LOCUS       NM_001081162            3201 bp    mRNA    linear   ROD 13-AUG-2024
DEFINITION  Mus musculus solute carrier family 4, sodium bicarbonate
            transporter-like, member 11 (Slc4a11), mRNA.
ACCESSION   NM_001081162 XM_194050
VERSION     NM_001081162.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3201)
  AUTHORS   Murugan,S., de Campos,V.S., Ghag,S.A., Ng,M. and Shyam,R.
  TITLE     Characterization of a Novel Mouse Model for Fuchs Endothelial
            Corneal Dystrophy
  JOURNAL   Invest Ophthalmol Vis Sci 65 (4), 18 (2024)
   PUBMED   38587441
REFERENCE   2  (bases 1 to 3201)
  AUTHORS   Ogando,D.G., Kim,E.T., Li,S. and Bonanno,J.A.
  TITLE     Corneal Edema in Inducible Slc4a11 Knockout Is Initiated by
            Mitochondrial Superoxide Induced Src Kinase Activation
  JOURNAL   Cells 12 (11), 1528 (2023)
   PUBMED   37296649
  REMARK    GeneRIF: Corneal Edema in Inducible Slc4a11 Knockout Is Initiated
            by Mitochondrial Superoxide Induced Src Kinase Activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3201)
  AUTHORS   Quade,B.N., Marshall,A. and Parker,M.D.
  TITLE     Corneal dystrophy mutations R125H and R804H disable SLC4A11 by
            altering the extracellular pH dependence of the intracellular pK
            that governs H+(OH-) transport
  JOURNAL   Am J Physiol Cell Physiol 323 (4), C990-C1002 (2022)
   PUBMED   35993514
  REMARK    GeneRIF: Corneal dystrophy mutations R125H and R804H disable
            SLC4A11 by altering the extracellular pH dependence of the
            intracellular pK that governs H(+)(OH(-)) transport.
REFERENCE   4  (bases 1 to 3201)
  AUTHORS   Ogando,D.G. and Bonanno,J.A.
  TITLE     RNA sequencing uncovers alterations in corneal endothelial
            metabolism, pump and barrier functions of Slc4a11 KO mice
  JOURNAL   Exp Eye Res 214, 108884 (2022)
   PUBMED   34871568
  REMARK    GeneRIF: RNA sequencing uncovers alterations in corneal endothelial
            metabolism, pump and barrier functions of Slc4a11 KO mice.
REFERENCE   5  (bases 1 to 3201)
  AUTHORS   Alvarez,B.V., Piche,M., Aizouki,C., Rahman,F., Derry,J.M.J.,
            Brunette,I. and Casey,J.R.
  TITLE     Altered gene expression in slc4a11-/- mouse cornea highlights
            SLC4A11 roles
  JOURNAL   Sci Rep 11 (1), 20885 (2021)
   PUBMED   34686736
  REMARK    GeneRIF: Altered gene expression in slc4a11(-/-) mouse cornea
            highlights SLC4A11 roles.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3201)
  AUTHORS   Kant,S., Kumar,A. and Singh,S.M.
  TITLE     Bicarbonate transport inhibitor SITS modulates pH homeostasis
            triggering apoptosis of Dalton's lymphoma: implication of novel
            molecular mechanisms
  JOURNAL   Mol Cell Biochem 397 (1-2), 167-178 (2014)
   PUBMED   25123669
  REMARK    GeneRIF: the declined tumor cell survival following inhibition of
            BCT could be the consequence of interplay of several
            inter-connected regulatory molecular events.
REFERENCE   7  (bases 1 to 3201)
  AUTHORS   Vilas,G.L., Loganathan,S.K., Liu,J., Riau,A.K., Young,J.D.,
            Mehta,J.S., Vithana,E.N. and Casey,J.R.
  TITLE     Transmembrane water-flux through SLC4A11: a route defective in
            genetic corneal diseases
  JOURNAL   Hum Mol Genet 22 (22), 4579-4590 (2013)
   PUBMED   23813972
  REMARK    GeneRIF: Data shows that the function of SLCA11 is to facilitate
            the movement of water across the basolateral corneal epithelium.
REFERENCE   8  (bases 1 to 3201)
  AUTHORS   Han,S.B., Ang,H.P., Poh,R., Chaurasia,S.S., Peh,G., Liu,J.,
            Tan,D.T., Vithana,E.N. and Mehta,J.S.
  TITLE     Mice with a targeted disruption of Slc4a11 model the progressive
            corneal changes of congenital hereditary endothelial dystrophy
  JOURNAL   Invest Ophthalmol Vis Sci 54 (9), 6179-6189 (2013)
   PUBMED   23942972
  REMARK    GeneRIF: Successful knockout of the Slc4a11 gene was confirmed by
            immunohistochemistry and RT-PCR. Slit-lamp photography and AS-OCT
            showed progressive corneal edema.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3201)
  AUTHORS   Groger,N., Frohlich,H., Maier,H., Olbrich,A., Kostin,S., Braun,T.
            and Boettger,T.
  TITLE     SLC4A11 prevents osmotic imbalance leading to corneal endothelial
            dystrophy, deafness, and polyuria
  JOURNAL   J Biol Chem 285 (19), 14467-14474 (2010)
   PUBMED   20185830
  REMARK    GeneRIF: Loss of SLC4A11 leads to morphological changes in the
            fibrocytes and deafness.
REFERENCE   10 (bases 1 to 3201)
  AUTHORS   Lopez,I.A., Rosenblatt,M.I., Kim,C., Galbraith,G.C., Jones,S.M.,
            Kao,L., Newman,D., Liu,W., Yeh,S., Pushkin,A., Abuladze,N. and
            Kurtz,I.
  TITLE     Slc4a11 gene disruption in mice: cellular targets of
            sensorineuronal abnormalities
  JOURNAL   J Biol Chem 284 (39), 26882-26896 (2009)
   PUBMED   19586905
  REMARK    GeneRIF: Results demonstrate the importance of NaBC1 in the
            audio-vestibular system and provide support for the hypothesis that
            SLC4A11 should be considered a potential candidate gene in patients
            with isolated sensorineural vestibular hearing abnormalities.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772162.4.
            
            On Feb 6, 2007 this sequence version replaced XM_194050.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158115.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AL772162.4         41039-41199         c
            162-269             AL772162.4         40328-40435         c
            270-332             AL772162.4         39721-39783         c
            333-497             AL772162.4         35846-36010         c
            498-547             AL772162.4         35709-35758         c
            548-779             AL772162.4         35229-35460         c
            780-861             AL772162.4         35070-35151         c
            862-985             AL772162.4         34513-34636         c
            986-1189            AL772162.4         31634-31837         c
            1190-1283           AL772162.4         31467-31560         c
            1284-1409           AL772162.4         31243-31368         c
            1410-1523           AL772162.4         31051-31164         c
            1524-1656           AL772162.4         30839-30971         c
            1657-1730           AL772162.4         30564-30637         c
            1731-1989           AL772162.4         29711-29969         c
            1990-2096           AL772162.4         29429-29535         c
            2097-2265           AL772162.4         29175-29343         c
            2266-2439           AL772162.4         28911-29084         c
            2440-2635           AL772162.4         28538-28733         c
            2636-2805           AL772162.4         28292-28461         c
            2806-3201           AL772162.4         27788-28183         c
FEATURES             Location/Qualifiers
     source          1..3201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.24 cM"
     gene            1..3201
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /note="solute carrier family 4, sodium bicarbonate
                     transporter-like, member 11"
                     /db_xref="GeneID:269356"
                     /db_xref="MGI:MGI:2138987"
     exon            1..161
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..269
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..332
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..2875
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /note="bicarbonate transporter-related protein 1; sodium
                     borate cotransporter 1; sodium bicarbonate
                     transporter-like protein 11"
                     /codon_start=1
                     /product="solute carrier family 4 member 11"
                     /protein_id="NP_001074631.1"
                     /db_xref="CCDS:CCDS38244.1"
                     /db_xref="GeneID:269356"
                     /db_xref="MGI:MGI:2138987"
                     /translation="MSQNEHCQDSGEYFSAGTQGYFKNNMEDNLEVREDSLGDEVFDT
                     VNSSIVSGESIRFFVNVNLEVQPSKSDLEAATGGCVLLHTSRKYLKLKNFEEEVRAHR
                     DLDGFLAQASIILNETATSLDDVLRTMLNRFALDPNHAEPDCDLDLLMAKLFTDAGAP
                     MESKVHLLSDTIQGVTATVRGVQYEQSWLCIICTMKTLQKRHVCISRLVRPQNWGENS
                     CEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFRQKLLKTRTEEEFKEALVHQR
                     QLLTMMMPRAAGHSMSSLHTHRHPQPPKCKDFFPFGKGIWMDIMRRFPVYPMDFTDGI
                     IGKSKSVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQSIGGLLYAL
                     FSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSL
                     LMNLFKRSTEEIIALFISITFVLDAVKGMVKIFGKYYYGHHYHTKRTSSLVSLLGIGR
                     SPNSSLHTALNASLLASPVEMATTSSPGSTHSGQATAVLSLLIMLGTLWLGYTLYQFK
                     KSPYLHPCVRETLSDCALPIAVLSFSLIGSYGFQEIEMSKFRYNPSESLFEVAQIHSL
                     SFKAIGSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLS
                     LFGLPWIHAAYPHSPLHVRALALVEERVENGHIYETIVDVKETRLTALGASVLVGLSL
                     LLLPFPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQR
                     KIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVM
                     DAEHRP"
     exon            333..497
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..547
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..779
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..861
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..985
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1189
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1283
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1409
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1523
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1656
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1730
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1989
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2096
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2265
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2439
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2635
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2805
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..3201
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3170..3175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /note="hexamer: AATAAA"
     polyA_site      3196
                     /gene="Slc4a11"
                     /gene_synonym="BTR1; NaBC1"
                     /note="major polyA site"
ORIGIN      
        1 ggagttcctc caagctttta aaacaggcgc gccccttccc tccgggctcc agtgagtgtc
       61 cctgcactgc tctgaaactt cgtagtccct cccaggccgg caccccacga ctctcaggcc
      121 tgcgcacgcg agccgccgag gatccagaac agacctcgcg ggcccatcct cccgtgcgtc
      181 cttctttgca caaacatctc ggatagtacc tccaatctct gtgtactgca cacccactct
      241 accccttctt tccggcatcg caggacacga aaactgtcct tgggccatgt cacagaatga
      301 acactgtcag gactccggtg aatacttctc agccggcact cagggatact tcaagaacaa
      361 catggaggat aaccttgaag tccgggaaga cagcctaggg gatgaggtct ttgacaccgt
      421 caactcctcc attgtgtctg gcgagagcat ccggtttttt gtcaatgtca accttgaagt
      481 gcagccctcc aaatctgact tagaagctgc aacgggtggc tgcgtgctct tacacacctc
      541 tcgcaagtat ctgaaattga agaactttga ggaagaggtc cgtgcacacc gggacctgga
      601 tggcttcctg gcccaggcca gcatcatcct gaatgagaca gctacctcac tggatgatgt
      661 cctccgaact atgctaaacc gctttgccct ggaccctaac cacgcagaac ctgactgtga
      721 cctggacctg ctcatggcta agctctttac agatgctgga gcccctatgg agagcaaggt
      781 ccacctgctg tcagatacca tccagggagt cactgccact gtccgagggg tgcagtacga
      841 gcagtcttgg ctctgcatca tctgtaccat gaagacccta cagaaacggc atgtgtgcat
      901 cagccgcctg gttcgaccac agaactgggg ggagaactcc tgtgaggttc gctttgtcat
      961 cctggtgctg gccccaccca agatgaaaag caccaagact gcaatggagg tggcacgcac
     1021 ctttgccacc atgttctcag acatcacctt ccgccagaag ctcctgaaga ctcgcacaga
     1081 ggaagaattc aaggaggctc tggtgcatca gagacagctg ctcaccatga tgatgccaag
     1141 agccgcaggg cacagcatga gctccctcca tactcacaga caccctcagc ccccgaaatg
     1201 caaggacttt ttcccttttg gaaagggcat ctggatggat atcatgcgca ggtttcctgt
     1261 gtacccaatg gacttcactg atggcatcat tgggaaaagc aagagcgtgg gcaaatatgt
     1321 caccaccaca ctcttcctct acttcgcctg cctcctaccg accattgctt ttggatccct
     1381 caacgatgag aacacaaacg gggccatcga tgtgcagaag accatagctg gacagagcat
     1441 cggaggcctc ttgtatgcac tgttctctgg gcagcccctg gtgatactgt tgacaaccgc
     1501 acccctggcc atctacaccc aggtgattcg agtcatctgt gatgactaca atctggactt
     1561 caacgccttc tatgcatgga cgggcctgtg gaacagtttc ttccttgcac tttatgcctt
     1621 cctcaacctc agcctgctta tgaatctctt taagaggtct acagaggaaa tcattgctct
     1681 gttcatttcc atcacgtttg tgctggatgc tgtcaagggc atggtcaaaa tcttcgggaa
     1741 gtactactat ggtcaccact accacacaaa aaggacttcc tccttggtga gcctgttggg
     1801 cattggcaga agccccaaca gcagtctcca cactgcactc aacgccagcc tcttggccag
     1861 ccccgtagag atggccacaa ccagcagccc cggcagcaca cactcgggcc aggctacagc
     1921 ggtgctcagc ctcctcatca tgttgggcac actctggcta ggctacaccc tctaccagtt
     1981 caagaaaagc ccctacctgc acccatgtgt gcgtgagacc ctgtctgact gtgccctgcc
     2041 catcgccgtg ctctccttct ccctcatcgg ctcctatggc ttccaggaaa ttgagatgag
     2101 caagttccgg tataacccca gcgagagcct ttttgaggtg gcacagatcc actctctgtc
     2161 cttcaaggcc atcggcagtg ccatgggtct tggtttcctg ctctccttgc ttttcttcat
     2221 tgagcagaac ctggtggcgg ccctggtcaa tgcaccagag aacaggctgg tgaagggcac
     2281 tgcctatcac tgggatctcc tgctacttgc catcatcaat acggggctgt ctctgtttgg
     2341 gctaccctgg atccacgccg cctatcccca ctcccctctg catgtgcggg cactggcctt
     2401 agtggaggaa cgcgtggaga atgggcacat ttatgaaacg attgtggatg ttaaggagac
     2461 tcggctgacg gcgctgggtg ccagtgtcct ggtgggcctg tccttgctgc tgctgccatt
     2521 ccctctgcag tggatcccca agcctgtgct gtatgggctc tttctgtaca ttgcactgac
     2581 ctccctggac ggcaaccagc tcttctcgcg tgtggccctg ctgctcaagg agcagacatc
     2641 atacccaccc acacactaca tccggagagt gccccaaagg aagatccact acttcacagg
     2701 cctgcagatc ctgcagctgc tactgctctg tgccttcggc atgagctccc tgccctacat
     2761 gaagatggtc tttcccctca tcatgattgc catgattcca atccgctaca atctgctacc
     2821 ccgaatcatt gaggccaagt acttggatgt catggatgct gagcataggc cctgacctgc
     2881 gccacccccc cccccattct tcaggcctgc tctgtggcaa catatgggga ggtatgagct
     2941 ggctgtggct ctggcccatc ctcattgctg tcttatagcc taaaggccct tggcactgtg
     3001 gttttcaaag gtgtgtgctc actcctcacc ctgttaacat tcagtttggg gtcagaaaca
     3061 ctgtcgggtg gggctaagaa gagtggatat tcttttgata aaagagttga tgcccaggag
     3121 agagcccatt tccttgattg tataaggaac tcagttgtgc acattagtga ataaaagtct
     3181 tgtttctatg ctttcacatg c
//
