LOCUS       NM_028064               2244 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus solute carrier family 39 (zinc transporter), member 4
            (Slc39a4), mRNA.
ACCESSION   NM_028064
VERSION     NM_028064.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2244)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2244)
  AUTHORS   Hennigar,S.R., Olson,C.I., Kelley,A.M. and McClung,J.P.
  TITLE     Slc39a4 in the small intestine predicts zinc absorption and
            utilization: a comprehensive analysis of zinc transporter
            expression in response to diets of varied zinc content in young
            mice
  JOURNAL   J Nutr Biochem 101, 108927 (2022)
   PUBMED   34843931
  REMARK    GeneRIF: Slc39a4 in the small intestine predicts zinc absorption
            and utilization: a comprehensive analysis of zinc transporter
            expression in response to diets of varied zinc content in young
            mice.
REFERENCE   3  (bases 1 to 2244)
  AUTHORS   Chun,H., Korolnek,T., Lee,C.J., Coyne,H.J. 3rd, Winge,D.R.,
            Kim,B.E. and Petris,M.J.
  TITLE     An extracellular histidine-containing motif in the zinc transporter
            ZIP4 plays a role in zinc sensing and zinc-induced endocytosis in
            mammalian cells
  JOURNAL   J Biol Chem 294 (8), 2815-2826 (2019)
   PUBMED   30593504
REFERENCE   4  (bases 1 to 2244)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2244)
  AUTHORS   Bin,B.H., Bhin,J., Takaishi,M., Toyoshima,K.E., Kawamata,S.,
            Ito,K., Hara,T., Watanabe,T., Irie,T., Takagishi,T., Lee,S.H.,
            Jung,H.S., Rho,S., Seo,J., Choi,D.H., Hwang,D., Koseki,H.,
            Ohara,O., Sano,S., Tsuji,T., Mishima,K. and Fukada,T.
  TITLE     Requirement of zinc transporter ZIP10 for epidermal development:
            Implication of the ZIP10-p63 axis in epithelial homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 114 (46), 12243-12248 (2017)
   PUBMED   29078349
REFERENCE   6  (bases 1 to 2244)
  AUTHORS   Wang,F., Dufner-Beattie,J., Kim,B.E., Petris,M.J., Andrews,G. and
            Eide,D.J.
  TITLE     Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and
            ZIP3 zinc uptake transporters
  JOURNAL   J Biol Chem 279 (23), 24631-24639 (2004)
   PUBMED   15054103
REFERENCE   7  (bases 1 to 2244)
  AUTHORS   Wang,F., Kim,B.E., Dufner-Beattie,J., Petris,M.J., Andrews,G. and
            Eide,D.J.
  TITLE     Acrodermatitis enteropathica mutations affect transport activity,
            localization and zinc-responsive trafficking of the mouse ZIP4 zinc
            transporter
  JOURNAL   Hum Mol Genet 13 (5), 563-571 (2004)
   PUBMED   14709598
REFERENCE   8  (bases 1 to 2244)
  AUTHORS   Kim,B.E., Wang,F., Dufner-Beattie,J., Andrews,G.K., Eide,D.J. and
            Petris,M.J.
  TITLE     Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates
            its location at the plasma membrane
  JOURNAL   J Biol Chem 279 (6), 4523-4530 (2004)
   PUBMED   14612438
  REMARK    GeneRIF: Zinc deficiency increased mZIP4 protein levels at the
            plasma membrane, and this was associated with increased zinc
            uptake.
REFERENCE   9  (bases 1 to 2244)
  AUTHORS   Kambe,T., Yamaguchi-Iwai,Y., Sasaki,R. and Nagao,M.
  TITLE     Overview of mammalian zinc transporters
  JOURNAL   Cell Mol Life Sci 61 (1), 49-68 (2004)
   PUBMED   14704853
  REMARK    Review article
REFERENCE   10 (bases 1 to 2244)
  AUTHORS   Dufner-Beattie,J., Wang,F., Kuo,Y.M., Gitschier,J., Eide,D. and
            Andrews,G.K.
  TITLE     The acrodermatitis enteropathica gene ZIP4 encodes a
            tissue-specific, zinc-regulated zinc transporter in mice
  JOURNAL   J Biol Chem 278 (35), 33474-33481 (2003)
   PUBMED   12801924
  REMARK    GeneRIF: results provide compelling evidence that ZIP4 is a zinc
            transporter that plays an important role in zinc homeostasis, a
            process that is defective in acrodermatitis enteropathica in humans
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157566.6.
            
            On Jul 12, 2018 this sequence version replaced NM_028064.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023498.1, AK147107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AC157566.6         19517-19814
            299-583             AC157566.6         20228-20512
            584-779             AC157566.6         21148-21343
            780-943             AC157566.6         21474-21637
            944-1115            AC157566.6         21729-21900
            1116-1288           AC157566.6         22158-22330
            1289-1447           AC157566.6         22442-22600
            1448-1567           AC157566.6         22670-22789
            1568-1622           AC157566.6         22876-22930
            1623-1775           AC157566.6         23031-23183
            1776-1963           AC157566.6         23445-23632
            1964-2244           AC157566.6         23724-24004
FEATURES             Location/Qualifiers
     source          1..2244
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.16 cM"
     gene            1..2244
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /note="solute carrier family 39 (zinc transporter), member
                     4"
                     /db_xref="GeneID:72027"
                     /db_xref="MGI:MGI:1919277"
     exon            1..298
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2092
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /note="zinc transporter ZIP4; zrt- and Irt-like protein 4;
                     activated in W/Wv mouse stomach 2"
                     /codon_start=1
                     /product="zinc transporter ZIP4 precursor"
                     /protein_id="NP_082340.1"
                     /db_xref="CCDS:CCDS27578.1"
                     /db_xref="GeneID:72027"
                     /db_xref="MGI:MGI:1919277"
                     /translation="MLPKSVTQGLVLALLVGTVAVARPRNLLSLLALGQGALDRLELD
                     GLLNTLVARVHCTDGPCEKCLSVENVLALGKPDKPQPAPESVLESRHIIYLSAAAALY
                     LNNPEKTCKDIQAGLLASHVDDYLATLESPEAMTLGLSQLLQKIEAHAASQPTGEKTC
                     VDLPQLLEEAEAAGVSKSAGLVLTALLDHVINGSCFQGLPSPQYFVDFVFRLHSSDPP
                     NITLHELENLMHHLGVGGEDHSDHDDHGDHADHSHPDRKASHQDSELHTPHNSNSSVW
                     DTLCLSAKDIMAVYGLSEEAGVSPQAWAQLTPALVQQQLSGACSPYPTIRIQDQLSQT
                     ERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIP
                     KVLGLHTHGGEGHTHEEEVGVGGQATWRLLAVLGGFYIFFLFESFFNLLLPRDQDSEK
                     DGPCSHGGHSHGISLQLAPSNLRQSKQTHESSRSDLVAEETPELLNPETRRLRAELRL
                     LPYLITLGDAVHNFADGLAVGAAFSSSWKTGLATSLAVFCHELPHELGDFAALLHAGL
                     SVKRALLLNLASALTAFAGLYVALAVGVGEEGEAWILAVATGLFLYVALCDMLPAMMN
                     VRDQRPWLLFLLHNVGLLGGWTVLLLLSLYEDNITF"
     exon            299..583
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            584..779
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            780..943
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1115
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1288
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1447
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1567
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1622
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1775
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1963
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2244
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2219..2224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /note="hexamer: AATAAA"
     polyA_site      2244
                     /gene="Slc39a4"
                     /gene_synonym="1600025H15Rik; AWMS2; ZIP4"
                     /note="major polyA site"
ORIGIN      
        1 aaggcaagtt gaacccagct ccagtctggc cccggacagt cccagctgtc tccagctagc
       61 ccagaagtca gcacctctac aaggaacgct tttgggggcc tgaggcgtga tgctcccaaa
      121 gtcggtcaca cagggacttg tgttggctct gctggtgggc acagtggcag tggcccggcc
      181 caggaacctg ctcagcctgc tcgccttggg ccagggtgct ctggatcgcc tggaactgga
      241 cggcctgtta aatacgctgg tggcccgtgt gcactgcacc gacgggccgt gtgaaaagtg
      301 tctgtctgtg gagaatgtct tggctctagg caaacctgac aagccacagc ctgccccaga
      361 atcagtcctg gagtccagac acattattta ccttagtgct gctgctgccc tctaccttaa
      421 caacccagag aaaacatgca aggacatcca agctggcctc ttggcctccc atgtggacga
      481 ttacctggcc acactggaga gtccagaggc catgaccctg ggtctgagcc agctactgca
      541 gaagattgag gcccatgctg ccagccaacc caccggggag aagacctgtg tagatcttcc
      601 ccaactgctg gaggaggctg aggcagcagg ggtttccaaa agcgccggcc tggtcttgac
      661 tgccttgctg gatcatgtca ttaatgggtc ctgcttccaa ggcctgccta gccctcagta
      721 ctttgtggac tttgtgttca ggctacacag tagtgaccct cccaatatca cgctgcatga
      781 actggagaat ttgatgcatc accttggggt gggtggagag gaccacagtg accatgatga
      841 ccacggtgat catgctgacc acagtcatcc ggacaggaaa gccagccacc aagactctga
      901 gctccatact ccccacaaca gcaactctag tgtatgggac acgctgtgcc tgagtgccaa
      961 agatataatg gctgtgtatg ggctatctga agaggctggg gtgagccctc aggcctgggc
     1021 ccaactgacc cctgccttgg tccagcagca gctaagtgga gcctgcagcc cctaccccac
     1081 tatccgtatt caggaccagc tcagtcaaac agagaggtat ctctatggct cgctggccac
     1141 cctgctcatc tgcctctgtg ctgtgttcgg tcttctgctg ctgacctgtg ccaaatgcag
     1201 cacagccacc cactacatca tgcagacctt cctaagcttg gctgtgggcg cacttaccgg
     1261 cgatgctctt ctgcacctga tacccaaggt gctgggactg cacacacatg gtggagaggg
     1321 tcacacccat gaggaggagg tgggcgttgg tgggcaggcc acctggcgcc tgctggctgt
     1381 acttggaggc ttctacatct tcttcctgtt tgagagcttc ttcaacctct tgttgcccag
     1441 ggaccaggat tctgagaaag atgggccttg tagccatggt gggcacagcc atggaatatc
     1501 tctgcagctg gcaccaagca atctccgaca gtccaaacag acccatgaaa gctctcgttc
     1561 agacttggtg gcagaggaga ccccggaact actgaaccca gagacccggc gactgagagc
     1621 agagctgaga ctgttgccct atctgatcac actgggcgac gcggtacaca acttcgctga
     1681 cgggctcgct gtgggcgccg ccttctcatc ctcgtggaag actgggctgg ccacttcatt
     1741 ggcggtgttc tgtcatgagc tgccccatga actcggggac ttcgctgctc tgctgcatgc
     1801 cgggctgagt gtgaagcgtg cgcttttgct gaatctggcc tcagcgctca cagcattcgc
     1861 aggcctctac gtggctctag cagtcggagt aggcgaggag ggcgaggctt ggattctggc
     1921 ggtagcaacc ggcctcttcc tttacgtggc gctttgtgac atgctcccag ccatgatgaa
     1981 tgtgcgcgac cagcggccct ggcttctttt cctgctccac aacgtgggtc tgctgggcgg
     2041 ctggaccgtc ctgctgctgc tgtcattgta cgaagacaac atcaccttct gacagctcta
     2101 tcccatccca gtccttgtcc ctgtctgttg actctgcttt accttcttaa gccacctaat
     2161 tgttggcccc actacgggta gccagaggct ttgagcctca tttccttgct ctgacttcaa
     2221 taaagacttt tcaatcaaac ccaa
//
