LOCUS       NM_009205               2307 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 3, member 1 (Slc3a1), mRNA.
ACCESSION   NM_009205 XM_001003828
VERSION     NM_009205.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2307)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2307)
  AUTHORS   Niborski,L.L., Paces-Fessy,M., Ricci,P., Bourgeois,A.,
            Magalhaes,P., Kuzma-Kuzniarska,M., Lesaulnier,C., Reczko,M.,
            Declercq,E., Zurbig,P., Doucet,A., Umbhauer,M. and Cereghini,S.
  TITLE     Hnf1b haploinsufficiency differentially affects developmental
            target genes in a new renal cysts and diabetes mouse model
  JOURNAL   Dis Model Mech 14 (5) (2021)
   PUBMED   33737325
REFERENCE   3  (bases 1 to 2307)
  AUTHORS   Wu,K.C., Reisman,S.A. and Klaassen,C.D.
  TITLE     Tissue distribution, hormonal regulation, ontogeny, diurnal
            expression, and induction of mouse cystine transporters Slc3a1 and
            Slc7a9
  JOURNAL   Free Radic Res 54 (7), 525-534 (2020)
   PUBMED   32873097
  REMARK    GeneRIF: Tissue distribution, hormonal regulation, ontogeny,
            diurnal expression, and induction of mouse cystine transporters
            Slc3a1 and Slc7a9.
REFERENCE   4  (bases 1 to 2307)
  AUTHORS   Beckermann,T.M., Welch,R.C., Williams,F.M., Mortlock,D.P., Sha,F.,
            Ikizler,T.A., Woodard,L.E. and Wilson,M.H.
  TITLE     CRISPR/Cas9 engineering of albino cystinuria Type A mice
  JOURNAL   Genesis 58 (5), e23357 (2020)
   PUBMED   32078250
  REMARK    GeneRIF: CRISPR/Cas9 engineering of albino cystinuria Type A mice.
REFERENCE   5  (bases 1 to 2307)
  AUTHORS   Woodard,L.E., Welch,R.C., Veach,R.A., Beckermann,T.M., Sha,F.,
            Weinman,E.J., Ikizler,T.A., Tischfield,J.A., Sahota,A. and
            Wilson,M.H.
  TITLE     Metabolic consequences of cystinuria
  JOURNAL   BMC Nephrol 20 (1), 227 (2019)
   PUBMED   31221135
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2307)
  AUTHORS   Fernandez,E., Carrascal,M., Rousaud,F., Abian,J., Zorzano,A.,
            Palacin,M. and Chillaron,J.
  TITLE     rBAT-b(0,+)AT heterodimer is the main apical reabsorption system
            for cystine in the kidney
  JOURNAL   Am J Physiol Renal Physiol 283 (3), F540-F548 (2002)
   PUBMED   12167606
  REMARK    GeneRIF: a decreasing expression gradient of heterodimeric
            rBAT-b(0,+)AT along the proximal tubule is responsible for
            virtually all apical cystine reabsorption
REFERENCE   7  (bases 1 to 2307)
  AUTHORS   Henthorn,P.S., Liu,J., Gidalevich,T., Fang,J., Casal,M.L.,
            Patterson,D.F. and Giger,U.
  TITLE     Canine cystinuria: polymorphism in the canine SLC3A1 gene and
            identification of a nonsense mutation in cystinuric Newfoundland
            dogs
  JOURNAL   Hum Genet 107 (4), 295-303 (2000)
   PUBMED   11129328
REFERENCE   8  (bases 1 to 2307)
  AUTHORS   Segawa,H., Miyamoto,K., Ogura,Y., Haga,H., Morita,K., Katai,K.,
            Tatsumi,S., Nii,T., Taketani,Y. and Takeda,E.
  TITLE     Cloning, functional expression and dietary regulation of the mouse
            neutral and basic amino acid transporter (NBAT)
  JOURNAL   Biochem J 328 (Pt 2) (Pt 2), 657-664 (1997)
   PUBMED   9371728
REFERENCE   9  (bases 1 to 2307)
  AUTHORS   Calonge,M.J., Gasparini,P., Chillaron,J., Chillon,M., Gallucci,M.,
            Rousaud,F., Zelante,L., Testar,X., Dallapiccola,B., Di Silverio,F.
            et al.
  TITLE     Cystinuria caused by mutations in rBAT, a gene involved in the
            transport of cystine
  JOURNAL   Nat Genet 6 (4), 420-425 (1994)
   PUBMED   8054986
REFERENCE   10 (bases 1 to 2307)
  AUTHORS   Lee,W.S., Wells,R.G., Sabbag,R.V., Mohandas,T.K. and Hediger,M.A.
  TITLE     Cloning and chromosomal localization of a human kidney cDNA
            involved in cystine, dibasic, and neutral amino acid transport
  JOURNAL   J Clin Invest 91 (5), 1959-1963 (1993)
   PUBMED   8486766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA493293.1, AK132275.1 and AI326967.1.
            
            On Dec 8, 2006 this sequence version replaced NM_009205.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D88533.1, AK132275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CA493293.1         46-74
            30-2301             AK132275.1         2-2273
            2302-2307           AI326967.1         1-6                 c
FEATURES             Location/Qualifiers
     source          1..2307
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 55.17 cM"
     gene            1..2307
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /note="solute carrier family 3, member 1"
                     /db_xref="GeneID:20532"
                     /db_xref="MGI:MGI:1195264"
     exon            1..512
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2143
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /note="b(0,+)-type amino acid transport protein; neutral
                     and basic amino acid transport protein rBAT; b(0,+)-type
                     amino acid transporter-related heavy chain"
                     /codon_start=1
                     /product="amino acid transporter heavy chain SLC3A1"
                     /protein_id="NP_033231.2"
                     /db_xref="CCDS:CCDS37711.1"
                     /db_xref="GeneID:20532"
                     /db_xref="MGI:MGI:1195264"
                     /translation="MDEDKGKRDPIQMSLKGCRTNNGFVQNEDIPEQDPDPGSRDTPQ
                     PNAVSIPAPEEPHLKAVRPYAGMPKEVLFQFSGQARYRVPREILFWLTVVSVFLLIGA
                     TIAIIVISPKCLDWWQAGPIYQIYPRSFKDSDKDGNGDLKGIQEKLDYITALNIKTLW
                     ITSFYKSSLKDFRYAVEDFKEIDPIFGTMKDFENLVAAIHDKGLKLIIDFIPNHTSDK
                     HPWFQSSRTRSGKYTDYYIWHNCTHVNGVTTPPNNWLSVYGNSSWHFDEVRKQCYFHQ
                     FLKEQPDLNFRNPAVQEEIKEIITFWLSKGVDGFSFDAVKFLLEAKDLRNEIQVNTSQ
                     IPDTVTHYSELYHDFTTTQVGMHDIVRDFRQTMNQYSREPGRYRFMGAEASAESIERT
                     MMYYGLPFIQEADFPFNKYFTTIGTLSGHTVYEVITSWMENMPEGKWPNWMTGGPETP
                     RLTSRVGSEYVNAMHMLLFTLPGTPITYYGEEIGMGDISVTNFNESYDSTTLVSKSPM
                     QWDNSSNAGFTEANHTWLPTNSDYHTVNVDVQKTQPSSALRLYQDLSLLHATELVLSR
                     GWFCLLRDDSHSVVYTRELDGIDNVFLVVLNFGESSTVLNLQGIISDLPPELRIRLST
                     NSASKGSAVDTRAISLEKGEGLVLEHSTKAPLHQQAAFRDRCFVSSRACYSSALDILY
                     SSC"
     exon            513..692
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            693..847
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            848..973
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1093
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1218
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1414
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1582
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1699
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..2305
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2285..2290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /note="hexamer: ACTAAA"
     polyA_site      2305
                     /gene="Slc3a1"
                     /gene_synonym="D2; D2H; NBAT; NTAA; RBAT"
                     /note="major polyA site"
ORIGIN      
        1 cattaacaaa gcacagcgct cagcaagaca cctttctacc tctgtccctg ctggaaagca
       61 ccaggaagag ctacacaggg tagacatgga tgaggacaaa ggcaagagag accccatcca
      121 aatgagtttg aagggatgcc gaaccaataa cgggtttgtc caaaatgaag acattccgga
      181 gcaggaccca gacccaggct ccagggacac cccacagccc aacgccgtga gtatccctgc
      241 tccagaggag cctcacctaa aggcggtgcg gccctatgca gggatgccca aggaagtact
      301 cttccagttc tccggccagg ctcgctaccg ggtgccccga gagatcctct tctggctcac
      361 cgtggtttcc gtgttcctgc tcattggagc caccatagcc atcatcgtca tctctccaaa
      421 atgccttgac tggtggcaag caggtcccat ataccagatc tacccgaggt cttttaagga
      481 cagtgacaag gatgggaatg gagacctgaa aggtatccag gagaagctgg actatatcac
      541 tgctttaaac ataaagactc tttggatcac ttccttttat aaatcatctt tgaaagactt
      601 cagatacgct gttgaggatt tcaaagaaat tgaccctatt tttggaacaa tgaaagattt
      661 tgagaatttg gttgctgcca tccatgacaa aggtttaaaa ttaataattg atttcatacc
      721 aaaccacact agtgacaaac atccttggtt ccaatcgagt aggacacgga gcggaaaata
      781 caccgattac tacatctggc acaactgtac ccatgtcaac ggtgtaacca cccctcccaa
      841 caactggctg agtgtgtatg gaaactccag ctggcacttt gatgaagtac gaaagcaatg
      901 ttattttcac cagtttttga aagagcaacc agatttaaat ttccgaaatc ctgctgttca
      961 agaggaaata aaggaaataa taacgttctg gctctcgaag ggtgttgatg ggtttagttt
     1021 tgatgcagtt aaatttcttc tggaagcgaa ggatctgaga aatgaaatcc aagtgaatac
     1081 atcccaaatt ccggacacgg tcacccacta ctcagagctg taccatgact tcaccacaac
     1141 tcaggtggga atgcatgaca tcgtccgaga cttccggcag accatgaacc agtacagcag
     1201 ggagcctggc agataccggt tcatgggggc cgaagcctca gctgagagca tcgagaggac
     1261 catgatgtac tatggcttgc catttatcca ggaagccgac tttcctttca acaagtactt
     1321 caccacaata ggcactctct ctgggcatac tgtctatgaa gttatcacat cctggatgga
     1381 aaacatgcct gaaggaaaat ggcccaattg gatgactggc ggaccggaga ctcctcggct
     1441 gacttctcga gtagggagtg agtatgtcaa cgccatgcac atgctcctgt tcacactccc
     1501 gggaacgccc atcacttact atggagagga aatcgggatg ggagacattt ccgttacaaa
     1561 tttcaacgag agctatgata gtactaccct tgtctccaag tcaccgatgc agtgggacaa
     1621 tagttccaat gctgggttta ctgaggccaa ccacacctgg ctacccacaa actctgacta
     1681 ccacaccgtc aatgtggatg tccaaaagac ccagccgagc tcagcactga ggctgtatca
     1741 ggatctgagt ctactccatg ccacagagct ggtcctcagc cggggctggt tttgcctctt
     1801 gagagacgac agtcactctg tggtgtacac aagagagctg gacggcatag ataacgtctt
     1861 cctcgtggtt ctgaattttg gagaatcatc aactgtgcta aatctacagg ggatcatttc
     1921 agatcttcct ccagagctga gaataaggtt aagtaccaac tcagcctcca aaggcagtgc
     1981 tgttgacacc cgtgccattt ctctggagaa gggagagggc ctggtcttgg agcacagcac
     2041 gaaggctccc ctccatcagc aggccgcttt cagagacaga tgctttgttt ccagtcgggc
     2101 gtgctactcc agtgcactgg acatcctcta tagctcgtgt taggaaggaa gctccctaag
     2161 agatggccac ccagaacatc acgtacgcac agggctgagc agactcatga atggcatcaa
     2221 ttcttagata tttctgtagc acgaatgcac tgtttttaaa gtgtttaaaa gattatgcca
     2281 aaatactaaa gcatttaaat atgaaaa
//
