LOCUS       NM_001161413            2128 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus solute carrier family 3 (activators of dibasic and
            neutral amino acid transport), member 2 (Slc3a2), transcript
            variant 1, mRNA.
ACCESSION   NM_001161413
VERSION     NM_001161413.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2128)
  AUTHORS   Huang,N., Winans,T., Wyman,B., Oaks,Z., Faludi,T., Choudhary,G.,
            Lai,Z.W., Lewis,J., Beckford,M., Duarte,M., Krakko,D., Patel,A.,
            Park,J., Caza,T., Sadeghzadeh,M., Morel,L., Haas,M., Middleton,F.,
            Banki,K. and Perl,A.
  TITLE     Rab4A-directed endosome traffic shapes pro-inflammatory
            mitochondrial metabolism in T cells via mitophagy, CD98 expression,
            and kynurenine-sensitive mTOR activation
  JOURNAL   Nat Commun 15 (1), 2598 (2024)
   PUBMED   38519468
  REMARK    GeneRIF: Rab4A-directed endosome traffic shapes pro-inflammatory
            mitochondrial metabolism in T cells via mitophagy, CD98 expression,
            and kynurenine-sensitive mTOR activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2128)
  AUTHORS   Xiang,J., Pompetti,A.J., Faranda,A.P., Wang,Y., Novo,S.G., Li,D.W.
            and Duncan,M.K.
  TITLE     ATF4 May Be Essential for Adaption of the Ocular Lens to Its
            Avascular Environment
  JOURNAL   Cells 12 (22), 2636 (2023)
   PUBMED   37998373
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2128)
  AUTHORS   Xiang,P., Chen,Q., Chen,L., Lei,J., Yuan,Z., Hu,H., Lu,Y., Wang,X.,
            Wang,T., Yu,R., Zhang,W., Zhang,J., Yu,C. and Ma,L.
  TITLE     Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular
            endothelial ferroptosis and aggravates atherosclerosis progression
            in ApoE-/-mice
  JOURNAL   Theranostics 13 (14), 4993-5016 (2023)
   PUBMED   37771765
  REMARK    GeneRIF: Metabolite Neu5Ac triggers SLC3A2 degradation promoting
            vascular endothelial ferroptosis and aggravates atherosclerosis
            progression in ApoE[-/-]mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2128)
  AUTHORS   Puris,E., Saveleva,L., de Sousa Maciel,I., Kanninen,K.M.,
            Auriola,S. and Fricker,G.
  TITLE     Protein Expression of Amino Acid Transporters Is Altered in
            Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's
            Disease
  JOURNAL   Mol Neurobiol 60 (2), 732-748 (2023)
   PUBMED   36367657
  REMARK    GeneRIF: Protein Expression of Amino Acid Transporters Is Altered
            in Isolated Cerebral Microvessels of 5xFAD Mouse Model of
            Alzheimer's Disease.
REFERENCE   5  (bases 1 to 2128)
  AUTHORS   Eom,J., Choi,J., Suh,S.S. and Seo,J.B.
  TITLE     SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced
            Adipocyte Differentiation
  JOURNAL   Mol Cells 45 (12), 963-975 (2022)
   PUBMED   36572564
  REMARK    GeneRIF: SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced
            Adipocyte Differentiation.
REFERENCE   6  (bases 1 to 2128)
  AUTHORS   Rochelle,J.M., Watson,M.L., Oakey,R.J. and Seldin,M.F.
  TITLE     A linkage map of mouse chromosome 19: definition of comparative
            mapping relationships with human chromosomes 10 and 11 including
            the MEN1 locus
  JOURNAL   Genomics 14 (1), 26-31 (1992)
   PUBMED   1358795
REFERENCE   7  (bases 1 to 2128)
  AUTHORS   Fowler,K.J., Clouston,W.M., Fournier,R.E. and Evans,B.A.
  TITLE     The relaxin gene is located on chromosome 19 in the mouse
  JOURNAL   FEBS Lett 292 (1-2), 183-186 (1991)
   PUBMED   1959604
REFERENCE   8  (bases 1 to 2128)
  AUTHORS   Horlick,K.R., Cheng,I.C., Wong,W.T., Wakeland,E.K. and Nick,H.S.
  TITLE     Mouse lipocortin I gene structure and chromosomal assignment: gene
            duplication and the origins of a gene family
  JOURNAL   Genomics 10 (2), 365-374 (1991)
   PUBMED   1676980
REFERENCE   9  (bases 1 to 2128)
  AUTHORS   Chainani,M., Sampsell,B. and Elliott,R.W.
  TITLE     Localization of the gene for plasma retinol binding protein to the
            distal half of mouse chromosome 19
  JOURNAL   Genomics 9 (2), 376-379 (1991)
   PUBMED   2004789
REFERENCE   10 (bases 1 to 2128)
  AUTHORS   Levanon,D., Hsieh,C.L., Francke,U., Dawson,P.A., Ridgway,N.D.,
            Brown,M.S. and Goldstein,J.L.
  TITLE     cDNA cloning of human oxysterol-binding protein and localization of
            the gene to human chromosome 11 and mouse chromosome 19
  JOURNAL   Genomics 7 (1), 65-74 (1990)
   PUBMED   1970801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025794.9.
            
            On Aug 15, 2022 this sequence version replaced NM_001161413.1.
            
            Transcript Variant: This variant (1) represents the longer variant
            and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161280.1, SRR13948564.4926512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-386               AC025794.9         185755-186140       c
            387-797             AC025794.9         176113-176523       c
            798-971             AC025794.9         175501-175674       c
            972-1066            AC025794.9         174605-174699       c
            1067-1135           AC025794.9         172486-172554       c
            1136-1194           AC025794.9         172321-172379       c
            1195-1375           AC025794.9         172001-172181       c
            1376-1516           AC025794.9         171776-171916       c
            1517-1600           AC025794.9         170965-171048       c
            1601-2128           AC025794.9         170338-170865       c
FEATURES             Location/Qualifiers
     source          1..2128
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.44 cM"
     gene            1..2128
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /note="solute carrier family 3 (activators of dibasic and
                     neutral amino acid transport), member 2"
                     /db_xref="GeneID:17254"
                     /db_xref="MGI:MGI:96955"
     exon            1..386
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1972
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /note="isoform a is encoded by transcript variant 1;
                     antigen identified by monoclonal antibodies 4F2; 4F2
                     cell-surface antigen heavy chain; CD98 heavy chain; type
                     II transmembrane protein; CD98 antigen; solute carrier
                     family 3 member 2; amino acid transporter heavy chain
                     SLC3A2"
                     /codon_start=1
                     /product="amino acid transporter heavy chain SLC3A2
                     isoform a"
                     /protein_id="NP_001154885.1"
                     /db_xref="CCDS:CCDS50381.1"
                     /db_xref="GeneID:17254"
                     /db_xref="MGI:MGI:96955"
                     /translation="MDPEPTEHSTDGVSVPRQPPSAQTGLDVQVVSAAGDSGTMSQDT
                     EVDMKDVELNELEPEKQPMNAADGAAAGEKNGLVKIKVAEDETEAGVKFTGLSKEELL
                     KVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPVQRWWHKGALYRIG
                     DLQAFVGRDAGGIAGLKSHLEYLSTLKVKGLVLGPIHKNQKDEINETDLKQINPTLGS
                     QEDFKDLLQSAKKKSIHIILDLTPNYQGQNAWFLPAQADIVATKMKEALSSWLQDGVD
                     GFQFRDVGKLMNAPLYLAEWQNITKNLSEDRLLIAGTESSDLQQIVNILESTSDLLLT
                     SSYLSNSTFTGERTESLVTRFLNATGSQWCSWSVSQAGLLADFIPDHLLRLYQLLLFT
                     LPGTPVFSYGDELGLQGALPGQPAKAPLMPWNESSIFHIPRPVSLNMTVKGQNEDPGS
                     LLTQFRRLSDLRGKERSLLHGDFHALSSSPDLFSYIRHWDQNERYLVVLNFRDSGRSA
                     RLGASNLPAGISLPASAKLLLSTDSARQSREEDTSLKLENLSLNPYEGLLLQFPFVA"
     exon            387..797
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            798..971
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1066
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1135
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1194
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1375
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1516
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1600
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..2128
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2102..2107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /note="hexamer: AATAAA"
     polyA_site      2128
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /note="major polyA site"
ORIGIN      
        1 gtgggtagag gaatccgccc aaaggggcgt gcggagagct ccgcctctga ttttgcagcg
       61 cgaaaaagag gcgcaggcgc tttaggggag tgcgacgcta cgcctttggc gctgcggcta
      121 ggcggttctt actcactgcg ggtaaaacgt catcgctgga gattttggtt cgcgacccat
      181 acagctcgac tgtctgggtc acaactacca atatccatac gttgaggcga tttctcaccc
      241 tcactcacgc taagccgcgt gttgatccat ctctatggat cctgaaccta ctgaacactc
      301 caccgacggt gtctcggttc cccgccagcc gcccagcgcg cagacggggc ttgatgtcca
      361 ggttgtcagc gcagcgggcg actcaggcac catgagccag gacaccgaag tggacatgaa
      421 agatgtggag ctgaacgagc tagaaccgga gaagcagccc atgaatgcag cggacggggc
      481 ggcggccggg gagaagaacg gtctggtgaa gatcaaggtg gcggaggacg agacggaggc
      541 cggggtcaag ttcaccggct tatccaagga ggagctactg aaggtagcgg gcagccctgg
      601 ctgggtgcgc acccgctggg cgctgctgct gctcttctgg ctcggttggc tgggcatgct
      661 ggcgggcgcc gtggttatca tcgttcgggc gccgcgctgc cgtgagctgc ctgtacagag
      721 gtggtggcac aagggcgccc tctaccgcat cggcgacctt caggcctttg taggccggga
      781 tgcgggaggc atagctggtc tgaagagcca tctggagtac ttgagcaccc tgaaggtgaa
      841 gggcctggtg ttaggcccaa ttcacaagaa ccagaaggat gaaatcaatg aaaccgacct
      901 gaaacagatt aatcccactt tgggctccca ggaagatttt aaagaccttc tacaaagtgc
      961 caagaaaaag agcattcaca tcattttgga cctcactccc aactaccagg gccagaatgc
     1021 gtggttcctc cctgctcagg ctgacattgt agccaccaaa atgaaggaag ctctgagttc
     1081 ttggttgcag gacggtgtgg atggtttcca attccgggat gtgggaaagc tgatgaatgc
     1141 acccttgtac ttggctgagt ggcagaatat caccaagaac ttaagtgagg acaggctttt
     1201 gattgcaggg actgagtcct ctgacctgca gcaaattgtc aacatacttg aatccaccag
     1261 cgacctgctg ttgaccagct cctacctgtc aaattccact ttcactgggg agcgtactga
     1321 atccctagtc actaggtttt tgaatgccac tggcagccaa tggtgcagct ggagtgtgtc
     1381 gcaagcagga ctcctcgcag actttatacc ggaccatctt ctccgactct accagctgct
     1441 gctcttcact ctgccaggga ctcctgtttt tagctacggg gatgagcttg gccttcaggg
     1501 tgcccttcct ggacagcctg cgaaggcccc actcatgccg tggaatgagt ccagcatctt
     1561 tcacatccca agacctgtaa gcctcaacat gacagtgaag ggccagaatg aagaccctgg
     1621 ctccctcctt acccagttcc ggcggctgag tgaccttcgg ggtaaggagc gctctctgtt
     1681 gcacggtgac ttccatgcac tgtcttcctc acctgacctc ttctcctaca tacgacactg
     1741 ggaccagaat gagcgttacc tggtggtgct caacttccga gattcgggcc ggtcagccag
     1801 gctaggggcc tccaacctcc ctgctggcat aagcctgcca gccagcgcta aacttttgct
     1861 tagtaccgac agtgcccggc aaagccgtga ggaggacacc tccctgaagc tggaaaacct
     1921 gagcctgaat ccttatgagg gcttgctgtt acagttcccc tttgtggcct gatccttcct
     1981 atgcagaacc taccaccctc ctttgttctc cccaggcctt ttggattcta gtcttcctct
     2041 ccttgttttt aaacttttgc agattacata cgaattctta tactgggtgt ttttgtcttc
     2101 aaataaaaac atcacccctg cctcatga
//
