LOCUS       NM_001135149            3383 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus solute carrier family 39 (metal ion transporter),
            member 8 (Slc39a8), transcript variant 2, mRNA.
ACCESSION   NM_001135149
VERSION     NM_001135149.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3383)
  AUTHORS   Choi,E.K., Aring,L., Peng,Y., Correia,A.B., Lieberman,A.P.,
            Iwase,S. and Seo,Y.A.
  TITLE     Neuronal SLC39A8 deficiency impairs cerebellar development by
            altering manganese homeostasis
  JOURNAL   JCI Insight 9 (20), e168440 (2024)
   PUBMED   39435657
  REMARK    GeneRIF: Neuronal SLC39A8 deficiency impairs cerebellar development
            by altering manganese homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3383)
  AUTHORS   Choi,E.K., Rajendiran,T.M., Soni,T., Park,J.H., Aring,L.,
            Muraleedharan,C.K., Garcia-Hernandez,V., Kamada,N., Samuelson,L.C.,
            Nusrat,A., Iwase,S. and Seo,Y.A.
  TITLE     The manganese transporter SLC39A8 links alkaline ceramidase 1 to
            inflammatory bowel disease
  JOURNAL   Nat Commun 15 (1), 4775 (2024)
   PUBMED   38839750
  REMARK    GeneRIF: The manganese transporter SLC39A8 links alkaline
            ceramidase 1 to inflammatory bowel disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3383)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3383)
  AUTHORS   Liu,Z., Huang,J., Li,D., Zhang,C., Wan,H., Zeng,B., Tan,Y.,
            Zhong,F., Liao,H., Liu,M., Chen,Z.S., Zou,C., Liu,D. and Qin,B.
  TITLE     Targeting ZIP8 mediated ferroptosis as a novel strategy to protect
            against the retinal pigment epithelial degeneration
  JOURNAL   Free Radic Biol Med 214, 42-53 (2024)
   PUBMED   38309537
  REMARK    GeneRIF: Targeting ZIP8 mediated ferroptosis as a novel strategy to
            protect against the retinal pigment epithelial degeneration.
REFERENCE   5  (bases 1 to 3383)
  AUTHORS   Sunuwar,L., Tomar,V., Wildeman,A., Culotta,V. and Melia,J.
  TITLE     Hepatobiliary manganese homeostasis is dynamic in the setting of
            inflammation or infection in mice
  JOURNAL   FASEB J 37 (9), e23123 (2023)
   PUBMED   37561548
REFERENCE   6  (bases 1 to 3383)
  AUTHORS   Wang,B., Schneider,S.N., Dragin,N., Girijashanker,K., Dalton,T.P.,
            He,L., Miller,M.L., Stringer,K.F., Soleimani,M., Richardson,D.D.
            and Nebert,D.W.
  TITLE     Enhanced cadmium-induced testicular necrosis and renal proximal
            tubule damage caused by gene-dose increase in a Slc39a8-transgenic
            mouse line
  JOURNAL   Am J Physiol Cell Physiol 292 (4), C1523-C1535 (2007)
   PUBMED   17108009
  REMARK    GeneRIF: Cd treatment caused acute renal failure and signs of
            proximal tubular damage in the BTZIP8-3 but not nontransgenic
            littermates. BTZIP8-3 mice should be a useful model for studying
            Cd-induced disease in kidney.
REFERENCE   7  (bases 1 to 3383)
  AUTHORS   He,L., Girijashanker,K., Dalton,T.P., Reed,J., Li,H., Soleimani,M.
            and Nebert,D.W.
  TITLE     ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter
            family: characterization of transporter properties
  JOURNAL   Mol Pharmacol 70 (1), 171-180 (2006)
   PUBMED   16638970
REFERENCE   8  (bases 1 to 3383)
  AUTHORS   Dufner-Beattie,J., Huang,Z.L., Geiser,J., Xu,W. and Andrews,G.K.
  TITLE     Mouse ZIP1 and ZIP3 genes together are essential for adaptation to
            dietary zinc deficiency during pregnancy
  JOURNAL   Genesis 44 (5), 239-251 (2006)
   PUBMED   16652366
REFERENCE   9  (bases 1 to 3383)
  AUTHORS   Dalton,T.P., He,L., Wang,B., Miller,M.L., Jin,L., Stringer,K.F.,
            Chang,X., Baxter,C.S. and Nebert,D.W.
  TITLE     Identification of mouse SLC39A8 as the transporter responsible for
            cadmium-induced toxicity in the testis
  JOURNAL   Proc Natl Acad Sci U S A 102 (9), 3401-3406 (2005)
   PUBMED   15722412
REFERENCE   10 (bases 1 to 3383)
  AUTHORS   Sousa-Nunes,R., Rana,A.A., Kettleborough,R., Brickman,J.M.,
            Clements,M., Forrest,A., Grimmond,S., Avner,P., Smith,J.C.,
            Dunwoodie,S.L. and Beddington,R.S.
  TITLE     Characterizing embryonic gene expression patterns in the mouse
            using nonredundant sequence-based selection
  JOURNAL   Genome Res 13 (12), 2609-2620 (2003)
   PUBMED   14613977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY730883.1, AK016853.1, AK028215.1 and AC107690.10.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 through 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK028215.1, AK089060.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-637               BY730883.1         1-637
            638-1321            AK016853.1         525-1208
            1322-1972           AK028215.1         1220-1870
            1973-3383           AC107690.10        84624-86034
FEATURES             Location/Qualifiers
     source          1..3383
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 63.04 cM"
     gene            1..3383
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /note="solute carrier family 39 (metal ion transporter),
                     member 8"
                     /db_xref="GeneID:67547"
                     /db_xref="MGI:MGI:1914797"
     exon            1..144
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /inference="alignment:Splign:2.1.0"
     exon            145..595
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..1765
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /note="Zrt- and Irt-like protein 8; zinc transporter ZIP8;
                     metal cation symporter ZIP8"
                     /codon_start=1
                     /product="metal cation symporter ZIP8 precursor"
                     /protein_id="NP_001128621.1"
                     /db_xref="CCDS:CCDS17859.1"
                     /db_xref="GeneID:67547"
                     /db_xref="MGI:MGI:1914797"
                     /translation="MAPGRAVAGLLLLAATSLGHPSEGPELAFSEDVLSVFGANRSLS
                     AAQLGRLLERLGAASQQGALDLGQLHFNQCLSAEDIFSLHGFSNVTQITSSNFSAICP
                     AILQQLNFHPCEDLRKHNAKPSLSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPK
                     ILTYFVGLAIGTLFSNAIFQLIPEAFGFNPKIDNYVEKAVAVFGGFYMLFFVERTLKM
                     LLKTYGQNDHTHFRNDDFGSKEKTHQPKTLPLPAVNGVTCYANPAVTEPNGHIHFDTV
                     SVVSLQDGKTEPSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASCTLSLLQ
                     GLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNF
                     APNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRQTDFTFFMIQNAGMLTGFTAIL
                     LITLYAGDIELQ"
     exon            596..758
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /inference="alignment:Splign:2.1.0"
     exon            759..928
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1051
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1222
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1430
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1615
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..3383
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3184..3189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /note="hexamer: AGTAAA"
     polyA_site      3203
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /note="major polyA site"
     regulatory      3358..3363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
                     /note="hexamer: AATAAA"
     polyA_site      3383
                     /gene="Slc39a8"
                     /gene_synonym="4933419D20Rik; BIGM103; ZIP-8; Zip8"
ORIGIN      
        1 agagtttctt agagaaagga gagagaaaga cagacagaga gagagagaga gagagagaga
       61 gagagagaga gagagagaga gagagagaga gagagaagta ttttgaatat atttgaacct
      121 caggggctga catagacagt agaggctccg caggaggctc cgagaggcca cactgcctat
      181 cgcccttctg gctgttctac ctcttcaatg ccccgaaggt ctgagactgc agagcggggg
      241 cacggagtgt ctcgctaact gggccaggca gtgacgcggg accggcgcac cctcccaccc
      301 ccaccctaac ggcactgaca ccggggcacc ggcgcgggtc cctgcatcag ctagctccgg
      361 agctgcgcgc tccacgatgg ctccgggccg ggcagtggcc gggctgctgc tgctggcggc
      421 caccagcctg ggacacccct cggagggacc ggagctcgcc ttcagtgagg atgtgctgag
      481 cgtgttcggc gccaaccgga gcctgtcggc cgcgcagctg gggcgcctgc tggagcgtct
      541 gggggctgca tcccagcagg gagcgctgga cctgggccag ctgcacttca accagtgttt
      601 gtcagcagaa gacatctttt ctcttcatgg tttctcaaat gtcacccaga taaccagctc
      661 gaacttctct gccatctgcc ccgcgatctt acagcagctg aacttccatc cctgcgagga
      721 tctaagaaag cacaacgcaa agcccagtct ttccgaagtc tggggctatg gattcctgtc
      781 agtgacaatt atcaatctgg cctctctcct gggattgatt ttaaccccct tgataaagaa
      841 gtcttatttc cccaagattt taacttattt cgtgggactc gctattggga ctcttttctc
      901 aaacgccatt ttccagctta ttccagaggc atttggattt aatcccaaaa ttgacaatta
      961 cgttgagaaa gcagttgctg tgtttggtgg attttacatg cttttctttg tcgagagaac
     1021 acttaagatg ctactgaaaa catatggcca gaatgaccat actcacttca ggaatgatga
     1081 ctttggttct aaagaaaaaa cccaccaacc caaaacgtta ccattgcctg cagtcaacgg
     1141 tgtgacttgc tatgccaacc ccgctgtcac tgagcctaac ggacacatcc acttcgacac
     1201 tgtcagcgtt gtatccctcc aggatggaaa aacagagcca agctcatgta cctgtctgaa
     1261 ggggcccaaa ctgtcagaaa taggaacaat tgcctggatg atcacgcttt gtgatgccct
     1321 ccacaatttc atcgacggct tggcgattgg ggcatcttgt actttgtctc ttcttcaggg
     1381 gctcagtacg tccatagcga tcctgtgtga ggagtttcct catgagttag gggactttgt
     1441 gatcttgctc aatgcaggaa tgagcacccg gcaagccttg ctgttcaact tcctctccgc
     1501 gtgttcctgc tacgtgggac tagctttcgg cattttggtg ggcaacaatt ttgctcccaa
     1561 tattatattt gcactcgctg gaggcatgtt cctctacatt tctctggcag atatgtttcc
     1621 agagatgaac gacatgctga gagaaaaagt aactggaaga caaacggatt tcaccttctt
     1681 catgatccag aatgcaggga tgttaaccgg cttcactgcc atcctgctca tcaccttgta
     1741 cgcaggagac atcgaattgc agtagccgga agtggagtat aacgtcaacg cgggaaggca
     1801 tttaataaca acacagaaac atctccatag ggatttttgt ttttttaaaa gtatatccta
     1861 tttagttaaa agagattttt tttttattat tttcaactaa aggctaagga atctaatgac
     1921 tggtttcaga tatgtagaat aggtgaaatt tgttgttaaa atttttcctt aaaaggtttt
     1981 cggtttcaga ctgcaaaggc tggtgtatgg ggcctttggt aaatacctgg ttttcaatat
     2041 tttatgcata ttagaaaatt atcatgaagc aaacacgtgc attcacaagc agacatacag
     2101 atccagagaa aaacacaatc tgggtcatgt aaggtttcag aacttgcttg ggtaaacaac
     2161 aacaacaaca acaacaacaa caacaacaac aaaaacctca agcgttttca gagtggtttt
     2221 cttccaatta atgtgtttga ctgcttttaa aggcaggtgc atcaaatgag gaagaaaatc
     2281 aagacagaca gctccagtgc atgcaggacc gatcccagtg ccttaacgaa ccccagaaag
     2341 atagcgcaca gcgtttgttc agctttatgt ctcagttggc gacctgtagg attgttttga
     2401 aagctaatac aaagtaacat gaattaggaa aggatgaaag gcttgctagc ccagcaaggc
     2461 ttgggctcag ggcttggtcc ctgagttata agcttgaaca caccctgcag aagaccagaa
     2521 ttgctttgct atgatttatg ctgtggttcc agccaacaga aatgcctgag gagtatgcga
     2581 gactggttag aactcagtct tgccatgctc tgggattgct ttgtcatggt ggagaatatg
     2641 ttgggtggga gagagaaatt gaatgtaatt gtgagcaatt tactttttaa aagatgagca
     2701 taattattta gcagggggaa tttcaataaa tgcaaaaatc acagctgggc tgggctgtgt
     2761 cagagactga tggtggagga ggcatgtgct cattaggggt gattgacagt cagcagagac
     2821 ggcttctttt atgtgcagtg tgctttgttc ccatatggta taccgttgga tggaaaacct
     2881 cagcatactc tttctacctt tcgtaaaaca cacagctcac tgagtgtttg agcacgttgt
     2941 agacgatcag tctgaattga acatcctaat ttcaattcac actcccaagt aacttaaaaa
     3001 aaagatgatt tgacagtgat gagaattagt aatagaagcc aagttatctc aggaattatg
     3061 ttttcctata agcccaaaca cattttcatg taataacagt gcagatttga taaactttaa
     3121 catatatgtt tatgtgtatt ctcactttat gactgacaat taaaaaatat tatttgacca
     3181 aacagtaaaa gcttttgaaa ccatgtaccg tgtcagttat ttttctctta atatgtcttt
     3241 attttgagtg acatcatgtg gctggtgtta tgagaagaga ggcaagtaga gaactgatgt
     3301 tgtattattt taaaaatatc tagcaaaaaa atcctacaaa gactaatttt tcatttcaat
     3361 aaacacaatc tatattagta taa
//
