LOCUS       NM_173865               4675 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 41, member 1 (Slc41a1), mRNA.
ACCESSION   NM_173865 NM_181883 XM_129431
VERSION     NM_173865.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4675)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4675)
  AUTHORS   Ilenwabor,B.P., Franken,G.A.C., Sponder,G., Bos,C., Racay,P.,
            Kolisek,M., Hoenderop,J.G.J. and de Baaij,J.H.F.
  TITLE     SLC41A1 knockout mice display normal magnesium homeostasis
  JOURNAL   Am J Physiol Renal Physiol 323 (5), F553-F563 (2022)
   PUBMED   36049064
  REMARK    GeneRIF: SLC41A1 knockout mice display normal magnesium
            homeostasis.
REFERENCE   3  (bases 1 to 4675)
  AUTHORS   Zocchi,M., Locatelli,L., Zuccotti,G.V., Mazur,A., Bechet,D.,
            Maier,J.A. and Castiglioni,S.
  TITLE     Magnesium Homeostasis in Myogenic Differentiation-A Focus on the
            Regulation of TRPM7, MagT1 and SLC41A1 Transporters
  JOURNAL   Int J Mol Sci 23 (3), 1658 (2022)
   PUBMED   35163580
  REMARK    GeneRIF: Magnesium Homeostasis in Myogenic Differentiation-A Focus
            on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4675)
  AUTHORS   Franken,G.A.C., Seker,M., Bos,C., Siemons,L.A.H., van der
            Eerden,B.C.J., Christ,A., Hoenderop,J.G.J., Bindels,R.J.M.,
            Muller,D., Breiderhoff,T. and de Baaij,J.H.F.
  TITLE     Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and
            developmental defects
  JOURNAL   Sci Rep 11 (1), 8217 (2021)
   PUBMED   33859252
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4675)
  AUTHORS   Tatarkova,Z., de Baaij,J.H.F., Grendar,M., Aschenbach,J.R.,
            Racay,P., Bos,C., Sponder,G., Hoenderop,J.G.J., Rontgen,M.,
            Turcanova Koprusakova,M. and Kolisek,M.
  TITLE     Dietary Mg2+ Intake and the Na+/Mg2+ Exchanger SLC41A1 Influence
            Components of Mitochondrial Energetics in Murine Cardiomyocytes
  JOURNAL   Int J Mol Sci 21 (21), 8221 (2020)
   PUBMED   33153064
  REMARK    GeneRIF: Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger
            SLC41A1 Influence Components of Mitochondrial Energetics in Murine
            Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4675)
  AUTHORS   Tsao,Y.T., Shih,Y.Y., Liu,Y.A., Liu,Y.S. and Lee,O.K.
  TITLE     Knockdown of SLC41A1 magnesium transporter promotes mineralization
            and attenuates magnesium inhibition during osteogenesis of
            mesenchymal stromal cells
  JOURNAL   Stem Cell Res Ther 8 (1), 39 (2017)
   PUBMED   28222767
  REMARK    GeneRIF: Knockdown of SLC41A1 magnesium transporter promotes
            mineralization and attenuates magnesium inhibition during
            osteogenesis of mesenchymal stromal cells.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4675)
  AUTHORS   Mastrototaro,L., Smorodchenko,A., Aschenbach,J.R., Kolisek,M. and
            Sponder,G.
  TITLE     Solute carrier 41A3 encodes for a mitochondrial Mg(2+) efflux
            system
  JOURNAL   Sci Rep 6, 27999 (2016)
   PUBMED   27302215
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4675)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 4675)
  AUTHORS   Goytain,A. and Quamme,G.A.
  TITLE     Functional characterization of human SLC41A1, a Mg2+ transporter
            with similarity to prokaryotic MgtE Mg2+ transporters
  JOURNAL   Physiol Genomics 21 (3), 337-342 (2005)
   PUBMED   15713785
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161805.4, BC116280.1 and BC037033.1.
            
            On May 15, 2009 this sequence version replaced NM_173865.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096596.1, AK089802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AC161805.4         104421-104668       c
            249-2640            BC116280.1         57-2448
            2641-4675           BC037033.1         950-2984
FEATURES             Location/Qualifiers
     source          1..4675
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.2 cM"
     gene            1..4675
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /note="solute carrier family 41, member 1"
                     /db_xref="GeneID:98396"
                     /db_xref="MGI:MGI:2444823"
     exon            1..382
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            383..1362
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             994..2532
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /codon_start=1
                     /product="solute carrier family 41 member 1"
                     /protein_id="NP_776290.1"
                     /db_xref="CCDS:CCDS15275.1"
                     /db_xref="GeneID:98396"
                     /db_xref="MGI:MGI:2444823"
                     /translation="MSSKPEPKDIHQPNGTGPTPSPCSSDGPGREPLAGTSEFLGPDG
                     VEVVVIESRANAKGIREEDALLENGSQSNESDDVSTDRGPAPPSPLKETSFSIGLQVL
                     FPFLLAGFGTVAAGMVLDIVQHWEVFQKVTEVFILVPALLGLKGNLEMTLASRLSTAA
                     NIGQMDTPKELWRMITGNMALIQVQATVVGFLASIAAVVFGWIPDGHFSIPHAFLLCA
                     SSVATAFIASLVLGMIMIGVIIGSRKIGINPDNVATPIAASLGDLITLALLSGISWGL
                     YLELKHWRYIYPLVCAFFVALLPVWVVLARRSPATREVLYSGWEPVIIAMAISSVGGL
                     ILDKTVSDPNFAGMAVFTPVINGVGGNLVAVQASRISTFLHMNGMPGENSEPTPRRCP
                     SPCTTFFSPDVNSRSARVLFLLVVPGHLVFLYTISCMQGGHTTLTLIFIIFYMTAALL
                     QVLILLYIADWMVHWMWGRGLDPDNFSIPYLTALGDLLGTGLLALSFHVLWLIGDRDT
                     DVGD"
     exon            1363..1470
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1542
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1687
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1834
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1982
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2062
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2197
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2346
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..4660
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4638..4643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4660
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /note="major polyA site"
ORIGIN      
        1 agatcacgtt tgccacccac agccaaacac tcttgtccaa gtccgcgggc aagaggcgat
       61 tggggacgag cgagctcggc atctcaggcc cagtccggtc cacaccagcc cgaggcggaa
      121 tatcctgatc gccccccacc aggccacctc ccctcgtgga atcggagcgg cggcctcaca
      181 ggaaggcaga agcgaaatgt agcgagccgg gtgtcgcggt tggacgctcg ccttgcctgg
      241 gggtgtagcg gggaacacgc gggggctcga ggaggacggc tgagggggag gagtgatgag
      301 aagagggggt accctacatc ccccaattcc gcgggcccct gctaccactc tccaggcgcc
      361 ctttctcccc agcaaggcgc aggtgttcca caccaattct tgtgacttta aggaccaggc
      421 aactgagaaa gtacaagatc ctctcaagaa gggaagacat ctctgggaga gagaggaaag
      481 atagcagaca ctgggaccag ctgagcccag ccacggtgct gtgagaagct gaagccaccc
      541 agcaggagtg agaagaaacc ctggcctcag attgaggctt cgttctcaac gatctgaact
      601 cattcagctt ttcccaagag agggctgcag catcaggcac tccagactca ggttgagctc
      661 ttctgctcct gctctgagga gctggccact gagaaccaaa gattgcccct ggcacaacac
      721 agagctgctg ggagcaggca cccactaccc atagaggcag ctgctgcatc tggtgaggac
      781 tttgtttcct tccagctcca ggctgcattg cttgatgggg ctgtcttttg gtagatcagt
      841 ttttacagtg cccggtagga gtggagagcc gtgggaagag gtcttgcggc aatcaagcct
      901 gggttcaccc caagactaag ttctttccca agtcagagtc gaagagagaa agaaaaataa
      961 ataaattctc ccctcctctc ctccctgcct gtcatgtcct ctaagccaga gccaaaggac
     1021 atccaccagc cgaatggtac tggccctact ccttctccct gttcttcgga tggccctggg
     1081 cgagagccct tggctgggac ctcagagttc ctggggcctg atggggtgga ggtggtagtg
     1141 attgagtccc gagctaacgc caagggaatt cgggaggagg acgccctact ggagaacggg
     1201 agccagagta acgagagtga cgatgtcagc acagaccggg gccccgcgcc accctctccg
     1261 ctcaaggaga cctccttttc cattggactg caagtgctgt tccccttcct actggcaggc
     1321 tttgggactg tggcagctgg catggtgctg gacattgtgc agcactggga ggtcttccag
     1381 aaggtgacag aggtcttcat cctggtgcct gcactgctgg ggctcaaagg gaacttggaa
     1441 atgaccctgg cgtcgaggct gtccactgca gccaacattg gacaaatgga cacacctaag
     1501 gagctctggc ggatgatcac ggggaatatg gcccttatcc aggtacaagc cacggtggta
     1561 ggcttcctgg catccatcgc agccgtcgtc tttggctgga tccctgatgg ccactttagc
     1621 atcccacacg ccttcctgct atgcgccagc agtgtggcta cagccttcat tgcctccttg
     1681 gtcctgggta tgatcatgat cggagtcatc attgggtctc gaaagattgg gatcaaccca
     1741 gacaacgtag ccacgcccat cgccgctagc ctgggcgacc tcatcacctt ggcactcctc
     1801 tcaggcatca gctggggact ctacctggaa ctgaagcact ggcgatacat ctatcccctg
     1861 gtgtgtgcct tctttgtggc cctgctgcct gtctgggtgg tgctggcccg aagaagcccg
     1921 gccacaaggg aggtgttgta ttcaggctgg gagcctgtca tcattgctat ggctatcagc
     1981 agtgtgggag gtctcatcct ggacaagacc gtctcggacc ccaactttgc aggaatggct
     2041 gtcttcacac ctgtgattaa tggtgtcggg ggcaatctgg tggctgtgca ggccagccgc
     2101 atctccacct tcctccacat gaacggcatg ccaggggaga actctgagcc aactcctcgc
     2161 cgctgcccca gtccatgcac caccttcttc agccctgatg tgaattcacg ctcggcccgt
     2221 gtcctcttcc tccttgtggt cccaggacac ctagtgttcc tctacaccat cagctgtatg
     2281 cagggcgggc acaccaccct caccctcatc ttcatcatct tctacatgac tgctgcactg
     2341 ctccaggtgc tgattctcct gtacatcgca gactggatgg tgcactggat gtggggccgg
     2401 ggcctggacc ccgacaactt ctccatccca tacttgactg ctttggggga cctgcttggc
     2461 accggactcc tggcactcag cttccatgtg ctctggctca ttggggacag agacacagat
     2521 gttggggact agcttagcca ttcagtcttt cccccacccc tctgcacttt ctatttggat
     2581 ttttattttc cttttgtttc cctaccccac cctacactac actcccatgc ctttctggga
     2641 tttcactttg ataccaaatt ctcattattt tcaatgggaa ttttttatac attgagccaa
     2701 gtttggatag gaagaattcg ggacagacag atgggctgac ataagcagta aaagtagact
     2761 tttgagacaa tcaccaagtg caattccacg gtgggtgcct ccagaggagg ttagatcggg
     2821 accttggcat cctgtccagc atcggggacc tttgcattag ctttagcgac ctcagcctcg
     2881 gccctaatga gaaactctca agtgggctct gggttgttta gggtttggct gaacagaggg
     2941 aggagggata attaacactc ccacacatgc acgcactttt atagatgtgg accaacttca
     3001 cagcactggg caggggaacg ttgcttcaac tcctcgtaat cacaggcctg ctccaggcca
     3061 gcctgcccgc agagtcacgt gcactggaga ttccatctgc gcacatgtgc cttgcccaac
     3121 tgcctgattg cttcccagct gaaatgagtg gtagtgaccc gggctcttca cggatccatg
     3181 tcatccacag gtttccaaag gtccatgtgc cccctgagtc tagagaaccg agttcaagcc
     3241 tcctctcttt aattctctcc acacactccg tctccgcgca gcttgccaga tgggcttcta
     3301 agattgggga taggacaagg gaatgtgcca aatgacctgg agattgaggc aacggggagg
     3361 ggtggggggt gtctcactgc cgtctctcat gacataatca cgtggtcagt cttggcctct
     3421 gtcacttcct aaacacactc attctatcac acgagggctc cgttggcctt tctctcggct
     3481 tctgcccaca gacatgcatc aaccattcac tcattcagca aatctcagcc tccccgagat
     3541 gagcccttcc acagcaccgg cctgcaataa ttcttcactg agcagtcgtt acggggcgca
     3601 tactgtgcta agttcagtgc ctggcatcaa cccaccagtg ctaagggaat cgctgctcta
     3661 acctcacctc atcccctagg ctacagaggc cattgtgcct cttcaacctg acagtaaatg
     3721 ttccctcgtt cgcccctaac tctgcagtga ctgccaaccc cgttgctcaa gcagcagcat
     3781 gtcctccaat accctcctcc cgcagcctct ctcctctcca catcttgcta cccactcaga
     3841 agagggcttg gaattagcaa gctggatatc aataggctgc ttcagtatct gcctcgtcca
     3901 tgattcaaag aaaaccaaag tcccttccct acacatgccc caaactgttc aacaaatggg
     3961 gtgcaggctg tacttctggc ctgtctgtct ggaatccata aattcttccc cctgtgtagc
     4021 ctaaagggtc agcctccaag aaaaggatta agcagtgctc cgtgtctacc aacactgtgc
     4081 ttagacctag agactcttct cggcctcatt tcctctgtca tcacctgaaa tcagaactgt
     4141 cgaattggac agattcatag agattgtcta gttggggttg tgtcaggcag atcagtgtgg
     4201 atctgagttt atttctgctc ttccctctgg cctaactcca tctcaaaaca caagactctt
     4261 gcacaggcat cataccctaa gactgtgacc ccagggtccc cagccacttg ctctatcctg
     4321 acatctggag ttggatcagg ctgtctggag actgaagcat ccttcttcct ttgcctagaa
     4381 aacagaaagg taggggcgcc caggctcagc gcatgtgagt ggaggggcct ggagtgacag
     4441 gagagtgact tcaggagatt catttcttcc caccgggttg cacctattgc atgtactttt
     4501 ggcctgactg gaagaaacaa aattggttta ctttcatatc cttcaaaagt tacagaactg
     4561 tgtcttaaga gaattattta tagttactat aactgaattg acaaatgtcg acttaactga
     4621 taaattatat ttggtaaaat aaaatggaag tttatttcaa aaaaaaaaaa aaaaa
//
