LOCUS       NM_001357150            4128 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Mus musculus solute carrier family 4 (anion exchanger), member 3
            (Slc4a3), transcript variant 3, mRNA.
ACCESSION   NM_001357150 XM_006496449
VERSION     NM_001357150.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4128)
  AUTHORS   Morikawa,R., Rodrigues,T.M., Schreyer,H.M., Cowan,C.S., Nadeau,S.,
            Graff-Meyer,A., Patino-Alvarez,C.P., Khani,M.H., Juttner,J. and
            Roska,B.
  TITLE     The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at
            the first synapse of vision
  JOURNAL   Neuron 112 (22), 3715-3733 (2024)
   PUBMED   39317184
REFERENCE   2  (bases 1 to 4128)
  AUTHORS   Vairamani,K., Wang,H.S., Medvedovic,M., Lorenz,J.N. and Shull,G.E.
  TITLE     RNA SEQ Analysis Indicates that the AE3 Cl-/HCO3- Exchanger
            Contributes to Active Transport-Mediated CO2 Disposal in Heart
  JOURNAL   Sci Rep 7 (1), 7264 (2017)
   PUBMED   28779178
  REMARK    GeneRIF: These results support a model in which the AE3
            Cl(-)/HCO3(-) exchanger, coupled with parallel Cl(-) and
            H(+)-extrusion mechanisms and extracellular carbonic anhydrase, is
            responsible for active transport-mediated disposal of CO2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4128)
  AUTHORS   Salameh,A.I., Hubner,C.A. and Boron,W.F.
  TITLE     Role of Cl- -HCO3- exchanger AE3 in intracellular pH homeostasis in
            cultured murine hippocampal neurons, and in crosstalk to adjacent
            astrocytes
  JOURNAL   J Physiol 595 (1), 93-124 (2017)
   PUBMED   27353306
  REMARK    GeneRIF: These findings suggest a new type of neuron-astrocyte
            communication, based on the expression of AE3 in neurons, which
            could explain how AE3 reduces seizure susceptibility
REFERENCE   4  (bases 1 to 4128)
  AUTHORS   Taylor-Burds,C., Cheng,P. and Wray,S.
  TITLE     Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons:
            Implications for GABAA Mediated Excitation
  JOURNAL   PLoS One 10 (6), e0131076 (2015)
   PUBMED   26110920
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4128)
  AUTHORS   Kampik,N.B., Gehring,N., Schnitzbauer,U., Hennings,J.C.,
            Hubner,C.A. and Wagner,C.A.
  TITLE     The murine Cl/HCO exchanger Ae3 (Slc4a3) is not required for
            acid-base balance but is involved in magnesium handling by the
            kidney
  JOURNAL   Cell Physiol Biochem 34 (5), 1566-1577 (2014)
   PUBMED   25402438
  REMARK    GeneRIF: Ae3 is expressed in murine kidney at very low levels.
REFERENCE   6  (bases 1 to 4128)
  AUTHORS   Zhao,Y., Chauvet,P.J., Alper,S.L. and Baltz,J.M.
  TITLE     Expression and function of bicarbonate/chloride exchangers in the
            preimplantation mouse embryo
  JOURNAL   J Biol Chem 270 (41), 24428-24434 (1995)
   PUBMED   7592657
REFERENCE   7  (bases 1 to 4128)
  AUTHORS   White,R.A., Geissler,E.N., Adkison,L.R., Dowler,L.L., Alper,S.L.
            and Lux,S.E.
  TITLE     Chromosomal location of the murine anion exchanger genes encoding
            AE2 and AE3
  JOURNAL   Mamm Genome 5 (12), 827-829 (1994)
   PUBMED   7894173
REFERENCE   8  (bases 1 to 4128)
  AUTHORS   Linn,S.C., Kudrycki,K.E. and Shull,G.E.
  TITLE     The predicted translation product of a cardiac AE3 mRNA contains an
            N terminus distinct from that of the brain AE3 Cl-/HCO3- exchanger.
            Cloning of a cardiac AE3 cDNA, organization of the AE3 gene, and
            identification of an alternative transcription initiation site
  JOURNAL   J Biol Chem 267 (11), 7927-7935 (1992)
   PUBMED   1560021
REFERENCE   9  (bases 1 to 4128)
  AUTHORS   Kudrycki,K.E., Newman,P.R. and Shull,G.E.
  TITLE     cDNA cloning and tissue distribution of mRNAs for two proteins that
            are related to the band 3 Cl-/HCO3- exchanger
  JOURNAL   J Biol Chem 265 (1), 462-471 (1990)
   PUBMED   2294114
REFERENCE   10 (bases 1 to 4128)
  AUTHORS   Kopito,R.R., Lee,B.S., Simmons,D.M., Lindsey,A.E., Morgans,C.W. and
            Schneider,K.
  TITLE     Regulation of intracellular pH by a neuronal homolog of the
            erythrocyte anion exchanger
  JOURNAL   Cell 59 (5), 927-937 (1989)
   PUBMED   2686841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115011.27.
            
            On Oct 23, 2017 this sequence version replaced XM_006496449.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.31343.1,
                                           SRR1660817.154328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC115011.27        37717-37868         c
            153-302             AC115011.27        37409-37558         c
            303-468             AC115011.27        36932-37097         c
            469-746             AC115011.27        36109-36386         c
            747-862             AC115011.27        35899-36014         c
            863-1059            AC115011.27        35265-35461         c
            1060-1208           AC115011.27        33678-33826         c
            1209-1389           AC115011.27        33395-33575         c
            1390-1525           AC115011.27        32948-33083         c
            1526-1709           AC115011.27        32510-32693         c
            1710-1809           AC115011.27        32078-32177         c
            1810-1994           AC115011.27        31523-31707         c
            1995-2220           AC115011.27        30849-31074         c
            2221-2439           AC115011.27        30488-30706         c
            2440-2588           AC115011.27        30022-30170         c
            2589-2783           AC115011.27        29634-29828         c
            2784-3002           AC115011.27        29189-29407         c
            3003-3092           AC115011.27        28830-28919         c
            3093-3259           AC115011.27        28225-28391         c
            3260-3513           AC115011.27        27333-27586         c
            3514-3683           AC115011.27        26888-27057         c
            3684-3857           AC115011.27        26530-26703         c
            3858-4128           AC115011.27        25247-25517         c
FEATURES             Location/Qualifiers
     source          1..4128
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 39.16 cM"
     gene            1..4128
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /note="solute carrier family 4 (anion exchanger), member
                     3"
                     /db_xref="GeneID:20536"
                     /db_xref="MGI:MGI:109350"
     exon            1..152
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            153..302
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            303..468
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            469..746
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            747..862
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1059
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1208
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1389
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1525
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1709
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1809
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1994
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2220
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2439
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2588
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2783
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..3002
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3092
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3259
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..3513
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3683
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..3857
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     exon            3858..4128
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4106..4111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /note="hexamer: ATTACA"
     polyA_site      4128
                     /gene="Slc4a3"
                     /gene_synonym="A930038D23Rik; Ae3"
                     /note="major polyA site"
ORIGIN      
        1 gtggactgca ggctccggcg cctgcgtccg cctggccggg ctctgcgcgg cgagaggccg
       61 gacgggaacc cggcagccgc gccccggagc ttgcggggag ggacatgggg cgcggcggct
      121 ctcccaagcc ccgcaggttc cggagcccgg aggctcccca agaggtctct gcagcgcccc
      181 cttcttctca cccagggttt gggtcccata gtgattgaga gactcctaag tcttcagtct
      241 tcagccctgc catggctaat ggggtgatcc cgccgcccgg gggcgcctcc cccctacccc
      301 aggtccgggt gcccttggag gagccccctc tgggtccaga tgtagaagag gaagatgatg
      361 acttgggcaa gaccttggct gtgagcaggt ttggggacct catcagcaag accccggcct
      421 gggaccccga gaagcctagc cgcagctaca gcgagcggga ctttgagttt caccggcaca
      481 catcccacca cacccatcac ccgctctcag cccgcctgcc tccaccccac aagcttcggc
      541 gaccgccccc cacctctgct cggcacacca ggaggaagag gaagaaagag aaaacctctg
      601 ctcccccatc agaagggaca ccccctatcc aggaggaggg gggagctgga gcagaagagg
      661 aggaggagga agaagaggaa gaagagggag agtctgaggc agagcctgtg gagcctctac
      721 ccccaggtcc cccacagaaa gcaaagttct ccattggaag tgatgaagat gacagcccag
      781 gccttcctgt caaggctccc tgtgccaagg ccttgccttc tgtgggcctg cagtctgacc
      841 agagccccca gcgctccggc agctccccca gtccccgggc ccgggcttcc cgaatctcca
      901 cagagaagag ccggccctgg agtccatcag ccagctatga cctgcgggag cgattgtgcc
      961 caggcagtgc cctgggcaac cctgggccag agcagcgggt gcccactgac gaggcggagg
     1021 ctcaaatgtt gggttctgcc gatctggacg acatgaagag tcatcggctg gaggataacc
     1081 ccggggtgcg gcgacacttg gtgaagaaac catcccggat acagggtggg agaggcagcc
     1141 ccagtggcct ggcgcccatc ttgcgcagga aaaagaagaa gaagaagctg gatcggaggc
     1201 ctcatgaggt gttcgtggag ctgaatgagc tgatgttgga ccggagccag gagccacact
     1261 ggcgggagac agcacgctgg atcaagttcg aggaggatgt ggaggaggag acggagcgct
     1321 gggggaagcc tcacgttgct tcgctctcct tccgtagcct gctggaactt aggaggacca
     1381 ttgcccaggg agcggctctc ctggacctgg aacagaccac cctgccgggt atcgctcacc
     1441 ttgtggtgga gaccatgatt gtatctgacc agatccggcc tgaggacagg gctagtgttc
     1501 tgaggactct actcctgaaa cacagccatc ccaacgatga caaggacagt ggctttttcc
     1561 cccgaaatcc gtcaagctcc agtgtgaact cagtcttggg gaatcaccac ccaactccta
     1621 gtcatggccc tgatggtgcg gtccccacca tggctgatga ccaaggagag ccagccccgt
     1681 tgtggccaca tgaccctgat gctaaggaga agcccctcca catgcctggg ggagacggtc
     1741 accgagggaa aagcctgaaa ctgctggaga agatcccgga ggacgccgag gccactgtcg
     1801 tgcttgtggg ctgcgtgcct ttcttggagc agccggcggc agcttttgtg cggctcagcg
     1861 aggctgttct cttggagtct gtgctggagg tccccgtgcc tgttcgcttc ctctttgtga
     1921 tgctggggcc cagccatacc agcactgact atcacgaatt agggcgctcc attgccacac
     1981 tcatgtctga caagctcttt cacgaggctg cctatcaggc agatgaccgg caggaccttt
     2041 tgggtgccat cagcgagttt ttggatggta gcattgtgat tcccccgtcg gaggtggagg
     2101 gccgagacct actacgttcg gtggctgcct tccagcgaga gctgctgagg aagcggcggg
     2161 agcgggaaca gaccaaggtg gagatgacca cccggggggg ctatgcggcc cctggcaaag
     2221 agctgtcttt ggagatgggg ggctccgagg caacctctga agacgatccc ctgcagcgga
     2281 caggctcagt gtttgggggg ctagtgcgag atgtgaagcg ccgttacccg cactacccca
     2341 gtgacctgcg ggatgctctg cactcccagt gtgtggctgc tgtgctcttt atctatttcg
     2401 cggccctcag tcctgctatc acctttgggg ggcttttagg agagaaaaca gaggggctca
     2461 tgggcgtgtc agagctgatt gtgtccacgg ctgtgcttgg ggtccttttc tctctgctcg
     2521 gggcccagcc gctgctcgtg gtaggcttct ctgggcctct gctggtcttt gaagaagctt
     2581 tcttcaagtt ctgccgagct caggacctgg agtacctcac cggtcgagtg tgggtgggcc
     2641 tctggctggt ggtcttcgtc ctggccctgg tggctgcgga gggcagcttc cttgtccgct
     2701 acatctcgcc attcacccag gagatctttg ctttcctcat ctcgctaatt ttcatctatg
     2761 agacgtttca caagctctac aaggtgttca cagagcatcc tctgctgcca ttctacccac
     2821 cggatgaggc cctggagact ggcttggaac tgaatagtag tgccctgccc cccacagagg
     2881 gaccaccagg cccgaggaac caacccaaca cagctctgct gtccctcatt ctcatgctgg
     2941 ggacgttcct cattgccttc ttcttgcgca agttcaggaa cagccgcttc ctggggggca
     3001 aggctcggcg catcatcggg gattttggca ttcccatctc catcctggtg atggtccttg
     3061 tggattattc tatcacagac acctacacac agaagctgac ggtgcctaca gggctctcag
     3121 tgacttcccc tcataagcgc acatggttca tcccaccctt gggcagtgcc cgccccttcc
     3181 caccatggat gatggtggct gctgctgtcc ccgcgctctt ggtcctcatc ctcatattca
     3241 tggagacaca gatcactgcg ctcattgtca gccagaaggc acggaggcta ctcaagggct
     3301 ccggcttcca tcttgacctg cttttgattg gctctttggg cggcctctgt ggcttgttcg
     3361 gcttgccctg gctcacagct gccactgtgc gctctgtcac tcatgtcaac gcgttgacgg
     3421 taatgcggac tgccattgcg cccggtgaca agccccagat ccaggaggtg cgggagcagc
     3481 gggtcaccgg ggtgctcatt gccagcctcg tgggcctgtc tatcgtcatg ggagctgtgt
     3541 tgcgccggat cccattggct gtactcttcg ggattttcct gtacatgggc gtcacatcac
     3601 tgtctggtat ccaattgtcc caacgtctgc tgctcatttt catgccagca aagcaccatc
     3661 ctgagcagcc ctacgtgacc aaggtgaaga catggcggat gcacctgttc acctgcatcc
     3721 agctgggctg cattgcactt ctctgggtgg tcaagtcaac ggcggcctcg ctggcctttc
     3781 ctttcctgct cttgctcacg gtgcctctga ggcgttgcct tttgccccgg ctcttccagg
     3841 acagggagct gcaggcgctg gactctgaag atgcggagcc gaactttgac gaggatggtc
     3901 aggacgagta caacgagctg cacatgcctg tgtgacctgc aggatggtgc ccctccgaga
     3961 ccccaccttg gcgattcaca gaccctagga acccagcacc agggccaggc attcctcaga
     4021 cccagggatg tgcctggagt cactgcccat gccaggccag tggccccttg actttcacag
     4081 cccagacggc accggctttg aagtcattac aacacactcc gtgtcttg
//
