     bicarbonate cotransporter NBCn1-D; sodium bicarbonate
                     cotransporter NBCn1-H; sodium bicarbonate cotransporter
                     NBCn1-A"
                     /codon_start=1
                     /product="sodium bicarbonate cotransporter 3 isoform 1"
                     /protein_id="NP_001347433.1"
                     /db_xref="CCDS:CCDS88573.1"
                     /db_xref="GeneID:218756"
                     /db_xref="MGI:MGI:2443878"
                     /translation="MEADGAGEQMRPLLTRGPDEEAVVDLGKTSSTVNTKFEKEELES
                     HRAVYVGVHVPFSKESRRRHKHRGHKHHHRRRKDKDSDKEDGRESPSYDTPSQRVQFI
                     LGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVA
                     TLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDDSIRENVREALL
                     KRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLS
                     LRGESPLSLLLSHLLPSSRAGTPAGSRCTTPVPTPQSSPPSSPDLSRLASRSFQQTQP
                     QAPEVLVSPDRDDIPRVVIHPPEEDIEALKGQEQKNEENTAFTPGILASPQSAPGNLD
                     NSKSGEMKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAF
                     VRLAPAVLLSGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKA
                     KDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFPNGSAAMSVD
                     PPKEDDHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACM
                     SPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKIL
                     FKFCRDYHLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFI
                     YEALEKLFHLGEIYAFNMHNNLDELTSYTCVCAEPSNPSNETLELWKRKNITAYSVSW
                     GNLTVSECKTFHGMFVGSACGPHGPYVPDVLFWCVVLFFTTFFLSSFLKQFKTKRYFP
                     TKVRSTISDFAVFLTIVIMVAIDYLVGIPSPKLHVPEKFEPTDPSRGWIISPLGDNPW
                     WTLLIAAVPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSIM
                     GLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMT
                     SVLKFIPMPVLYGVFLYMGVSSLKGIQFFDRIKLFGMPAKHQPDLIYLRYVPLWKVHV
                     FTVVQLTCLVLLWVIKASAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESK
                     KKKEDDKKKKEKEEAERMLQDDEDTVHLPFERGSLLQIPVKTLKYSIDPSVVNISDEM
                     AKTAQWKALSMNTENAKVTRPNTSPEKPVSVTINFEDEPSKKYMDAETSL"
     exon            257..338
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            339..485
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            486..624
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            625..785
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            786..974
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1343
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1459
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1617
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1705
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1852
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1959
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2134
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2268
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2514
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2620
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2782
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2896
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3058
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3310
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3379
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3553
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3685
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3783
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..3891
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     exon            3892..7758
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7569..7574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /note="hexamer: AATAAA"
     polyA_site      7591
                     /gene="Slc4a7"
                     /gene_synonym="E430014N10Rik; NBC3; NBCn1; NBCn1-G;
                     Tg(Thy1-SNCA)12Mjff"
                     /note="major polyA site"
ORIGIN      
        1 gggcgccgct gcctcctccg cgccgcgtcc tctgcccgtc tcagtcctcg cggcacgccg
       61 ttgcctctct ctcccggaga acgtcccgcg ctcgcagcgg tcgccgcact ccggggccag
      121 ctctcggcgg ccagcgctcc gcacagggtc tccctccgcg tgcccgtctc tgctgcggtc
      181 gcggcctctc agagctccgg ggcgggccat ggaggcagac ggggccggcg agcagatgag
      241 accgctactc acgcggggtc cagatgaaga agctgttgtg gatcttggca aaactagctc
      301 aactgtgaac accaagtttg aaaaagaaga attagaaagt catcgagctg tatatgttgg
      361 tgttcatgta ccatttagta aagagagtcg tcggcgtcac aagcatcgag ggcacaaaca
      421 tcaccaccgg agaagaaaag acaaagactc agataaagaa gatggacggg aatctccttc
      481 ttatgacacg ccatcgcaga gggtgcagtt catcctcggg actgaagacg acgatgagga
      541 gcacattccc cacgacctct tcacagagat ggatgagctc tgctacagag acggagaaga
      601 gtacgagtgg aaggagacgg ccaggtggct gaaatttgaa gaggatgttg aagatggtgg
      661 tgaccgatgg agtaaaccct atgtggcaac tctgtctcta cacagtctct ttgaattgag
      721 gagttgtatc ctgaatggaa cagttatgct ggatatgaga gcaagcactc ttgatgaaat
      781 tgcagatatg gtgttagaca acatgatagc atctggccag ttagatgact ccataaggga
      841 gaacgtcaga gaagctcttc tgaagagaca tcatcatcaa aatgagaaaa ggttcacgag
      901 tcggattccc ctggttcgat cctttgcaga tataggcaag aaacattctg accctcactt
      961 gcttgaaagg aatggggaag gcctgtcagc ctcccgccat tctttgcgaa caggtctgtc
     1021 tgcctcaaac ctttccttga gaggagaatc gcctttatcc cttcttctca gccatcttct
     1081 tccttcttca agagctggca cccctgcagg ctcaaggtgt accaccccag tacccactcc
     1141 ccagagcagt cctccctcca gccccgactt aagtcgtctg gcctccagaa gtttccaaca
     1201 gacccagcct caggccccag aagtactggt gtcacctgac agggatgata ttcccagagt
     1261 agtaattcat ccgcctgagg aagacataga agcactcaaa ggccaagagc agaagaatga
     1321 ggaaaatact gccttcactc cagggatttt ggcttctcca cagtctgctc ctggaaactt
     1381 ggacaatagt aaaagtggtg aaatgaaagg taacggaagt ggaggaagca gagaaaatag
     1441 tactgttgac tttagcaagg ttgacatgaa tttcatgagg aaaattccta caggagctga
     1501 ggcatccaat gttttggtag gagaagtgga cttcttggag agaccgatca ttgcatttgt
     1561 gagactggct cctgcagttc tcctctcagg gttgactgag gtccctgtgc ccactaggtt
     1621 tttgtttctg ttactgggcc cagcagggaa agccccacag taccatgaaa ttggcagatc
     1681 catagcaact ctcatgacag atgagatttt tcatgatgtg gcttataaag caaaagatcg
     1741 taatgacctc ctatctggaa ttgatgaatt cttagatcaa gtaactgttc ttcctccagg
     1801 agagtgggat ccttccatac gcatagagcc tccaaaaagt gttccttctc aggaaaaaag
     1861 gaagattcct gtgtttccta atggatctgc tgcaatgtct gttgaccctc ccaaggagga
     1921 tgatcaccat gctgggcctg agctgcagag gactggacgg ctttttggtg gtttgatact
     1981 tgacatcaaa aggaaagcac cttttttctt gagtgacttc aaggatgcat taagtctgca
     2041 gtgcctggcc tcgattcttt tcctatactg tgcctgtatg tctcctgtaa tcacttttgg
     2101 agggctgctt ggagaagcta cagaaggcag aataagtgca atagagtctc tttttggagc
     2161 gtcattaact gggattgcct attcattgtt tgctgggcaa cctctaacaa tactggggag
     2221 cacaggtcca gtcctagtgt ttgaaaaaat tttatttaaa ttctgtagag attatcacct
     2281 ttcctatcta tcattaagaa ccagtattgg tctgtggaca tctttcttgt gcattgtatt
     2341 ggtcgcaaca gatgcaagca gccttgtttg ttacattact cggttcacag aagaagcttt
     2401 tgcggctctc atttgtatca tattcatcta tgaagctctg gagaagctct ttcacttagg
     2461 agaaatatat gcatttaata tgcacaacaa cttggatgaa ttgaccagtt acacatgtgt
     2521 atgtgctgag ccatctaacc ctagcaacga aactctagaa ctgtggaaga ggaagaatat
     2581 aacagcatac agtgtttcct ggggcaacct tactgtttct gagtgtaaga ccttccatgg
     2641 tatgtttgtg ggatcagctt gtgggcctca tggaccttat gttcctgacg tgctcttctg
     2701 gtgtgtcgtc ttgtttttca cgacgttctt tctgtcttca ttcctcaagc agtttaagac
     2761 caagagatat tttcctacca aggtacgatc aacaatcagt gactttgctg tatttctcac
     2821 aatagtaata atggttgcaa ttgactacct tgtaggaatt ccatctccta aacttcatgt
     2881 gcctgaaaag ttcgagccta ctgatccaag taggggctgg atcataagcc ctttgggaga
     2941 taacccttgg tggaccttac taattgcagc agttccagct ctcctttgta ctattctcat
     3001 ctttatggac cagcagatca cagctgtaat catcaacaga aaagaacaca aactcaagaa
     3061 aggagctggc taccaccttg acttgctcat ggttggtgtc atgttgggag tctgctctat
     3121 catgggcttg ccgtggtttg tggctgcgac agtgttgtct ataagtcatg tcaacagctt
     3181 gaaagtggag tctgagtgtt ctgctccagg ggagcagccc aagtttctgg gaattcgtga
     3241 acagcgggtt acagggctga tgatttttat cctgatgggc ctctctgtgt tcatgacttc
     3301 agtattaaag tttatcccaa tgccagtttt gtacggtgtt tttctttata tgggagtttc
     3361 atcgttgaaa ggaattcagt tttttgaccg tatcaagtta tttggaatgc ctgccaagca
     3421 ccagcccgac ctaatctacc tccgctatgt ccccctgtgg aaggtgcacg tgttcacggt
     3481 cgtccagctg acctgcctag tcctgctgtg ggtgatcaaa gcctctgctg ctgcagtagt
     3541 ttttcccatg atggttcttg cattagtctt tgtgcgcaag ctcatggatc tctgtttcac
     3601 aaagagagaa ctcagttggc ttgatgacct catgccagaa agtaagaaaa agaaagaaga
     3661 tgacaaaaag aaaaaagaga aagaggaagc tgaacggatg cttcaggatg atgaggacac
     3721 tgtgcacctc ccattcgaaa gagggagtct cctgcagatt ccagtgaaaa ctctaaaata
     3781 tagtattgac ccttcagttg ttaacatatc agatgaaatg gccaaaactg cccagtggaa
     3841 ggcactttcc atgaatactg agaatgccaa agtaacgaga cctaacacga gccctgaaaa
     3901 gcctgtgagt gtgacaataa atttcgaaga tgaaccgtca aaaaaataca tggatgctga
     3961 aacttcattg taaagtcaaa ccaaaaggaa tatatagaga tatatgccta tctgtatata
     4021 tacacatata tatgtataaa aagcacatgt gccatgccat tatgtataac agtactttgg
     4081 ggctttttca agtagcgtca gatatttgtt gtggacacca tagagactac attaattaag
     4141 tgctctctta gaagcaaggt tcatgaattt ttactccaga tttttttggg gggtggggta
     4201 aagcctttct gttatgcaat agaaagatgt ggagcactgc gttccatctg cttttctttg
     4261 atctgtcagt ggcaatcaat cataacaatc ttaagtctac atacttaaaa ttcgacctga
     4321 atttcaaaag atgtttgttt tcccttttgg tagtgtttat aggtagaata aggagtctgc
     4381 ccatgtggtg ggaaaatgac atgtcctggc ttctctgtgg gctttcttca tgtaactgtc
     4441 aatcatactt cacaggatag tggagatttt ctaagaagga actttatgtc ttaggagtta
     4501 tttttaaatt ttaaaacttt ctgagtttcc attttgatgg acaggttaaa aatttttatg
     4561 tcacttctaa tttaacaccc acacaagtca taacgttttc agttttagaa cctatgaagt
     4621 gcccatttac agtaattaac tattgttagt tttgtggcag ggctttgccg gtactcagta
     4681 cttgcctaga aaccagagtc ccactcttct ttgtctttgt ttttctttac tgaggtggtc
     4741 tggtgtgcca ggctcagtta tctttctgtt gtaagtagca aaaagagtca gcccactttc
     4801 aataggcttg tgaccagtgt gcctgtagaa gaattacctt tcattttctg tgtgtattct
     4861 ttctatttat atacagtgta tttaattggt taccacccat aatttccttt taaaatattt
     4921 tatttattat agttgatgtg atacttcaat atataaatat ttgagacagt aaaaatatag
     4981 agtaaattgt tcctgttgta gatatttggt gcttgtattt cttttcacat cctgaaagca
     5041 ggtgacaaat tttacatctt tactataaag cactgccata tttatatttt taaaaggaag
     5101 ttggatattt cctgtacagc tcagatcaat ggcatttttt tctgttttgt gatagcattg
     5161 tgtttccaat atttctgagc tgtttcttaa acatgtagca aatattcata gctcctcaca
     5221 aaataagtaa aggctatttt agcctttggg acagagagtt tggggctatg aaacttgatt
     5281 tggcaagagg acagataata catagaaatg gtgagcaaca ctagagacac cgaaggtgat
     5341 gaaatgcgaa ggttcaggca gatgttttaa ggaaattcta atgttctcta gccactgcaa
     5401 actaacattt aaaagtatga agaaactgat ctttaaatca aattattttt agcaagttta
     5461 ttctaaactt tagcaaatca ttttcgttta ttctaaacaa tgtaccaatt aatgtaattc
     5521 cctcatctga gatcatgtag ttggattctt attagaatag tagctggcag catttggtac
     5581 tatctgacga gttctattgg gcttcttagc atgtgatagg gaaggttgcc atggtgctta
     5641 tggtcacagg tgacctccat tgaagtggtt cctttgcact cagcagcaca ttcatttcca
     5701 aagttcccat ttgctgctaa atataaccct accccaaccc ctgaagtacc caaacaagag
     5761 aatttcctca caccattttc ttgtgtaagg acatcaaagg gttaaatcta ttttacagga
     5821 agtgatttta aaatttaaac tgaagactac ctgttatcat aatcttcctg tgatttattt
     5881 aattatatat gttttgtcca gtgccagggg cggaaaaacc atgacttacg gaatattttg
     5941 tatctaagat gtttcactgt ggttttggtt attaatggct tctgctttct tttgactact
     6001 tgacttacaa agtgatctaa taggactact cccctgaaga gcagaggtaa tttactgctt
     6061 ctttcaggtg gttacatttc ttgtgctatt tttgaaaata acaatcatga ataacattca
     6121 ttgcaagaca gcaagagaga taattttaaa tatatatata catatatatg tgtgtgtgta
     6181 tatatatata tatttttaat gctgccttaa ataggtgtat atgagcagta gtaattgcta
     6241 tgtactgatt tacctcaagg tgcaaaataa ttaaatttgt acatacccat ttacagaata
     6301 agttcagaga cacagccctg cactttctta gatgccttga ttttcaaacg gagcttagtg
     6361 ctactgaaca ccacggccat ggggccacct caggacgttc ttccctccac catattttat
     6421 ttatttatag atgtccgttt acaaagacta taatgaaacc tggtgtaaac tatctgatac
     6481 ttatttcctt tctattgcta tttcaatcta aagtaggagc ttttgagaaa acagtaaact
     6541 agcttcccaa tgctaaaggg ttgattctat atatattttt aataatatta gatatgcaaa
     6601 agttaaagta caaggtcttt aaaatattgt gtgagtgttt gtgtatgtgt atgaaatcac
     6661 tcttaactct cttaactttt ttaaaactcg tggcatacca atgttcagat ttgccaagct
     6721 ttctctaaga catgtaggat gaaatgtttt tgtgtgttaa tgcatgtatt tataaagatt
     6781 tgtttactgc tgagaatcac taactcttgt tttcatcccc aaagtgtttg tttcttccac
     6841 atgctggaag gcttggcttg agtatacgct ttctggcttt cctttcacaa aggcacgttc
     6901 aaaattgttc agaaagaaga atggtctctg acagtgaggt gtgatgccag agctttctga
     6961 agtttgagca gtgtgtgcag ctctgcatgt gtgtcctgac agagtcagat atgtgagcca
     7021 ttaaaagaac attgtaattc agagtgttta tttaagtaac ttacatgtct gaaatttatt
     7081 tatgtagatt ccatcattgt tatcatttgt agtgcaaata catgaactgt cttcatttag
     7141 tcccaacaat tatttatttt tagaaagtaa atttaaagcc aagctgcatt caacttttaa
     7201 aatagtgttc taatcataag atgtgatcat tgtaaggtct cttttaactt tctggaaagt
     7261 aaatggtcaa aaggaatcac ataaagattg ttttacattt ttaacctgta tgtacttaga
     7321 gggtaagccc cagttctctg gtttctaatc attttttgca cattgattgt ttctgttctg
     7381 tagcttttct tttgctcctt tggttttggc tttgtagggg taaggtgtct tccaatgttt
     7441 actatgttag gcttaaatta aattttaaat ttattgtcca tttatataat atttgatacc
     7501 ttggtgtaac ttctcaatac aattacaatt tttatgacat ttataattgc gatggtattt
     7561 tcttttataa taaaatccaa agtcaattaa acaaattgta gacctgatat ttttcatcta
     7621 tatgaagtac aagtctctac ctgagtctat aatgtgaacc atcctgcctt tcacatttgt
     7681 ttcctaattg ttagagaaaa ctattttctg tagatgttat tgtaagttga aagagcaata
     7741 aaagtctaca tatcacggaa aaaaaaaaaa aaaaaaa
//
