LOCUS       NM_016917               3380 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus solute carrier family 40 (iron-regulated transporter),
            member 1 (Slc40a1), mRNA.
ACCESSION   NM_016917
VERSION     NM_016917.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3380)
  AUTHORS   Song,J.X., Xu,S., Chen,Q., Gou,Y., Zhao,C.B., Jia,C.L., Liu,H.,
            Zhang,Z., Li,B.L., Gao,Y., Zhao,Y. and Ji,E.S.
  TITLE     Cardiomyocyte-specific overexpression of FPN1 diminishes cardiac
            hypertrophy induced by chronic intermittent hypoxia
  JOURNAL   J Cell Mol Med 28 (14), e18543 (2024)
   PUBMED   39054575
  REMARK    GeneRIF: Cardiomyocyte-specific overexpression of FPN1 diminishes
            cardiac hypertrophy induced by chronic intermittent hypoxia.
REFERENCE   2  (bases 1 to 3380)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3380)
  AUTHORS   Feng,R., Wang,D., Li,T., Liu,X., Peng,T., Liu,M., Ren,G., Xu,H.,
            Luo,H., Lu,D., Qi,B., Zhang,M. and Li,Y.
  TITLE     Elevated SLC40A1 impairs cardiac function and exacerbates
            mitochondrial dysfunction, oxidative stress, and apoptosis in
            ischemic myocardia
  JOURNAL   Int J Biol Sci 20 (2), 414-432 (2024)
   PUBMED   38169607
  REMARK    GeneRIF: Elevated SLC40A1 impairs cardiac function and exacerbates
            mitochondrial dysfunction, oxidative stress, and apoptosis in
            ischemic myocardia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3380)
  AUTHORS   Ohta,K., Ito,M., Chida,T., Nakashima,K., Sakai,S., Kanegae,Y.,
            Kawasaki,H., Aoshima,T., Takabayashi,S., Takahashi,H., Kawata,K.,
            Shoji,I., Sawasaki,T., Suda,T. and Suzuki,T.
  TITLE     Role of hepcidin upregulation and proteolytic cleavage of
            ferroportin 1 in hepatitis C virus-induced iron accumulation
  JOURNAL   PLoS Pathog 19 (8), e1011591 (2023)
   PUBMED   37585449
  REMARK    GeneRIF: Role of hepcidin upregulation and proteolytic cleavage of
            ferroportin 1 in hepatitis C virus-induced iron accumulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3380)
  AUTHORS   Zheng,H., Guo,X., Kang,S., Li,Z., Tian,T., Li,J., Wang,F., Yu,P.,
            Chang,S. and Chang,Y.Z.
  TITLE     Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during
            the acute phase and inhibitory effects during the recovery phase of
            ischemic stroke
  JOURNAL   Cell Death Dis 14 (2), 161 (2023)
   PUBMED   36841833
  REMARK    GeneRIF: Cdh5-mediated Fpn1 deletion exerts neuroprotective effects
            during the acute phase and inhibitory effects during the recovery
            phase of ischemic stroke.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3380)
  AUTHORS   Abboud,S. and Haile,D.J.
  TITLE     A novel mammalian iron-regulated protein involved in intracellular
            iron metabolism
  JOURNAL   J Biol Chem 275 (26), 19906-19912 (2000)
   PUBMED   10747949
REFERENCE   7  (bases 1 to 3380)
  AUTHORS   Donovan,A., Brownlie,A., Zhou,Y., Shepard,J., Pratt,S.J.,
            Moynihan,J., Paw,B.H., Drejer,A., Barut,B., Zapata,A., Law,T.C.,
            Brugnara,C., Lux,S.E., Pinkus,G.S., Pinkus,J.L., Kingsley,P.D.,
            Palis,J., Fleming,M.D., Andrews,N.C. and Zon,L.I.
  TITLE     Positional cloning of zebrafish ferroportin1 identifies a conserved
            vertebrate iron exporter
  JOURNAL   Nature 403 (6771), 776-781 (2000)
   PUBMED   10693807
REFERENCE   8  (bases 1 to 3380)
  AUTHORS   McKie,A.T., Marciani,P., Rolfs,A., Brennan,K., Wehr,K., Barrow,D.,
            Miret,S., Bomford,A., Peters,T.J., Farzaneh,F., Hediger,M.A.,
            Hentze,M.W. and Simpson,R.J.
  TITLE     A novel duodenal iron-regulated transporter, IREG1, implicated in
            the basolateral transfer of iron to the circulation
  JOURNAL   Mol Cell 5 (2), 299-309 (2000)
   PUBMED   10882071
REFERENCE   9  (bases 1 to 3380)
  AUTHORS   Haile,D.J.
  TITLE     Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to
            human chromosome 2q32 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 328-329 (2000)
   PUBMED   10828623
REFERENCE   10 (bases 1 to 3380)
  AUTHORS   McKie,A.T., Wehr,K., Simpson,R.J., Peters,T.J., Hentze,M.W. and
            Farzaneh,F.
  TITLE     Molecular cloning and characterisation of a novel duodenal-specific
            gene implicated in iron absorption
  JOURNAL   Biochem Soc Trans 26 (3), S264 (1998)
   PUBMED   9765983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB625854.1 and AK144780.1.
            
            On Jan 27, 2007 this sequence version replaced NM_016917.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144780.1, AK147137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               BB625854.1         17-477
            462-3380            AK144780.1         449-3367
FEATURES             Location/Qualifiers
     source          1..3380
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 23.96 cM"
     gene            1..3380
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /note="solute carrier family 40 (iron-regulated
                     transporter), member 1"
                     /db_xref="GeneID:53945"
                     /db_xref="MGI:MGI:1315204"
     exon            1..374
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..2044
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /note="ferroportin 1; solute carrier family 40 member 1;
                     metal transporter protein 1; iron-regulated transporter 1;
                     solute carrier family 39 (iron-regulated transporter),
                     member 1; duodenal-specific; solute carrier family 11
                     (proton-coupled divalent metal ion transporters), member
                     3; metal transporting protein 1; polycythaemia; SLC11A3
                     iron transporter; ferroportin1"
                     /codon_start=1
                     /product="ferroportin"
                     /protein_id="NP_058613.2"
                     /db_xref="CCDS:CCDS14933.1"
                     /db_xref="GeneID:53945"
                     /db_xref="MGI:MGI:1315204"
                     /translation="MTKARDQTHQEGCCGSLANYLTSAKFLLYLGHSLSTWGDRMWHF
                     AVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVS
                     VILCGIILMMVFLHKNELLTMYHGWVLTVCYILIITIANIANLASTATAITIQRDWIV
                     VVAGENRSRLADMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCV
                     EYFLLWKVYQKTPALAVKAALKVEESELKQLTSPKDTEPKPLEGTHLMGEKDSNIREL
                     ECEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYT
                     QGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLFSGLAQLSCLILCVISVF
                     MPGSPLDLSVSPFEDIRSRFVNVEPVSPTTKIPETVFTTEMHMSNMSNVHEMSTKPIP
                     IVSVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFI
                     MVILAPNPEAFGLLVLISVSFVAMGHLMYFRFAQKTLGNQIFVCGPDEKEVTDENQPN
                     TSVV"
     exon            375..442
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..602
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..718
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..845
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1091
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1730
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..3380
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3252..3257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /note="hexamer: CATAAA"
     regulatory      3267..3272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /note="hexamer: TATAAA"
     polyA_site      3273
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /note="major polyA site"
     polyA_site      3290
                     /gene="Slc40a1"
                     /gene_synonym="Dusg; Fpn1; IREG1; MTP; MTP1; Ol5; Pcm;
                     Slc11a3; Slc39a1"
                     /note="major polyA site"
ORIGIN      
        1 gcccgcggcg gtggcggcgg cggcggcggc ggcgagagca ggctcggggt ctcctgcggc
       61 cggtggatcc tccaacccgc tcccataagg ctttggcttt ccaacttcag ctacagtgtt
      121 agctaagttt ggaaagaaga caaaaagaag accccgtgac agctttgctg ttgttgtttg
      181 ccttagttgt cctttggggt ctttcggcat aaggctgttg tgcttatact ggtgctatct
      241 tcggttcctc tcactcctgt gaacaagctc ccgggcaaga gcagctaaag ctaccagcat
      301 cagaacaaac aaggggagaa cgcctggtgt catgaccaag gcaagagatc aaacccatca
      361 ggaaggatgc tgtggatcct tagcaaacta cctgacctca gcaaaattcc tcctctacct
      421 tggccactct ctctccactt ggggggatcg gatgtggcac tttgcagtgt ctgtgtttct
      481 ggtggaactc tatggaaaca gccttctctt gacagctgtc tatggactgg tggtggcagg
      541 ctctgttctg gtcctgggag ccatcattgg tgactgggtg gataagaatg ccagacttaa
      601 agtggcccag acgtcactgg tggttcagaa tgtgtccgtc atcctctgcg gaatcatcct
      661 gatgatggtt ttcctacaca agaatgagct cctgaccatg taccatggat gggtccttac
      721 tgtctgctac atcctgatca tcactattgc aaacattgca aatttggcca gtactgccac
      781 tgcgatcaca atccaaaggg actggattgt tgttgtggca ggagaaaaca ggagcagatt
      841 agcagacatg aatgctacca ttagaaggat tgaccagcta accaacatcc tggcccccat
      901 ggctgtcggc cagattatga catttggttc tccagtcatt ggctgtggtt ttatttccgg
      961 ttggaatttg gtgtccatgt gtgtggagta cttcttgctc tggaaggttt accagaagac
     1021 ccctgctctg gctgtaaaag ctgctctcaa ggtagaggag tcagaactga agcagctgac
     1081 ctcacctaaa gatactgagc caaaaccttt ggagggaact catctaatgg gtgagaaaga
     1141 ctccaacatc cgtgaacttg aatgtgaaca agagcccacc tgtgcctccc agatggcaga
     1201 gcccttccgc actttccgag atggatgggt ctcctactat aaccagccag tgtttctggc
     1261 tggcatgggc ctggctttcc tctatatgac agtcctgggc tttgactgta tcactacagg
     1321 gtacgcctac actcaggggc tgagtggatc catccttagt attttgatgg gagcatcagc
     1381 aataactgga ataatgggaa ctgtggcctt cacctggcta cgtcgaaaat gtggccttgt
     1441 tcggactggt ctattctcag gactagccca gctttcctgt ttaatcttgt gtgtgatctc
     1501 cgtattcatg cctggaagcc ccttggacct gtctgtttct ccatttgaag atatccgttc
     1561 taggtttgtg aatgtggagc cagtgtcccc aactaccaaa atacctgaga ccgtctttac
     1621 aacagaaatg catatgtcca acatgtctaa tgtccatgag atgagtacta aacccatccc
     1681 catagtctct gtcagcctgc tgtttgcagg agtcattgct gctagaatcg gtctttggtc
     1741 ctttgatttg acggtgacac agttgctgca agaaaatgta attgaatctg aaagaggcat
     1801 tatcaatggt gtgcagaact ccatgaacta ccttcttgac cttctgcatt tcatcatggt
     1861 catcttggcc ccaaatcctg aagcttttgg cttgctggta ttgatttcag tctcctttgt
     1921 ggcaatggga catcttatgt atttccgatt tgcccagaag actctgggca accagatttt
     1981 tgtttgtggt cctgatgaaa aagaagttac agatgaaaat caaccgaata catctgttgt
     2041 ataaaaatag tttagctgtg gcccctgtta ctagattgtg gagagcatgt gtgcttattt
     2101 tgtactgcag aatcccaata aatgcctgca tttctctctg gttttaccac atctgtgcct
     2161 taagggctag gagcactaac taaccatcgc cagcaaagat ggttatttct ccttacatgt
     2221 aaacattgga aaataggaag agggagaggc agtcagcgtg tgtataggaa gggtttaatg
     2281 gtaaaatgaa cttcccttac tcttatgagt atattaaatt ttaaagagtg gttgtcaggt
     2341 gagtaaaatt attccttagc agatatttat tatctactgg aatgataaat caattcaccc
     2401 taaaactcac tcttgtaaaa ctctgctcca cttccttttt ttaagatcag tgatattttt
     2461 ctcagttaca ttacagaaac aagtttttcc tccatgtatg aaggttatag ttagataatg
     2521 aatgttatcc ttattaatcc cattgaactt aaggaattta ttgtatgtgg aggatgaaat
     2581 gtgtaactag acttgtccaa aaggttcatg gaataacttt tgcattttga ccatcagaaa
     2641 gggcaaaata ttacagtaat gtgtgtatgg tggctcttca taaaatgact ctcaaaatct
     2701 gcagaaagaa gaaaagttgt aggtttctag tgtggtacag aaggacttaa agcttgttat
     2761 tagtgtgatt gtagaaactg gaagctaagg gtgaggacct catgtaacca gagtcactgt
     2821 catcagccat cactaactat tttggtaaat gagagaactg acctggcacc ttacaagcag
     2881 aaaagcggcc cacactaaga aaggactgca aatcagtgag tctgtataga acattttacc
     2941 ttcactgact tgggccgatg tgtttgtcat ctctgtgttt ttctagagca agaatagtca
     3001 caaaagttcc cctttcaata tccctgagaa gaataaagaa aaaactgttt gtaaatattt
     3061 ttttaaaact gttctgcaag tctttttgta acatgcagta ccaacatggg acattgcctt
     3121 aacttttgat gcactttcat ggagactgac tgccatgcat tgctgtgagc actttctttg
     3181 tcgttcagtt taatcttttc cttcaccttt attacagtat gacataatga tctactatgt
     3241 tgtcaaagct tcataaaata tttctatata aaatgtttgt agaatcttca tttgccttta
     3301 ctgagttgtg ttctcccaat tattgttact tatttcaaaa ttagcatata aaaagtgttt
     3361 gatatcatca tcgccctttg
//
