LOCUS       NM_008202               2398 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus solute carrier family 39 (zinc transporter), member 7
            (Slc39a7), transcript variant 1, mRNA.
ACCESSION   NM_008202
VERSION     NM_008202.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2398)
  AUTHORS   Zhang,H., Yang,N., He,H., Chai,J., Cheng,X., Zhao,H., Zhou,D.,
            Teng,T., Kong,X., Yang,Q. and Xu,Z.
  TITLE     The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion
            injury by regulating mitophagy
  JOURNAL   Basic Res Cardiol 116 (1), 54 (2021)
   PUBMED   34581906
  REMARK    GeneRIF: The zinc transporter ZIP7 (Slc39a7) controls myocardial
            reperfusion injury by regulating mitophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2398)
  AUTHORS   Hasna,J., Bohic,S., Lemoine,S., Blugeon,C. and Bouron,A.
  TITLE     Zinc Uptake and Storage During the Formation of the Cerebral Cortex
            in Mice
  JOURNAL   Mol Neurobiol 56 (10), 6928-6940 (2019)
   PUBMED   30941734
REFERENCE   3  (bases 1 to 2398)
  AUTHORS   Lee,M.G. and Bin,B.H.
  TITLE     Different Actions of Intracellular Zinc Transporters ZIP7 and ZIP13
            Are Essential for Dermal Development
  JOURNAL   Int J Mol Sci 20 (16), 3941 (2019)
   PUBMED   31412620
  REMARK    GeneRIF: we have clarified the functional differences between ZIP7
            and ZIP13 and show that their different regulation of cellular zinc
            homeostasis is critical for dermal development and homeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2398)
  AUTHORS   Norouzi,S., Adulcikas,J., Henstridge,D.C., Sonda,S., Sohal,S.S. and
            Myers,S.
  TITLE     The Zinc Transporter Zip7 Is Downregulated in Skeletal Muscle of
            Insulin-Resistant Cells and in Mice Fed a High-Fat Diet
  JOURNAL   Cells 8 (7), 663 (2019)
   PUBMED   31266232
  REMARK    GeneRIF: Study identified that Zip7 is upregulated by glucose in
            normal skeletal muscle cells and downregulated in insulin-resistant
            skeletal muscle. The overexpression of Zip7 in skeletal muscle
            cells led to the modulation of key genes involved in the insulin
            signaling axis and glucose metabolism. In vivo mouse model revealed
            a reduction in Glut4 and Zip7 in the skeletal muscle of mice fed a
            high-fat diet.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2398)
  AUTHORS   Anzilotti,C., Swan,D.J., Boisson,B., Deobagkar-Lele,M.,
            Oliveira,C., Chabosseau,P., Engelhardt,K.R., Xu,X., Chen,R.,
            Alvarez,L., Berlinguer-Palmini,R., Bull,K.R., Cawthorne,E.,
            Cribbs,A.P., Crockford,T.L., Dang,T.S., Fearn,A., Fenech,E.J., de
            Jong,S.J., Lagerholm,B.C., Ma,C.S., Sims,D., van den Berg,B.,
            Xu,Y., Cant,A.J., Kleiner,G., Leahy,T.R., de la Morena,M.T.,
            Puck,J.M., Shapiro,R.S., van der Burg,M., Chapman,J.R.,
            Christianson,J.C., Davies,B., McGrath,J.A., Przyborski,S.,
            Santibanez Koref,M., Tangye,S.G., Werner,A., Rutter,G.A.,
            Padilla-Parra,S., Casanova,J.L., Cornall,R.J., Conley,M.E. and
            Hambleton,S.
  TITLE     An essential role for the Zn2+ transporter ZIP7 in B cell
            development
  JOURNAL   Nat Immunol 20 (3), 350-361 (2019)
   PUBMED   30718914
REFERENCE   6  (bases 1 to 2398)
  AUTHORS   Maxwell,M.M., Nearing,J. and Aziz,N.
  TITLE     Ke 6 gene. Sequence and organization and aberrant regulation in
            murine polycystic kidney disease
  JOURNAL   J Biol Chem 270 (42), 25213-25219 (1995)
   PUBMED   7559658
REFERENCE   7  (bases 1 to 2398)
  AUTHORS   Nagata,T., Weiss,E.H., Abe,K., Kitagawa,K., Ando,A.,
            Yara-Kikuti,Y., Seldin,M.F., Ozato,K., Inoko,H. and Taketo,M.
  TITLE     Physical mapping of the retinoid X receptor B gene in mouse and
            human
  JOURNAL   Immunogenetics 41 (2-3), 83-90 (1995)
   PUBMED   7806300
REFERENCE   8  (bases 1 to 2398)
  AUTHORS   Hanson,I.M. and Trowsdale,J.
  TITLE     Colinearity of novel genes in the class II regions of the MHC in
            mouse and human
  JOURNAL   Immunogenetics 34 (1), 5-11 (1991)
   PUBMED   1855816
REFERENCE   9  (bases 1 to 2398)
  AUTHORS   St-Jacques,B., Han,T.H., MacMurray,A. and Shin,H.S.
  TITLE     A putative transmembrane protein with histidine-rich charge
            clusters encoded in the H-2K/tw5 region of mice
  JOURNAL   Mol Cell Biol 10 (1), 138-145 (1990)
   PUBMED   2294398
REFERENCE   10 (bases 1 to 2398)
  AUTHORS   Abe,K., Wei,J.F., Wei,F.S., Hsu,Y.C., Uehara,H., Artzt,K. and
            Bennett,D.
  TITLE     Searching for coding sequences in the mammalian genome: the H-2K
            region of the mouse MHC is replete with genes expressed in embryos
  JOURNAL   EMBO J 7 (11), 3441-3449 (1988)
   PUBMED   2463160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY288782.1, AK167344.1, AK159968.1 and AA170090.1.
            
            On Nov 19, 2006 this sequence version replaced NM_008202.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC115426.2, AK159968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BY288782.1         2-43
            43-867              AK167344.1         2-826
            868-1477            AK167344.1         916-1525
            1478-2141           AK159968.1         1354-2017
            2142-2386           AK167344.1         2190-2434
            2387-2398           AA170090.1         391-402
FEATURES             Location/Qualifiers
     source          1..2398
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2398
                     /gene="Slc39a7"
                     /gene_synonym="H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Zip7"
                     /note="solute carrier family 39 (zinc transporter), member
                     7"
                     /db_xref="GeneID:14977"
                     /db_xref="MGI:MGI:95909"
     exon            1..867
                     /gene="Slc39a7"
                     /gene_synonym="H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Zip7"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..1863
                     /gene="Slc39a7"
                     /gene_synonym="H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Zip7"
                     /note="zinc transporter SLC39A7; solute carrier family 39
                     member 7; histidine-rich membrane protein Ke4; H2-K region
                     expressed gene 4; zrt-, Irt-like protein 7"
                     /codon_start=1
                     /product="zinc transporter SLC39A7 precursor"
                     /protein_id="NP_032228.2"
                     /db_xref="CCDS:CCDS37576.1"
                     /db_xref="GeneID:14977"
                     /db_xref="MGI:MGI:95909"
                     /translation="MTMGLRAPHWVAVGLLTWAALGLLVAGHEGHGDLHKDVEEDFHG
                     HSHGHSHEDFHHGHSHGHSHEDFHHGHGHTHESIWHGHAHSHDHGHSREELHHGHSHG
                     HSHDSLHHGGHGHAHREHSHGTSREAGAPGIKHHLDTVTLWAYALGATVLISAAPFFV
                     LFLIPVESNSPRHRSLLQILLSFASGGLLGDAFLHLIPHALEPHSHHAPEQPGHGHSH
                     SGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGDRHAHGDSHTHGDRHEC
                     SSKEKPSTEEEKEVGGLRKRRGGNTGPRDGPVKPQSPEEEKAGSDLRVSGYLNLAADL
                     AHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQL
                     VTAIGALAGTACALLTEGGAVDSDVAGGAGPGWVLPFTAGGFIYVATVSVLPELLREA
                     SPLQSLLEVLGLLGGVAMMVLIAHLE"
     exon            868..1036
                     /gene="Slc39a7"
                     /gene_synonym="H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Zip7"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1090
                     /gene="Slc39a7"
                     /gene_synonym="H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Zip7"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1255
                     /gene="Slc39a7"
                     /gene_synonym="H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Zip7"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1393
                     /gene="Slc39a7"
                     /gene_synonym="H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Zip7"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1590
                     /gene="Slc39a7"
                     /gene_synonym="H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Zip7"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..2393
                     /gene="Slc39a7"
                     /gene_synonym="H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Zip7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2360..2365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a7"
                     /gene_synonym="H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Zip7"
                     /note="hexamer: AATAAA"
     polyA_site      2387
                     /gene="Slc39a7"
                     /gene_synonym="H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Zip7"
                     /note="major polyA site"
ORIGIN      
        1 gtggccgcgc cgccctcggg gcgccgccat gttggtaaag gtatcggggc gcaggcaaga
       61 aagggagctt ccggatctcg cgggagctcg aggcgtgagt gccacgtccc agcaaaccga
      121 gaaccgagag gatcccggag ccggtgagag gtccctgctg ctcccttacg gcgctttcca
      181 ggcctttacc ccaaccagtg ggccatagag acgcgggccc agagagaccg taaagttgct
      241 gatcaaaggc tagagcggtg tcgggggtgg ggggctgcat ccaggaaggg tgttggggat
      301 gaggtggacc ggccttgggg acaatgtaag agcggagcaa gtagtataga ggaagggctt
      361 caagggacgc ggatcccgaa taggtagatt gagagtcaag tcgagtcgtc tcttgttcct
      421 ccggtcagcg tgatgaccat gggcctgcgg gccccccact gggtggctgt gggactgctg
      481 acctgggcgg ctttggggct gctggtggcc ggacacgagg gtcatggtga cctgcacaaa
      541 gatgtggaag aggacttcca tggccacagt cacgggcact cacatgaaga tttccaccat
      601 ggccacagcc acgggcactc gcatgaagat ttccaccatg gccacggcca cactcatgaa
      661 agcatctggc atgggcatgc ccacagccac gaccatggac actcacgtga ggaattacac
      721 catggccata gccatggcca ctcccacgat agcctccacc acggaggaca tggacatgcc
      781 catcgtgaac atagccatgg gacttctagg gaggctgggg ctccaggcat caaacaccac
      841 ctggacactg tcaccctctg ggcctacgca ctgggggcca cagtgctgat ctccgcagct
      901 ccgttcttcg tgctgttcct catcccagta gaatctaact ctcccaggca ccgctctctg
      961 ctccagatcc tgctcagttt tgcttccggg gggctcctgg gtgatgcgtt cctccacctc
     1021 atcccgcatg ccttggaacc tcattctcac cacgctccag agcagcctgg acatggacac
     1081 tcccacagtg gccagggccc cattctctct gtggggctgt gggttctcag tgggattgtc
     1141 gccttcctcg tggtggagaa atttgtgaga cacgtgaaag gaggacatgg acacagtcac
     1201 ggacacggag acaggcatgc gcatggagac agtcacaccc atggagatag acatgagtgt
     1261 tcttcaaagg aaaagcccag cacagaggaa gagaaggaag tgggcgggtt gcggaaaagg
     1321 agaggaggaa acactgggcc cagagatggc ccggtgaaac ctcagagccc tgaagaagaa
     1381 aaagcaggct cagacctgcg tgtgtctggg tacctgaatc tggctgctga cttggcacac
     1441 aacttcacag acggtctggc cattggtgct tcctttcgtg ggggccgagg gctagggatc
     1501 ctgaccacaa tgacagtcct gctgcacgaa gtgcctcatg aggttgggga ttttgccatc
     1561 ctggtccagt ctggctgcag caagaagcag gcgatgcgtc tgcaactcgt gactgcaatt
     1621 ggagcattgg caggcactgc ctgtgccctt ctcaccgagg gaggggcagt ggacagtgac
     1681 gtggcaggtg gtgcaggtcc tggctgggtc ctgccattca ctgcaggcgg atttatctac
     1741 gtagcaacag tgtctgtgct gcctgagcta ttgagagagg catctccact gcagtcactg
     1801 ttggaggtgc tggggctgct ggggggtgtt gccatgatgg tactgattgc ccatcttgag
     1861 tgaggggtga ggtgacctgt ccttccccta actcctaata aaggcagttg gtagtcctgg
     1921 ccagtgctaa tgccagaagg agtgtcagcc ttggagatta gcagagcctc tgtttgaggc
     1981 cttagaggta tgaggatcat acggagcatg agaggccaga aggaccacgg agtgggagac
     2041 tgcccagcag cgttgttgct tttggaaaaa tcaatgggac catgaagaag actgggaaga
     2101 cggtagccta cccgatggtc cctaatctac gatttctcag cgccagcgtg ccgcaggggt
     2161 ccctccaagg cccatctccc tctgaactag ttagtgatgg cttcagggaa gacctggcag
     2221 aaggactggg gtagacatca atcgtgtgtc ctgatttgaa gggggagggg ggctccttgg
     2281 gaagatgtct cagcctgatt ttttgtctct actcatttta taccactgtt tgaatgggtg
     2341 cggaggaacg gtgaccagga ataaaagacc ttggatcttc ggccccacat gcaaaaaa
//
