LOCUS       NM_001136237            1944 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus solute carrier family 39 (metal ion transporter),
            member 5 (Slc39a5), transcript variant 3, mRNA.
ACCESSION   NM_001136237
VERSION     NM_001136237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1944)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1944)
  AUTHORS   Liu,Z., Hu,Z., Cai,X. and Liu,S.
  TITLE     SLC39A5 promotes lung adenocarcinoma cell proliferation by
            activating PI3K/AKT signaling
  JOURNAL   Pathol Res Pract 224, 153541 (2021)
   PUBMED   34252710
  REMARK    GeneRIF: SLC39A5 promotes lung adenocarcinoma cell proliferation by
            activating PI3K/AKT signaling.
REFERENCE   3  (bases 1 to 1944)
  AUTHORS   Wang,X., Gao,H., Wu,W., Xie,E., Yu,Y., He,X., Li,J., Zheng,W.,
            Wang,X., Cao,X., Meng,Z., Chen,L., Min,J. and Wang,F.
  TITLE     The zinc transporter Slc39a5 controls glucose sensing and insulin
            secretion in pancreatic beta-cells via Sirt1- and
            Pgc-1alpha-mediated regulation of Glut2
  JOURNAL   Protein Cell 10 (6), 436-449 (2019)
   PUBMED   30324491
  REMARK    GeneRIF: The authors show that Slc39a5-mediated zinc influx induces
            expression of Glut2 (Glucose Transporter Type 2) via Sirt1 (sirtuin
            1)-mediated Pgc-1alpha (peroxisome proliferative activated
            receptor, gamma, coactivator 1 alpha) activation.
REFERENCE   4  (bases 1 to 1944)
  AUTHORS   Bin,B.H., Bhin,J., Takaishi,M., Toyoshima,K.E., Kawamata,S.,
            Ito,K., Hara,T., Watanabe,T., Irie,T., Takagishi,T., Lee,S.H.,
            Jung,H.S., Rho,S., Seo,J., Choi,D.H., Hwang,D., Koseki,H.,
            Ohara,O., Sano,S., Tsuji,T., Mishima,K. and Fukada,T.
  TITLE     Requirement of zinc transporter ZIP10 for epidermal development:
            Implication of the ZIP10-p63 axis in epithelial homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 114 (46), 12243-12248 (2017)
   PUBMED   29078349
REFERENCE   5  (bases 1 to 1944)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   6  (bases 1 to 1944)
  AUTHORS   Huang,Z.L., Dufner-Beattie,J. and Andrews,G.K.
  TITLE     Expression and regulation of SLC39A family zinc transporters in the
            developing mouse intestine
  JOURNAL   Dev Biol 295 (2), 571-579 (2006)
   PUBMED   16682017
  REMARK    GeneRIF: temporal and spatial patterns of expression of the mouse
            ZIP1, 3, 4, and 5 genes in the developing intestine and the effects
            of maternal dietary zinc deficiency on these patterns of expression
            were examined
REFERENCE   7  (bases 1 to 1944)
  AUTHORS   Dufner-Beattie,J., Huang,Z.L., Geiser,J., Xu,W. and Andrews,G.K.
  TITLE     Mouse ZIP1 and ZIP3 genes together are essential for adaptation to
            dietary zinc deficiency during pregnancy
  JOURNAL   Genesis 44 (5), 239-251 (2006)
   PUBMED   16652366
REFERENCE   8  (bases 1 to 1944)
  AUTHORS   Wang,F., Kim,B.E., Petris,M.J. and Eide,D.J.
  TITLE     The mammalian Zip5 protein is a zinc transporter that localizes to
            the basolateral surface of polarized cells
  JOURNAL   J Biol Chem 279 (49), 51433-51441 (2004)
   PUBMED   15322118
  REMARK    GeneRIF: Zip5 protein is a zinc transporter that localizes to the
            basolateral surface of polarized cells
REFERENCE   9  (bases 1 to 1944)
  AUTHORS   Dufner-Beattie,J., Kuo,Y.M., Gitschier,J. and Andrews,G.K.
  TITLE     The adaptive response to dietary zinc in mice involves the
            differential cellular localization and zinc regulation of the zinc
            transporters ZIP4 and ZIP5
  JOURNAL   J Biol Chem 279 (47), 49082-49090 (2004)
   PUBMED   15358787
  REMARK    GeneRIF: ZIP4 and ZIP5 have roles in the adaptive response to
            dietary zinc in mice [ZIP5]
REFERENCE   10 (bases 1 to 1944)
  AUTHORS   Sousa-Nunes,R., Rana,A.A., Kettleborough,R., Brickman,J.M.,
            Clements,M., Forrest,A., Grimmond,S., Avner,P., Smith,J.C.,
            Dunwoodie,S.L. and Beddington,R.S.
  TITLE     Characterizing embryonic gene expression patterns in the mouse
            using nonredundant sequence-based selection
  JOURNAL   Genome Res 13 (12), 2609-2620 (2003)
   PUBMED   14613977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA492656.1, AK008448.1 and AI413122.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028990.1, SRR5189685.188315.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               CA492656.1         41-230
            191-1939            AK008448.1         154-1902
            1940-1944           AI413122.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.55 cM"
     gene            1..1944
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /note="solute carrier family 39 (metal ion transporter),
                     member 5"
                     /db_xref="GeneID:72002"
                     /db_xref="MGI:MGI:1919336"
     exon            1..55
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     exon            56..149
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     exon            150..502
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     exon            503..683
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     exon            684..846
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1016
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1157
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1251
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1410
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1491
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1682
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1942
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /note="hexamer: AATAAA"
     polyA_site      1942
                     /gene="Slc39a5"
                     /gene_synonym="1810013D05Rik; 2010205A06Rik; Zip5"
                     /note="major polyA site"
ORIGIN      
        1 aaggctgggt cccccttcct cttggtgtct tttgtgtctc ctgtcctgcc gtcagccctc
       61 cttgtgacgt ggcttccact gcatctgaag gctgagctcc ttccctcgga tctcctaagg
      121 tccacagtga ggccttccag ggacctgagg gtacagtcct caggatgtct caaaggaaat
      181 agaagtcaga aacagagcct ctaaccatag ccctagtgat ggggccccca gtacatcatc
      241 tgctgactgg cctatgtgtg ggggtggcct tgggctgggt aggaggctcc gtcccaaacc
      301 tgggcccagc tgaacaggaa cagaaccact acctggccca gttgtttggt ctatatggag
      361 agaacgggac actgactgca gggggcctgg cgcggcttct ccacagccta ggactaggcc
      421 gagtccaggg gctccgtctg ggacaccatg agcctccaac tgggcgggct gcacccacaa
      481 gtggagacaa tttcacacac aggctgcaag agccggagct gagtgtggac atctgggcag
      541 gaatgcctct gggcccttca ggttggggtg accaggagga atcaaaggct cctgacctgc
      601 acgggtcagg gccctcgagc ctagacctct tccagaggct tctgctgttg gaccattcgt
      661 tggctgacca tctgaatgag gattgtctga atggctccca gctgctggtc aattttggac
      721 tgagccctgt tgctcctctg acccctcgtc agttcgctct gctgtgccca gccctgcttt
      781 atcagattga cagccgtgtt tgcatcaaaa ccccagctcc agcacctccg ggggatgtac
      841 tgtctgccct gcttcacagt ggcctggcag tcctgttcct cagcctccct gctcccctct
      901 ctctgctgtt gctgcggctc ctgggacctc gtctgttgcg gccagtgctg ggcttcctgg
      961 gggccctggc cgtgggtact ctctgtgggg atgccctgct acacctgctc ccacatgcgc
     1021 aaggagggcg gcacacagga cctagtgagc aatcagagga ggacctgggt ccgggactgt
     1081 cggtgcttgg tggcctcttc ctgctcttca tgctagagaa cacactagga cttgtgcggc
     1141 acagagggct caggccaaga tgctgcagga acaaaaggga tcttggagaa ccaaaccctg
     1201 acccagagga tggcagtggg atggtccttc gacccctaca ggcagcttca gaaccagagg
     1261 ttcagggcca gagggagaac agacagtcct caccatctct agcccctcct gggcaccaag
     1321 gccacagcca tgagcaccgg ggtggcagta tcgcatggat ggtcctcctg ggagattgcc
     1381 tgcacaacct caccgacggg ctggcattag gtgctgcttt ctcagacggc ttctccagtg
     1441 gcctcagcac taccctagca gtcttctgcc acgagctgcc ccacgaactg ggtgactttg
     1501 ccatgctgct tcaggaaggg ttatcctttc ggaagctgct gctgctgagc ctcgtttctg
     1561 gagccctggg actggggggt gcagccctgg gggtggggct cagcttgggc cctgtgcccc
     1621 tcaccccctg ggtgtttggg accacggctg gggttttcct ctatgtggcc ctagtggata
     1681 tgctgccaac cctgcttcgt cctcctgagc ccctgcctgt gttccacgtg cttctgcagg
     1741 ggctggggct gctactgggg ggcagcctca tgtttaccat agccctattg gaggagcagc
     1801 tagtgcccac ggttcctgac ggctgatgtg ggccagtggc agaggatcca ggttgccctt
     1861 ccttcccccc accacaggaa tggaggcggg acacagggcc agtaggagca ataggatttt
     1921 aataaacaga acccatccca aaaa
//
