LOCUS       NM_001039676            2334 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus solute carrier family 39 (zinc transporter), member 2
            (Slc39a2), mRNA.
ACCESSION   NM_001039676 XM_139051 XM_359330 XM_900619 XM_900624 XM_903834
            XM_903835 XM_907024 XM_920169 XM_920179
VERSION     NM_001039676.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2334)
  AUTHORS   Zhao,L., Zhang,R., Zhang,S., Zhang,H., Yang,Q. and Xu,Z.
  TITLE     Upregulation of p67phox in response to ischemia/reperfusion is
            cardioprotective by increasing ZIP2 expression via STAT3
  JOURNAL   Free Radic Res 56 (1), 115-126 (2022)
   PUBMED   35296207
  REMARK    GeneRIF: Upregulation of p67(phox) in response to
            ischemia/reperfusion is cardioprotective by increasing ZIP2
            expression via STAT3.
REFERENCE   2  (bases 1 to 2334)
  AUTHORS   Du,L., Zhang,H., Zhao,H., Cheng,X., Qin,J., Teng,T., Yang,Q. and
            Xu,Z.
  TITLE     The critical role of the zinc transporter Zip2 (SLC39A2) in
            ischemia/reperfusion injury in mouse hearts
  JOURNAL   J Mol Cell Cardiol 132, 136-145 (2019)
   PUBMED   31095941
  REMARK    GeneRIF: Loss of Zip2 expression is associated with myocardial
            ischemia/reperfusion injury.
REFERENCE   3  (bases 1 to 2334)
  AUTHORS   Inoue,Y., Hasegawa,S., Ban,S., Yamada,T., Date,Y., Mizutani,H.,
            Nakata,S., Tanaka,M. and Hirashima,N.
  TITLE     ZIP2 protein, a zinc transporter, is associated with keratinocyte
            differentiation
  JOURNAL   J Biol Chem 289 (31), 21451-21462 (2014)
   PUBMED   24936057
  REMARK    GeneRIF: results of this study suggest that ZIP2, a zinc
            transporter expressed specifically in the epidermis, and zinc taken
            up by ZIP2 are necessary for the differentiation of keratinocytes
REFERENCE   4  (bases 1 to 2334)
  AUTHORS   Kambe,T., Geiser,J., Lahner,B., Salt,D.E. and Andrews,G.K.
  TITLE     Slc39a1 to 3 (subfamily II) Zip genes in mice have unique
            cell-specific functions during adaptation to zinc deficiency
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 294 (5), R1474-R1481 (2008)
   PUBMED   18353881
  REMARK    GeneRIF: Slc39a2 apparently plays a critical role in zinc
            homeostasis when zinc is replete, but they play important,
            noncompensatory roles when this metal is deficient
REFERENCE   5  (bases 1 to 2334)
  AUTHORS   Peters,J.L., Dufner-Beattie,J., Xu,W., Geiser,J., Lahner,B.,
            Salt,D.E. and Andrews,G.K.
  TITLE     Targeting of the mouse Slc39a2 (Zip2) gene reveals highly
            cell-specific patterns of expression, and unique functions in zinc,
            iron, and calcium homeostasis
  JOURNAL   Genesis 45 (6), 339-352 (2007)
   PUBMED   17506078
  REMARK    GeneRIF: These studies suggest that active expression of the Zip2
            gene in these few specific cell types, aforementioned, plays a
            particularly important role during zinc deficiency.
REFERENCE   6  (bases 1 to 2334)
  AUTHORS   Kambe,T., Yamaguchi-Iwai,Y., Sasaki,R. and Nagao,M.
  TITLE     Overview of mammalian zinc transporters
  JOURNAL   Cell Mol Life Sci 61 (1), 49-68 (2004)
   PUBMED   14704853
  REMARK    Review article
REFERENCE   7  (bases 1 to 2334)
  AUTHORS   Dufner-Beattie,J., Langmade,S.J., Wang,F., Eide,D. and Andrews,G.K.
  TITLE     Structure, function, and regulation of a subfamily of mouse zinc
            transporter genes
  JOURNAL   J Biol Chem 278 (50), 50142-50150 (2003)
   PUBMED   14525987
  REMARK    GeneRIF: ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc
            homeostasis rather than primary roles in the acquisition of dietary
            zinc
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY200549.1, AK089322.1 and AC125087.2.
            
            On Mar 21, 2009 this sequence version replaced NM_001039676.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089322.1, BC113769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               BY200549.1         3-154
            153-683             AK089322.1         105-635
            684-2334            AC125087.2         105978-107628
FEATURES             Location/Qualifiers
     source          1..2334
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.71 cM"
     gene            1..2334
                     /gene="Slc39a2"
                     /gene_synonym="F730005G13Rik; Gm1789; Gm289; hZIP2; ZIP-2;
                     Zip2"
                     /note="solute carrier family 39 (zinc transporter), member
                     2"
                     /db_xref="GeneID:214922"
                     /db_xref="MGI:MGI:2684326"
     exon            1..305
                     /gene="Slc39a2"
                     /gene_synonym="F730005G13Rik; Gm1789; Gm289; hZIP2; ZIP-2;
                     Zip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1120
                     /gene="Slc39a2"
                     /gene_synonym="F730005G13Rik; Gm1789; Gm289; hZIP2; ZIP-2;
                     Zip2"
                     /note="zrt- and Irt-like protein 2; solute carrier family
                     39 member 2"
                     /codon_start=1
                     /product="zinc transporter ZIP2"
                     /protein_id="NP_001034765.2"
                     /db_xref="CCDS:CCDS36914.1"
                     /db_xref="GeneID:214922"
                     /db_xref="MGI:MGI:2684326"
                     /translation="MEVLLGVKIGCLLALLVLTLGCGLTPIYVKWFQMDAATGHHHRV
                     LSLLGCTSAGVFLGAGLMHMTAEALEGIESEIQKFVEQNSTGSKGNSSRDAASSYVEY
                     PYGELVISLGFFFVFLLESLALQCCHGAAGGSTVQEEEWGGTHAFGFHKHPAVPSPSR
                     GPLRALVLLLSLSFHSVFEGLAVGLQATVAATIQLCVAVLAHKGLVVFSVGLRLGKIG
                     TGPRWATFCILSLALMSPVGLALGLTVAGGASGQTQGLAQAVLEGIAAGTFLYVTFLE
                     ILPRELACPEAPLAKYSCVAAGFAFMALIALWA"
     exon            306..436
                     /gene="Slc39a2"
                     /gene_synonym="F730005G13Rik; Gm1789; Gm289; hZIP2; ZIP-2;
                     Zip2"
                     /inference="alignment:Splign:2.1.0"
     exon            437..487
                     /gene="Slc39a2"
                     /gene_synonym="F730005G13Rik; Gm1789; Gm289; hZIP2; ZIP-2;
                     Zip2"
                     /inference="alignment:Splign:2.1.0"
     exon            488..2334
                     /gene="Slc39a2"
                     /gene_synonym="F730005G13Rik; Gm1789; Gm289; hZIP2; ZIP-2;
                     Zip2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1366..1371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a2"
                     /gene_synonym="F730005G13Rik; Gm1789; Gm289; hZIP2; ZIP-2;
                     Zip2"
                     /note="hexamer: AATAAA"
     polyA_site      1397
                     /gene="Slc39a2"
                     /gene_synonym="F730005G13Rik; Gm1789; Gm289; hZIP2; ZIP-2;
                     Zip2"
                     /note="major polyA site"
ORIGIN      
        1 agggttggtg actggggctg agccctcgtc tgctatgcgg gtgagagctg tgtaaaccca
       61 gacagtccag ggacaagaag gttatcagca gtcctgaaat tcacgagagg aaatactcca
      121 ctttgaccac ttcaactgct cctgactgct tttgcctttc tgaggtctct acttacccta
      181 caacccaaag atggaggtac tactaggagt aaaaatcggc tgcctgcttg ctcttctggt
      241 tctcacactg ggctgtggcc ttactcccat ctacgtgaaa tggttccaga tggatgcagc
      301 tacaggtcat caccacaggg tcctcagcct cctgggctgc acctctgcag gtgtcttctt
      361 gggagcaggg ttgatgcata tgactgctga agctctggag ggaattgagt cagaaattca
      421 gaaattcgtg gaacagaata gtacaggaag taagggaaat tcttctcgtg atgctgcttc
      481 tagttacgtg gagtatccct atggagagct cgtcatctcc ctgggctttt tctttgtctt
      541 ccttttggag tcgctggcat tgcagtgctg tcacggggct gctggaggat cgacagtaca
      601 ggaagaggaa tggggaggga ctcatgcctt tggattccac aagcatccag cggtaccctc
      661 accctcacgg ggtcccttgc gcgccctggt ccttctgctc tccctgtcct ttcattccgt
      721 gttcgaaggc ctggctgtgg gactacaggc cacagtggcg gccaccatac agctctgtgt
      781 cgctgtgctg gctcataagg ggcttgtggt gttcagtgtg ggcctgaggc tggggaagat
      841 cggcactgga ccacgatggg ccacgttctg catactgtca ctagctctca tgtctcctgt
      901 gggcctagcc ctggggctga ccgtggctgg aggagcctca ggacaaacac agggattagc
      961 ccaggctgta ttagagggca tagccgctgg cacgttttta tatgtcacct tcctagaaat
     1021 tttgccccgg gagctggctt gtcctgaggc ccctctggcc aagtatagct gtgtggctgc
     1081 tgggtttgcc ttcatggccc ttattgcttt gtgggcctga gacatttctc actgctctga
     1141 tagacctacc taggataact acttctaagg acactccctc aataacttcg gtcctcagac
     1201 attattttca gtgagactaa acacttacta gacacggact gactcagatt tcatacacgt
     1261 gagatcctgt ccttgctcag gacttagaaa gaatgttttg tttgcatgcc tatttaactg
     1321 gaaaattggt atcaagacca tcactccaga tttgttattg tgtgtaataa aagtcccatt
     1381 ttacctgttc ccttcaacct cattgcaatt ctgcctctga tagaggaaaa gtgggtgggg
     1441 tggaaccagt agtcatttta gtggctatag gccattcccg ccccccaaaa tcatagactg
     1501 ctataaacat caacaacccc ttatcccctt acccatgata gctgagaaac agaccagcat
     1561 ttagaggaag atagacgttt agaaacagaa actaggagat aaatattttt ccttcgctaa
     1621 ttaccttacc ccacgctcag tgcctgttgt cagccccacc aagttcctat tttcacactg
     1681 agtcttgtgt agcctccctc taggatacta ctgctatcct ctgagcttct ctggctgcca
     1741 caggctaaag gattaaaaac ctgtgtttgc agaaggggac cggcgccaga taaataccta
     1801 gtgtgattat ctgaggtgta accacctagt gacttccttc tgtctccctg accaactgct
     1861 actaaagata gtgcagaagg cagttactcc tgacagacgg actctctgcc ctcacctggc
     1921 tggaggatct cacacttagt gaagagttgg ggaaggacaa acgggctctg cagttggttt
     1981 gcccccacca gtttgccctt tcttgtgatt ttcaatgtga tagcccaaat agccttagca
     2041 tgaaaaaact cctgaagtca ttcatgtctc aatcttcttt cctctgtgtt cccctcctga
     2101 aaaagtaaga aagctaaatc cagtctccac acaaccaggg atcaaggaaa aagcaaatgg
     2161 gtgggcaatg ctgggaggga gaaggggggt ggggatattt tctgtgaaac acagtccggt
     2221 tgctgtgtgc tcagcatgag ttgcacagag caaggtgctc aggagagcct ggtgtgtgcc
     2281 gatggcacgg gcagggaaca cctgtgatgt gacaggtgct gcgctgctgt ttgt
//
