LOCUS       NM_009207               4202 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 4 (anion exchanger), member 2
            (Slc4a2), transcript variant 1, mRNA.
ACCESSION   NM_009207
VERSION     NM_009207.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4202)
  AUTHORS   Xue,J.Y., Ikegawa,S. and Guo,L.
  TITLE     SLC4A2, another gene involved in acid-base balancing machinery of
            osteoclasts, causes osteopetrosis
  JOURNAL   Bone 167, 116603 (2023)
   PUBMED   36343920
  REMARK    GeneRIF: SLC4A2, another gene involved in acid-base balancing
            machinery of osteoclasts, causes osteopetrosis.
            Review article
REFERENCE   2  (bases 1 to 4202)
  AUTHORS   Parichha,A., Suresh,V., Chatterjee,M., Kshirsagar,A.,
            Ben-Reuven,L., Olender,T., Taketo,M.M., Radosevic,V.,
            Bobic-Rasonja,M., Trnski,S., Holtzman,M.J., Jovanov-Milosevic,N.,
            Reiner,O. and Tole,S.
  TITLE     Constitutive activation of canonical Wnt signaling disrupts choroid
            plexus epithelial fate
  JOURNAL   Nat Commun 13 (1), 633 (2022)
   PUBMED   35110543
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4202)
  AUTHORS   Pena-Munzenmayer,G., Kondo,Y., Salinas,C., Sarmiento,J., Brauchi,S.
            and Catalan,M.A.
  TITLE     Activation of the Ae4 (Slc4a9) cation-driven Cl-/HCO3- exchanger by
            the cAMP-dependent protein kinase in salivary gland acinar cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 321 (6), G628-G638 (2021)
   PUBMED   34585968
REFERENCE   4  (bases 1 to 4202)
  AUTHORS   Itoh,R., Hatano,N., Murakami,M., Mitsumori,K., Kawasaki,S.,
            Wakagi,T., Kanzaki,Y., Kojima,H., Kawaai,K., Mikoshiba,K.,
            Hamada,K. and Mizutani,A.
  TITLE     Both IRBIT and long-IRBIT bind to and coordinately regulate
            Cl-/HCO3- exchanger AE2 activity through modulating the lysosomal
            degradation of AE2
  JOURNAL   Sci Rep 11 (1), 5990 (2021)
   PUBMED   33727633
  REMARK    GeneRIF: Both IRBIT and long-IRBIT bind to and coordinately
            regulate Cl(-)/HCO3(-) exchanger AE2 activity through modulating
            the lysosomal degradation of AE2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4202)
  AUTHORS   Vong,K.I., Ma,T.C., Li,B., Leung,T.C.N., Nong,W., Ngai,S.M.,
            Hui,J.H.L., Jiang,L. and Kwan,K.M.
  TITLE     SOX9-COL9A3-dependent regulation of choroid plexus epithelial
            polarity governs blood-cerebrospinal fluid barrier integrity
  JOURNAL   Proc Natl Acad Sci U S A 118 (6) (2021)
   PUBMED   33526661
REFERENCE   6  (bases 1 to 4202)
  AUTHORS   Zhao,Y., Chauvet,P.J., Alper,S.L. and Baltz,J.M.
  TITLE     Expression and function of bicarbonate/chloride exchangers in the
            preimplantation mouse embryo
  JOURNAL   J Biol Chem 270 (41), 24428-24434 (1995)
   PUBMED   7592657
REFERENCE   7  (bases 1 to 4202)
  AUTHORS   Lindsey,A.E., Schneider,K., Simmons,D.M., Baron,R., Lee,B.S. and
            Kopito,R.R.
  TITLE     Functional expression and subcellular localization of an anion
            exchanger cloned from choroid plexus
  JOURNAL   Proc Natl Acad Sci U S A 87 (14), 5278-5282 (1990)
   PUBMED   2371270
REFERENCE   8  (bases 1 to 4202)
  AUTHORS   Kudrycki,K.E., Newman,P.R. and Shull,G.E.
  TITLE     cDNA cloning and tissue distribution of mRNAs for two proteins that
            are related to the band 3 Cl-/HCO3- exchanger
  JOURNAL   J Biol Chem 265 (1), 462-471 (1990)
   PUBMED   2294114
REFERENCE   9  (bases 1 to 4202)
  AUTHORS   Alper,S.L., Kopito,R.R., Libresco,S.M. and Lodish,H.F.
  TITLE     Cloning and characterization of a murine band 3-related cDNA from
            kidney and from a lymphoid cell line
  JOURNAL   J Biol Chem 263 (32), 17092-17099 (1988)
   PUBMED   3182834
REFERENCE   10 (bases 1 to 4202)
  AUTHORS   Palumbo,A.P., Isobe,M., Huebner,K., Shane,S., Rovera,G., Demuth,D.,
            Curtis,P.J., Ballantine,M., Croce,C.M. and Showe,L.C.
  TITLE     Chromosomal localization of a human band 3-like gene to region
            7q35----7q36
  JOURNAL   Am J Hum Genet 39 (3), 307-316 (1986)
   PUBMED   3020980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ110714.1, AK145930.1 and BC054102.1.
            
            On Nov 28, 2007 this sequence version replaced NM_009207.2.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145930.1, SRR11927938.3909485.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                CJ110714.1         1-77
            78-1327             AK145930.1         3-1252
            1328-2409           BC054102.1         1137-2218
            2410-3726           AK145930.1         2335-3651
            3727-4202           BC054102.1         3536-4011
FEATURES             Location/Qualifiers
     source          1..4202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.74 cM"
     gene            1..4202
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /note="solute carrier family 4 (anion exchanger), member
                     2"
                     /db_xref="GeneID:20535"
                     /db_xref="MGI:MGI:109351"
     exon            1..204
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            205..318
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..3981
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /note="isoform 1 is encoded by transcript variant 1; anion
                     exchange protein 2; AE 2; band 3-related protein; solute
                     carrier family 4 member 2; non-erythroid band 3-like
                     protein; anion exchanger 2 type b2; anion exchanger 2 type
                     b1; anion exchanger 2 type c1; anion exchanger 2 type c2"
                     /codon_start=1
                     /product="anion exchange protein 2 isoform 1"
                     /protein_id="NP_033233.2"
                     /db_xref="CCDS:CCDS19119.1"
                     /db_xref="GeneID:20535"
                     /db_xref="MGI:MGI:109351"
                     /translation="MSSAPRRPASGADSLHTPEPESLSPGTPGFPEQEEDELRTLGVE
                     RFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPG
                     RKPRRRPGASPTGETPTIEEGEEDEEEASEAEGFRAPPQQPSPATTPSAVQFFLQEDE
                     GAERKPERTSPSPPTQTPHQEAAPRASKGAQTGTLVEEMVAVASGTAGGDDGGAAGRP
                     LTKAQPGHRSYNLQERRRIGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFED
                     VPGVRRHLVRKNAKGSTQAAREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEP
                     QWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPG
                     VAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKEFSFPRNISAGSLGSLLGHH
                     HAQGTESDPHVTEPLIGGVPETRLEVDRERELPPPAPPAGITRSKSKHELKLLEKIPE
                     NAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYH
                     EIGRSISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELLRSVAH
                     FQRQMLKKREEQGRLLPPGAGLEPKSAQDKALLQMVEVAGAAEDDPLRRTGRPFGGLI
                     RDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTKDLIGVSELI
                     MSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNELEYLVGRVWIGFWLVF
                     LALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPLHGCSGSND
                     SEAGSSSSSNMTWATTILVPDNSSASGQSGQEKPRGQPNTALLSLVLMAGTFFIAFFL
                     RKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKR
                     GWVINPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHL
                     DLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVT
                     GLLVALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHP
                     DVTYVKKVRTMRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIF
                     TEREMKCLDANEAEPVFDECEGVDEYNEMPMPV"
     exon            319..481
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            482..726
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            727..845
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1078
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1221
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1402
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1538
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1704
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1819
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..2004
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2230
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2446
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2595
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2790
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..3045
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3135
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3302
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3556
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3726
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3900
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..4176
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4156..4161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /note="hexamer: AGTAAA"
     polyA_site      4176
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; B3RP"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgcgca cggcgcgctg cggggggcgc gcacgctgga ggctggcctg cccgcagcgc
       61 gggggaaagt tgagttggga gaagttggga gcggcggggg cgcgccccgg ggtgggcacc
      121 gggaaatcgt cgggagcgcg cgagggttcc ggaggatcag gggagacccg gagacccccg
      181 ggacacgaaa tctagagcta gcgggttatg cctccacctt gttgccctga aagccgaagc
      241 gacagcgaga agggctaaga tttggccatg agcagcgccc ccaggcgccc cgcctcgggc
      301 gcagattctt tgcacacgcc agagccagag agcctgagcc ccggaacacc tgggttcccc
      361 gagcaagagg aagatgaact tcgtacctta ggtgtggagc ggttcgagga gatcctccag
      421 gaggctggat cccggggagg agaagagcca ggacgaagct atggagagga agactttgaa
      481 taccaccgcc agtcctccca ccatatccat catccgctat ccacccacct gcctcctgat
      541 gcccgccgtc gcaagactcc ccagggccca ggacggaaac ctcggaggcg ccctggtgcc
      601 tctcccactg gagagacccc cactattgag gaaggggagg aagatgagga agaagctagt
      661 gaagctgaag ggttcagagc tcccccacaa caaccatctc ctgctactac accctctgca
      721 gttcagttct ttctccaaga ggatgaaggt gcagaaagga agccagagag aaccagccca
      781 tctcccccta cacagacgcc ccaccaggag gcagctcccc gggccagcaa aggggcacag
      841 acaggaactc tggtggagga gatggtggcg gtggccagtg gcacagctgg aggtgacgac
      901 ggaggtgctg cggggcgtcc cttgaccaaa gcccagcctg gacatcgaag ttacaacctt
      961 caggagcgaa gacgaattgg cagtatgaca ggggtggagc aggcgctgtt gcctagggtc
     1021 cctactgatg aaagtgaggc tcagacactg gccacagccg accttgacct catgaaaagt
     1081 caccgatttg aggatgttcc tggggtacgg cgacacttgg tgaggaagaa tgccaaaggg
     1141 tctacacagg ctgcccggga aggtcgagag cctggcccca cacctcgggc acggccacgg
     1201 gccccgcata agccccatga ggtgtttgtg gagctgaatg agctgctgtt ggacaaaaac
     1261 caggagcctc agtggcggga gacagcccgc tggataaaat tcgaggagga tgtggaagag
     1321 gagactgagc gctgggggaa gcctcatgtg gcctcactgt ccttccgcag cctcctggag
     1381 ctccgcagga ctctggccca tggagctgtg ctcttagacc tcgatcagca gaccctgcct
     1441 ggggtggccc atcaggtggt cgagcagatg gtcatctctg accagatcaa ggcagaggat
     1501 agagccaatg tgctacgggc cctcctgcta aagcacagcc acccaagtga cgagaaagag
     1561 ttctccttcc cccgaaacat ctcagcgggc tctctaggct ctctactggg gcatcaccat
     1621 gcccagggga ccgagagtga tcctcatgtc actgagcctc tcattggtgg tgttcctgag
     1681 acccgactgg aggtggatag agagcgtgag ctaccacccc cagcaccacc tgcaggtatt
     1741 acccgctcca agtccaagca tgagctgaag ctgctggaga agatccctga gaatgcggag
     1801 gctacagtgg tcctcgtggg ctgtgtggag ttcctctccc gccctaccat ggccttcgtg
     1861 cggttgcggg aggctgtgga gctggatgcc gtgctagagg tgcctgtgcc tgtgcgcttc
     1921 ctcttcttgc tgctgggtcc cagcagtgct aacatggact accatgagat cggccgctcc
     1981 atttccaccc tcatgtctga caagcaattt catgaggcag cctacctggc ggatgaacga
     2041 gacgacttgc tgactgctat caatgccttc ctggactgca gtgttgtgct accgccttct
     2101 gaagtgcagg gcgaggagct gctgcgttct gttgcccatt tccaacgcca gatgctaaag
     2161 aagcgagagg agcagggccg cctgctgccc ccaggggctg ggctagagcc caagtctgcc
     2221 caagataagg cactcctgca gatggtagag gtggcaggtg cagctgaaga tgatcccctt
     2281 cggaggacag gccggccctt tggggggctg atccgtgacg tgcggcggcg ctacccccac
     2341 tacctaagtg acttccgcga tgcacttgac ccccagtgcc tggctgctgt tattttcatc
     2401 tactttgccg ccctgtctcc tgccatcacc tttggggggc tactggggga gaagacaaag
     2461 gacctgatag gagtgtcaga gctgatcatg tccacagcgc tgcagggagt ggtcttctgc
     2521 ctgctggggg ctcagcccct gctggtcatc ggcttttctg ggcctctgct ggtcttcgag
     2581 gaggccttct tctcgttctg cagtagcaat gagttggagt acttggtggg ccgagtgtgg
     2641 attggcttct ggctggtgtt cctggccctg ctcatggtgg ctctggaggg gagcttcctg
     2701 gtccgctttg tatcccgatt cacccaggag atctttgcct tcctcatatc actcatcttc
     2761 atctacgaga ccttctataa gctgatcaag atcttccagg agcacccact ccatggctgc
     2821 tcaggctcca acgactcaga ggcaggcagc agcagcagca gcaatatgac atgggcaaca
     2881 accatactgg taccagacaa cagcagcgct tctgggcagt ctgggcagga gaagccccgg
     2941 ggccagccca acacagcttt gctatcgctg gtgctaatgg ctggcacttt cttcattgcc
     3001 ttcttcctgc gcaagttcaa gaacagccgg ttcttccctg gccggatccg gcgggtaatt
     3061 ggggactttg gggtgcccat cgcgatcctc atcatggtgc ttgtggatta cagtattgag
     3121 gacacctaca cccagaaact gagtgtgccc agcggattct cagtgacagc cccagacaag
     3181 cggggctggg tcatcaaccc ccttggagaa aagaccccct tccctgtgtg gatgatggtg
     3241 gccagcctgc tgcctgctgt tctggtgttc atcctcatct tcatggagac acagatcacc
     3301 acgctgatca tctccaagaa agagaggatg ctgcagaagg gctctggctt ccatctcgac
     3361 ctgttgctca ttgtagccat gggtggcatc tgtgccctct ttggcctgcc ttggttggcc
     3421 gctgccactg tccgctctgt cacccatgcc aatgcactca ctgtcatgag caaggctgtg
     3481 gcacctgggg acaaacccaa gattcaggaa gtcaaggaac agcgtgtgac agggctgctg
     3541 gtggccctgc ttgtgggcct ctccatggtc attggggacc tcctgcggca gatccccctg
     3601 gctgtgctct ttggcatttt cttgtacatg ggagtcacct ccctcaatgg gatccagttc
     3661 tacgagcggc tgcacctgct gctcatgccg cccaaacacc acccagatgt cacctatgtc
     3721 aaaaaggttc ggaccatgcg gatgcacctg ttcactgcct tgcagttgct ctgcctggcc
     3781 ctgctttggg cagtcatgtc cacagccgct tccctggcct tccccttcat cctcatcctc
     3841 acagtgcctt tgcgcatggt ggtacttacc cgaatcttca ctgagcgaga aatgaaatgt
     3901 ctggatgcta atgaggcaga gccagtgttt gacgagtgtg aaggtgtgga tgagtacaac
     3961 gagatgccca tgcctgtgta gctgctgtcc agaggcacag cagagggact gaggggcagg
     4021 gggcccatgc ctgtgtaact gctgtccaga ggcacagcag agggactaag gggtgagggc
     4081 tgggggtcct ctcctcctgc ccctcctcat ttttatttaa gtgaataatt taaagccccc
     4141 ttctccctat cctgcagtaa agtgcttcaa ccccaaaaaa aaaaaaaaaa aaaaaaaaaa
     4201 aa
//
