LOCUS       NM_001358898            3683 bp    mRNA    linear   ROD 03-AUG-2024
DEFINITION  Mus musculus solute carrier family 39 (zinc transporter), member 3
            (Slc39a3), transcript variant 2, mRNA.
ACCESSION   NM_001358898 XM_006513024
VERSION     NM_001358898.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3683)
  AUTHORS   Elgheznawy,A., Oftering,P., Englert,M., Mott,K., Kaiser,F.,
            Kusch,C., Gbureck,U., Bosl,M.R., Schulze,H., Nieswandt,B.,
            Vogtle,T. and Hermanns,H.M.
  TITLE     Loss of zinc transporters ZIP1 and ZIP3 augments platelet
            reactivity in response to thrombin and accelerates thrombus
            formation in vivo
  JOURNAL   Front Immunol 14, 1197894 (2023)
   PUBMED   37359521
  REMARK    GeneRIF: Loss of zinc transporters ZIP1 and ZIP3 augments platelet
            reactivity in response to thrombin and accelerates thrombus
            formation in vivo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3683)
  AUTHORS   Bogdanovic,M., Asraf,H., Gottesman,N., Sekler,I., Aizenman,E. and
            Hershfinkel,M.
  TITLE     The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and
            Is Required for Kainate-Induced Degeneration of CA3 Neurons
  JOURNAL   J Neurosci 42 (13), 2824-2834 (2022)
   PUBMED   35169020
  REMARK    GeneRIF: The ZIP3 Zinc Transporter Is Localized to Mossy Fiber
            Terminals and Is Required for Kainate-Induced Degeneration of CA3
            Neurons.
REFERENCE   3  (bases 1 to 3683)
  AUTHORS   Qian,J., Xu,K., Yoo,J., Chen,T.T., Andrews,G. and Noebels,J.L.
  TITLE     Knockout of Zn transporters Zip-1 and Zip-3 attenuates
            seizure-induced CA1 neurodegeneration
  JOURNAL   J Neurosci 31 (1), 97-104 (2011)
   PUBMED   21209194
  REMARK    GeneRIF: Znt-3-deficient mice lacking synaptic Zn also show less
            hippocampal cell damage following kainic acid injection. Zip
            transporters may provide selective therapeutic targets to protect
            these neurons from early Zn-induced neurodegeneration following
            injury.
REFERENCE   4  (bases 1 to 3683)
  AUTHORS   Martel,G., Hevi,C., Friebely,O., Baybutt,T. and Shumyatsky,G.P.
  TITLE     Zinc transporter 3 is involved in learned fear and extinction, but
            not in innate fear
  JOURNAL   Learn Mem 17 (11), 582-590 (2010)
   PUBMED   21036893
  REMARK    GeneRIF: ZnT3 KO mice showed abnormality in trace fear conditioning
            is involved in associative fear memory and extinction, but not in
            innate fear.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3683)
  AUTHORS   Kelleher,S.L., Lopez,V., Lonnerdal,B., Dufner-Beattie,J. and
            Andrews,G.K.
  TITLE     Zip3 (Slc39a3) functions in zinc reuptake from the alveolar lumen
            in lactating mammary gland
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 297 (1), R194-R201 (2009)
   PUBMED   19458277
  REMARK    GeneRIF: Zip3 does not participate in the acquisition of Zn from
            maternal circulation for secretion into milk but, in contrast,
            primarily plays a role in the reuptake and cellular retention of Zn
            in the mammary gland from the previously secreted milk pool.
REFERENCE   6  (bases 1 to 3683)
  AUTHORS   Wang,F., Dufner-Beattie,J., Kim,B.E., Petris,M.J., Andrews,G. and
            Eide,D.J.
  TITLE     Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and
            ZIP3 zinc uptake transporters
  JOURNAL   J Biol Chem 279 (23), 24631-24639 (2004)
   PUBMED   15054103
  REMARK    GeneRIF: ZIP1 and ZIP3 zinc uptake transporter activity is
            controlled by zinc-stimulated endocytosis
REFERENCE   7  (bases 1 to 3683)
  AUTHORS   Kambe,T., Yamaguchi-Iwai,Y., Sasaki,R. and Nagao,M.
  TITLE     Overview of mammalian zinc transporters
  JOURNAL   Cell Mol Life Sci 61 (1), 49-68 (2004)
   PUBMED   14704853
  REMARK    Review article
REFERENCE   8  (bases 1 to 3683)
  AUTHORS   Dufner-Beattie,J., Langmade,S.J., Wang,F., Eide,D. and Andrews,G.K.
  TITLE     Structure, function, and regulation of a subfamily of mouse zinc
            transporter genes
  JOURNAL   J Biol Chem 278 (50), 50142-50150 (2003)
   PUBMED   14525987
  REMARK    GeneRIF: ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc
            homeostasis rather than primary roles in the acquisition of dietary
            zinc
REFERENCE   9  (bases 1 to 3683)
  AUTHORS   Danscher,G., Wang,Z., Kim,Y.K., Kim,S.J., Sun,Y. and Jo,S.M.
  TITLE     Immunocytochemical localization of zinc transporter 3 in the
            ependyma of the mouse spinal cord
  JOURNAL   Neurosci Lett 342 (1-2), 81-84 (2003)
   PUBMED   12727323
  REMARK    GeneRIF: ZnT3-immunoreactive ependymal cells possess secretory
            activity directed towards the central canal.
REFERENCE   10 (bases 1 to 3683)
  AUTHORS   Valente,T. and Auladell,C.
  TITLE     Developmental expression of ZnT3 in mouse brain: correlation
            between the vesicular zinc transporter protein and chelatable
            vesicular zinc (CVZ) cells. Glial and neuronal CVZ cells interact
  JOURNAL   Mol Cell Neurosci 21 (2), 189-204 (2002)
   PUBMED   12401442
  REMARK    GeneRIF: The expression of zinc transporter 3 (ZnT3) starts early
            in development, lasts throughout embryonic life, and is detected in
            proliferative and differentiating areas of the brain in distinct
            chelatable vesicular zinc pools.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152500.7.
            
            On May 22, 2019 this sequence version replaced NM_001358898.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087519.1, ERR3363658.5645956.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC152500.7         60931-61042
            113-200             AC152500.7         63241-63328
            201-522             AC152500.7         64313-64634
            523-3683            AC152500.7         66546-69706
FEATURES             Location/Qualifiers
     source          1..3683
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3683
                     /gene="Slc39a3"
                     /gene_synonym="ZIP-3; Zip3"
                     /note="solute carrier family 39 (zinc transporter), member
                     3"
                     /db_xref="GeneID:106947"
                     /db_xref="MGI:MGI:2147269"
     exon            1..112
                     /gene="Slc39a3"
                     /gene_synonym="ZIP-3; Zip3"
                     /inference="alignment:Splign:2.1.0"
     exon            113..200
                     /gene="Slc39a3"
                     /gene_synonym="ZIP-3; Zip3"
                     /inference="alignment:Splign:2.1.0"
     exon            201..522
                     /gene="Slc39a3"
                     /gene_synonym="ZIP-3; Zip3"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1266
                     /gene="Slc39a3"
                     /gene_synonym="ZIP-3; Zip3"
                     /note="zrt- and Irt-like protein 3; solute carrier family
                     39 member 3"
                     /codon_start=1
                     /product="zinc transporter ZIP3"
                     /protein_id="NP_001345827.2"
                     /db_xref="CCDS:CCDS24041.1"
                     /db_xref="GeneID:106947"
                     /db_xref="MGI:MGI:2147269"
                     /translation="MTKLLVAKVLCMVGVFFFMLLGSLLPVKVIEADLEKAHRSKKVL
                     SLCNTFGGGVFLATCFNALLPAVRDKLQQVLSLGHISTDYPLAETLMMVGFFLTVFVE
                     QLVLTFRRERPPFIDLETFNAGSDAGSDSEYESPFVGVGNRSHSLYPEPTAHTHGAGL
                     RLRELGRPGPLRLLSLVFALSAHSVFEGLALGLQEEGERVVSLFVGVAIHETLVAVAL
                     GISMARSAVPLRDAAKLAVTVSAMIPVGIGLGLGIESARSVASSVASALLQGLAGGTF
                     LFVTFLEILAKELEERSEQLLKVLFLVLGYAVLAGMVFLKW"
     exon            523..3683
                     /gene="Slc39a3"
                     /gene_synonym="ZIP-3; Zip3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1430
                     /gene="Slc39a3"
                     /gene_synonym="ZIP-3; Zip3"
                     /note="major polyA site"
     regulatory      3663..3668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a3"
                     /gene_synonym="ZIP-3; Zip3"
                     /note="hexamer: AACAAG"
     polyA_site      3683
                     /gene="Slc39a3"
                     /gene_synonym="ZIP-3; Zip3"
ORIGIN      
        1 aggtagcagc tcgcagcccc gggggtctcg gctggtccgc tgcggcgggg tccggaccgc
       61 ggggcagttg gcggcaggtg gcactggctg gaggcctgag gagctgtcag aggagaacac
      121 gtaagaacaa ccctacattt tggccaccac atccactgag ccagctgcca ccttgcacct
      181 gccctgcacc aagcctcaag cttctgagca gagccatgaa tgcctggccc tgcgactggg
      241 gccggtagcc cccacagcct ttggcctgtg actccatttg tgctttggcc ctgtgtgacc
      301 ctggcggcca ccatgacgaa gcttctggtg gccaaggtcc tctgcatggt gggcgtgttc
      361 ttcttcatgc tgctgggctc cctgctgcct gtgaaggtca tcgaggctga cttggagaag
      421 gcgcaccgct ccaagaaggt cctgtccctc tgcaacacct tcgggggtgg cgtattcctg
      481 gctacatgct ttaatgcact gctgcctgca gtgagggaca agctgcagca ggtgctgagc
      541 ctgggccaca tcagcaccga ctacccgctg gcggagacgc tcatgatggt gggtttcttc
      601 ctcactgtgt tcgtggagca gctggtgctg accttccgcc gggagcggcc tccctttata
      661 gacctggaga ccttcaacgc cggctcagat gcgggcagcg actcggagta cgagagcccg
      721 ttcgtgggtg tgggcaaccg tagccacagc ctgtaccctg agcccacagc gcacacccat
      781 ggcgcggggc tgcggctgcg ggaactgggc cgcccagggc ctctgcggct gctcagcctg
      841 gtcttcgcgc tgtctgcaca ctctgtgttc gagggcctgg cgctggggct gcaggaggag
      901 ggtgagcgtg tggtcagcct gtttgttggc gtggccatcc acgagacgct ggtggccgtg
      961 gccctgggca tcagcatggc ccgcagtgcg gtacccctga gggatgcggc caagttggct
     1021 gtgaccgtga gcgccatgat cccagtgggc attgggttgg gcctgggcat cgagagtgcc
     1081 cgcagcgtgg ccagcagtgt ggcatcggcg ctgctacagg gcctggccgg tggcaccttc
     1141 ctgtttgtca ccttcctgga gatcctggcc aaggagctgg aggagaggag cgagcagctg
     1201 ctgaaggtgc tgttcctggt gctgggctac gccgttctgg ccggaatggt ctttctcaag
     1261 tggtgagccc tgaatccctg aaggacacag agcacgtccc ttgacaacca cgctcatggg
     1321 ccatggttca cacacagagg cctcccgggc tggtcaccgg tctctgccat ccgccagaat
     1381 ctggccctac agacactgct tttaaaaacg tcttaaagtt ctctaccaaa gcctgtgtgg
     1441 ccatgtcacc tcatatcccg tcacccctcc agtttttgtt gtcattcctg agccatcaag
     1501 aatggagccc agggtgggga ctggcagatg gggatcaaag tgacctcagg gaccctgcca
     1561 tgttctctgt ggagcccagg ccctccctgc cactgccacc cgagtttttc tggttgctcc
     1621 tgtgtgacag gtgacagttt atgaaaggaa cagtacatgt gggtcacatg agcaagggga
     1681 cagcccagac tgtttgcctg gccctcagga acagcccttc ttgttctctt gctctgtggt
     1741 gtggcgatca ccagagtgga ggggcctcct ctgcagaggg catagcagtg agactccagg
     1801 gccacatcct gacagggaca actcccagga tgcaggcagg agcaggggaa actcagcagc
     1861 tggcaacgtt ggtgcatgtc accatggtaa tgccagcatc ttgggacagc ctgagtgagg
     1921 actctctggg gacataagcc tgccacagct caccaccttc cctaacctgg ggtctgtgta
     1981 gcaggcttca cctcagcact gccttccctc cgttagctga atgtcagact cctccctagt
     2041 gccctgtcgc catggccagg tgaccaaaat gacttgtcga gtgtgcccct acccagcgac
     2101 actcagatga tacaaggcac aaagagacat ggccttgggg acagctgggg cttgggcatt
     2161 gtcctcagag ccccaatgcc tgggctccct tagtgctgta atacacccag gttcacacgc
     2221 cgcttggcac acattcagaa ccccgggctc ccagtgaagg gcccactctg ccagtggttg
     2281 aagcctctgc tagcagtttc tggggttctt tcccgaggag ccccatcatg tagatgtggt
     2341 gatgtaccca cagtgccacc tgggcttact gtccttctat cctctactta actatgggtg
     2401 ggtggggggc atccaaatgg ttctccagct tcccttggcc ccaggtgggc cccacggggc
     2461 caccatgccc ctgcaggtat gggctcaggt gacaaagact aggccagggt aggaaggtcc
     2521 ttagtctggc catcccaaca gggagtctgc acctcccaca tgggtgcata caatggcatt
     2581 ctctcctttc cagcaccaac tgctctgccc ctggggacag cagcagcagt ggatctggac
     2641 cctccccatt agatctcttg agtctctgag agtcatccca agtgccagct cactggcaac
     2701 tgggggcctc tgtgtctctt actgaaagtt ccagtttagc tgacagccct tgccccagct
     2761 gcaggagacc ctgggccatg ctaggacctg tgcagctgtc aggaggaatg ggcatggagg
     2821 agaaatggac atgccgggat gctgcagggg ccaggccacc cccaccccac tgcctcctgt
     2881 gggggacaca gcaggaacac agctagacag gaggaaagag ggcggtgcgg gtggcccagc
     2941 ttcactgctg atctgtgtgt gtaataacag catgtcagct tctcctatgg cttgtttgtg
     3001 ttcctgtaat agaagttatt agtgcaggcg ggatccggca cagccagctc ctggcatcct
     3061 gccctcattg cactgcaggg gcctgaccga tctttgccct gcatcccacc tgcccaagga
     3121 agcttttcag cttggtattc ccccacgggg cgagggtgtt gtctgtgggg caccccgggc
     3181 tccacgtgca ccttccccca ctgttgtctc tggagtccac ctgctctgag ccaggagctc
     3241 catgacatgt gtcccagatg tcatgcatag tcctcctggg gaggggtccc acctgtaagt
     3301 cagcccccaa tgatgagagg gatgacacca gaacaccaca gcatcattag tgaacgctcc
     3361 cacagaaggg aaatccaggg acgctgtcgg tgaggagcaa gcgtggcaga cctgagtgcg
     3421 attccagggg ctcacgtgct gacagaactg actcctgcac tgtcccgatc tccacgggtg
     3481 cttagtggca cacatgcaca cacttgtgtg tgctcgtccc acaccccctg atatgtgtaa
     3541 taacagtttt taagctagcc atggttaccc actccgttaa tccatgcact ccagatacag
     3601 gtggatttct gtgagttcca ggccagccag ggttgcaagt gggccctttt gcaaaataaa
     3661 taaacaagtg aagatttaaa cta
//
