LOCUS       NM_023557               2345 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus solute carrier family 44, member 4 (Slc44a4), mRNA.
ACCESSION   NM_023557
VERSION     NM_023557.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2345)
  AUTHORS   Sabui,S., Anthonymuthu,S., Ramamoorthy,K., Skupsky,J.,
            Jennings,T.S.K., Rahmatpanah,F., Fleckenstein,J.M. and Said,H.M.
  TITLE     Effect of knocking out mouse Slc44a4 on colonic uptake of the
            microbiota-generated thiamine pyrophosphate and colon physiology
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 327 (1), G36-G46 (2024)
   PUBMED   38713615
  REMARK    GeneRIF: Effect of knocking out mouse Slc44a4 on colonic uptake of
            the microbiota-generated thiamine pyrophosphate and colon
            physiology.
REFERENCE   2  (bases 1 to 2345)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2345)
  AUTHORS   Nabokina,S.M., Ramos,M.B. and Said,H.M.
  TITLE     Mechanism(S) Involved in the Colon-Specific Expression of the
            Thiamine Pyrophosphate (Tpp) Transporter
  JOURNAL   PLoS One 11 (2), e0149255 (2016)
   PUBMED   26901654
  REMARK    GeneRIF: epigenetic mechanisms (histone modifications) play a role
            in determining the tissue-specific pattern of expression of the
            TPPT along the GI tract.
            Erratum:[PLoS One. 2017 Oct 11;12(10):e0186550. doi:
            10.1371/journal.pone.0186550. PMID: 29020075]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2345)
  AUTHORS   Nabokina,S.M., Inoue,K., Subramanian,V.S., Valle,J.E., Yuasa,H. and
            Said,H.M.
  TITLE     Molecular identification and functional characterization of the
            human colonic thiamine pyrophosphate transporter
  JOURNAL   J Biol Chem 289 (7), 4405-4416 (2014)
   PUBMED   24379411
  REMARK    Erratum:[J Biol Chem. 2017 Oct 6;292(40):16526. doi:
            10.1074/jbc.A113.528257. PMID: 28986434]
REFERENCE   5  (bases 1 to 2345)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 2345)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   7  (bases 1 to 2345)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164684.1, AK145621.1 and AK166620.1.
            
            On Feb 2, 2010 this sequence version replaced NM_023557.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145621.1, BC010808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AK164684.1         2-10
            10-2263             AK145621.1         2-2255
            2264-2345           AK166620.1         2166-2247
FEATURES             Location/Qualifiers
     source          1..2345
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.46 cM"
     gene            1..2345
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /note="solute carrier family 44, member 4"
                     /db_xref="GeneID:70129"
                     /db_xref="MGI:MGI:1917379"
     exon            1..55
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            56..104
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            105..178
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            179..257
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            258..357
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            358..480
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            481..541
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            542..632
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            633..716
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            717..952
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1052
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1145
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1248
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1499
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1594
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1698
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1772
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1843
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1938
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2023
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2345
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2238..2243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /note="hexamer: ATTAAA"
     polyA_site      2265
                     /gene="Slc44a4"
                     /gene_synonym="2210409B01Rik; mTPPT1; NG22"
                     /note="major polyA site"
ORIGIN      
        1 aatcactccg gagactgagc catggggaga aagcagaatg agaacgaggc tcacgggaat
       61 tcggccaaat atgacccctc ctttcgaggc cccatcaaaa acaggggctg cacagacatc
      121 atctgctgtg tcctcttcct gatcttcatt ttgggttaca tcatagtggg gcttgtggcc
      181 tgggtgtatg gagaccctcg gcaagtgctc taccccagaa actccacggg ggcctactgc
      241 ggcgtgggcg acaacaagga taaaccctac gttctatact tcgacatctt aagctgtgcg
      301 gcagctatca acatcatctc catcgctgag aatggcctac agtgccccac accccaggtg
      361 tgcgtctctt cctgcccact ggccccatgg gctgtggagg tgttccagtt ctcaaagaca
      421 gtcggtgaag tttatggtga aaggagaaac ttttgtcttc cagcggtgtc cccagatatg
      481 atagtggagg agagcctgca gaagggactc tgtccccgtt tccttcttcc ttctactcca
      541 gctctgggac gttgtttccc actccccaac atcaacttca cgttacctga agacttacgg
      601 atcaataaca ccaccgtctc taatggcatc agtggcctcc tggacagcat caatgcccgg
      661 gatgtctctg tgaagatctt tgaagatttt gcccagtcct ggtactggat tctcgtagcg
      721 ctgggtgtgg ccctggcact aagtctgctg ttcatcctcc tcctgcgcct ggtggcggca
      781 cccctggtgc tgctgctgat tgtcggggtg ctcgctgtgc tcgcctatgg catctaccac
      841 tgctggcaac agtaccaagt gtttcgggac aagggcgcct ccatcaccca actgggcttc
      901 actaccaact tcagtgccta ccagagtgtg aaggagactt ggctggctgc tttgattgtc
      961 ctggctgtcc tggagggcat cttgttgctt atgctcattt tcctgcgcca gaggatccgg
     1021 atcgccatcg ctctgctgaa ggaagccagc agggctgtgg ggcagatgat gtcaactatg
     1081 ttctaccctc tggtcacctt cgtcctcctg gtcatttgca ttggttactg ggccgtgaca
     1141 gctctatacc tggccacatc cgggcaaccc cagtacatct actgggcgtc caacaccagt
     1201 acaccgggct gtgagaacgt tcctgtgaac atgacttgtg acccgatggc cccgttgaat
     1261 tcctcgtgcc caaacctcaa gtgcgtcttc aagggctact cgaccacggg cctagctcag
     1321 cgttctctct tcaacctgca aatctacgga gtcctggggc tcttctggac tgttaactgg
     1381 gtactggccc tgggccagtg tgtccttgcc ggggccttcg cctctttcta ctgggccttt
     1441 cacaagcctc gagacatccc taccttccct ttgagctcag ccttcatccg cacactccgt
     1501 taccacactg gctcactggc gtttggagcc ctcatcctgt cccttgtgca gatagcccgg
     1561 gttatcctgg agtatatcga ccacaagcta agaggatccc agaaccctgt ggcccgctgc
     1621 atcatctgct gcttcaagtg ttgcctctgg tgtctggaga agtttattaa gttcctcaac
     1681 cgcaatgcct acatcatgat cgccatctat ggaaagaatt tttgtgtctc ggccaaaaat
     1741 gccttcatgc tgctcatgag gaatgttctc agggtcgtcg tcctggataa agtcactgat
     1801 ctgctgctgt tctttgggaa gctgctggtg gttggaggtg tcggcgttct gtccttcttc
     1861 tttttctccg gtcgtatcaa ggggctgggg aaagactttg agaaccccaa cctcaactat
     1921 tattggctgc ccatcatgac ctccatcatg ggagcctacg tcattgccag tggcttcttc
     1981 agcgtctttg gaatgtgtgt agatacgctc ttcctctgct tcctcgagga cctggagaga
     2041 aatgatggtt cccaggagcg gccttactac atgcccaagg cactcctgaa gattctgggc
     2101 aagaagaatg aggcacctac agggggaaag accaggaaga agtgagagac tcatcgtgac
     2161 ctggaaatgc agccctcctg tacagaagcc ctgccgtcaa tgccttgaga atcacgattt
     2221 tgtagaaaac agattttatt aaagactaat attttatatt cttgataagt ttatggcttt
     2281 attttcagtg aaaacttgct tccttttttt ttttttttaa ttaaaatcca aattgctatc
     2341 acacg
//
