LOCUS       NM_026353               2526 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 48 (heme transporter), member 1
            (Slc48a1), mRNA.
ACCESSION   NM_026353
VERSION     NM_026353.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2526)
  AUTHORS   Pek,R.H., Yuan,X., Rietzschel,N., Zhang,J., Jackson,L.,
            Nishibori,E., Ribeiro,A., Simmons,W., Jagadeesh,J., Sugimoto,H.,
            Alam,M.Z., Garrett,L., Haldar,M., Ralle,M., Phillips,J.D.,
            Bodine,D.M. and Hamza,I.
  TITLE     Hemozoin produced by mammals confers heme tolerance
  JOURNAL   Elife 8, e49503 (2019)
   PUBMED   31571584
  REMARK    Erratum:[Elife. 2023 Oct 20;12:e93253. doi: 10.7554/eLife.93253..
            PMID: 37860965]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2526)
  AUTHORS   White,C., Yuan,X., Schmidt,P.J., Bresciani,E., Samuel,T.K.,
            Campagna,D., Hall,C., Bishop,K., Calicchio,M.L., Lapierre,A.,
            Ward,D.M., Liu,P., Fleming,M.D. and Hamza,I.
  TITLE     HRG1 is essential for heme transport from the phagolysosome of
            macrophages during erythrophagocytosis
  JOURNAL   Cell Metab 17 (2), 261-270 (2013)
   PUBMED   23395172
  REMARK    GeneRIF: These results reveal HRG1 as the long-sought heme
            transporter for heme-iron recycling in macrophages and suggest that
            genetic variations in HRG1 could be modifiers of human iron
            metabolism.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104225.18 and AC158787.14.
            
            On Apr 16, 2010 this sequence version replaced NM_026353.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022913.1, AK089421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               AC104225.18        6414-6665           c
            253-420             AC104225.18        960-1127            c
            421-863             AC104225.18        1-443               c
            864-2526            AC158787.14        23829-25491
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 53.78 cM"
     gene            1..2526
                     /gene="Slc48a1"
                     /gene_synonym="4930570C03Rik"
                     /note="solute carrier family 48 (heme transporter), member
                     1"
                     /db_xref="GeneID:67739"
                     /db_xref="MGI:MGI:1914989"
     exon            1..252
                     /gene="Slc48a1"
                     /gene_synonym="4930570C03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..557
                     /gene="Slc48a1"
                     /gene_synonym="4930570C03Rik"
                     /note="solute carrier family 48 member 1; heme-responsive
                     gene 1 protein homolog"
                     /codon_start=1
                     /product="heme transporter HRG1"
                     /protein_id="NP_080629.1"
                     /db_xref="CCDS:CCDS49715.1"
                     /db_xref="GeneID:67739"
                     /db_xref="MGI:MGI:1914989"
                     /translation="MAPSRLQLGLRAAYSGFSSVAGFSIFFVWTVVYRQPGTAAMGGL
                     AGVLALWVLVTHVMYMQDYWRTWLRGLRGFFFVGALFSAVSVSAFCTFLALAITQHQS
                     LKDPNSYYLSCVWSFISFKWAFLLSLYAHRYRADFADISILSDF"
     exon            253..420
                     /gene="Slc48a1"
                     /gene_synonym="4930570C03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            421..2526
                     /gene="Slc48a1"
                     /gene_synonym="4930570C03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1619..1624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc48a1"
                     /gene_synonym="4930570C03Rik"
                     /note="hexamer: AATACA"
     polyA_site      1640
                     /gene="Slc48a1"
                     /gene_synonym="4930570C03Rik"
                     /note="major polyA site"
     regulatory      2504..2509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc48a1"
                     /gene_synonym="4930570C03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2526
                     /gene="Slc48a1"
                     /gene_synonym="4930570C03Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggggcggag cgccgggcgg cagcggctct ggctcgggct cgggctgggg ctggggcttg
       61 ggctccagct cgggccctgc acctgtgact cggcggcgtt gctcctccgc tgccccatgg
      121 ccccgtcccg gctgcagctc ggcctccgcg ccgcctactc cggcttcagc tcggtagccg
      181 gcttctccat cttcttcgtc tggacggtgg tctaccgaca accggggact gcggcgatgg
      241 ggggtctcgc aggtgtcctg gcactgtggg tcttggtgac tcacgtgatg tacatgcagg
      301 attactggag gacctggctc agagggctgc gcggcttctt cttcgtgggt gctctcttct
      361 cggcagtctc cgtttccgcc ttctgcacct tcctggcatt ggccatcacc cagcatcaga
      421 gtctcaaaga cccgaacagc tactacctct cctgtgtctg gagcttcatt tccttcaagt
      481 gggccttcct acttagcctc tacgcccacc gctaccgggc tgactttgcg gacatcagca
      541 tccttagtga tttctaaccc agggaatgag gtcaccacag cctgggggcc ctcgggatct
      601 ggactcagct tccgagtcag caagggagct caccccaacc cctggggaac tccagaacca
      661 tggcagagta tatgggcccg ttcagtttct cagaaatctg tctggtcccc ttttggggaa
      721 gatatagagc tgttaaaggg atactgccaa tctgcccaat ctgcccgtta gcccagctag
      781 agggcagctt agacctttcc aaatagatct attttcttag ccctctgagg gatctctgta
      841 agtagggcca cgacaatgaa ttcaatgggt aggattggaa ctatggctag tgacaggggc
      901 tgggacaggc ttccttgcta ccccagactt cattgaagct gtgtgtgggg gaggcatcaa
      961 aggtctggtc aagagaggaa tctttagtac agatctccat cccctgttcc ccaccctgtt
     1021 accctgaagt gtcgggtagc caaactcacc ggtccttagg gaattgacaa ttggctcctt
     1081 ccctaagcag cacagttgga cagaatccag cgtccgtccg tcctaccttc ccatccagag
     1141 tttgtttccc atgagggtgc tagcgccagc caaccattcc catgtgtcgc atatgcacac
     1201 atgaccacac acaccagagc aggactcctc ggatgaggct agacttgagg accacaggaa
     1261 acacacccct gcacttagaa gggctttggg atcgggggca acctggtggg ggcaagtggg
     1321 agctctccat ctgtactgag tctccaacct tgcccctcac tgcacaagac caccctgacc
     1381 gtgaggacct cctccctgca ccagatccta actctgacct ttcaccttct ctctctcctg
     1441 aaggaactct tctgagtgga catgggccca aggccttacc taagcggaga gggagggcag
     1501 gggctgctac tcttctctgt aaccttctct gatgggttgt cactttgcac gtctactctt
     1561 ccacttgggc actgccccca gctctctgcc ttacctgtgt tatgggcact taagcagaaa
     1621 tacagcggcc attttaacca gcctcagggt gtttctttgg gggggtgggc ggttttgaga
     1681 ggggacaaga gtgggcaaga tgggggctct agctgtctga tcatctccct aagtttgggg
     1741 ctactagacg gtattcctca tctctggtcc cctatgggga gaccaccagc tgagatctcc
     1801 tttgctctcc cagttctgtc ccagccaggg ttaggatgcc cacagactca acatccctgc
     1861 agattccatc tccccaccct aagccaaggt agatgggaaa gggaatcttt ctttttctac
     1921 cccagccaga ctacttgggg ctccaagttg accaggatgt gtggattcag aagcagaaag
     1981 gcaggagcta gcacctctct cacgctgggt acacttgtcc tggcctgtgt ttgcctcacc
     2041 ctggccttta cagtgtaaaa acaccatggg actttagagc agggaaggat aaggaacagt
     2101 gtcacttcta gagccttctg ctggtagacg ctcctactga tagaggaggt aaagactact
     2161 gacctcccgg ctaggcctgg cttaagccag gcgtgcctgc gtcacaacct tttgcggtgt
     2221 cttagcaacc tgaacctgag atcttattcc cgaatcccac agggcccaat gtgcagggct
     2281 cagcctgggg ccatctccct tttcacctgg gttggtgagc atgtatttgg agtggtttct
     2341 tcctgcatgt attagccaag gaaggacaag ggactagagg gtctgagtta ggtccagact
     2401 tgtccccttt ccccagccca tcacaggatg ctgggtgcac acccactcca ctgacgatgt
     2461 cccaccaaca tccaggaggc gttctcccaa ggactttaaa gcaaataaaa catatattgt
     2521 tcagaa
//
