LOCUS       NM_053077               2983 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus solute carrier family 45, member 2 (Slc45a2), mRNA.
ACCESSION   NM_053077
VERSION     NM_053077.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2983)
  AUTHORS   Liu,Y., Chi,W., Tao,L., Wang,G., Deepak,R.N.V.K., Sheng,L.,
            Chen,T., Feng,Y., Cao,X., Cheng,L., Zhao,X., Liu,X., Deng,H.,
            Fan,H., Jiang,P. and Chen,L.
  TITLE     Ablation of Proton/Glucose Exporter SLC45A2 Enhances Melanosomal
            Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma
            Metastasis
  JOURNAL   J Invest Dermatol 142 (10), 2744-2755 (2022)
   PUBMED   35469906
REFERENCE   2  (bases 1 to 2983)
  AUTHORS   Bartolke,R., Heinisch,J.J., Wieczorek,H. and Vitavska,O.
  TITLE     Proton-associated sucrose transport of mammalian solute carrier
            family 45: an analysis in Saccharomyces cerevisiae
  JOURNAL   Biochem J 464 (2), 193-201 (2014)
   PUBMED   25164149
  REMARK    GeneRIF: mRNA expression of SLC45A2 in eyes and skin and of SLC45A3
            primarily in the prostate, but also in other tissues, whereas
            SLC45A4 showed a predominantly ubiquitous expression
REFERENCE   3  (bases 1 to 2983)
  AUTHORS   Xia,Y., Won,S., Du,X., Lin,P., Ross,C., La Vine,D., Wiltshire,S.,
            Leiva,G., Vidal,S.M., Whittle,B., Goodnow,C.C., Koziol,J.,
            Moresco,E.M. and Beutler,B.
  TITLE     Bulk segregation mapping of mutations in closely related strains of
            mice
  JOURNAL   Genetics 186 (4), 1139-1146 (2010)
   PUBMED   20923982
REFERENCE   4  (bases 1 to 2983)
  AUTHORS   Blasius,A.L., Arnold,C.N., Georgel,P., Rutschmann,S., Xia,Y.,
            Lin,P., Ross,C., Li,X., Smart,N.G. and Beutler,B.
  TITLE     Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required
            for Toll-like receptor signaling in plasmacytoid dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (46), 19973-19978 (2010)
   PUBMED   21045126
REFERENCE   5  (bases 1 to 2983)
  AUTHORS   Loftus,S.K., Baxter,L.L., Buac,K., Watkins-Chow,D.E., Larson,D.M.
            and Pavan,W.J.
  TITLE     Comparison of melanoblast expression patterns identifies distinct
            classes of genes
  JOURNAL   Pigment Cell Melanoma Res 22 (5), 611-622 (2009)
   PUBMED   19493314
REFERENCE   6  (bases 1 to 2983)
  AUTHORS   Swank,R.T., Reddington,M., Howlett,O. and Novak,E.K.
  TITLE     Platelet storage pool deficiency associated with inherited
            abnormalities of the inner ear in the mouse pigment mutants muted
            and mocha
  JOURNAL   Blood 78 (8), 2036-2044 (1991)
   PUBMED   1912584
REFERENCE   7  (bases 1 to 2983)
  AUTHORS   Oguro,K., Ito,M., Tsuda,H., Mutoh,K., Shiraishi,H., Shirasaka,Y.
            and Mikawa,H.
  TITLE     Association of NMDA receptor sites and seizures of El mice
  JOURNAL   Epilepsy Res 9 (3), 225-230 (1991)
   PUBMED   1835927
REFERENCE   8  (bases 1 to 2983)
  AUTHORS   LaVail,J.H., Nixon,R.A. and Sidman,R.L.
  TITLE     Genetic control of retinal ganglion cell projections
  JOURNAL   J Comp Neurol 182 (3), 399-421 (1978)
   PUBMED   102659
REFERENCE   9  (bases 1 to 2983)
  AUTHORS   Teicher,L.S. and Caspari,E.W.
  TITLE     The genetics of blind--a lethal factor in mice
  JOURNAL   J Hered 69 (2), 86-90 (1978)
   PUBMED   670679
REFERENCE   10 (bases 1 to 2983)
  AUTHORS   Eicher,E.M. and Womack,J.E.
  TITLE     Chromosomal location of soluble glutamic-pyruvic transaminase-1
            (Gpt-1) in the mouse
  JOURNAL   Biochem Genet 15 (1-2), 1-8 (1977)
   PUBMED   849243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029155.1.
            
            On Apr 5, 2007 this sequence version replaced NM_053077.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029155.1, AK148207.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849379,
                                           SAMN00849382 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2983              AK029155.1         2-2984
FEATURES             Location/Qualifiers
     source          1..2983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.4 cM"
     gene            1..2983
                     /gene="Slc45a2"
                     /gene_synonym="Aim-1; Aim1; blanc-sale; bls; Dbr; Matp;
                     Oca4; uw"
                     /note="solute carrier family 45, member 2"
                     /db_xref="GeneID:22293"
                     /db_xref="MGI:MGI:2153040"
     exon            1..481
                     /gene="Slc45a2"
                     /gene_synonym="Aim-1; Aim1; blanc-sale; bls; Dbr; Matp;
                     Oca4; uw"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1689
                     /gene="Slc45a2"
                     /gene_synonym="Aim-1; Aim1; blanc-sale; bls; Dbr; Matp;
                     Oca4; uw"
                     /note="B/AIM-1-like protein; protein AIM-1; protein
                     underwhite; melanoma antigen AIM1; dominant brown"
                     /codon_start=1
                     /product="membrane-associated transporter protein"
                     /protein_id="NP_444307.1"
                     /db_xref="CCDS:CCDS27382.1"
                     /db_xref="GeneID:22293"
                     /db_xref="MGI:MGI:2153040"
                     /translation="MSGSNGPTDTHTYQSLAEDCPFGSVEQPKRSTGRLVMHSMAMFG
                     REFCYAVEAAYVTPVLLSVGLPKSLYSMVWLLSPILGFLLQPVVGSASDHCRARWGRR
                     RPYILTLAIMMLLGMALYLNGDAVVSALVANPRQKLIWAISITMVGVVLFDFSADFID
                     GPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYILGAIDWVHLDLGRLLGTEFQVM
                     FFFSALVLILCFITHLCSIPEAPLRDAATDPPSQQDPQGSSLSASGMHEYGSIEKVKN
                     GGADTEQPVQEWKNKKPSGQSQRTMSMKSLLRALVNMPSHYRCLCVSHLIGWTAFLSN
                     MLFFTDFMGQIVYHGDPYGAHNSTEFLIYERGVEVGCWGLCINSVFSSVYSYFQKAMV
                     SYIGLKGLYFMGYLLFGLGTGFIGLFPNVYSTLVLCSMFGVMSSTLYTVPFNLIAEYH
                     REEEKEKGQEAPGGPDNQGRGKGVDCAALTCMVQLAQILVGGGLGFLVNMAGSVVVVV
                     ITASAVSLIGCCFVALFVRYVD"
     exon            482..658
                     /gene="Slc45a2"
                     /gene_synonym="Aim-1; Aim1; blanc-sale; bls; Dbr; Matp;
                     Oca4; uw"
                     /inference="alignment:Splign:2.1.0"
     exon            659..984
                     /gene="Slc45a2"
                     /gene_synonym="Aim-1; Aim1; blanc-sale; bls; Dbr; Matp;
                     Oca4; uw"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1128
                     /gene="Slc45a2"
                     /gene_synonym="Aim-1; Aim1; blanc-sale; bls; Dbr; Matp;
                     Oca4; uw"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1252
                     /gene="Slc45a2"
                     /gene_synonym="Aim-1; Aim1; blanc-sale; bls; Dbr; Matp;
                     Oca4; uw"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1464
                     /gene="Slc45a2"
                     /gene_synonym="Aim-1; Aim1; blanc-sale; bls; Dbr; Matp;
                     Oca4; uw"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..2983
                     /gene="Slc45a2"
                     /gene_synonym="Aim-1; Aim1; blanc-sale; bls; Dbr; Matp;
                     Oca4; uw"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccatctct gttggttgct ctgacaggct ccatgtcaga cccggtttgg agcacaaatc
       61 tgaggaccac gcaagaaggc tattttctcc gtggtcatga gtggaagcaa tgggccgact
      121 gacacccata cctatcaatc cttagccgag gattgcccct ttggctctgt ggagcaaccc
      181 aagagatcca cagggagact tgtcatgcac agcatggcca tgtttggccg agagttttgc
      241 tatgcggtgg aggcagctta tgtgactcca gttctgctca gcgtgggcct gcctaagagc
      301 ctgtacagca tggtgtggct cctaagcccc atcttgggat tcctgctcca gcctgtggtg
      361 ggatcagcca gtgatcactg cagggcccgt tggggtcgcc ggagaccata catcctgact
      421 ctggccatta tgatgctctt gggaatggct ctgtacctca atggagatgc ggtcgtatca
      481 gctttggttg ctaacccaag gcagaagctg atctgggcca taagcatcac catggtaggt
      541 gtggttctct tcgatttttc tgctgacttc attgacgggc ccatcaaagc ctacttattt
      601 gatgtctgct cccaccagga caaggagaag ggcctccact accatgccct cttcacaggt
      661 tttggaggtg cccttggcta cattttgggt gccatagact gggtgcatct agatctggga
      721 aggctgctgg gcacagaatt ccaggtcatg ttcttcttct ctgccctggt tctcatcttg
      781 tgcttcatca cacacctgtg cagtatccct gaagctccac tcagagatgc tgcaactgac
      841 cctccctcac agcaggaccc tcagggctcg tcgctgtcag ccagtgggat gcatgaatac
      901 ggttctattg agaaagttaa aaatggaggt gcagacacag agcagccagt acaggaatgg
      961 aaaaacaaaa agccttctgg ccagagtcag aggacaatgt cgatgaagtc actccttcgg
     1021 gcattagtaa acatgccttc ccattatcgc tgcctttgcg tcagccacct gattggatgg
     1081 actgccttcc tgtcaaacat gctcttcttc acagatttca tgggacagat tgtataccat
     1141 ggggatccct acggtgcaca caactccacg gagtttctca tctatgaaag aggagttgag
     1201 gtcggatgtt ggggcttgtg catcaactct gtgttttctt cagtttattc atactttcag
     1261 aaagctatgg tctcctacat tggattaaaa ggcctttatt tcatgggata tttgctcttt
     1321 ggcctgggaa caggattcat aggactcttt ccaaatgtgt actctactct ggtcctctgt
     1381 tctatgtttg gtgtaatgtc cagcacattg tacactgtgc cctttaacct cattgctgag
     1441 taccaccgtg aagaggagaa agagaagggg caggaagcgc caggaggccc tgacaaccag
     1501 gggagaggca aaggcgtgga ctgcgctgct ctcacctgca tggtacagct ggctcagatc
     1561 ttggttggag gtggcctggg cttcctggtc aacatggctg ggagtgtcgt cgtcgtggtg
     1621 atcacagcgt ctgcggtgtc cctgataggc tgttgctttg tggcgctctt cgtaagatat
     1681 gtagattagg ttcataaaaa gacacccacc aaacctcaga caaaagaagc ccatggcaag
     1741 aaaccgctct tttctcggac tcttcggtgt tgttggggac tgtatgcctc atgctggcac
     1801 tgcgccttgc acatacatgt ggggaaggtg tggtgggatt gcccgctccc ctgcatcttc
     1861 cttactgccc cgcaatgcag gatgagagag tcaagttctg cttctcaaga gaatttcaag
     1921 cctccatcat gtcttaggaa caaatgcatc ttacctgtaa tgcttataaa taatttttaa
     1981 aagtcaattc atataccact gggaaatcac acatttcatc aaattcagaa gcacttaaaa
     2041 catgaccgag tgtttctttt atcgtgttga tttattcaga tttaatttgc tcataattaa
     2101 ttcccgtcta atgtatgaca ttctgaacaa gcctgcgttg gaggtctcat tccgaaagca
     2161 cagcaactta aaagtgttca ttcatttcac tgatgcagta aaaatctttt tcttgagtcg
     2221 gtaccttcac ttcatgctct gaaattgaca atttcaagaa gcgattctgg ggtttctcct
     2281 acgatattct atctcactcc caatagagca catttgcttt aattaaaacc ttcagcgggc
     2341 tcccatgtgg gaatttttac cagcctgaag agactgtact gaacccatgc tgagagacca
     2401 catcacttaa taacaaaacc agcagtgggc tttggagcct ggctgtgttt tgaacctctg
     2461 tttggtactc agaggcgaag tatttagcat cctgaaccat gcatgcttgt gtgtacgcta
     2521 gtatgaggaa ttccattctc agagcatcga gaccgtgagt ttacaatgct tgtgaagtgc
     2581 ttccccttac cgcaaagtct tagccttcct cgatacagca attttgacca tggacgctac
     2641 agctgatctt cactcttaca tgagggaacc agagcaaagc tccattaggt gcctcactga
     2701 agccacacaa gtcatatgtg gcaaagctgg gctttcaatc cagggctttg gctctactgc
     2761 ttcccgtgga gggcaagcat aggctggcgg cctacgtgct cagggctcaa tgaatgtcat
     2821 ggtcattgct ggcaaacccc atcaccagcc ctctctcctt aggttttctg cagccttggt
     2881 taagtgccat ctgtatgact ccagatgtgc ctgagccatg cagaaaggaa atttgtccat
     2941 gtgccttcag atgtaaaaga taaagctatg ggtttccact ctc
//
