LOCUS       NM_001083809            2478 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus solute carrier family 43, member 1 (Slc43a1),
            transcript variant 3, mRNA.
ACCESSION   NM_001083809
VERSION     NM_001083809.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2478)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2478)
  AUTHORS   Chung,J., Bauer,D.E., Ghamari,A., Nizzi,C.P., Deck,K.M.,
            Kingsley,P.D., Yien,Y.Y., Huston,N.C., Chen,C., Schultz,I.J.,
            Dalton,A.J., Wittig,J.G., Palis,J., Orkin,S.H., Lodish,H.F.,
            Eisenstein,R.S., Cantor,A.B. and Paw,B.H.
  TITLE     The mTORC1/4E-BP pathway coordinates hemoglobin production with
            L-leucine availability
  JOURNAL   Sci Signal 8 (372), ra34 (2015)
   PUBMED   25872869
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2478)
  AUTHORS   Fukuhara,D., Kanai,Y., Chairoungdua,A., Babu,E., Bessho,F.,
            Kawano,T., Akimoto,Y., Endou,H. and Yan,K.
  TITLE     Protein characterization of NA+-independent system L amino acid
            transporter 3 in mice: a potential role in supply of branched-chain
            amino acids under nutrient starvation
  JOURNAL   Am J Pathol 170 (3), 888-898 (2007)
   PUBMED   17322374
REFERENCE   4  (bases 1 to 2478)
  AUTHORS   Bodoy,S., Martin,L., Zorzano,A., Palacin,M., Estevez,R. and
            Bertran,J.
  TITLE     Identification of LAT4, a novel amino acid transporter with system
            L activity
  JOURNAL   J Biol Chem 280 (12), 12002-12011 (2005)
   PUBMED   15659399
REFERENCE   5  (bases 1 to 2478)
  AUTHORS   Cole,K.A., Chuaqui,R.F., Katz,K., Pack,S., Zhuang,Z., Cole,C.E.,
            Lyne,J.C., Linehan,W.M., Liotta,L.A. and Emmert-Buck,M.R.
  TITLE     cDNA sequencing and analysis of POV1 (PB39): a novel gene
            up-regulated in prostate cancer
  JOURNAL   Genomics 51 (2), 282-287 (1998)
   PUBMED   9722952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031215.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and has
            multiple coding region differences, compared to variant 1. These
            differences cause translation initiation from a distinct ATG and an
            isoform (3) with a shorter, distinct N-terminus, compared to
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031215.1, SRR11927935.2208009.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2478              AK031215.1         4-2481
FEATURES             Location/Qualifiers
     source          1..2478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..2478
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /note="solute carrier family 43, member 1"
                     /db_xref="GeneID:72401"
                     /db_xref="MGI:MGI:1931352"
     exon            1..380
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1921
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /note="isoform 3 is encoded by transcript variant 3; large
                     neutral amino acids transporter small subunit 3; L-type
                     amino acid transporter 3; prostate cancer overexpressed
                     gene 1"
                     /codon_start=1
                     /product="large neutral amino acids transporter small
                     subunit 3 isoform 3"
                     /protein_id="NP_001077278.1"
                     /db_xref="CCDS:CCDS38162.1"
                     /db_xref="GeneID:72401"
                     /db_xref="MGI:MGI:1931352"
                     /translation="MMEYPSQGPLGSPSLSALFLCRVSATMAPTLKQAYRRRWWMACT
                     AVVENLFFSAVLLGWASLLIMLKKEGFYSSLCPAENRTNTTQDEQHQWTSCDQQEKML
                     NLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPL
                     IFLALSLNGFAGICLTFTSLTLPNMFGNLRSTFMALMIGSYASSAITFPGIKLIYDAG
                     VPFTVIMFTWSGLACLIFLNCALNWPAEAFPAPEEVDYTKKIKLIGLALDHKVTGDRF
                     YTHVTIVGQRLSQKSPSLEEGADAFISSPDIPGTSEETPEKSVPFRKSLCSPIFLWSL
                     VTMGMTQLRVIFYMGAMNKILEFIVTGGKERETNEQRQKVEETVEFYSSIFGVMQLLC
                     LLTCPLIGYIMDWRIKDCVDAPTEGTLNENASFGDARDGASTKFTRPRYRKVQKLTNA
                     INAFTLTNILLVGFGIACLIKNLHLQLLAFVLHTIVRGFFHSACGGLYAAVFPSNHFG
                     TLTGLQSLISAVFALLQQLLFMAMVGPLHGDPFWVNLGLLLLSFLGFLLPSYLYYYRS
                     RLQREYATNLVDPQKVLNTSKVAT"
     exon            381..558
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            559..614
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            615..691
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            692..784
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            785..918
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1097
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1244
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1280
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1434
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1576
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1650
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1774
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..2478
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2455..2460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /note="hexamer: AATAAA"
     polyA_site      2469
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
     polyA_site      2473
                     /gene="Slc43a1"
                     /gene_synonym="2610016F07Rik; Lat3; PB39; Pov1; R00504"
                     /note="major polyA site"
ORIGIN      
        1 tttctggttc ctgatagcgc cctgcgggcc agtggcgcgt tcgctcctgg cactgccaga
       61 gcgcgcggag ccagctccgc agcaccgggc tctatggggc ctccatgaag gctccatctc
      121 tttggctcca ggggtctcag gagccaccat gatggagtac ccttcccaag ggccgctagg
      181 aagcccttct ctgagcgctc tgtttctctg cagagtctcg gccaccatgg ctcccacgct
      241 gaagcaggcg taccgcaggc gctggtggat ggcttgcacc gctgtggtgg agaacctctt
      301 cttctccgcg gtgctcctgg gctgggcctc cctgctgatc atgctcaaga aggaaggctt
      361 ctattccagc ctgtgcccag ctgagaacag gaccaatacc acccaagatg aacagcatca
      421 gtggacaagc tgtgaccagc aggaaaagat gctcaacctg ggtttcacca ttggctcctt
      481 cctgctgagt gctaccacac tgcctctggg aattctcatg gaccgctttg ggcccaggcc
      541 tcttcgactg gtgggcagtg cctgctttgc cgcatcctgc actctaatgg ccttggcctc
      601 cagggacact gaagttttgt ctccattgat attcctggca ctgtccttga atggatttgc
      661 tggcatctgc ttaacgttta cctcactcac gctgcccaac atgtttggga atttgcgatc
      721 cactttcatg gccctcatga ttggctccta tgcgtcttct gccatcacgt tccctggaat
      781 caagctgatc tacgatgccg gagtcccctt cactgtcatc atgttcacat ggtctggcct
      841 ggcctgtctc atctttttga actgtgctct caactggcct gcagaagcct ttcctgcccc
      901 tgaggaagtt gactacacga agaagatcaa actcattggg ttagccttgg accacaaggt
      961 cacaggtgac cgcttctaca cccatgtaac cattgtgggt cagcggctga gtcagaagtc
     1021 ccccagcctg gaggagggcg ctgacgcctt tatttcatcc ccggatatcc ctggtacctc
     1081 agaggagact cctgaaaagt ctgtcccttt tcgcaagagc ctctgctccc ccattttcct
     1141 gtggagcctt gtcaccatgg gcatgaccca gcttcgggtc atcttctata tgggtgctat
     1201 gaacaagatc ctggagttca ttgtgactgg tggcaaggaa cgtgagacaa atgagcagag
     1261 acagaaggtg gaggagacag ttgagttcta ctcttccatc tttggagtca tgcagctgtt
     1321 gtgtcttctc acctgccccc tcattggcta catcatggac tggcgcatca aggactgtgt
     1381 ggatgctcca acggagggca ccctgaatga gaatgcttcc tttggagatg ccagagatgg
     1441 ggctagcacc aagttcacta gaccacgcta ccgcaaggta caaaagctca ccaatgccat
     1501 caatgccttc accctgacca acatcctgct tgtgggtttc ggcatcgcct gcctcatcaa
     1561 gaacttacac ctgcagttgc tggcctttgt cctgcatacc atagttcgcg gtttcttcca
     1621 ctcagcctgt ggaggtctct acgctgctgt gttcccgtcc aatcattttg ggacactgac
     1681 aggtcttcag tctctcatca gtgccgtgtt tgctctgctg caacagctac tcttcatggc
     1741 catggtggga cccctgcatg gagatccctt ctgggtgaac ctgggcctcc tacttctctc
     1801 gttcctggga tttctcctac cttcctacct ctactactac cggtctcgcc tgcagagaga
     1861 gtatgccacc aatttggtag acccacagaa ggtgctcaat acttcgaagg tggctacata
     1921 gactcctgag gccaagagac ttggaggaca ggcagtcaag gcctgataaa ccgaagggaa
     1981 tggcctgtgg ctttctacct gcatcgtgtt catagagccg ggttctgtgg atttataaat
     2041 actaagagtt ctatttttgt agggacttgc aaaaaaggaa acaaacagaa caaaaccccc
     2101 aaaccaaaaa cagcccttaa aaaactcccc ccaaccaagc tatccatcaa ctgaagacag
     2161 tgcccgttcc agtggtattg ggccatcgtc tttgaaaaga aagtgtgggg ctgccctttc
     2221 tccacacttg gcctaggagc ctctgtggag ttgccttctg aaaactcatg ggatcagtga
     2281 acagaccaca ctaagattcc agccgccaag tgtgcacaca tatatgttac gcacatgcat
     2341 attgcatcct ttcctgcagg agaaggactg aggggctggc tgtatccagg atggggtgtg
     2401 ggggctggag ggcgggttcc ctccctgatg ctgtttctta caggtcttag aggaaataaa
     2461 aagggaaatg aaatctgg
//
