LOCUS       NM_001033542            2377 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 47, member 2 (Slc47a2), mRNA.
ACCESSION   NM_001033542 XM_354611 XM_914375
VERSION     NM_001033542.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2377)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2377)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2377)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2377)
  AUTHORS   Toyama,K., Yonezawa,A., Tsuda,M., Masuda,S., Yano,I., Terada,T.,
            Osawa,R., Katsura,T., Hosokawa,M., Fujimoto,S., Inagaki,N. and
            Inui,K.
  TITLE     Heterozygous variants of multidrug and toxin extrusions (MATE1 and
            MATE2-K) have little influence on the disposition of metformin in
            diabetic patients
  JOURNAL   Pharmacogenet Genomics 20 (2), 135-138 (2010)
   PUBMED   20016398
  REMARK    GeneRIF: The purpose of this study was to evaluate the effects of
            heterozygous MATE variants on the disposition of metformin in mice
            and humans.
REFERENCE   5  (bases 1 to 2377)
  AUTHORS   Lickteig,A.J., Cheng,X., Augustine,L.M., Klaassen,C.D. and
            Cherrington,N.J.
  TITLE     Tissue distribution, ontogeny and induction of the transporters
            Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression
            levels in mice
  JOURNAL   Life Sci 83 (1-2), 59-64 (2008)
   PUBMED   18573474
  REMARK    GeneRIF: MATE2 mRNA expression levels were the highest in the
            testis, where high expression was localized to Sertoli cells, a
            critical cell type of the blood testis barrier.
REFERENCE   6  (bases 1 to 2377)
  AUTHORS   Hiasa,M., Matsumoto,T., Komatsu,T., Omote,H. and Moriyama,Y.
  TITLE     Functional characterization of testis-specific rodent multidrug and
            toxic compound extrusion 2, a class III MATE-type polyspecific
            H+/organic cation exporter
  JOURNAL   Am J Physiol Cell Physiol 293 (5), C1437-C1444 (2007)
   PUBMED   17715386
  REMARK    GeneRIF: testes-specific multidrug and toxic compound extrusion 2
            (MATE2) act as a polyspecific H(+)/organic cation exporter in
            Leydig cells.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK133432.1.
            
            On Apr 5, 2007 this sequence version replaced NM_001033542.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133432.1, BC147619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2377              AK133432.1         2-2378
FEATURES             Location/Qualifiers
     source          1..2377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..2377
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /note="solute carrier family 47, member 2"
                     /db_xref="GeneID:380701"
                     /db_xref="MGI:MGI:3588190"
     exon            1..244
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1804
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /note="MATE-2; mMATE-2; h(+)/organic cation antiporter
                     kidney-specific"
                     /codon_start=1
                     /product="multidrug and toxin extrusion protein 2"
                     /protein_id="NP_001028714.1"
                     /db_xref="CCDS:CCDS24810.1"
                     /db_xref="GeneID:380701"
                     /db_xref="MGI:MGI:3588190"
                     /translation="MEPAEDSLGATIQPPELVRVPRGRSLRILLGLRGALSPDVRREA
                     AALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVGTGLA
                     SACDTLMSQSFGGKNLKRVGVILQRGILILLLCCFPCWAIFLNTERLLLLLRQDPDVA
                     RLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLYAL
                     DLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRLAIPSM
                     FMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALG
                     AGNADQARCSCTTVLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFA
                     PFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVSLMFAAKLGIIGLWAG
                     LIVCVSFQAFSYLIYILRTNWSRVAEQAQVRAGLKSTKELIPTPADLPILEREVMDGV
                     ILPDIIRPESQTGQLVVEENSQCAVPTVGEVLTGRQLVFYRGMALTVSVAVLIAGIVV
                     RVFNDRG"
     exon            245..346
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            347..415
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            416..564
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            565..607
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            608..652
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            653..750
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            751..848
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            849..962
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1030
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1139
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1215
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1285
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1418
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1513
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1568
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..2377
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2377
                     /gene="Slc47a2"
                     /gene_synonym="4933429E10Rik"
                     /note="putative"
ORIGIN      
        1 cccgcccggc tccctgcact tcgcagtggc tactcgactc acggctccac gtgtggatcg
       61 cgccactatc tgagcctgtg ccatggagcc ggccgaggac agcctgggag ccaccatcca
      121 gcccccggag ctggtccgcg tcccacgggg gcgcagtctg aggatcctgc tgggccttcg
      181 aggagcgctg tcccccgacg tgagacggga ggcggccgcg ctagtggcgc tcgcgggccc
      241 ggtgttcctg gcgcagctga tgatctttct catcagcatc gtcagttcca tcttctgcgg
      301 acacctgggc aaagtcgagt tggacgccgt gacactcgct gtttccgttg tgaatgtcac
      361 tggaatttca gtagggactg gcttggcctc ggcttgtgac acactgatgt ctcagtcctt
      421 tggaggcaag aacttgaagc gcgtgggggt catactccaa aggggcatcc tcatcctgct
      481 gctctgctgc ttcccatgct gggccatctt cctcaacacc gagcgcctgc tgctgctcct
      541 aaggcaggac ccggatgtcg ccaggctagc ccaggtttat gtgatgatat gcatccctgc
      601 tcttcctgca gcgttcctat tccagctgca gacgcggtat ttacagagcc agggcatcat
      661 tatgccccaa gttattgttg ggatcgcagc aaatgtcgtc aacgtgggca tgaacgcctt
      721 cttgctgtat gccttggacc tcggagtggt agggtcggcc tgggccaaca ccacctctca
      781 gttcttcctg tctgccctgc ttttcctcta cgtgtggtgg aagagaatcc acatccacac
      841 ttggggaggg tggacaaggg agtgcttcca ggagtggagc tcctacacgc gcctggccat
      901 ccccagtatg ttcatggtgt gcatcgagtg gtggaccttc gagattggga ccttccttgc
      961 aggccttgtt aatgtgacag aactgggagc ccaggccgtc atctatgaac tggcttctgt
     1021 cgcctacatg gtgccctttg gctttggtgt ggctgccagc gtccgagtgg gcaatgctct
     1081 gggggcaggg aacgctgacc aggcccggtg ttcctgtacc actgttcttc tgtgtgctgg
     1141 tgtctgtgca ctcctggtgg ggattctgct cgcagccttg aaggatgtgg ttgcctacat
     1201 cttcaccaat gacaaggaca tcatttccct tgtgagtcaa gtgatgccca tttttgctcc
     1261 ctttcatctc tttgatgcac ttgcgggcac ctgtggcggg gtcctgagag gcacgggaaa
     1321 acaaaagata ggcgctgtcc tgaacactat cggttactac gggtttggtt ttcctattgg
     1381 agtgtccctg atgtttgctg ctaagcttgg gataataggc ctctgggctg gactgatagt
     1441 ctgtgtctcc ttccaagcct tctcctattt aatctacatc ctgaggacaa actggagcag
     1501 agtcgcagag caggcacaag ttcgagctgg gctaaaaagc accaaggagt tgatacccac
     1561 gccagcagat ctgcccatct tggaaagaga agttatggat ggagtgattt tgcctgatat
     1621 catcaggcca gagagtcaga ccggccagct ggtggtggaa gagaacagcc agtgtgcagt
     1681 gcccaccgtt ggggaggtct tgacggggag acagctggtt ttctatcgtg ggatggctct
     1741 gactgtttct gttgctgtcc tcatagcagg gattgtggtg cgagttttca atgaccgtgg
     1801 ctaagatagg actgtctccg gtctgtggac tggtaatact tgtgtgccac atcctgagcg
     1861 tggctgtgag cttgtcattc tctcaactgc cggtagaaag gctgccagtg agcttgtcct
     1921 tggttaagct tctgtatggc cctgtggccc tgtcgtactg caggtcacga aaggagcagc
     1981 tcatgtgcct agtgtgtgca aggcccttgt ttgatgtcat cctttgtagg atgaggggag
     2041 gggagaatga acagataaat gaataaatgg ctatccagat tgtggggggg gggggagggt
     2101 gctggggagg gaaccccggg acctcagctc aagctaggca agaactctta acactgagca
     2161 ctccgagcac tcgctcccac ccccagaagc tctgctggta ggaaagcttt tccccaatga
     2221 ctttatcatg atttctctac tgtgagtgtg ctttcctctc cccagcatcc tctgctgctg
     2281 cgttcttgcc atgagcgagc tgactatcag gtacctgttc tcgctctgtc tgggaactgt
     2341 gtcacagaag cattgataaa ataaaaatct aagatct
//
