LOCUS       NM_001177628            3267 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 45, member 3 (Slc45a3),
            transcript variant 2, mRNA.
ACCESSION   NM_001177628
VERSION     NM_001177628.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3267)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3267)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 3267)
  AUTHORS   Bartolke,R., Heinisch,J.J., Wieczorek,H. and Vitavska,O.
  TITLE     Proton-associated sucrose transport of mammalian solute carrier
            family 45: an analysis in Saccharomyces cerevisiae
  JOURNAL   Biochem J 464 (2), 193-201 (2014)
   PUBMED   25164149
  REMARK    GeneRIF: Real-time PCR of mouse tissues confirmed mRNA expression
            of SLC45A2 in eyes and skin and of SLC45A3 primarily in the
            prostate, but also in other tissues, whereas SLC45A4 showed a
            predominantly ubiquitous expression.
REFERENCE   4  (bases 1 to 3267)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3267)
  AUTHORS   Shin,D., Howng,S.Y., Ptacek,L.J. and Fu,Y.H.
  TITLE     miR-32 and its target SLC45A3 regulate the lipid metabolism of
            oligodendrocytes and myelin
  JOURNAL   Neuroscience 213, 29-37 (2012)
   PUBMED   22521588
  REMARK    GeneRIF: our data suggest that miR-32 and its downstream target
            SLC45A3 play important roles in myelin maintenance
REFERENCE   6  (bases 1 to 3267)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 3267)
  AUTHORS   Hsia,N. and Cornwall,G.A.
  TITLE     DNA microarray analysis of region-specific gene expression in the
            mouse epididymis
  JOURNAL   Biol Reprod 70 (2), 448-457 (2004)
   PUBMED   14561649
REFERENCE   8  (bases 1 to 3267)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY713333.1, AK035428.1 and AC107837.11.
            
            On Oct 12, 2012 this sequence version replaced NM_001177628.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035428.1, SRR7652917.1178920.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY713333.1         1-52
            53-2610             AK035428.1         3-2560
            2611-3267           AC107837.11        70576-71232
FEATURES             Location/Qualifiers
     source          1..3267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.24 cM"
     gene            1..3267
                     /gene="Slc45a3"
                     /gene_synonym="2210413P12Rik; IPCA-6; Pcanap6; PRST"
                     /note="solute carrier family 45, member 3"
                     /db_xref="GeneID:212980"
                     /db_xref="MGI:MGI:1922082"
     exon            1..138
                     /gene="Slc45a3"
                     /gene_synonym="2210413P12Rik; IPCA-6; Pcanap6; PRST"
                     /inference="alignment:Splign:2.1.0"
     exon            139..533
                     /gene="Slc45a3"
                     /gene_synonym="2210413P12Rik; IPCA-6; Pcanap6; PRST"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..2023
                     /gene="Slc45a3"
                     /gene_synonym="2210413P12Rik; IPCA-6; Pcanap6; PRST"
                     /note="prostate cancer-associated protein 6; Prostein"
                     /codon_start=1
                     /product="solute carrier family 45 member 3"
                     /protein_id="NP_001171099.1"
                     /db_xref="CCDS:CCDS15278.1"
                     /db_xref="GeneID:212980"
                     /db_xref="MGI:MGI:1922082"
                     /translation="MIQRLWASRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLL
                     EVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDQWRGRYGRRRPFIWALSLGVLLSLFL
                     IPRAGWLAGLLYPDTRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQA
                     FSVYAFMISLGGCLGYLLPAIDWDTSVLAPYLGTQEECLFGLLTLIFLICMAATLFVT
                     EEAVLGPPEPAEGLLVSAVSRRCCPCHVGLAFRNLGTLFPRLQQLCCRMPRTLRRLFV
                     AELCSWMALMTFTLFYTDFVGEGLYQGVPRAEPGTEARRHYDEGIRMGSLGLFLQCAI
                     SLVFSLVMDRLVQKFGTRSVYLASVMTFPVAAAATCLSHSVVVVTASAALTGFTFSAL
                     QILPYTLASLYHREKQVFLPKYRGDAGGSSGEDSQTTSFLPGPKPGALFPNGHVGSGS
                     SGILAPPPALCGASACDVSMRVVVGEPPEARVVTGRGICLDLAILDSAFLLSQVAPSL
                     FMGSIVQLSHSVTAYMVSAAGLGLVAIYFATQVVFDKNDLAKYSV"
     exon            534..1319
                     /gene="Slc45a3"
                     /gene_synonym="2210413P12Rik; IPCA-6; Pcanap6; PRST"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1585
                     /gene="Slc45a3"
                     /gene_synonym="2210413P12Rik; IPCA-6; Pcanap6; PRST"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..3267
                     /gene="Slc45a3"
                     /gene_synonym="2210413P12Rik; IPCA-6; Pcanap6; PRST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3237..3242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc45a3"
                     /gene_synonym="2210413P12Rik; IPCA-6; Pcanap6; PRST"
                     /note="hexamer: ATTAAA"
     polyA_site      3264
                     /gene="Slc45a3"
                     /gene_synonym="2210413P12Rik; IPCA-6; Pcanap6; PRST"
                     /note="major polyA site"
ORIGIN      
        1 tggcagcccc agcgcgcatg ctctctcccc ccactgagta acctggagat ttaaaaggcg
       61 cccgctggcg cgcgttggtg aagcaggggt ccgagctcgc acgcgccagc cccaggtgac
      121 agccgcacgc cgggccagga tctgaccgac gagatgtgtc cccatcaagc aaggcactag
      181 atggtgacgt gtttagcgtg ggacgagatg ctgaattggc actaaagggc tggcagaaat
      241 gggaacctgg ctgcacccta ggaggttagt gctagtgagg aggagaagcc acggcagggc
      301 tgactcaaag cagctgtgga gtatgtgagt agcccctgga accctacctg ccctgtccat
      361 catgatccag aggctgtggg ccagccgtct gctacggcac cggaaagctc agctcctgct
      421 ggtcaacctg ctcacctttg gcctggaggt gtgcctggct gccggcatta cctatgtgcc
      481 accccttctg ctggaagtcg gggtggagga gaaattcatg accatggtgt tgggcattgg
      541 cccagtgcta ggcctggttt ctgttccact cctaggctca gccagtgacc agtggcgtgg
      601 gcgctatggc cgccggagac cctttatctg ggctttgtcc ctgggtgtcc tgctaagcct
      661 ctttctcatc ccgagggctg gctggctggc aggactgctg tacccagaca ccaggcccct
      721 ggagttggcc ctgctgatct tgggagtggg gctgctggac ttttgtggcc aggtgtgctt
      781 tactccattg gaggccttac tctccgacct cttccgggac ccagaccact gccgccaagc
      841 cttctctgtc tacgccttca tgatcagcct tgggggctgc ctgggctacc tcttacctgc
      901 cattgactgg gacaccagcg ttctggcccc ctacctgggt actcaggaag aatgcctctt
      961 tggcctcctc accctcattt tcctcatctg catggcagcc actctgtttg tgacggagga
     1021 ggcagtactg ggcccacccg agccggcaga agggttgttg gtctctgccg tgtcgcgccg
     1081 atgctgccca tgccacgttg gcctggcttt ccggaatctg ggtaccctgt ttccccggct
     1141 gcagcagctg tgctgccgca tgcctcgcac cctacgccga ctctttgtgg ctgagctgtg
     1201 cagctggatg gcacttatga ctttcacact gttctacacg gacttcgtgg gagaggggct
     1261 gtaccagggt gtacccagag ccgagccagg caccgaggcc cggagacact atgatgaagg
     1321 cattcgaatg ggcagcctgg ggctcttcct gcagtgtgcc atctccctgg tcttctccct
     1381 ggtcatggac aggctggtac agaagttcgg cacacggtca gtctatctgg ccagtgtgat
     1441 gacctttcct gtggctgccg ctgccacctg cctgtcccac agcgtggtgg tagtgacagc
     1501 ctcagctgcc ctcaccgggt tcaccttctc ggccttgcag atcctgcctt acacgctcgc
     1561 ctccctctac caccgtgaga agcaggtgtt cctgcccaaa taccgagggg acgctggagg
     1621 tagcagcggt gaggacagcc agacaaccag cttcttgcca ggccctaagc caggagctct
     1681 cttccccaat ggacacgtgg gctctggcag cagcggcatc ctggcccctc cacctgcact
     1741 ctgtggggcc tctgcctgcg atgtctccat gcgagtggtg gtgggtgagc cacctgaggc
     1801 cagggttgtt acgggacggg gcatttgcct ggacctggcc attctggaca gtgcctttct
     1861 gctgtcccag gtggctccgt ccctgttcat gggctccatt gtccagctga gccactctgt
     1921 cactgcctat atggtatcag ctgcaggctt gggtctggtc gccatttact ttgctacaca
     1981 ggtagtgttt gacaagaacg acttggccaa atactcagtg tagaattgtg taaggcatca
     2041 aagagagggt ctgcctcatg ggttctcagc ccttagaggg ctgcagagct ggcctctcca
     2101 ggtctttgtc gcctaagtgg ctctctgctg ccaccctaag gcagtgaggt gtattgttgc
     2161 acagatagga gccagagctt tcggggctct ggcttcagag tctggctggc ctactggcag
     2221 cctctcgcat ggaagtcatt ctgaagttct gcagggattg aaatgtggtc tgttcaggtg
     2281 tcctgtatca aggctccagg ttaacagcta acctcctgct taagtcacca gagggaggat
     2341 ttgggggacc tgaacaaact tccctccaag tcccttgacc agattctgcc actgttgctc
     2401 ttgcatggga gtttcttgta ggatgctctc ctccacaggg tttggcaggg tggaagttgg
     2461 aaggaggaac cctagcaggc aagatgaaac cccgtgatct acagcactgc ctttctgctg
     2521 agtctcccac cccccacttg tttcaggaaa tggctcagct tgttggccac agagacacag
     2581 gcctttaaat atttaattta ttatttattt aacaaatgag aagaaaattc attcccagcc
     2641 tttttatgtt gtgcctagga gttgagtagg gtgggattcc ccaaaactgg gtcccctaaa
     2701 atagctggtc actgtgttag atattgccag actcctcttc tggggtgata gatatggtcc
     2761 cccaaactgc tcagcccagt acctcgggca atctcttcat cctaattgag agccataaga
     2821 tgttcctgct caaggattgg gacccaaggt ctccacagca taccaaatcc caattctctc
     2881 ttgacccagt ttggttccct gattgcccac ttctccctat gggaaaggac tgtgaagaga
     2941 ttgcccttcc aagtctgtcc cctggctcca ggacctctct atggggcttt ctgaatccta
     3001 agcacaaatg tggttcctta ggcttctgcc catctcagcc tctggggcat atctgtcaca
     3061 gcctggggaa tctcacacaa actcaggagt actccccgcc agagccagtg agctcatcac
     3121 gtcgaggggg atttcagtgc tgattgcaat aatgttatct atgtcttatt tatttagcag
     3181 agtaaatatt ttataccgta tgtgataaat cagagtataa tgtttatggt gatgaaatta
     3241 aaagcttcgt atatgtttac ttgatat
//
