LOCUS       NM_026183               2634 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus solute carrier family 47, member 1 (Slc47a1), mRNA.
ACCESSION   NM_026183
VERSION     NM_026183.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2634)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2634)
  AUTHORS   Smyth,L.C.D., Xu,D., Okar,S.V., Dykstra,T., Rustenhoven,J.,
            Papadopoulos,Z., Bhasiin,K., Kim,M.W., Drieu,A., Mamuladze,T.,
            Blackburn,S., Gu,X., Gaitan,M.I., Nair,G., Storck,S.E., Du,S.,
            White,M.A., Bayguinov,P., Smirnov,I., Dikranian,K., Reich,D.S. and
            Kipnis,J.
  TITLE     Identification of direct connections between the dura and the brain
  JOURNAL   Nature 627 (8002), 165-173 (2024)
   PUBMED   38326613
REFERENCE   3  (bases 1 to 2634)
  AUTHORS   Nies,A.T., Konig,J., Leuthold,P., Damme,K., Winter,S., Haag,M.,
            Masuda,S., Kruck,S., Daniel,H., Spanier,B., Fromm,M.F., Bedke,J.,
            Inui,K.I., Schwab,M. and Schaeffeler,E.
  TITLE     Novel drug transporter substrates identification: An innovative
            approach based on metabolomic profiling, in silico ligand screening
            and biological validation
  JOURNAL   Pharmacol Res 196, 106941 (2023)
   PUBMED   37775020
REFERENCE   4  (bases 1 to 2634)
  AUTHORS   Waissbluth,S., Martinez,A.D., Figueroa-Cares,C., Sanchez,H.A. and
            Maass,J.C.
  TITLE     MATE1 expression in the cochlea and its potential involvement in
            cisplatin cellular uptake and ototoxicity
  JOURNAL   Acta Otolaryngol 143 (3), 242-249 (2023)
   PUBMED   36943799
  REMARK    GeneRIF: MATE1 expression in the cochlea and its potential
            involvement in cisplatin cellular uptake and ototoxicity.
REFERENCE   5  (bases 1 to 2634)
  AUTHORS   Lin,Z., Liu,J., Long,F., Kang,R., Kroemer,G., Tang,D. and Yang,M.
  TITLE     The lipid flippase SLC47A1 blocks metabolic vulnerability to
            ferroptosis
  JOURNAL   Nat Commun 13 (1), 7965 (2022)
   PUBMED   36575162
  REMARK    GeneRIF: The lipid flippase SLC47A1 blocks metabolic vulnerability
            to ferroptosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2634)
  AUTHORS   Tsuda,M., Terada,T., Mizuno,T., Katsura,T., Shimakura,J. and
            Inui,K.
  TITLE     Targeted disruption of the multidrug and toxin extrusion 1 (mate1)
            gene in mice reduces renal secretion of metformin
  JOURNAL   Mol Pharmacol 75 (6), 1280-1286 (2009)
   PUBMED   19332510
  REMARK    GeneRIF: This is the first report to demonstrate an essential role
            of MATE1 in systemic clearance of metformin.
REFERENCE   7  (bases 1 to 2634)
  AUTHORS   Lickteig,A.J., Cheng,X., Augustine,L.M., Klaassen,C.D. and
            Cherrington,N.J.
  TITLE     Tissue distribution, ontogeny and induction of the transporters
            Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression
            levels in mice
  JOURNAL   Life Sci 83 (1-2), 59-64 (2008)
   PUBMED   18573474
  REMARK    GeneRIF: MATE1 mRNA levels were highest in the kidney, where male
            expression was higher than female.
REFERENCE   8  (bases 1 to 2634)
  AUTHORS   Kobara,A., Hiasa,M., Matsumoto,T., Otsuka,M., Omote,H. and
            Moriyama,Y.
  TITLE     A novel variant of mouse MATE-1 H+/organic cation antiporter with a
            long hydrophobic tail
  JOURNAL   Arch Biochem Biophys 469 (2), 195-199 (2008)
   PUBMED   17983590
  REMARK    GeneRIF: mMATE1b is a functional variant of mMATE1 and seems to be
            the true counterpart to other MATE1 transporters
REFERENCE   9  (bases 1 to 2634)
  AUTHORS   Hiasa,M., Matsumoto,T., Komatsu,T. and Moriyama,Y.
  TITLE     Wide variety of locations for rodent MATE1, a transporter protein
            that mediates the final excretion step for toxic organic cations
  JOURNAL   Am J Physiol Cell Physiol 291 (4), C678-C686 (2006)
   PUBMED   16641166
  REMARK    GeneRIF: mMATE1 is polyspecific H(+)/(organic cation)OC exchanger.
            Unexpectedly wide distribution of mMATE1 suggests involvement in
            diverse biological functions other than excretion of OCs from the
            body. (Multidrug and toxin extrusion 1, MATE1)
REFERENCE   10 (bases 1 to 2634)
  AUTHORS   Douglas,K.R. and Camper,S.A.
  TITLE     Partial transcriptome of the developing pituitary gland
  JOURNAL   Genomics 70 (3), 335-346 (2000)
   PUBMED   11161784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY006577.1, BB661673.1, AK009038.1 and BB556514.1.
            
            On Jan 29, 2008 this sequence version replaced NM_026183.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031436.1, ERR3363660.600624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BY006577.1         2-4
            4-586               BB661673.1         1-583
            587-2627            AK009038.1         207-2247
            2628-2634           BB556514.1         305-311
FEATURES             Location/Qualifiers
     source          1..2634
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..2634
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /note="solute carrier family 47, member 1"
                     /db_xref="GeneID:67473"
                     /db_xref="MGI:MGI:1914723"
     exon            1..163
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            164..265
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..334
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..483
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..526
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..571
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..669
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..767
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..881
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..949
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1058
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1134
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1204
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1337
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1432
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1505
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..2634
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2611..2616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /note="hexamer: ATTAAA"
     polyA_site      2630
                     /gene="Slc47a1"
                     /gene_synonym="1300013J15Rik; MATE1; mMATE1"
                     /note="major polyA site"
ORIGIN      
        1 ttccgagccc tgacaccacg gaggccacat ggaacgcacg gaggagtccg ctcccgggcc
       61 gggaggcgcg gacgctgcgt ccgagcgccg tgggctacgc tgcctgctgc tgcccggctt
      121 cctagaggag ctgcgggcac tcttggtcct ggcgggtcct gcgttcttgg cccagctgat
      181 gatgttccta atcagtttca taagctcagt gttctgtggc cacttgggca agctggagtt
      241 ggatgcagtc acactggcaa ttgcggttat caatgtcaca ggcatttcag tgggacatgg
      301 cttgtcttct gcttgtgaca cgctcatctc ccagacatac gggagccaga acttaaagca
      361 cgtaggggtt atcctgcaaa gggggacact catcctgctc ctctgctgct ttccctgctg
      421 ggcactcttc atcaacaccg agcaaattct gctgctcttc agacaggacc cggatgtatc
      481 caggctcacc cagacttacg tcatgatctt catcccagcg cttcctgcag cttttcttta
      541 tacgttacaa gttaaatact tgctcaacca gggcatcgtt ctgcctcaga ttatgacggg
      601 catcgcagct aaccttgtca acgccctggc caactatgtg tttctctatc acctgcatct
      661 tggggtgatg ggttcagcat tggccaacac catctcccag tttgccctgg ccattttcct
      721 gttcctctac atcctctgga gaagactaca ccaagccacc tggggagggt ggtcctggga
      781 gtgtctgcag gactgggcct ccttcctgcg actggctatc cccagcatgc tcatgctgtg
      841 catagagtgg tgggcctatg aggttggcag cttcctgagt ggtatccttg gcatggtgga
      901 gttgggagcc cagtccatca cctatgaatt ggctatcatt gtatacatga tcccttcagg
      961 cttcagtgtg gctgccaacg tccgggtggg aaatgcactg ggcgcaggaa acattgacca
     1021 ggccaagaag tcctcagcta tttccttgat agtcacagag ctctttgctg tgaccttctg
     1081 cgtcctgctg ctaggctgta aggatctcgt gggctacatt ttcactaccg atcgggatat
     1141 cgtggccttg gtggctcaag tgatccccat ttatgctgtg tcccacctct ttgaaggtct
     1201 tgcttgtacc tgtggtggta tcctgagggg cactgggaac cagaaggttg gagccatcgt
     1261 taatgccatc gggtattatg tcattggcct ccccatcggg atcgcgctga tgtttgctgc
     1321 taagctggga gtgatcggcc tgtggtcagg catcatcatc tgcactacct gtcagaccac
     1381 gtgcttcctg gcttttattg ctcggctcaa ttggaaacgc gcctgtcaac aggctcaagt
     1441 acatgccaat ttgaaggtaa acgtggccct gaattccgct gtctctcacg agcctgctca
     1501 cccagtgtgt cctgagagcc atggagaaat tatgatgacg gatcttgaaa aaaaagacga
     1561 gactcagttg gaccagccga tgaaccagca acaagctttg cctatccgtc caaaggacag
     1621 caataaactg tctgggaaac agttggcctt acggagagga ctcctgctcc taggggtagt
     1681 cttagtcttg gtgggtggga ttttagtgag agtctatatc agaattgaat aatgtgggaa
     1741 tgccatcaat ccagcaactt gggtgctcct cagtctgtga agttaatgct gaacaaatcc
     1801 accccacatt gaaacatcag ggctggggat actgcagaca gcaatatgtt cagcatgttc
     1861 tgggccctct aacataagtt ctctctctct ctctctctct ctctctctgt atgtgtctct
     1921 ctttgggtgt gtgtttgaga gagacagaga gagggagaca cccccccaag agatataaac
     1981 agaaagacaa agagacatag atgagacaga ggcagaggag atgctctgga gtggacaatg
     2041 cctgcaatat acttacctac caaataccag tattcgaaac attgtaccaa ccggaatgtt
     2101 gattttgcac ccctgggatt gcagggagtc acctggagac tctagctcac tgccactgtc
     2161 cccatgtttc caaaggatag tgtcacacat tgtgaaccca ggaaaagctc cccgttcaaa
     2221 aacagtctct tctgaatgcg tgtcactttt gcatcaatgt taaagttgag cccctggaaa
     2281 gtgaatcact gtttaagtct gggcccacgt gcagttttga acatagagac aattcagagc
     2341 cagtcattat agttaacaga attcaactgt gcccatggga attatgaact gagaattcaa
     2401 aaattttgtt tctctaataa ataaggtaaa caccatatag tgcaatgtgg gggagactat
     2461 gggggagtat taattcatct gccactgtca aacatgcact gctgtctact gtcttcattc
     2521 cgggctggaa ttcctatttc ttctgcctat tgttttctat gctacaaaac tatatctgaa
     2581 ctgcttctat attcttgctg tgtgacttct attaaataca ttttatgata tgtc
//
