LOCUS       NM_153550               5409 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 49 member 4 (Slc49a4), mRNA.
ACCESSION   NM_153550 XM_358799
VERSION     NM_153550.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5409)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129574.8 and AC154653.2.
            
            On Apr 20, 2018 this sequence version replaced NM_153550.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034214.1, AK172331.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               AC129574.8         160860-161331
            473-566             AC154653.2         153616-153709       c
            567-832             AC154653.2         138506-138771       c
            833-962             AC154653.2         137057-137186       c
            963-1071            AC154653.2         133406-133514       c
            1072-1139           AC154653.2         125873-125940       c
            1140-1267           AC154653.2         122432-122559       c
            1268-1450           AC154653.2         107874-108056       c
            1451-5409           AC154653.2         97182-101140        c
FEATURES             Location/Qualifiers
     source          1..5409
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 25.43 cM"
     gene            1..5409
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /note="solute carrier family 49 member 4"
                     /db_xref="GeneID:224132"
                     /db_xref="MGI:MGI:2387188"
     exon            1..472
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1566
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /note="disrupted in renal carcinoma protein 2 homolog;
                     disrupted in renal carcinoma 2"
                     /codon_start=1
                     /product="solute carrier family 49 member 4"
                     /protein_id="NP_705778.1"
                     /db_xref="CCDS:CCDS28141.1"
                     /db_xref="GeneID:224132"
                     /db_xref="MGI:MGI:2387188"
                     /translation="MGSGWSSEEEERQPLLGPGLGPAPGAARRGREATAVLPAAGPNP
                     GRVYGRRWLVLLLFSLLAFAQGLVWNTWGPIQNSARQAYGFSGWDIALLVLWGPIGFL
                     PCFAFMWLLDKRGLRVTVLLTSFLMVLGTGLRCIPVSDLALKKRLIHGGQILNGLAGP
                     TVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTAPLLAAE
                     SSRAHIKDRIETVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAASQRLSYRRSFCRL
                     LSNLRFLMIALAYAIPLGVFAGWSGVLDLILTPVHVSQVDAGWIGFWSIVGGCVVGIA
                     MARFADFIRGMLKLILLLLFSGATLSSTWFTLTCLNSITHLPLTTVTLYASCILLGVF
                     LNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGVLLFFVTFYHTELSWFNWCLP
                     GSCLLSLLLILCFRESYDRLYLDVVVSV"
     exon            473..566
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            567..832
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            833..962
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1071
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1139
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1267
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1450
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..5409
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /note="hexamer: AATAAA"
     polyA_site      2090
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /note="major polyA site"
     regulatory      2478..2483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /note="hexamer: AATATA"
     regulatory      2494..2499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /note="hexamer: AATGAA"
     polyA_site      2499
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
     polyA_site      2518
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
     regulatory      3876..3881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /note="hexamer: AATAAA"
     polyA_site      3896
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
     regulatory      4374..4379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /note="hexamer: AGTAAA"
     polyA_site      4396
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
     regulatory      5381..5386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /note="hexamer: AATAAA"
     regulatory      5387..5392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
                     /note="hexamer: AATACA"
     polyA_site      5403
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
     polyA_site      5409
                     /gene="Slc49a4"
                     /gene_synonym="Dirc2; RCC4"
ORIGIN      
        1 gcagacgcgc ccgggaggcc gaggactaga gcagctccgg ctccggctcc cgctccaccc
       61 gcccagtcag ctcccggctg gtctgcggcc accgggacgc gtcgggcagg gccggcgggc
      121 ggcgtcgcca tgggctcggg ttggagcagc gaggaggagg agcggcagcc gctgctgggg
      181 ccggggctcg ggcctgcgcc gggggctgcg cgcaggggcc gggaggcgac ggccgtgctg
      241 cctgcggcgg gcccgaaccc cgggagggtg tacgggcgcc gctggctggt gctgctgctc
      301 ttctcgctcc tcgcgttcgc ccagggcctg gtctggaaca cctggggccc catccagaac
      361 tcggcgcgcc aggcctatgg cttctccgga tgggacatcg cgctcctggt cctctggggg
      421 cccataggct tcctgccctg cttcgcgttc atgtggctgc tggacaagag aggtctgcgg
      481 gtcactgtgc ttctgacgtc atttcttatg gttttgggaa ctggtctacg atgcatacct
      541 gtatcagact tagcccttaa gaaaaggcta atccatgggg gacagatact gaacggactg
      601 gcaggtccga ctgtcatgaa tgcggcgcca ttcctctcta cgacgtggtt ctctgctgac
      661 gagcgagcca ctgccacagc aatcgcatca atgctgagtt acctcggtgg agcgtgtgcg
      721 tttctcgtcg ggcccctggt tgttccagct cccaacggga cggcacccct tctcgctgcg
      781 gagagtagca gggctcatat taaagaccga atcgagaccg tgttgtatgc agaatttgga
      841 gttgtctgcc taatattctc tgccacgcta gcttattttc cgccccggcc tcctcttcct
      901 cccagtgtcg ctgctgcgag ccagcggctg agttaccggc ggagcttttg taggttacta
      961 agcaatttga ggtttttgat gattgcttta gcatacgcaa taccacttgg tgtgtttgct
     1021 ggctggtctg gagttctgga cttaatttta acaccagtgc atgtcagtca agtagacgct
     1081 ggctggattg gattctggtc catagttgga ggctgtgttg ttgggatagc tatggcaagg
     1141 tttgcggatt ttatccgggg catgctgaaa ctgatcctgc tcctcctgtt ttctggggct
     1201 accctgtcgt ccacgtggtt caccctgacc tgcctaaaca gcatcaccca cttgcctttg
     1261 acaacagtga cattgtatgc ctcctgcatc ctcctgggag tgttcctgaa cagcagcgtc
     1321 cccatattct ttgagctttt tgtggaaacg gtctaccccg ttccagaagg gatcacctgt
     1381 ggagttgtca cctttttaag taatatgttc atgggagtgc ttttattttt tgtcacattt
     1441 tatcatacag agttgtcttg gttcaactgg tgccttcctg ggtcgtgtct gctcagtctc
     1501 cttctgattc tgtgcttcag ggaatcctat gacagactct accttgacgt ggtcgtctcg
     1561 gtttaagaag acagacttgt aggactttaa agggaccgta ctttagtagt gcacctttgc
     1621 ttgggtgcac atgcaatggg agaaaaggcg aagaaagaga tttctttcag aggttctgtt
     1681 aagttacaga gtctcacatt aatttaatga ctactaggta ataatagtgc aggacgtgag
     1741 tgtcgtgagg atgtgaaaac tctgtggaca gcacagctgt gttggcggca ctcttgtgtg
     1801 gagctgtgac agctcacaca ggacgcactg cccgagttgg tcacccccat gtgcactgta
     1861 cccgtgctga cccactgatg agctgaacta cggcaagaag catgggtggt cctatgaaga
     1921 tgacccctcc caggcacaca gcagagggat gggactcacg ccgctaactt ctgaagacat
     1981 cagaaccctg cgtcagactt taattacaaa atagcagagc tgtataccag tgatagaagt
     2041 tagtcctgtg tacactacat gtttttctaa taaagccatt tcttatatga ctccttactt
     2101 ttaaccaggt tggaagcctt tcactgtcct tgggaacagg ccctggctcc ttcccaccca
     2161 cccttgtttc tgtgagtatg gcgtcagtca cgccagcaag gtaacgaaat gcctgatagg
     2221 gttgcattaa ctgttgtgtg aaaagcgtaa ctctgttatg atttagcact ttgttaaaaa
     2281 tgaactgaga accacatgaa gcatgtgtgt cttcagacgt gtgtggcaca cgtgtaaagt
     2341 ccagcaccca ctgtaactta ccaggttaga ttgtagtcag atgagccccc acttgaaaag
     2401 aacagtgtat aactttgaag gtttgaagat ctgtgcgtga tttctgaatt gcacctgtgt
     2461 attttaactt agattgtaat atactcagtt ctaaatgaag tcattgtatt tgattggaca
     2521 gatttttgcc aatacctatt tctttctata aataatggat ttttaaaaaa aacaaaaaca
     2581 aaaacatact cattgcatgg ctcctggacc cgtctttcag gaggtcataa actgactgtg
     2641 gcgggcctgt gacactgacc actggtgttc cgtagctcct cttagacaga accttcccta
     2701 agcttccaga gccgcagcaa ctccattgcc agccagttct ccttacagcc cagtctcgtg
     2761 caggcatcag cagctcctgg tagcccgggt ggacaggctg cgcagtactg acttctgctc
     2821 acccgtgtgt accattgcac acctgcagac gcacctctca ccagaaattc acgatgtacc
     2881 aacttacccg ggtcttgaag gagggttctg ggattgccca gtatcttctg aggctcaaaa
     2941 ttgtgaagtc agagggggaa agtcctcaga gttaacacca gtctttagtc acctctgtgt
     3001 cgattccagt tctaaccagt ctgcttcctt agcatgggag gaagggaggg agggagggag
     3061 ggaggaagga aggatgaatt agctctgctt acttcatcct catctttctt aaagtgaaac
     3121 cgaaggtaga attctgaagg tgacaggaag ctagtcacta aggacatgca aaatagccac
     3181 caccccctcc catttgagga ggagagagga agcagagggg aggagtgtgg agagtgttgg
     3241 gtggtgttac ataaaatctg ctatacagct tcccatgagg aacactttaa ttcatggtta
     3301 attctacttt taccacaaag tacagactaa tactttaaaa ataggaccta aaaatagcta
     3361 atcacttgaa gacatttcca gtccattgta tcagtcacct gtctcaactg tgtggcttcc
     3421 cctccagcaa acaactgctc tacccatgca ttgcagcttt tcttagtgat gaaaacttca
     3481 caggggcagg cagccagtgg gcctgaagga aagggaagga cagggcatta tgtgtctttg
     3541 ctggataatc ctgtgccaac ctgacacaaa ccagtatcct ccgaaaggaa ggaatctcaa
     3601 ctgagaaaaa atgcttccat aagctccagg tgaagggtat tttcttaatt agtgattgat
     3661 aggggagggc ccagcccact gtgggtgggg acgcccttgg gctgatgatc ctgggttcta
     3721 taagaaagca ggctgagcaa accagaggga gcaatccagt aagcagcact cctccatggc
     3781 ttctgcatcg gctcctgcct ccaggtttct gccctgtttg agttcctgtc caaaacttcc
     3841 tttggtgatg aacagcaatg tgcaagtgta agctgaataa accctttcct ccccaacttg
     3901 tcttttggtc acggtgttcc gttgcagcaa tagaaaccct aagacaagtt ggtacaagaa
     3961 gtgaggtatg gctgtgacca cctgaccgtg ctttgggaaa gattactgaa ggacttggga
     4021 actttggact agaaaagcca ttgagtgttg agagctcagt gagctgctct gtaggagctt
     4081 ggaagataag agtattggga gcagtgcaga agatggaggc ctgccttgtg aagtttcaaa
     4141 gggaaattta aatactcaac gggtctgttt gctatatgaa ttctgtcgtc cagtcagccg
     4201 gggcggaaga gtcagcactg attaatgaga gaccccacag tacctgaatg cctcaaatcc
     4261 tcatatttct catcaacaca tactaggttt gcccttgttt catactggaa gaagccttag
     4321 ccctccacca atccaagctc tgtatggaga atgtatagag atggccccaa agaagtaaat
     4381 gcctttggat cgtcaagtcc tctgtagtat ctgcttatcg cctccacaca ccgctaaggt
     4441 attttaaacc atgttctagg atccttgaat tacccagtac aacatgtaaa tagctatgct
     4501 gtttggttag gaagtaagaa aaaagtctgt acatgctcat ttcaattgta ctattgtcca
     4561 aaaatctcaa atctgcagtg gattgagtcc aaagatgcag aagtggcagg gcactatggt
     4621 gacaaggacg tgtcttttct aaaatctcaa actcatgcct tttccccaag cctcacagta
     4681 ttatagctca atttaaaata cttagggtat tcatgaagat tctcgagtcc agaagggagg
     4741 ggctggtggt acatagaccg ccaccgagtg taagaagggc agggtctgac ccgcatcgat
     4801 tagttcttgt gtcaagttta aagtgcgtgg tatcgcaggt gccgtagcgc ccccctccag
     4861 tctttacctc accaggatct tatgcaaagg ttctgatgaa taattcagtc ctcataaatg
     4921 aacacgaggc attattaatt ggtgaggaca tattcccgta taagctccct gtggcttgtc
     4981 aattaatact ttacagttca tgggaagaag tgtttttaat atgatccatg gcagagatgt
     5041 aggaacaaga taattacaca gatgtatttc cctggaagaa ggaactgaca agaggggatc
     5101 aagtacacat gtaattttgc atatttaaat tcgtgtggcc taagggccag gtcttactct
     5161 ggatcatata ttcatgttta attattgaaa atgtttacag cttgttttta atgaagcctg
     5221 tctaacgagg gaatcccagc taagggattt aaagttgagg agattaactc cccatctact
     5281 tatcttttaa ttggtttttt ttaactctta tttttactaa aattgaagta ctcatcttgt
     5341 attctgcctg catacctgct ttatttttaa gttaagatca aataaaaata catagcaaat
     5401 ttactttca
//
