LOCUS       NM_001242378            5514 bp    mRNA    linear   ROD 19-APR-2022
DEFINITION  Mus musculus solute carrier family 4, sodium bicarbonate
            cotransporter-like, member 10 (Slc4a10), transcript variant 1,
            mRNA.
ACCESSION   NM_001242378
VERSION     NM_001242378.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5514)
  AUTHORS   Parichha A, Suresh V, Chatterjee M, Kshirsagar A, Ben-Reuven L,
            Olender T, Taketo MM, Radosevic V, Bobic-Rasonja M, Trnski S,
            Holtzman MJ, Jovanov-Milosevic N, Reiner O and Tole S.
  TITLE     Constitutive activation of canonical Wnt signaling disrupts choroid
            plexus epithelial fate
  JOURNAL   Nat Commun 13 (1), 633 (2022)
   PUBMED   35110543
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5514)
  AUTHORS   Dani N, Herbst RH, McCabe C, Green GS, Kaiser K, Head JP, Cui J,
            Shipley FB, Jang A, Dionne D, Nguyen L, Rodman C, Riesenfeld SJ,
            Prochazka J, Prochazkova M, Sedlacek R, Zhang F, Bryja V,
            Rozenblatt-Rosen O, Habib N, Regev A and Lehtinen MK.
  TITLE     A cellular and spatial map of the choroid plexus across brain
            ventricles and ages
  JOURNAL   Cell 184 (11), 3056-3074 (2021)
   PUBMED   33932339
REFERENCE   3  (bases 1 to 5514)
  AUTHORS   Christensen IB, Wu Q, Bohlbro AS, Skals MG, Damkier HH, Hubner CA,
            Fenton RA and Praetorius J.
  TITLE     Genetic disruption of slc4a10 alters the capacity for cellular
            metabolism and vectorial ion transport in the choroid plexus
            epithelium
  JOURNAL   Fluids Barriers CNS 17 (1), 2 (2020)
   PUBMED   31906971
  REMARK    GeneRIF: Genetic disruption of slc4a10 alters the capacity for
            cellular metabolism and vectorial ion transport in the choroid
            plexus epithelium.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5514)
  AUTHORS   Huebner AK, Maier H, Maul A, Nietzsche S, Herrmann T, Praetorius J
            and Hubner CA.
  TITLE     Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice
  JOURNAL   J Assoc Res Otolaryngol 20 (3), 233-245 (2019)
   PUBMED   31001720
  REMARK    GeneRIF: Disruption of Slc4a10 results in loss of Slc4a7 expression
            specifically in inner ear fibrocytes but not in other tissues. At
            the ultrastructural level, mitochondria of spiral ligament knockout
            fibrocytes show severe alterations.
REFERENCE   5  (bases 1 to 5514)
  AUTHORS   Potter PK, Bowl MR, Jeyarajan P, Wisby L, Blease A, Goldsworthy ME,
            Simon MM, Greenaway S, Michel V, Barnard A, Aguilar C, Agnew T,
            Banks G, Blake A, Chessum L, Dorning J, Falcone S, Goosey L, Harris
            S, Haynes A, Heise I, Hillier R, Hough T, Hoslin A, Hutchison M,
            King R, Kumar S, Lad HV, Law G, MacLaren RE, Morse S, Nicol T,
            Parker A, Pickford K, Sethi S, Starbuck B, Stelma F, Cheeseman M,
            Cross SH, Foster RG, Jackson IJ, Peirson SN, Thakker RV, Vincent T,
            Scudamore C, Wells S, El-Amraoui A, Petit C, Acevedo-Arozena A,
            Nolan PM, Cox R, Mallon AM and Brown SD.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5514)
  AUTHORS   Yoshikawa T, Piao Y, Zhong J, Matoba R, Carter MG, Wang Y, Goldberg
            I and Ko MS.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   7  (bases 1 to 5514)
  AUTHORS   Hubner CA, Hentschke M, Jacobs S and Hermans-Borgmeyer I.
  TITLE     Expression of the sodium-driven chloride bicarbonate exchanger NCBE
            during prenatal mouse development
  JOURNAL   Gene Expr Patterns 5 (2), 219-223 (2004)
   PUBMED   15567717
  REMARK    GeneRIF: NCBE is expressed in the peripheral nervous system and in
            non-neuronal tissues as the choroid plexus, the dura, and some
            epithelia including the acid secreting epithelium of the stomach
            and the duodenal epithelium.
REFERENCE   8  (bases 1 to 5514)
  AUTHORS   Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J,
            Ohara O and Seino S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 5514)
  AUTHORS   Praetorius J, Nejsum LN and Nielsen S.
  TITLE     A SCL4A10 gene product maps selectively to the basolateral plasma
            membrane of choroid plexus epithelial cells
  JOURNAL   Am J Physiol Cell Physiol 286 (3), C601-C610 (2004)
   PUBMED   14592810
  REMARK    GeneRIF: SLC4A10 gene product and NBCn1 both function as
            basolateral HCO3- entry pathways and that the SLC4A10 gene product
            may be responsible for the stilbene-sensitive Na+-HCO3- uptake that
            is essential for cerebrospinal fluid production.
REFERENCE   10 (bases 1 to 5514)
  AUTHORS   Wang CZ, Yano H, Nagashima K and Seino S.
  TITLE     The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution,
            and functional characterization
  JOURNAL   J Biol Chem 275 (45), 35486-35490 (2000)
   PUBMED   10993873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF746204.1, AK043017.1, HQ533147.1, AL928804.5 and BP758238.1.
            
            [WARNING] On Jun 2, 2023 this sequence was replaced by
            NM_001242378.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HQ825316.1, SRR9219380.48952.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                CF746204.1         1-25
            26-988              AK043017.1         2-964
            989-3655            HQ533147.1         926-3592
            3656-5053           AL928804.5         58526-59923
            5054-5514           BP758238.1         1-461               c
FEATURES             Location/Qualifiers
     source          1..5514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..5514
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /note="solute carrier family 4, sodium bicarbonate
                     cotransporter-like, member 10"
                     /db_xref="GeneID:94229"
                     /db_xref="MGI:MGI:2150150"
     exon            1..178
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..3541
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium-driven chloride bicarbonate exchanger; sodium
                     bicarbonate cotransporter NBCn2-E; sodium bicarbonate
                     cotransporter member 10 variant NBCn2-E'"
                     /codon_start=1
                     /product="sodium-driven chloride bicarbonate exchanger
                     isoform 1"
                     /protein_id="NP_001229307.1"
                     /db_xref="GeneID:94229"
                     /db_xref="MGI:MGI:2150150"
                     /translation="MEIKDQGAQMEPLLPTRNDEEAVVDRGGTRSILKTHFEKEDLEG
                     HRTLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRERDSGLEDGRESPSFDTPSQRVQFI
                     LGTEDDDEEHLPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVA
                     TLSLHSLFELRSCILNGTVLLDMHANTIEEIADMVLDQQVSSGQLNEDVRHRVHEALM
                     KQHHHQNQKKLANRIPIVRSFADIGKKQSEPNSMDKNAGQVVSPQSAPACAENKNDVS
                     RENSTVDFSKGLGGQQKGHTSPCGMKQRLDKGPPHQQEREVDLHFMKKIPPGAEASNI
                     LVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGKGQQYHEIGRSIA
                     TLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKR
                     KIPAVPNGTAAHGEAEPHGGHSGPELQRTGRIFGGLILDIKRKAPFFWSDFRDAFSLQ
                     CLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTIL
                     GSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFT
                     EEAFASLICIIFIYEALEKLFELSETYPINMHNDLELLTQYSCNCMEPHSPSNDTLKE
                     WRESNLSASDIIWGNLTVSECRSLHGEYVGRACGHGHPYVPDVLFWSVILFFSTVTMS
                     ATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTRDD
                     RGWFVTPLGPNPWWTIIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDL
                     LMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGL
                     MIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLFWMPAKHQPDF
                     IYLRHVPLRKVHLFTVIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMDFLFTKR
                     ELSWLDDLMPESKKKKLEDAEKEEEQSMLAMEDEGTVQLPLEGHYRDDPSVINISDEM
                     SKTAMWGNLLVTADNSKEKESRFPSKSNESRKEKKADSGKGVDRETCL"
     exon            179..260
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            261..407
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            408..546
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            547..707
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            708..896
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            897..988
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1078
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1236
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1324
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1471
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1572
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1747
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1881
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2127
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2233
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2395
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2509
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2671
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2923
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..2992
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3166
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3289
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3357
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3474
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..5493
                     /gene="Slc4a10"
                     /gene_synonym="mKIAA4136; NCBE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtgtgca gttgcctcct gcttcagagc tacctgatcc gaatactaag cagagcgagt
       61 gcccggctga gtggaagaca ctgaagacac tgcagagcaa ggtgcttttt ttccagaggt
      121 gttacagaac atggagatta aagaccaggg agcccaaatg gagccgctgc tgcctacgag
      181 aaatgatgaa gaagccgttg tggatagagg tggaacacgc tctattctca aaacacattt
      241 tgagaaagaa gatttagaag gtcatcggac attatttatt ggagttcatg tgcccctggg
      301 tggaagaaaa agccatcgtc gtcacaggca tcgtggtcat aagcacagaa agagggacag
      361 agagagagat tcgggactgg aggatggaag agagtcccct tcttttgaca ccccatcgca
      421 gagggtgcag tttattcttg gaactgagga cgatgatgag gagcacctcc ctcatgacct
      481 tttcacagag ctggatgaga tttgctggcg tgaaggggaa gatgctgagt ggcgagagac
      541 agccaggtgg ttgaaatttg aagaggatgt ggaagatgga ggagaaagat ggagtaagcc
      601 ctatgtggcc acgctttcat tacacagctt gtttgagttg agaagctgca tcctgaatgg
      661 aactgtgcta ctggacatgc atgccaacac gatagaagaa attgcagata tggtccttga
      721 ccagcaggtc agctcaggcc agctgaatga agatgttcgc cacagggtcc acgaagcatt
      781 gatgaagcag catcatcacc agaatcagaa aaaactggct aacaggattc ctattgtccg
      841 atcttttgct gatattggca agaaacaatc agaaccaaat tccatggata aaaatgcagg
      901 tcaggttgtt tctcctcagt ctgctccagc ctgtgctgag aataaaaatg atgtcagcag
      961 ggaaaacagc actgtagact tcagcaaggg actgggaggc caacaaaagg ggcatactag
     1021 tccatgtggg atgaaacaaa ggcttgacaa aggacctcca caccagcagg agagagaggt
     1081 tgatctgcat tttatgaaaa agattcctcc gggtgctgaa gcttcaaaca tcttggtagg
     1141 agaactggag ttcctagaca gaactgtggt tgcctttgtc aggttgtctc cagctgtctt
     1201 gctccaagga cttgctgaag ttccaatccc aagcagattt ctgttcatcc ttctgggacc
     1261 cctgggaaag ggtcaacagt accacgagat tggcagatcg attgcgacct taatgactga
     1321 tgaggtgttt catgatgttg cttacaaagc taaagaccgc aatgacttgg tatcaggaat
     1381 tgatgagttt ctggatcagg ttaccgttct tcctcctgga gaatgggatc caagcatacg
     1441 aatagaacct cccaaaaatg tcccttccca ggagaagagg aagattcctg ctgtaccaaa
     1501 tggaacagca gctcatggcg aagctgagcc acatggagga cacagcggac ctgaactcca
     1561 gcgaactggg aggatttttg ggggacttat attagatatc aaaagaaagg ctccattctt
     1621 ctggagtgac ttcagggatg ctttcagcct gcagtgctta gcatcgttcc tgtttctcta
     1681 ctgtgcatgc atgtctcctg tcatcacatt tggaggactg ttgggagaag caactgaagg
     1741 tcgtataagt gcaatcgaat cactctttgg agcatctatg accgggatag cctattctct
     1801 ttttggtgga cagcccctga ccatattagg cagcacagga cctgttttgg tgtttgaaaa
     1861 gatcttgttt aagttttgca aggaatacgg cctgtcgtac ttgtccttac gggccagcat
     1921 tgggctctgg actgcaacac tgtgcatcat ccttgtggcc acggacgcga gctcactcgt
     1981 ctgctacatc acccggttta ccgaagaggc ttttgcttct ctcatttgca tcatttttat
     2041 ctatgaagcc ctggagaagt tgtttgagct cagtgaaacc tatccaatca atatgcacaa
     2101 tgatttggaa ctgctgacac aatactcatg taactgtatg gagccacata gtcccagcaa
     2161 tgacacactg aaggaatggc gggagtccaa cctttctgcc tctgacataa tctgggggaa
     2221 cctaactgtg tcagagtgca gatcactgca cggggagtat gtcgggcgag cctgtggcca
     2281 tggccacccc tacgtgccag atgttctctt ctggtcggtg atcctgttct tctccacagt
     2341 taccatgtca gccaccctga agcagttcaa gaccagccgc tatttcccaa ccaaggttcg
     2401 atccatagtg agtgattttg cggtttttct tacaattctg tgtatggttt taattgacta
     2461 tgccattggg atcccatcac caaaactaca agtaccaagc gttttcaagc cgaccagaga
     2521 cgaccgtggc tggtttgtta cacctttggg tccaaaccca tggtggacaa tcatagctgc
     2581 catcatccca gctttactct gtactattct gattttcatg gaccagcaga ttacagctgt
     2641 catcatcaac agaaaagagc acaagctaaa gaaaggttgt ggctatcacc tggatctgtt
     2701 aatggtggca gtcatgctcg gggtctgctc cattatgggc ctgccatggt ttgtggctgc
     2761 cacagttctc tccatcactc atgtcaacag cctcaagctc gaatcagagt gctctgctcc
     2821 aggagaacaa cccaagtttc tcggcattcg ggagcagagg gtgaccgggc tcatgatttt
     2881 tattcttatg ggttcatccg ttttcatgac cagcattctg aagtttatcc ccatgccagt
     2941 gttatacgga gtgtttcttt atatgggtgc ttcgtctctc aaaggaattc agttatttga
     3001 tagaataaag ctcttctgga tgccagccaa acatcaacca gatttcatct atctaaggca
     3061 cgtgcccctc cggaaagtcc atctcttcac agtcattcag atgagttgtc tcggccttct
     3121 gtggataatc aaagtttcga gagctgctat tgtctttcct atgatggtgt tggcactagt
     3181 gtttgtgaga aagttgatgg acttcttgtt taccaaacgg gaactcagct ggcttgatga
     3241 tttaatgcct gagagtaaaa agaagaaact tgaagatgct gagaaagaag aagaacaaag
     3301 tatgctagcc atggaggacg agggcacagt acaactccca ctggagggac actacagaga
     3361 cgacccgtct gtgatcaata tttctgatga aatgtcaaag actgccatgt gggggaacct
     3421 tctagttact gctgacaact caaaagaaaa ggagtcacgc tttccttcta aaagcaatga
     3481 aagccgaaag gagaagaaag ctgactcagg gaaaggcgtt gacagggaga cttgtctatg
     3541 acttgatctt caatttattt tttacatata tatatatgag aagagtgtca caattattaa
     3601 caaaactgct ttgatcatgt aattgtaaac cctctctccc atcccacctt catactgtaa
     3661 gtagtgcaag ccttcattct atttctgtgt tcagcctctg agcaggtcga cacccttgta
     3721 agcagatcca atagctaatg caagagtctc cagtgttact gccgtaagac attcgccaac
     3781 acaggattct cattgttgac attaagagaa caaagctttc tttaaaagat aagtcatatt
     3841 tgcctagttt gtattttcct accttagtaa cctgaagatg cctgataatt ttattcagaa
     3901 gaattttgaa aggtagtcgt actttttatt ttttatggct tagcattcgt tactggtttt
     3961 gaaagaccca aatcaaaaag ttactctgaa agcattttta ataattgtat ttatgtattt
     4021 ccttgactta atatgaaaca tttaatactt aataactgtt acttcaagtc atttgagaaa
     4081 gagacctgtt catatcttct taaaagacat actgcaaaga gtcaagtagt gttcacttag
     4141 aattcaagtt gtaaccatgc agtcaaaaac taggcttgta ttaaatgctt tagagatatt
     4201 tgaagagttt tgtggggctt ttcattttaa atctttacca gaaatatgct actgagtttc
     4261 tctcccattg acaagggttg cttcccgaat aagcctatga catacatact tacggaatgc
     4321 cacatggtgc aacattgtac atttgatgcc agccctggca gctgttctgc tgaccatggt
     4381 catgtgctgc taagtttggt tcctatcatg ttgtcatgtt agaccaacag gtctccaact
     4441 gtattttgtt ttttttgcaa agctcttttc cacattttaa ctaaatgcat gttgtggaaa
     4501 aatagtcttt gaaataaaat ttcagatttt gttagaaaag gttatgtaaa tacttcagtc
     4561 catatgaaac agttcaactt tattgaaaca ggaaggagat tatggatttt tgagtattac
     4621 taaatataaa tttcatttaa ttttcaataa atgtgcttta atacaaaaca aaatatcata
     4681 ggggtcttag ttcctaaaaa agtatcaatg attaacaacc ttataatctt tcaatgtcca
     4741 ggtttagaaa aattcagagc cttctgggtt ttataaatta catgtactct gtgtaaatac
     4801 acataattag aaaaatcctc tttgctttta agctaatgaa gacgagagac aacagagcct
     4861 acataacctt aatattctga tatctttgaa caaaaaattt cctcagaatc ctttcaggag
     4921 ccattttttt aatgagatat gagccaaaat tgtgagaaga attttcagtt cgtaaagtct
     4981 gtatttataa atggtaaaga aaaatgcaaa agtgtctttt ccaaatgtgc tacctttgtg
     5041 tatgttgtaa tagcgacact ctctctaaac attctcgctg tctatgactt agcaggccaa
     5101 tccccaaagc actctcctgg tgtctctaga gtgtgatgtc tgttctgttg aaatgaccag
     5161 tgagtgacac ttcacatgat cactggttta aacaggcaat cagcctatga aattctgtat
     5221 ttctgaatat ttttatagta attttgttct tgtgtgaatt ttaatgctat ctctatctta
     5281 atcttaatat tttgaaatca cataaaatat aagaaaatgt agtattctat atttactcct
     5341 aatttcagat tcctggtcaa aattactgaa tatcttgaat gtaatttatt gcaatgttta
     5401 agtactgtgt aaatgtgaca ggatattgtg tttttcaaaa ctaagaaatg ttatgtggaa
     5461 ataaatattt atcctaccta cttttcatgc ttaaaaaaaa aaaaaaaaaa aaaa
//
