LOCUS       NM_139143               3905 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 39 (metal ion transporter),
            member 6 (Slc39a6), mRNA.
ACCESSION   NM_139143
VERSION     NM_139143.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3905)
  AUTHORS   Chen,P., Wang,B., Mo,Q., Wu,P., Fang,Y., Tian,Y., Jin,X., Gao,Y.,
            Wu,Y., Cao,Y., Zhang,Y., Xi,L., Wang,S., Hu,J., Ma,D., Zhou,J.,
            Gao,Q. and Chen,G.
  TITLE     The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic
            agent-damaged mitosis
  JOURNAL   EBioMedicine 49, 26-39 (2019)
   PUBMED   31636012
  REMARK    GeneRIF: These data demonstrate that LIV-1-GRPEL1 axis dually
            regulates mitotic exit as well as apoptosis by interacting with
            PP2A B55alpha and AIF.
REFERENCE   2  (bases 1 to 3905)
  AUTHORS   Bin,B.H., Bhin,J., Takaishi,M., Toyoshima,K.E., Kawamata,S.,
            Ito,K., Hara,T., Watanabe,T., Irie,T., Takagishi,T., Lee,S.H.,
            Jung,H.S., Rho,S., Seo,J., Choi,D.H., Hwang,D., Koseki,H.,
            Ohara,O., Sano,S., Tsuji,T., Mishima,K. and Fukada,T.
  TITLE     Requirement of zinc transporter ZIP10 for epidermal development:
            Implication of the ZIP10-p63 axis in epithelial homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 114 (46), 12243-12248 (2017)
   PUBMED   29078349
REFERENCE   3  (bases 1 to 3905)
  AUTHORS   Brethour,D., Mehrabian,M., Williams,D., Wang,X., Ghodrati,F.,
            Ehsani,S., Rubie,E.A., Woodgett,J.R., Sevalle,J., Xi,Z., Rogaeva,E.
            and Schmitt-Ulms,G.
  TITLE     A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and
            integration into focal adhesion complexes during
            epithelial-to-mesenchymal transition
  JOURNAL   Sci Rep 7, 40313 (2017)
   PUBMED   28098160
  REMARK    GeneRIF: PrP and ZIP6 inherited the ability to interact with NCAM1
            from their common ZIP ancestors but have since diverged to control
            distinct posttranslational modifications of NCAM1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3905)
  AUTHORS   Taylor,K.M., Muraina,I.A., Brethour,D., Schmitt-Ulms,G.,
            Nimmanon,T., Ziliotto,S., Kille,P. and Hogstrand,C.
  TITLE     Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates
            embryonic development and cell migration
  JOURNAL   Biochem J 473 (16), 2531-2544 (2016)
   PUBMED   27274087
REFERENCE   5  (bases 1 to 3905)
  AUTHORS   Wong,C.P., Magnusson,K.R. and Ho,E.
  TITLE     Increased inflammatory response in aged mice is associated with
            age-related zinc deficiency and zinc transporter dysregulation
  JOURNAL   J Nutr Biochem 24 (1), 353-359 (2013)
   PUBMED   22981370
  REMARK    GeneRIF: Zip 6 dysregulation was involved in enhanced inflammation
            during aging.
REFERENCE   6  (bases 1 to 3905)
  AUTHORS   Croxford,T.P., McCormick,N.H. and Kelleher,S.L.
  TITLE     Moderate zinc deficiency reduces testicular Zip6 and Zip10
            abundance and impairs spermatogenesis in mice
  JOURNAL   J Nutr 141 (3), 359-365 (2011)
   PUBMED   21248196
  REMARK    GeneRIF: mice fed low-Zn diet had reduced number of terminal
            deoxynucleotidyl transferase dUTP nick end labeling-positive cells
            compromised seminiferous tubule structure, and reduced Zip10 and
            Zip6 abundance (>50%; P < 0.5) compared with control diet
REFERENCE   7  (bases 1 to 3905)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 3905)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   9  (bases 1 to 3905)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3905)
  AUTHORS   Suzuki,A. and Endo,T.
  TITLE     Ermelin, an endoplasmic reticulum transmembrane protein, contains
            the novel HELP domain conserved in eukaryotes
  JOURNAL   Gene 284 (1-2), 31-40 (2002)
   PUBMED   11891044
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK619600.1, AK028976.1 and BC055012.1.
            
            On Aug 17, 2007 this sequence version replaced NM_139143.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055012.1, AK028976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                CK619600.1         1-42
            43-3875             AK028976.1         2-3834
            3876-3905           BC055012.1         3546-3575
FEATURES             Location/Qualifiers
     source          1..3905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.18 cM"
     gene            1..3905
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /note="solute carrier family 39 (metal ion transporter),
                     member 6"
                     /db_xref="GeneID:106957"
                     /db_xref="MGI:MGI:2147279"
     exon            1..531
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /inference="alignment:Splign:2.1.0"
     exon            532..1356
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /inference="alignment:Splign:2.1.0"
     CDS             541..2838
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /note="endoplasmic reticulum membrane protein; zinc
                     transporter ZIP6; ZIP-6; zrt- and Irt-like protein 6;
                     solute carrier family 39 member 6; endoplasmic reticulum
                     membrane-linked protein"
                     /codon_start=1
                     /product="zinc transporter ZIP6 precursor"
                     /protein_id="NP_631882.2"
                     /db_xref="CCDS:CCDS50239.1"
                     /db_xref="GeneID:106957"
                     /db_xref="MGI:MGI:2147279"
                     /translation="MATDLSVIMILTFALWVTSPLHELQSTAAFSQTTEKINSNWEPG
                     VNVDLAVTMQRHHLQQLFYRYGENDSLSVEGFRKLLQNIGIDKIKRVHIHHDHEHHAD
                     HEHHSDHEHHSDHEHHSDHEHHSDHEHHSDHEHHSHRSHTVAGKNNRKAFCPDLDSDN
                     SGKNPRTSLGKGSRPAEHMNGRRNIKESASSSEVTSAVYNAVSEGTRFVETIETPKPG
                     RRTKDVNPSTPPSITEKSRVGRLSRLARKKSNESVSEPRKSFMYSRNTNDNIQECFNT
                     TKLLTSHGMSIQALLNATEFNYLCPAIINQIDARACLIHTASEKKAEIPPKTYSLQIA
                     WLGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDALLHLLPHSH
                     ASHQHSHSHEEPAMEMKRGPLFSHLSAQNIEESSYFDSTWKGLTALGGLYFMFLVEHV
                     LTLIKQFKDKKKKNQKKPENDEDVESKKQLSKYDSQLSSNEEKVDPGERPESYLRADS
                     QEPSPFDSQQPTMLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIH
                     HHHDYHHILHHHHHQNHHPHSHSQRYSREELKDAGIATLAWMVIMGDGLHNFSDGLAI
                     GAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGM
                     ATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNA
                     GILLGFGIMLLISIFEHKIVFRINF"
     exon            1357..1540
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1710
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1929
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2035
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2413
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2494
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2685
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..3882
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3860..3865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /note="hexamer: ATTAAA"
     polyA_site      3882
                     /gene="Slc39a6"
                     /gene_synonym="Ermelin; Zip6"
                     /note="major polyA site"
ORIGIN      
        1 tggcgtggtt ctcttcggta gccttcgctc gcctcgcgca tcactctgac cgctgctccg
       61 cgcgtgagcc aggcctgacc gctgtaggca gggcactctc gaaggagctc gtggtcccag
      121 acggttccat cgggcccggc tgcctacagc ggaccagact gggctgaagt cctggcgtgg
      181 agcggaaggg ctcgaggaaa ggactcgcgc ccgcccctcc atcgcggcga gcccgtggcg
      241 tctgagaaca cgcggaaaag cggatcggtc ttggcagacc gggctccggg gctgcactgc
      301 gcgtgcgcca cggtgctaga agcgggaggc ggcggtaatt accgattgtc ctgcttggag
      361 gaggcgcggc aaccccgggc ccgaggggtg gccgggctca tgattctgcc gctgctccac
      421 gcctcgtaaa ggcttctcgg agaccggagc tgcgcgggtt cccagtccct tcggacctcc
      481 cgcggggaac cgaacctgcg cgcggggccg ggcggcggga caccaggaga ggaaggtgca
      541 atggccacag atttatctgt aatcatgatc ttgacctttg ccctttgggt tacaagcccc
      601 cttcatgaac tacaatcaac agctgctttc tctcagacta ctgagaaaat aaattcaaat
      661 tgggaacctg gtgttaatgt tgacttggca gttaccatgc agcgacacca tctgcagcag
      721 ctattctacc gctacggaga gaatgattcc ttgtctgttg aaggcttcag aaaattgctt
      781 cagaacatag gcatagataa gattaaaaga gtccatatac accatgacca cgagcatcat
      841 gctgaccacg agcatcactc ggaccatgag catcactcgg accacgagca tcactcggac
      901 cacgagcatc actcggacca cgagcatcac tcggaccacg agcaccattc ccaccgcagt
      961 cacacggttg ctggtaaaaa caatcggaaa gccttttgtc cagaccttga ctctgataat
     1021 tcaggtaaaa atcctagaac tagtctaggg aaaggatctc gcccagcaga gcacatgaat
     1081 ggtaggagga acatcaagga gagtgcaagc tctagtgaag tgacctcggc ggtatacaac
     1141 gctgtctctg aaggaactcg ctttgtagag acaatagaga ctccaaaacc tgggagacgc
     1201 accaaagatg taaacccttc taccccaccc agcatcacgg agaaaagccg agtgggccgg
     1261 ctgagtcggc tagctaggaa gaaaagcaat gagtctgtga gtgagcccag aaagagcttt
     1321 atgtattcca gaaacacaaa tgacaatatt caggagtgtt tcaatacaac caagctgctg
     1381 acatcccatg gcatgagcat ccaggctctg ttgaatgcaa cggaatttaa ctatctctgc
     1441 ccagccatca tcaatcaaat tgatgctcgg gcttgtctga ttcatacagc aagtgagaag
     1501 aaggcagaaa tccctccaaa gacctattct ttacaaatag cctggcttgg tggcttcata
     1561 gccatttcca tcatcagttt cctgtctctg ctgggagtca tcttggtgcc actcatgaac
     1621 cgggtatttt tcaagttcct gctgagcttc ctcgtggcgc tggccgtcgg aacgctgagt
     1681 ggcgatgctc tgttacatct tctcccacac tctcatgcaa gtcatcagca cagtcatagc
     1741 catgaagagc cagcgatgga aatgaaaaga ggccccctgt tcagccacct gtcggctcag
     1801 aatatagaag aaagctccta ttttgattcc acgtggaaag gtctgacggc tctagggggc
     1861 ttatatttca tgtttcttgt ggaacacgta ctcacactga tcaagcaatt taaagataag
     1921 aaaaagaaga atcaaaagaa acctgaaaat gatgaggatg tggagagcaa gaagcagctg
     1981 tccaaatacg actctcagct ttcctcaaat gaagagaagg tggacccagg ggaacgacct
     2041 gaaagctatc tgcgagccga ctcccaagag ccctccccct ttgattccca gcagccgacg
     2101 atgttggaag aggaagaggt catgatagcc catgcacacc cacaagaagt ctacaatgaa
     2161 tatgtgccca ggggctgcaa gaacaagtgc cattcacact tccacgatac gctgggccag
     2221 tccgacgacc tcatccacca ccatcacgac taccatcaca ttctgcacca ccaccaccac
     2281 cagaaccacc accctcacag ccacagccag cgctactctc gagaggagct gaaggacgcc
     2341 ggcattgcca cattggcctg gatggtgatc atgggcgacg ggctgcacaa tttcagtgac
     2401 ggccttgcta ttggtgctgc cttcaccgag ggtttgtcca gtgggctaag cacctctgtc
     2461 gctgtgttct gtcatgaact gcctcatgaa ctaggtgact ttgctgtttt gctaaaggct
     2521 ggcatgactg tcaagcaggc tgtgctctat aatgctctgt cagccatgtt ggcctacctt
     2581 ggaatggcaa cagggatatt catcgggcat tatgcagaaa atgtttctat gtggatattc
     2641 gcactcactg ccggcttgtt catgtatgtc gctctggttg acatggtgcc tgagatgttg
     2701 cacaatgatg ctagtgatca cggatgcagc cgttggggat atttcttcct gcagaatgct
     2761 gggatacttc tcggttttgg aattatgtta ctcatttcca tatttgagca taaaattgtg
     2821 tttcgtataa atttctaatt aggttctaaa ccctagagca gcttaaagaa gtactgttgt
     2881 ttgtagttcc agtagatggt agaaatacgt tcatatgctg tgatacacag catttaaaac
     2941 tagtgagttt tgcaattttt ctatcaaatt ttgccatttg ttatgcttat aaagtcagtt
     3001 ccattgggta acataaaggt acgttttaat atttaagtta ttctgttttg gaaatgtaaa
     3061 ttctgtgtgt gatccaccag tattacccag ctgtatgttt cggcatgccg tgtcttgtct
     3121 attctagaga aaatgtcttt agtgctcttc tgtgtagctt tagcattact tccctgctgg
     3181 agttgggccc ttgctcgtgc tgagaaagaa tgggcacaaa acccaagaca ccaacagttc
     3241 acactgagca tagtcaggaa ataggaggaa aagagaactc gggaggattg aggaggtata
     3301 tattgctttg aaaaatcaca aggttggttg taacgttgag agggggaaat tctagatgtg
     3361 ttttaaaggg gcatgtttag ttccgagtac gtgcgtggac atctgtcaaa ttgttatgtt
     3421 cctgtgaaac aagtgaacac tctgatacac ttcatctgct tgtacatctg tatgatagag
     3481 aaatgtaaat atgttaatcc aagcaatgtg tcacttggct gagaaatgag gcatttaaat
     3541 ctgtgtgtgg agatgggcca aatgagtaac tagtgtgtca ccagaagact tggttttcac
     3601 catggtctct tatgcctgaa gttatgtgaa cattctagtt gtctaggctt ccaagtggca
     3661 agtattaaaa ctttagccca tgagaggatg ttaagacctg ttctgaaaat attttgactt
     3721 cttggattca aaaagcactt agctctcttt ctctctcagt gctttaaaat gtcattgtga
     3781 acaactgtcc tttgatgtat gacactgtag atacattggg gctgtctgta gcactgtctg
     3841 gatgtttctt tcttaaaaaa ttaaagtgtc aactcagtgg caaaaaaaaa aaaaaaaaaa
     3901 aaaaa
//
