LOCUS       NM_001166067            5141 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus solute carrier family 4, sodium bicarbonate
            cotransporter, member 5 (Slc4a5), mRNA.
ACCESSION   NM_001166067 XM_888058 XM_913146
VERSION     NM_001166067.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5141)
  AUTHORS   Morikawa,R., Rodrigues,T.M., Schreyer,H.M., Cowan,C.S., Nadeau,S.,
            Graff-Meyer,A., Patino-Alvarez,C.P., Khani,M.H., Juttner,J. and
            Roska,B.
  TITLE     The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at
            the first synapse of vision
  JOURNAL   Neuron 112 (22), 3715-3733 (2024)
   PUBMED   39317184
REFERENCE   2  (bases 1 to 5141)
  AUTHORS   Collin,G.B., Shi,L., Yu,M., Akturk,N., Charette,J.R., Hyde,L.F.,
            Weatherly,S.M., Pera,M.F., Naggert,J.K., Peachey,N.S., Nishina,P.M.
            and Krebs,M.P.
  TITLE     A Splicing Mutation in Slc4a5 Results in Retinal Detachment and
            Retinal Pigment Epithelium Dysfunction
  JOURNAL   Int J Mol Sci 23 (4), 2220 (2022)
   PUBMED   35216333
  REMARK    GeneRIF: A Splicing Mutation in Slc4a5 Results in Retinal
            Detachment and Retinal Pigment Epithelium Dysfunction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5141)
  AUTHORS   Maddala,R., Gao,J., Mathias,R.T., Lewis,T.R., Arshavsky,V.Y.,
            Levine,A., Backer,J.M., Bresnick,A.R. and Rao,P.V.
  TITLE     Absence of S100A4 in the mouse lens induces an aberrant
            retina-specific differentiation program and cataract
  JOURNAL   Sci Rep 11 (1), 2203 (2021)
   PUBMED   33500475
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5141)
  AUTHORS   Zhang,D., Liu,C., Li,H. and Jiao,J.
  TITLE     Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to
            Neurogenic Abnormalities and Autistic-Like Behaviors
  JOURNAL   Adv Sci (Weinh) 7 (23), 2002117 (2020)
   PUBMED   33304758
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5141)
  AUTHORS   Barbuskaite,D., Pedersen,F.D., Christensen,H.L., Johnsen,L.O.,
            Praetorius,J. and Damkier,H.H.
  TITLE     NBCe2 (Slc4a5) Is Expressed in the Renal Connecting Tubules and
            Cortical Collecting Ducts and Mediates Base Extrusion
  JOURNAL   Front Physiol 11, 560 (2020)
   PUBMED   32547422
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5141)
  AUTHORS   Groger,N., Vitzthum,H., Frohlich,H., Kruger,M., Ehmke,H., Braun,T.
            and Boettger,T.
  TITLE     Targeted mutation of SLC4A5 induces arterial hypertension and renal
            metabolic acidosis
  JOURNAL   Hum Mol Genet 21 (5), 1025-1036 (2012)
   PUBMED   22082831
  REMARK    GeneRIF: study has shown that SLC4A5 is involved in the regulation
            of the acid-base balance as well as in the regulation of blood
            pressure; concludes that the impairment of the function of SLC4A5
            favors development of a hypertensive state
REFERENCE   7  (bases 1 to 5141)
  AUTHORS   Kao,L., Kurtz,L.M., Shao,X., Papadopoulos,M.C., Liu,L., Bok,D.,
            Nusinowitz,S., Chen,B., Stella,S.L., Andre,M., Weinreb,J.,
            Luong,S.S., Piri,N., Kwong,J.M., Newman,D. and Kurtz,I.
  TITLE     Severe neurologic impairment in mice with targeted disruption of
            the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5
            gene)
  JOURNAL   J Biol Chem 286 (37), 32563-32574 (2011)
   PUBMED   21705333
  REMARK    GeneRIF: targeted disruption of the Slc4a5 gene encoding the
            electrogenic sodium bicarbonate cotransporter NBCe2 results in
            significant remodeling of choroid plexus epithelial cells,
            including abnormal mitochondrial distribution.
REFERENCE   8  (bases 1 to 5141)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   9  (bases 1 to 5141)
  AUTHORS   Millar,I.D. and Brown,P.D.
  TITLE     NBCe2 exhibits a 3 HCO3(-):1 Na+ stoichiometry in mouse choroid
            plexus epithelial cells
  JOURNAL   Biochem Biophys Res Commun 373 (4), 550-554 (2008)
   PUBMED   18588858
  REMARK    GeneRIF: The NBCe2 mediates the efflux of HCO3(-) and Na(+) from
            the cell into the cerebrospinal fluid at the apical membrane of the
            choroid plexus.
REFERENCE   10 (bases 1 to 5141)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY732178.1, CK626530.1, CX562762.1, CO431509.1, AC160400.12,
            CF725373.1, CA526642.1, CO424019.1, CK626745.1, BB398090.2,
            CO428205.1 and BQ175480.1.
            
            On or before Oct 7, 2009 this sequence version replaced
            XM_913146.3, XM_888058.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.209780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               BY732178.1         1-367
            368-1003            CK626530.1         1-636
            1004-1441           CX562762.1         316-753
            1442-1601           CO431509.1         492-651
            1602-1749           AC160400.12        196781-196928
            1750-1883           AC160400.12        197876-198009
            1884-1914           AC160400.12        198881-198911
            1915-2578           CF725373.1         1-664
            2579-2926           CA526642.1         253-600
            2927-3258           CO424019.1         244-575
            3259-3632           CK626745.1         264-637
            3633-3995           BB398090.2         340-702
            3996-4610           CO428205.1         28-642
            4611-5141           BQ175480.1         1-531               c
FEATURES             Location/Qualifiers
     source          1..5141
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..5141
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /note="solute carrier family 4, sodium bicarbonate
                     cotransporter, member 5"
                     /db_xref="GeneID:232156"
                     /db_xref="MGI:MGI:2443220"
     exon            1..388
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            389..518
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..3471
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /note="anion exchange protein; solute carrier family 4
                     member 5"
                     /codon_start=1
                     /product="electrogenic sodium bicarbonate cotransporter 4"
                     /protein_id="NP_001159539.1"
                     /db_xref="CCDS:CCDS51819.1"
                     /db_xref="GeneID:232156"
                     /db_xref="MGI:MGI:2443220"
                     /translation="MDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLH
                     SLFELRTCLQTGTVLLDLDSCSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRKHRH
                     QTKKPIHRSLADIGKSVSTTNRSSARSSSAGPTLHRSTEDLRIRQSTSYGHLCHAQSR
                     SMNDISHTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLVQSAMLGGV
                     TEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDE
                     FLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAEPGQMNGSVGGGGASAGGGG
                     SGGGAGGSGAGGVGSGDEAEMPAMHEIGEELIWTGRFFGGLCLDVKRKLPWFPSDFYD
                     GFHLQSISAVLFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQ
                     PLIILSSTGPILIFEKLLFDFSKANGLDYMEFRLWIGLHSAIQCLILVATDASFIIKY
                     ITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINTDFKPDFITTYKCECVAPDTVNT
                     TTVNASAPLAPNTNTSLYTPLNLTALDWSLLSKKECLSYGGRLLGSSCQFVPDLALMS
                     FILFFGTYSMTLTLKKFKFSRYFPTKVRTLVADFSIVFSILLFCGIDACFGLQTPKLH
                     VPSVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENK
                     LRKAAGYHLDLFWVGILMALCSFTGLPWYVAATVISIAHIDSLKMETETSAPGEQPQF
                     LGVREQRVTGVMVFILTGISVFLAPILKYIPMPVLYGVFLYMGVASLNGIQFWERCKL
                     FLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLALLWILKSTMAAIIFPVMILGLIIV
                     RRLLDLIFSQHDLAWIDNILPEKDKKETDKKKKRRKEVHETAEKEVAMPQFLPPSVVK
                     IPMEGIPSDPQNGIHCVARKRSSSWSYSL"
     exon            519..679
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            680..832
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            833..928
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            929..984
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1142
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1230
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1385
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1574
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1749
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1883
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2155
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2214
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2415
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2529
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2691
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2870
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2943
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3012
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3186
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3351
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3436
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3504
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..5124
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3910..3915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3939
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /note="major polyA site"
     regulatory      4321..4326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4340
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
     regulatory      5094..5099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5124
                     /gene="Slc4a5"
                     /gene_synonym="C330006M16; C330016K18Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcagc tgccaccacc ctgctgctga ggagcacaca ggtccctgtt tgagcttcag
       61 cgctaagcct cctctctcca tcatacctca gattcccccg ccccctttct ttctcatttg
      121 ctggtttctc ccaggatttc cacgaaatca ctcacaccca tcgctatttc tctcgagccc
      181 caatccccca ccttccctct cgtccttctc ctgccctcct cctccatgcc tcccttgctg
      241 cttaactaga aacaaaagtg agtttgtttt gtggggaaga ggatactgga ggagacccac
      301 agccagggta gcagccacag aagcaggctg gggccagagg cagcaccaac ctccggagac
      361 tccagcgctc agctgttcca gggagcaggg tctccagctg ctgagcagct gcaggacatc
      421 ctgggggagg aagatgaggc tcccaacccc accctcttca cagagatgga cactctacag
      481 catgatgggg accagatgga gtggaaggag tcagccaggt ggataaaatt tgaagaaaag
      541 gtagaggaag gaggagaacg atggagcaag ccccatgtgt ccacgctgtc cctgcacagt
      601 ctctttgagc tccgcacctg cctgcagaca gggacagtgc tactggatct ggacagctgc
      661 tccctaccac agatcataga tgatgtcatt gagaagcaga tagaggatgg acttctgcga
      721 cctgagctcc gggagagggt cagctacgtg ctcctgagga agcatcgtca ccaaaccaag
      781 aagcccatcc accgttccct tgcagacatc gggaagtcgg tttccacgac gaaccgaagc
      841 tctgcccgga gctcctcagc aggcccaact ctgcaccgct ccactgagga cctgaggatt
      901 cgacaaagca ccagctatgg tcatctgtgt catgcccaga gtagaagcat gaatgacatc
      961 tctcataccc caaacacaga ccagcggaaa aacaaattca tgaagaagat tcccaaggac
     1021 tcagaagctt ccaacgtgct cgtgggcgag gtggacttcc tggaccagcc attcattgca
     1081 tttgttcgtc ttgtccagtc tgccatgctg ggaggggtga cagaggtgcc tgtccccacc
     1141 agatttctgt tcatactatt aggaccttcc gggagagcaa agtcctataa tgagattggc
     1201 cgagccatcg caaccctcat ggtggatgat ctattcagcg atgtggctta taaagctcgg
     1261 aaccgagaag atctgatcgc agggattgat gaatttctag acgaggtcat tgtccttccc
     1321 cctggagagt gggacccaaa catcagaatt gagccaccca agaaagttcc ctcagctgac
     1381 aagaggaaat ctgtgttctc tctggcagag ccgggccaga tgaatggctc tgtgggcgga
     1441 ggcggagcct cggctggagg aggcggcagt ggcggagggg ctggaggcag cggggctggc
     1501 ggagtgggca gtggcgacga agctgagatg ccagctatgc acgaaatcgg ggaggagctg
     1561 atctggaccg gaaggttctt tggaggactg tgtctggatg tcaagaggaa gctgccctgg
     1621 ttcccaagcg acttctatga tggcttccac ctccagtcca tctctgctgt tctgttcatc
     1681 tacctcggct gtattaccaa cgcgatcacc tttggtgggc ttctggggga tgccacagac
     1741 aactaccagg gagtaatgga gagcttcctg ggcactgcca tggctggcag cttgttctgc
     1801 ctcttctcgg ggcagcctct tatcatcctc agcagcacag gacccatcct catctttgag
     1861 aagctcctct ttgacttcag caaggccaat ggcctggact acatggagtt ccgcctctgg
     1921 attggtcttc actcagccat ccagtgcctt attctggtgg ccacagatgc cagctttatc
     1981 atcaagtata tcacccgctt caccgaagag ggcttctcca ccctcatcag cttcatcttc
     2041 atctacgacg ccatcaaaaa gatgattggt gccttcaaat actatcccat taacacggac
     2101 ttcaagcctg acttcatcac cacctacaaa tgcgagtgcg tcgctcctga cacagtgaac
     2161 acaaccacgg tcaatgcctc agccccactg gcaccaaaca ccaacacgtc tctgtacacc
     2221 ccccttaacc tcacagcgct ggactggtcc ctgctgagca agaaggagtg cctgagctac
     2281 ggcgggcgcc tgctcgggag ctcctgccag ttcgtcccag acctggcgct catgtccttc
     2341 atccttttct ttgggactta ctccatgacc ttgactctga agaaattcaa gttcagccgc
     2401 tattttccca ccaaggtccg gaccctggtg gctgacttct ccattgtatt ctccatcctg
     2461 cttttctgtg gaatcgatgc ctgttttggc ctgcagaccc caaagctgca cgtgcctagt
     2521 gtcattaagc ccacaaggcc cgaccgaggc tggttcgttg ccccctttgg gaagaaccct
     2581 tggtgggtgt accctgccag catcctgccg gccctgctgg tgaccatcct gatcttcatg
     2641 gaccagcaga tcaccgcagt cattgtcaac cggaaggaga acaagctgag gaaggccgct
     2701 ggctaccatc tggacctgtt ctgggtaggc atcctcatgg ctctgtgctc cttcaccggg
     2761 ctcccctggt acgtggctgc cacggtcatc tccatcgccc acatcgacag cctcaagatg
     2821 gagacggaga ccagtgcccc gggggaacag ccccagttcc tgggggtcag ggagcagaga
     2881 gttactggag tcatggtctt catcctgaca ggcatctccg tcttcctggc tcctatcctg
     2941 aagtacatcc ccatgccagt gctctatgga gtcttcctct acatgggtgt ggcctccctg
     3001 aatggcatcc agttctggga acgctgtaag cttttcctca tgccagccaa gcaccagccg
     3061 gaccacgctt tcctgcgcca cgtgcccctt cgccgcattc acctgttcac cctggtgcag
     3121 atcctctgcc tggccctgct ctggatcctt aagtcaacca tggctgccat catcttcccg
     3181 gtcatgatcc tgggccttat cattgttcga aggctcctgg acttgatttt ctcccagcat
     3241 gacctggcct ggattgacaa tatcctccca gagaaggaca aaaaggagac agacaagaag
     3301 aagaagagaa ggaaagaggt ccatgagacg gcagagaagg aggtggcaat gccccagttc
     3361 cttcctccct cagttgtaaa gatccccatg gaaggtatcc catctgatcc ccaaaacggt
     3421 atccactgtg ttgccagaaa aagatcttcc agttggagtt actctctctg actcctccat
     3481 cagtggctca gaactggatc gaagcatcac cctgcatttc aaaatctctt gcccggcttc
     3541 acctgctttc agctactcac ggagtccggt cttcatggtg ccgcaggtga ggatagagat
     3601 ggaatctgag ctcaacctca cagacgacga cgaggaggac tatgggagag aggtgggcgg
     3661 ggagaccacc ctctagtcca gcgctgctct tccagactgg gggcagggga aagcctggct
     3721 ggcttcatct agagggtgtc aagccttaca cctgcttcct tacccaccga ccagagagac
     3781 aactggaggc ctttcaggga cctccgacat agacacagcg ctcccccctt ccccttgcag
     3841 ttctgaaaat accgaaaaca tacagcttaa aatgccaccc accatagata taacctttct
     3901 cgtgaaaaga ataaaaatgt tttccaaagt tacaaataag gcaagtggcc agtggtggac
     3961 ttacatttaa aatataaact gatttagtct tctctatgta agacaaatgc cagtttagta
     4021 tctttcaaag gtttgattga tgtctaagtg acttgatggt attgaaggtc tgaatgagtc
     4081 ctgcaggttt gcacggtagg acatggcttt cacctccttc tccttgaagt cctctgttca
     4141 gtgggcttgg ctttttaagt gtggctgggc cttccacaca ctgaatagcc agctctaaaa
     4201 ttattgctgt tagaatctgt gtattagtgg attgtttttg agatgggttc tcactgtgta
     4261 ccctcagctt tcctggaaag ccagctagcc tcagaattca gagacccacc tgtctctgag
     4321 attaaaggca tgtgccgcca catctggctc tgagtggatt gtttttaagg caaaatagtg
     4381 cccattagct gaactcttaa gtcacattag gtcaaccaaa tgacccttta agtttgtcac
     4441 tggcttcata acctggagtc catctacttg atgatgtatt tgagtaggtc ctctctctcc
     4501 ctgcacaatt ttgcaatagc taaagcccaa atttccaatc tcaagaacat tgcatgctag
     4561 gcagctaatg tttgtaatca aaggagtact ttataccagt ggttggaaga ggcaccattc
     4621 ccagctgggg taagactgcc agctcttcac tgatccaaac cctttccaac acaaaactgt
     4681 tcatcttcct ctgcaccaat cctgggagaa ctaacggcat ccacatttca atctcactga
     4741 tctgtagtag cactctctcc agatgattaa actgtagcat cgttacggac tcactctctc
     4801 cagattaaac tgtagcatcg ttacggactc actctctcca gattaaactg tagcatcgtt
     4861 acggactcac tctctccaga ttaaactgta gcatcgttac ggactcggag agaagcgtgc
     4921 ttccagtaac caaatgagct ggagaaccag ttagctttta aaaggctgat cattctgtct
     4981 cagttttacc ttaaataccg tttatatttt gtgtacacgt gaacactttc actggtgtat
     5041 tacccttcca ttcacttagg agtttctttc atctctaatg taaactgctc ttcaataaag
     5101 cctcaatcgt gtctgcttac cttaaaaaaa aaaaaaaaaa a
//
