LOCUS       NM_026740               1990 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus solute carrier family 46, member 1 (Slc46a1), mRNA.
ACCESSION   NM_026740
VERSION     NM_026740.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1990)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1990)
  AUTHORS   Wang,D., Wu,H., Yang,J., Li,M., Ling,C., Gao,Z., Lu,H., Shen,H. and
            Tang,Y.
  TITLE     Loss of SLC46A1 decreases tumor iron content in hepatocellular
            carcinoma
  JOURNAL   Hepatol Commun 6 (10), 2914-2924 (2022)
   PUBMED   35811443
  REMARK    GeneRIF: Loss of SLC46A1 decreases tumor iron content in
            hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 1990)
  AUTHORS   Li,H., Wang,D., Wu,H., Shen,H., Lv,D., Zhang,Y., Lu,H., Yang,J.,
            Tang,Y. and Li,M.
  TITLE     SLC46A1 contributes to hepatic iron metabolism by importing heme in
            hepatocytes
  JOURNAL   Metabolism 110, 154306 (2020)
   PUBMED   32621820
  REMARK    GeneRIF: SLC46A1 contributes to hepatic iron metabolism by
            importing heme in hepatocytes.
REFERENCE   4  (bases 1 to 1990)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1990)
  AUTHORS   Kooistra,M., Trasler,J.M. and Baltz,J.M.
  TITLE     Folate transport in mouse cumulus-oocyte complexes and
            preimplantation embryos
  JOURNAL   Biol Reprod 89 (3), 63 (2013)
   PUBMED   23904512
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1990)
  AUTHORS   Umapathy,N.S., Gnana-Prakasam,J.P., Martin,P.M., Mysona,B., Dun,Y.,
            Smith,S.B., Ganapathy,V. and Prasad,P.D.
  TITLE     Cloning and functional characterization of the proton-coupled
            electrogenic folate transporter and analysis of its expression in
            retinal cell types
  JOURNAL   Invest Ophthalmol Vis Sci 48 (11), 5299-5305 (2007)
   PUBMED   17962486
REFERENCE   7  (bases 1 to 1990)
  AUTHORS   Qiu,A., Min,S.H., Jansen,M., Malhotra,U., Tsai,E., Cabelof,D.C.,
            Matherly,L.H., Zhao,R., Akabas,M.H. and Goldman,I.D.
  TITLE     Rodent intestinal folate transporters (SLC46A1): secondary
            structure, functional properties, and response to dietary folate
            restriction
  JOURNAL   Am J Physiol Cell Physiol 293 (5), C1669-C1678 (2007)
   PUBMED   17898134
  REMARK    GeneRIF: Slc46a1/PCFT plays critical role in intestinal folate
            absorption.
REFERENCE   8  (bases 1 to 1990)
  AUTHORS   Shayeghi,M., Latunde-Dada,G.O., Oakhill,J.S., Laftah,A.H.,
            Takeuchi,K., Halliday,N., Khan,Y., Warley,A., McCann,F.E.,
            Hider,R.C., Frazer,D.M., Anderson,G.J., Vulpe,C.D., Simpson,R.J.
            and McKie,A.T.
  TITLE     Identification of an intestinal heme transporter
  JOURNAL   Cell 122 (5), 789-801 (2005)
   PUBMED   16143108
  REMARK    GeneRIF: heme carrier protein 1(HCP 1)is the long-sought intestinal
            heme transporter and was iron regulated and localized to the
            brush-border membrane of duodenal enterocytes in iron deficiency.
            Its mRNA was expressed in duodenum and regulated by hypoxia
REFERENCE   9  (bases 1 to 1990)
  AUTHORS   Cheung,C.C., Martin,I.C., Zenger,K.R., Donald,J.A., Thomson,P.C.,
            Moran,C. and Buckley,M.F.
  TITLE     Quantitative trait loci for steady-state platelet count in mice
  JOURNAL   Mamm Genome 15 (10), 784-797 (2004)
   PUBMED   15520881
REFERENCE   10 (bases 1 to 1990)
  AUTHORS   Mink,M., Fogelgren,B., Olszewski,K., Maroy,P. and Csiszar,K.
  TITLE     A novel human gene (SARM) at chromosome 17q11 encodes a protein
            with a SAM motif and structural similarity to
            Armadillo/beta-catenin that is conserved in mouse, Drosophila, and
            Caenorhabditis elegans
  JOURNAL   Genomics 74 (2), 234-244 (2001)
   PUBMED   11386760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX219335.1, AK003278.1, AL591177.14 and BE984585.1.
            
            On Jun 17, 2009 this sequence version replaced NM_026740.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003278.1, BC057976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CX219335.1         1-17
            18-1281             AK003278.1         1-1264
            1282-1282           AL591177.14        9867-9867
            1283-1595           AK003278.1         1266-1578
            1596-1596           AL591177.14        10700-10700
            1597-1959           AK003278.1         1580-1942
            1960-1990           BE984585.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..1990
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..1990
                     /gene="Slc46a1"
                     /gene_synonym="1110002C08Rik; D11Ertd18e; HCP1; Pcft"
                     /note="solute carrier family 46, member 1"
                     /db_xref="GeneID:52466"
                     /db_xref="MGI:MGI:1098733"
     exon            1..305
                     /gene="Slc46a1"
                     /gene_synonym="1110002C08Rik; D11Ertd18e; HCP1; Pcft"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1457
                     /gene="Slc46a1"
                     /gene_synonym="1110002C08Rik; D11Ertd18e; HCP1; Pcft"
                     /note="heme carrier protein 1; PCFT/HCP1"
                     /codon_start=1
                     /product="proton-coupled folate transporter"
                     /protein_id="NP_081016.2"
                     /db_xref="CCDS:CCDS25104.1"
                     /db_xref="GeneID:52466"
                     /db_xref="MGI:MGI:1098733"
                     /translation="MEGRVSSVGSPHSFLNAPVLFRGPVEPLVFLANFALVLQGPLTT
                     QYLWHRFSTELGYNGTRHRENCGNQSADPLMKEVETLTSHWTLYMNVGGFLVGLFWST
                     LLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLELHVGFFVLGRALCALLGDFNGL
                     LAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALAL
                     LIVMALYAAFCFGETVKEPKSTRLFTLRHHRSIARLYVVPAPEKSRMHLALYSLAIFV
                     VVTVHFGAQDILTLYELSAPLCWDSKLIGYGSAAQHLPYLTSLLGLRLLQFCLADTWV
                     AEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALF
                     SAVACVNSLAMLMASGIFNSIYPATLNFMKGFPFLLGAGLLFIPAILIGVLEKVNPHP
                     EFQQFPQSP"
     exon            306..1158
                     /gene="Slc46a1"
                     /gene_synonym="1110002C08Rik; D11Ertd18e; HCP1; Pcft"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1242
                     /gene="Slc46a1"
                     /gene_synonym="1110002C08Rik; D11Ertd18e; HCP1; Pcft"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1399
                     /gene="Slc46a1"
                     /gene_synonym="1110002C08Rik; D11Ertd18e; HCP1; Pcft"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1974
                     /gene="Slc46a1"
                     /gene_synonym="1110002C08Rik; D11Ertd18e; HCP1; Pcft"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1943..1948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc46a1"
                     /gene_synonym="1110002C08Rik; D11Ertd18e; HCP1; Pcft"
                     /note="hexamer: AGTAAA"
     polyA_site      1972
                     /gene="Slc46a1"
                     /gene_synonym="1110002C08Rik; D11Ertd18e; HCP1; Pcft"
                     /note="major polyA site"
ORIGIN      
        1 gcgcaggcgc agacagcaca gactggtcca ggcctcccgc agctggttcc gaggtgctag
       61 cccctccgtg tttgcgcatg gaggggcgcg tgagctccgt gggctcgccc cacagtttcc
      121 tcaacgctcc cgtgcttttc cgcggccccg tggagcccct agtcttcctg gccaactttg
      181 ccctggttct gcagggaccg ctcaccacac agtacctttg gcaccggttc agcacggagc
      241 tcggctacaa tggcacccgc caccgggaga actgtgggaa ccaaagcgcg gatcccctca
      301 tgaaggaagt ggagaccctg acatctcact ggaccctcta catgaacgtg ggaggcttcc
      361 tggtgggact cttctggtcc accctgctgg gagcctggag tgaccgcgtg ggtcgccgcc
      421 cattgctggt gctggcctct cttggtctgc tgctccaggc cgtggtgtcc atctttgtgg
      481 tgcagctaga actgcacgtc gggttcttcg tgcttggccg agctctttgt gcccttctgg
      541 gagacttcaa cggcctcctt gctgctagct ttgcctctgt ggcagatgtt agctctaacc
      601 acagtcgcac cttccggatg gctctgctgg aagcatgcat tggtgtggcc gggaccctgg
      661 caagccttct cgggggtcac tggctccggg cccagggtta tgccaacccc ttctggctgg
      721 ctttggccct gctgattgtc atggctctat acgcagcatt ttgttttggt gagacggtga
      781 aggagccaaa gtccaccagg cttttcacgc tccgccatca tcgatccatt gcccggctat
      841 atgtggttcc agccccagaa aagtccagga tgcatctagc cctgtactct ttggccatat
      901 tcgtggtggt tactgtgcat tttggggctc aagatatcct gacactctat gagctgagcg
      961 cacccctctg ctgggactcc aagctgattg gctatggctc agcagcccag cacctaccct
     1021 acctcaccag cctgctgggc ctaaggcttc tgcaattctg cctggctgac acctgggtgg
     1081 ctgagattgg cctggctttc aacatcctgg gaatggtggt ctttgcgttt gctaccatta
     1141 cacccctcat gttcacaggg tacggattgc tcttcctgtc attggtcacg acgcctgtca
     1201 tccgggccaa gctttccaag ctggtgagcg agtcggagca gggtgctctg ttctctgctg
     1261 tggcctgtgt gaatagcttg gccatgttga tggcctccgg catcttcaac tccatctacc
     1321 cggccactct gaacttcatg aagggcttcc ccttcctcct gggagctggc ctcctcttca
     1381 ttccagccat tctgattggg gtactggaaa aggttaatcc acacccggag ttccagcagt
     1441 ttcctcagag cccctgatct gcccgaagcc atgaggagca atggacccac actgacgatg
     1501 tatgcctaaa gcccagcaca ccagccacct cggaatccgt ccttgaccac agtctatcca
     1561 cccttgacct cagccttggc agtactcact ctggaaaggg agttcaagcc agttatgagc
     1621 aacacctact ctctgactga gccaatctct gctagataca gaatctaatc aggagaggtc
     1681 cactttaggg caggctgcaa ggagccattt gtggcaaggg tttcttcccc ccccccccat
     1741 gctattcatc actcagaacc ttctagagtg aaggagatgg catttcaggg accaagcgtg
     1801 agaccgacct ctccttctag cccatggtac taggtctctg ctgtgttcag tggcttccag
     1861 gcgatgaagc tctgtctatg gttgggaagc cgtccttgac cacagtctac ccacccttga
     1921 cctcagcctt ggcaattgtc acagtaaatt gtttgaatca gtctgaaaag tttaaaaaaa
     1981 aaaaaaaaaa
//
