LOCUS       NM_173388               6915 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus solute carrier family 43, member 2 (Slc43a2),
            transcript variant 3, mRNA.
ACCESSION   NM_173388
VERSION     NM_173388.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6915)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6915)
  AUTHORS   Rajendran,A., Poncet,N., Oparija-Rogenmozere,L., Herzog,B. and
            Verrey,F.
  TITLE     Tissue-specific deletion of mouse basolateral uniporter LAT4
            (Slc43a2) reveals its crucial role in small intestine and kidney
            amino acid transport
  JOURNAL   J Physiol 598 (22), 5109-5132 (2020)
   PUBMED   32841365
REFERENCE   3  (bases 1 to 6915)
  AUTHORS   Bian,Y., Li,W., Kremer,D.M., Sajjakulnukit,P., Li,S., Crespo,J.,
            Nwosu,Z.C., Zhang,L., Czerwonka,A., Pawlowska,A., Xia,H., Li,J.,
            Liao,P., Yu,J., Vatan,L., Szeliga,W., Wei,S., Grove,S., Liu,J.R.,
            McLean,K., Cieslik,M., Chinnaiyan,A.M., Zgodzinski,W., Wallner,G.,
            Wertel,I., Okla,K., Kryczek,I., Lyssiotis,C.A. and Zou,W.
  TITLE     Cancer SLC43A2 alters T cell methionine metabolism and histone
            methylation
  JOURNAL   Nature 585 (7824), 277-282 (2020)
   PUBMED   32879489
  REMARK    GeneRIF: Cancer SLC43A2 alters T cell methionine metabolism and
            histone methylation.
REFERENCE   4  (bases 1 to 6915)
  AUTHORS   Oparija-Rogenmozere,L., Rajendran,A., Poncet,N., Camargo,S.M.R. and
            Verrey,F.
  TITLE     Phosphorylation of mouse intestinal basolateral amino acid
            uniporter LAT4 is controlled by food-entrained diurnal rhythm and
            dietary proteins
  JOURNAL   PLoS One 15 (5), e0233863 (2020)
   PUBMED   32470053
  REMARK    GeneRIF: Phosphorylation of mouse intestinal basolateral amino acid
            uniporter LAT4 is controlled by food-entrained diurnal rhythm and
            dietary proteins.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6915)
  AUTHORS   Oparija,L., Rajendran,A., Poncet,N. and Verrey,F.
  TITLE     Anticipation of food intake induces phosphorylation switch to
            regulate basolateral amino acid transporter LAT4 (SLC43A2) function
  JOURNAL   J Physiol 597 (2), 521-542 (2019)
   PUBMED   30379325
  REMARK    GeneRIF: LAT4 is subject to a circadian regulation by
            phosphorylation in the mouse small intestine, and this novel
            regulatory mechanism is suggested to play an important role in the
            diurnal regulation of amino acid absorption.
REFERENCE   6  (bases 1 to 6915)
  AUTHORS   Guetg,A., Mariotta,L., Bock,L., Herzog,B., Fingerhut,R.,
            Camargo,S.M. and Verrey,F.
  TITLE     Essential amino acid transporter Lat4 (Slc43a2) is required for
            mouse development
  JOURNAL   J Physiol 593 (5), 1273-1289 (2015)
   PUBMED   25480797
  REMARK    GeneRIF: Mice lacking Lat4 display a slight intrauterine growth
            restriction, postnatal malnutrition and early death.
REFERENCE   7  (bases 1 to 6915)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   8  (bases 1 to 6915)
  AUTHORS   Bodoy,S., Martin,L., Zorzano,A., Palacin,M., Estevez,R. and
            Bertran,J.
  TITLE     Identification of LAT4, a novel amino acid transporter with system
            L activity
  JOURNAL   J Biol Chem 280 (12), 12002-12011 (2005)
   PUBMED   15659399
  REMARK    GeneRIF: In situ hybridization experiments show that LAT4 mRNA is
            restricted to the epithelial cells of the distal tubule and the
            collecting duct in the kidney. In the intestine, LAT4 is mainly
            present in the cells of the crypt.
REFERENCE   9  (bases 1 to 6915)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202700.1, CD550550.1, AK143773.1, AL591440.7 and AA017978.1.
            
            On Dec 2, 2010 this sequence version replaced NM_173388.1.
            
            Transcript Variant: This variant (3) contains a different segment
            from its 5' UTR, compared to variant 1. All three variants encode
            the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK005643.1, BC042513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BY202700.1         1-5
            6-400               CD550550.1         2-396
            401-3161            AK143773.1         499-3259
            3162-6552           AL591440.7         138866-142256       c
            6553-6915           AA017978.1         1-363
FEATURES             Location/Qualifiers
     source          1..6915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..6915
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /note="solute carrier family 43, member 2"
                     /db_xref="GeneID:215113"
                     /db_xref="MGI:MGI:2442746"
     exon            1..48
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            49..249
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1796
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /note="L-type amino acid transporter 4; L-type amino
                     L-acid transporter 4"
                     /codon_start=1
                     /product="large neutral amino acids transporter small
                     subunit 4"
                     /protein_id="NP_775564.1"
                     /db_xref="CCDS:CCDS25051.1"
                     /db_xref="GeneID:215113"
                     /db_xref="MGI:MGI:2442746"
                     /translation="MAPTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEG
                     FYSYLCTKPENVTNSTVGGSAEPEPEELSLVNGWLSCKAQDEILNLAFTVGSFLLSAI
                     TLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASNPDSLSVLIFIALALNGFGGMC
                     MTFTSLTLPNMFGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGASFIGILVVWAGCS
                     GLVFFNCFFNWPLEPFPGPEDMDYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVG
                     SSMRTAKEQAALQEGHKLCLSTVDLEVKCQPDAAAAPSFMHSVFSPLLVLSLVTMCVT
                     QLRLIFYMGAMNSILEFLVRGDQKTVALYTSIFGALQLLCLLTAPVIGYIMDWKLKEC
                     EDTSEEPEEKEGTQGEKKQKRDRQIQKVTNAMRAFAFTNVLLVGFGVTCLIPNLPLQI
                     FSFVLHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLVSALFALLQQPLYLAMMGP
                     LGGDPLWVNVGLLAMSMLGFCLPLYLICYRRQLERQLQQKREDSKLFLKINGSSNREA
                     FV"
     exon            250..457
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            458..513
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            514..590
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            591..683
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            684..817
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1020
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1167
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1306
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1436
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1510
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1634
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..6892
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3075..3080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
                     /note="hexamer: AATAAA"
     polyA_site      3111
                     /gene="Slc43a2"
                     /gene_synonym="7630402D21Rik; Lat4"
ORIGIN      
        1 ggacagaaaa ggcgccgggc gggcccgata cacactggta ggagccgggt gtctgcagaa
       61 ccggagcccg accaccgcca caccgcacca tggcgcccac cctggccact gcccatcggc
      121 gccgctggtg gatggcctgc accgctgtgt tggaaaacct ccttttctcc gcagtcctcc
      181 tgggctgggg ttcgctgctc atcatgctca agtccgaggg cttttactcc tacctgtgta
      241 cgaagccaga gaatgtcact aacagcacgg tcgggggcag cgcagagccg gaacccgagg
      301 agttgagcct ggtgaatggc tggctcagct gtaaggccca ggatgagatt ctgaatttgg
      361 ccttcaccgt gggctccttc ctgctcagtg ccatcaccct gcctctgggc atcatcatgg
      421 acaagtatgg tccaaggaag ctcaggctgc tgggcagtgc ttgctttgct gtctcctgct
      481 tgctgattgc atatggagca agtaacccag actcgctctc tgtgctcatc tttatcgcct
      541 tggctctgaa cggctttggg gggatgtgca tgacgttcac ttcgttaaca ctgcccaata
      601 tgttcggcga ccttcggtcc acatttattg ccttgatgat tggatcctac gcttcctcag
      661 cagttacctt cccaggaata aagctcatct acgacgctgg cgcctccttc attggcatcc
      721 tagtggtctg ggctggctgc tctggcctgg tttttttcaa ctgtttcttc aactggccac
      781 tcgagccctt cccaggccca gaggacatgg actactcggt gaagatcaag ttcagctggc
      841 taggctttga ccacaagatc acagggaagc agttctacaa gcaggtgacc acagtggggc
      901 gccgtctgag cgtgggcagc tctatgcgga ctgccaagga gcaagccgcc ctgcaggagg
      961 gccacaagct gtgtctgtcc actgtggacc tggaggtgaa gtgccagcct gatgctgcag
     1021 cggccccatc gtttatgcac agtgtgttca gccccctcct ggtgctcagc ctggtcacca
     1081 tgtgtgtcac acagctgcga cttatcttct acatgggggc tatgaacagc atccttgagt
     1141 tcctggtcag gggggaccag aagacagttg ccctctatac ctccatcttt ggcgcactcc
     1201 agctgctctg cctgctgaca gctcctgtca tcggctacat catggactgg aagctgaaag
     1261 agtgtgaaga tacttcagag gagcctgagg agaaagaagg cactcaaggt gaaaagaagc
     1321 agaaacgaga caggcagatt cagaaagtca cgaatgccat gcgggccttc gcctttacaa
     1381 acgtgctgct tgtgggtttt ggggtgacct gcctcattcc caacctgcct ctacagatct
     1441 tctccttcgt cctgcacaca attgtgcgag gattcatcca ctctgccgta gggggcctat
     1501 acgctgccgt gtacccctcc acacagtttg gtagcctcac tggactgcag tccctggtca
     1561 gtgcgctctt tgctctcctg cagcagccgc tgtatctggc catgatgggt cctctgggag
     1621 gagaccctct gtgggtgaac gtgggtctgc tcgccatgag catgctgggc ttctgcctgc
     1681 ccctttacct catctgctac cggcgccagc tggagaggca gctgcagcag aagagggaag
     1741 acagcaagct gttccttaag atcaatggct catccaaccg ggaggctttc gtgtagtgcc
     1801 cacccaccgc ctcagttgtg gcctcctgcc tgtgcttcag tgactgactg cagtcatctc
     1861 cccaccccag aggacctcat gctctccctg gatcctgccc ttcaccacac tggagcccat
     1921 acttcctcag aaccacctgg ccctgccgtg gagtgctggt gtggagggac aggagagggc
     1981 ctgggacaag tgaacctccc actgccagaa gctgggctgc cctggcctag ctgtcacccc
     2041 aggggctctg aagtctcccg atctccatgg ggcttgtacc tggagccaag gggacctttt
     2101 cagcgagcat ttctttcttt ttattttttc tttctctttc tcactgatcg gattctgcct
     2161 cttgccaaag cagaggggcc tgccatcctc cagcacacta cctgtccctg agctgcacgc
     2221 ccaccaacca cgcccacctg aggacaaagg cttgcgctgt ctgcactccc cttgcttggc
     2281 cccttacctc ccctggccag tctggctgcc tgaggaagga aggacccgct tcctgttgtt
     2341 ggtgctaacc cctttgtcat cccaacaccc ccctgcccgt ggctagtctc tggcccctct
     2401 tttccttgaa agcctgagaa gaagcccccc ctgtctcagg ctggggaagg agtggagggc
     2461 agactattta cacaaagcct caagagccct gggccaggct tcttcctccg gagccagagc
     2521 agtgtctctc tgctggcacg ctttgttcca gtctgcaacc tgaagggaac taaggggaca
     2581 ccacaagggc accctcccat ccacccacag ctgtttttct ggggtggaaa taaggctgtg
     2641 actagacatg aggagccaag cctaaatagg gaagaggatt agtgagtaac ccgaggggtg
     2701 tgtgtttatg tggtacgtgt gtgtgcatgt gtgtatatgg taggaggcta gccccagggg
     2761 ctgcttttat cagagtggac cagaccagaa gccagccagc cctacagcag gctcaaaata
     2821 ggagtcagcc ttgctttatg atggggacct gtgtgtatcg gtgtgatcac agtgccccct
     2881 gctggcagac tcacatcagg ggactggaac ggttcatgta gtagaagcct agccggcctg
     2941 cctggctcac taacccacct tgccttgaca acccctagaa accctgcctg agacctcttg
     3001 gggtgccaag aggggtacat tggtttttaa gtttatggtt ttctcttgtt ttatcatgat
     3061 tctttttatg aagcaataaa tccatttccc tgttggtaat ggatgcccct cctcacgtat
     3121 cagctaatta ctgtatgtgc ctattttata tttgagagga gagacagggc aaaagggtct
     3181 gccaggaaga aaagaaaaaa gaagccagac atagtggcac acattttaat cccagcatgg
     3241 gaacctgaag caggcagagt ttgaggccag tctagtctac atggagaatt ctagggctac
     3301 atagtcaaaa tctgtagatg ttctgctagt gacaaaccca gctacacctg ggtgacatgt
     3361 ccaggaaggg gcatgggcaa aggaaagccc tgtctaccct gtccagggaa atggggctgt
     3421 ggagaggtgt gggctgccct cactgctgtc tgttgcgact agacagacca atccagagag
     3481 agccttcatc tccactgttg gctgttaccg tgtaagccca agggttgtta tatggtgact
     3541 ccaggaaagt cctaggctaa ctagcaccca ggctaactga gatgccctca gtctcagtgc
     3601 aggccctgtt gtgagagtgg actgccaggt cttgactcca gtctgttcaa acagtaatca
     3661 cataacccca acagtgagct agtggaagcc ctttgaggct tctcatggct cagtggtaga
     3721 gctcactctt aacatggcta agaccctagg ttctgtttcc caagagagct attgtgtatt
     3781 ttccaaacca tctctcagaa cacttgtctg tgaaaaggtc tagtggggta cgctgagtta
     3841 aagtcagacc tgccacttca cagcagggat ccacagccct ttccccatgt tcctgagcat
     3901 tggagctggg ggtagcacca ggtgtagtgt caggaggacc tctttgagtt caagcccagc
     3961 ctcctgtaca tttcgagttc caggctagcc gggactattc aatgagaccc tgtccaaaaa
     4021 aaaatccaaa aacctgtttg caaggatgtg gagaaaaatt ggaagtttta ggcattgctg
     4081 tctgagtggt ggagctgaga gctgtggaaa catggcacag tcccgtaatg ccagcaccaa
     4141 aaggcaaagg gtgacatctt tcagcatgag ctgcaaccct gctcacacac aaggttgtga
     4201 catgctgagt ggtgacaaat catagccatg tgcgacatgg tggctacttg gctgaaatgt
     4261 ggattggctc caggcctggg tgtggatgta gctcagttgg tagcatgttt gcctagctta
     4321 cccaaagccc tgggtttgaa taaacctggc atggtagtgc agcacttgga aggtggtgac
     4381 atcaggatca aaagtccctc ttggtcagat agtgagtttg atgccaacct ggaatccaag
     4441 aactctcatc ttcggaaaaa agaatgacaa aatcagatgg cagaccactg gtctcaccta
     4501 tgtctcgatt tgattctggt gctgcccaga ggttaagatg cccctgtgag gaagagaaga
     4561 ggttgaggga atgtcccttc ctgctaggga tatagcctgc agacacaacc tgtgcagttc
     4621 ccagcaacac tgaggggccc acacttttga tcgtgatgct gtaagggtat atatcctagg
     4681 attgagacac tagaaaacta aatgtgggat ggaaaagagc caacggtact ggaagatgag
     4741 agacgtccac tggtagcaga gaacaggtgt ggcaagccag atgagctctc cctaatcaag
     4801 ggccatcctg cgctgacttg gcagacatgt cagtgtcttt gaatcacggt gacagcctag
     4861 agtggtatag atgcttggag aagcaacccc agaggactct cctgtgggtc tcaagtcact
     4921 aacacagccg aggctgtctc agctagaacc cccccccccc ccattggaag caaagagccc
     4981 aaagggtgca agctcagaat ggtttccata tcttggagcc aatgctttct caggtttgag
     5041 gcaagctatt tgcacaagag tcacgtgagc tctggaggct gatgggtcct tgcaggaata
     5101 atttccctga tctcttcaac ctcaagaaga gttaccccaa gataggcaca gaagcacagg
     5161 ctagacacag gctagaggca ccgatggaag gaacaggaag cgatgccagc cttgtggttt
     5221 tacccgtcaa ggacagtctc accagaagcc cctcctttgt ggtcttggcg ttcatcaagg
     5281 atggattccc ctgggactct acccttacga ctctgccggg acctattcac agctggctcc
     5341 aaccttcatt aaagccaagg tacaggccct cgggaccacc tcctgtgctc tgtcccctac
     5401 acccacatcc agaagttctg atcaaaactt gtacatagcc agccagtggt gctggtgcac
     5461 acctttaacc ccagctctcc cctgctcaaa gctcagcgct tgtctccaca gagcccagcc
     5521 acaggggctg ttatagcctc aacactgttc cctaggaagg gcagtaaggt agttgtgggt
     5581 tttatggcag tgacagtgcc ttatctgtga agctactagg cacaacctaa aattgagtaa
     5641 tatacatata tatatatata tatatatata tatatataga gagagagaga gagagagaga
     5701 gagagagaga gtgtattgac tcagctgtgt ggaaagagca cccaagggtt acaggagggc
     5761 tggcttctcc tcgggctgta gctcttccct ggattgaggg tcaagatgag gctgtgtccc
     5821 catgctctaa cctgccttgg gccctagagt gtggacagag cctcctgagc tgaggagagt
     5881 ccgtgtcctc tatgaggaag gtatcatggc tctgtcagca cagccaccaa ctatgcccct
     5941 tggtccctgc agtgagtcat tcttccatgg atagatccaa gacaggacca caggtcactt
     6001 cctaaccttg actgttctct gaggggaggc atgtgggtta gcagccactc cacattctca
     6061 gggaaagctc ctgccatttc ctcacgtgaa atggaggctt ctgtgctctc acgaggtggc
     6121 taaggggacc tgtaggtaaa tcgcaagaac agcagtgtgt gtagctcaca gcagaaactt
     6181 aacaccagga ccctggagaa aggcagacag cacgggagcc aggcaccccc cccccctcct
     6241 atgacaggac cctgacacaa ggggactgac catgtcagac tggtggccag ataaagatgg
     6301 tactgacctc agtctcttca gaagtcgtct tacagagaag ccttaagttc cccccttgcc
     6361 tacttttcta ttttgtcctt cacgtttttg gtaagaggct tggccaaaga gtcttgatgt
     6421 caaaagtccc agcagcccgt accgcctttt tgaatgacta cttggccagg ctgtgtgtgt
     6481 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgaga gagagagaga gagagagaga
     6541 gagagagaga gagaggtgtg ttggagagag gtgtgttctg gtgtgtctgt tgagagagat
     6601 gtataagtgt gcctatgtgc tgtaatactg ggaggcaaag gaaagggcca tggcgtccct
     6661 ttctgttacc aggagcatct aggcaggtca gaatgcaggc cacatggaag acccagacca
     6721 agccttagag tgaggcctga gggtgtgttc ttcagttcac ggggtcacat cgtgtcactg
     6781 ttaactcagc agctggcctt ggctcttccc tgtcacttct actgttccta gcccccagca
     6841 tactccttgg cacacagtaa gcacttaata aatgtatgct gagaatgatg aaaaaaaaaa
     6901 aaaaaaaaaa aaaaa
//
