LOCUS       NP_776290                512 aa            linear   ROD 30-APR-2024
DEFINITION  solute carrier family 41 member 1 [Mus musculus].
ACCESSION   NP_776290 NP_870999 XP_129431
VERSION     NP_776290.1
DBSOURCE    REFSEQ: accession NM_173865.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 512)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 512)
  AUTHORS   Ilenwabor,B.P., Franken,G.A.C., Sponder,G., Bos,C., Racay,P.,
            Kolisek,M., Hoenderop,J.G.J. and de Baaij,J.H.F.
  TITLE     SLC41A1 knockout mice display normal magnesium homeostasis
  JOURNAL   Am J Physiol Renal Physiol 323 (5), F553-F563 (2022)
   PUBMED   36049064
  REMARK    GeneRIF: SLC41A1 knockout mice display normal magnesium
            homeostasis.
REFERENCE   3  (residues 1 to 512)
  AUTHORS   Zocchi,M., Locatelli,L., Zuccotti,G.V., Mazur,A., Bechet,D.,
            Maier,J.A. and Castiglioni,S.
  TITLE     Magnesium Homeostasis in Myogenic Differentiation-A Focus on the
            Regulation of TRPM7, MagT1 and SLC41A1 Transporters
  JOURNAL   Int J Mol Sci 23 (3), 1658 (2022)
   PUBMED   35163580
  REMARK    GeneRIF: Magnesium Homeostasis in Myogenic Differentiation-A Focus
            on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 512)
  AUTHORS   Franken,G.A.C., Seker,M., Bos,C., Siemons,L.A.H., van der
            Eerden,B.C.J., Christ,A., Hoenderop,J.G.J., Bindels,R.J.M.,
            Muller,D., Breiderhoff,T. and de Baaij,J.H.F.
  TITLE     Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and
            developmental defects
  JOURNAL   Sci Rep 11 (1), 8217 (2021)
   PUBMED   33859252
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 512)
  AUTHORS   Tatarkova,Z., de Baaij,J.H.F., Grendar,M., Aschenbach,J.R.,
            Racay,P., Bos,C., Sponder,G., Hoenderop,J.G.J., Rontgen,M.,
            Turcanova Koprusakova,M. and Kolisek,M.
  TITLE     Dietary Mg2+ Intake and the Na+/Mg2+ Exchanger SLC41A1 Influence
            Components of Mitochondrial Energetics in Murine Cardiomyocytes
  JOURNAL   Int J Mol Sci 21 (21), 8221 (2020)
   PUBMED   33153064
  REMARK    GeneRIF: Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger
            SLC41A1 Influence Components of Mitochondrial Energetics in Murine
            Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 512)
  AUTHORS   Tsao,Y.T., Shih,Y.Y., Liu,Y.A., Liu,Y.S. and Lee,O.K.
  TITLE     Knockdown of SLC41A1 magnesium transporter promotes mineralization
            and attenuates magnesium inhibition during osteogenesis of
            mesenchymal stromal cells
  JOURNAL   Stem Cell Res Ther 8 (1), 39 (2017)
   PUBMED   28222767
  REMARK    GeneRIF: Knockdown of SLC41A1 magnesium transporter promotes
            mineralization and attenuates magnesium inhibition during
            osteogenesis of mesenchymal stromal cells.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 512)
  AUTHORS   Mastrototaro,L., Smorodchenko,A., Aschenbach,J.R., Kolisek,M. and
            Sponder,G.
  TITLE     Solute carrier 41A3 encodes for a mitochondrial Mg(2+) efflux
            system
  JOURNAL   Sci Rep 6, 27999 (2016)
   PUBMED   27302215
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 512)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (residues 1 to 512)
  AUTHORS   Goytain,A. and Quamme,G.A.
  TITLE     Functional characterization of human SLC41A1, a Mg2+ transporter
            with similarity to prokaryotic MgtE Mg2+ transporters
  JOURNAL   Physiol Genomics 21 (3), 337-342 (2005)
   PUBMED   15713785
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161805.4, BC116280.1 and BC037033.1.
            
            On or before Dec 17, 2003 this sequence version replaced
            XP_129431.2, NP_870999.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096596.1, AK089802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.2 cM"
     Protein         1..512
                     /product="solute carrier family 41 member 1"
                     /calculated_mol_wt=54797
     Region          1..40
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     Region          60..90
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     Site            101..121
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     Region          138..272
                     /region_name="MgtE"
                     /note="Divalent cation transporter; pfam01769"
                     /db_xref="CDD:460317"
     Site            184..204
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     Region          <218..>357
                     /region_name="CstA"
                     /note="Carbon starvation protein CstA (peptide/pyruvate
                     transporter) [Energy production and conversion, Amino acid
                     transport and metabolism]; COG1966"
                     /db_xref="CDD:441569"
     Site            221..241
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     Site            256..276
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     Site            285..305
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     Site            315..335
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     Site            345..365
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     Region          352..482
                     /region_name="MgtE"
                     /note="Divalent cation transporter; pfam01769"
                     /db_xref="CDD:460317"
     Site            410..430
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     Site            438..458
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     Site            483..503
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJA2.1)"
     CDS             1..512
                     /gene="Slc41a1"
                     /gene_synonym="B230315F01Rik"
                     /coded_by="NM_173865.3:994..2532"
                     /db_xref="CCDS:CCDS15275.1"
                     /db_xref="GeneID:98396"
                     /db_xref="MGI:MGI:2444823"
ORIGIN      
        1 msskpepkdi hqpngtgptp spcssdgpgr eplagtsefl gpdgvevvvi esranakgir
       61 eedallengs qsnesddvst drgpappspl ketsfsiglq vlfpfllagf gtvaagmvld
      121 ivqhwevfqk vtevfilvpa llglkgnlem tlasrlstaa nigqmdtpke lwrmitgnma
      181 liqvqatvvg flasiaavvf gwipdghfsi phafllcass vatafiaslv lgmimigvii
      241 gsrkiginpd nvatpiaasl gdlitlalls giswglylel khwryiyplv caffvallpv
      301 wvvlarrspa trevlysgwe pviiamaiss vgglildktv sdpnfagmav ftpvingvgg
      361 nlvavqasri stflhmngmp genseptprr cpspcttffs pdvnsrsarv lfllvvpghl
      421 vflytiscmq gghttltlif iifymtaall qvlillyiad wmvhwmwgrg ldpdnfsipy
      481 ltalgdllgt gllalsfhvl wligdrdtdv gd
//
