LOCUS       NM_144808               4927 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 39 (zinc transporter), member 14
            (Slc39a14), transcript variant 3, mRNA.
ACCESSION   NM_144808
VERSION     NM_144808.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4927)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4927)
  AUTHORS   Hung,Y.H., Kim,Y., Mitchell,S.B., Thorn,T.L. and Aydemir,T.B.
  TITLE     Absence of Slc39a14/Zip14 in mouse pancreatic beta cells results in
            hyperinsulinemia
  JOURNAL   Am J Physiol Endocrinol Metab 326 (1), E92-E105 (2024)
   PUBMED   38019082
  REMARK    GeneRIF: Absence of Slc39a14/Zip14 in mouse pancreatic beta cells
            results in hyperinsulinemia.
REFERENCE   3  (bases 1 to 4927)
  AUTHORS   Mitchell,S.B., Thorn,T.L., Lee,M.T., Kim,Y., Comrie,J.M.C.,
            Bai,Z.S., Johnson,E.L. and Aydemir,T.B.
  TITLE     Metal transporter SLC39A14/ZIP14 modulates regulation between the
            gut microbiome and host metabolism
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 325 (6), G593-G607 (2023)
   PUBMED   37873588
  REMARK    GeneRIF: Metal transporter SLC39A14/ZIP14 modulates regulation
            between the gut microbiome and host metabolism.
REFERENCE   4  (bases 1 to 4927)
  AUTHORS   Zhang,Y., Wu,X., Zhu,J., Lu,R. and Ouyang,Y.
  TITLE     Knockdown of SLC39A14 inhibits glioma progression by promoting
            erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma
            progression
  JOURNAL   BMC Cancer 23 (1), 1120 (2023)
   PUBMED   37978473
  REMARK    GeneRIF: Knockdown of SLC39A14 inhibits glioma progression by
            promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits
            glioma progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4927)
  AUTHORS   Liu,Q., Jenkitkasemwong,S., Prami,T.A., McCabe,S.M., Zhao,N.,
            Hojyo,S., Fukada,T. and Knutson,M.D.
  TITLE     Metal-ion transporter SLC39A8 is required for brain manganese
            uptake and accumulation
  JOURNAL   J Biol Chem 299 (8), 105078 (2023)
   PUBMED   37482277
REFERENCE   6  (bases 1 to 4927)
  AUTHORS   Girijashanker,K., He,L., Soleimani,M., Reed,J.M., Li,H., Liu,Z.,
            Wang,B., Dalton,T.P. and Nebert,D.W.
  TITLE     Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter:
            similarities to the ZIP8 transporter
  JOURNAL   Mol Pharmacol 73 (5), 1413-1423 (2008)
   PUBMED   18270315
  REMARK    GeneRIF: The present study provides the complete characterization
            of Slc39a14 gene and its ZIP14 mRNAs and proteins and for the first
            time demonstrates the significance of ZIP14 in Cd2+-mediated cell
            damage.
            Erratum:[Mol Pharmacol. 2008 Sep;74(3):924]
REFERENCE   7  (bases 1 to 4927)
  AUTHORS   Liuzzi,J.P., Aydemir,F., Nam,H., Knutson,M.D. and Cousins,R.J.
  TITLE     Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into
            cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (37), 13612-13617 (2006)
   PUBMED   16950869
  REMARK    GeneRIF: Zip14 can mediate the uptake of zinc and
            non-transferrin-bound iron into cells.
REFERENCE   8  (bases 1 to 4927)
  AUTHORS   Dufner-Beattie,J., Huang,Z.L., Geiser,J., Xu,W. and Andrews,G.K.
  TITLE     Mouse ZIP1 and ZIP3 genes together are essential for adaptation to
            dietary zinc deficiency during pregnancy
  JOURNAL   Genesis 44 (5), 239-251 (2006)
   PUBMED   16652366
REFERENCE   9  (bases 1 to 4927)
  AUTHORS   Liuzzi,J.P., Lichten,L.A., Rivera,S., Blanchard,R.K., Aydemir,T.B.,
            Knutson,M.D., Ganz,T. and Cousins,R.J.
  TITLE     Interleukin-6 regulates the zinc transporter Zip14 in liver and
            contributes to the hypozincemia of the acute-phase response
  JOURNAL   Proc Natl Acad Sci U S A 102 (19), 6843-6848 (2005)
   PUBMED   15863613
  REMARK    GeneRIF: Zip14 expression is up-regulated through IL-6
REFERENCE   10 (bases 1 to 4927)
  AUTHORS   Tominaga,K., Kagata,T., Johmura,Y., Hishida,T., Nishizuka,M. and
            Imagawa,M.
  TITLE     SLC39A14, a LZT protein, is induced in adipogenesis and transports
            zinc
  JOURNAL   FEBS J 272 (7), 1590-1599 (2005)
   PUBMED   15794747
  REMARK    GeneRIF: SLC39A14 plays a role as a zinc transporter during the
            early stages of adipogenesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY253316.1, AK158096.1, AK090193.1, CB521415.1 and AC025669.19.
            
            On Jul 14, 2006 this sequence version replaced NM_144808.3.
            
            Transcript Variant: This variant (3) lacks an in-frame exon and
            contains an alternate in-frame exon in the central coding region,
            compared to variant 1. The encoded isoform (b) is the same length
            as isoform a, but contains a distinct internal segment.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.3792722.1,
                                           SRR17253011.10744193.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY253316.1         2-11
            11-145              AK158096.1         1-135
            146-709             AK090193.1         111-674
            710-879             CB521415.1         38-207
            880-2111            AK090193.1         843-2074
            2112-4927           AC025669.19        56161-58976         c
FEATURES             Location/Qualifiers
     source          1..4927
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.32 cM"
     gene            1..4927
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /note="solute carrier family 39 (zinc transporter), member
                     14"
                     /db_xref="GeneID:213053"
                     /db_xref="MGI:MGI:2384851"
     exon            1..145
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /inference="alignment:Splign:2.1.0"
     exon            146..243
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /inference="alignment:Splign:2.1.0"
     exon            244..522
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1728
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /note="isoform b precursor is encoded by transcript
                     variant 3; zinc transporter ZIP14; Zrt- and Irt-like
                     protein 14; factor for adipocyte differentiation 123;
                     metal cation symporter ZIP14"
                     /codon_start=1
                     /product="metal cation symporter ZIP14 isoform b
                     precursor"
                     /protein_id="NP_659057.2"
                     /db_xref="CCDS:CCDS36969.1"
                     /db_xref="GeneID:213053"
                     /db_xref="MGI:MGI:2384851"
                     /translation="MKRLHPALPSCLLLVLFGIWRTAPQTHASSAGLPPLSATSFLED
                     LMDRYGKNDSLTLTQLKSLLDHLHVGVGRDNVSQPKEGPRNLSTCFSSGDLFAAHNLS
                     ERSQIGASEFQEFCPTILQQLDSQACTSENQKSEENEQTEEGKPSAIEVWGYGFLCVT
                     VISLCSLMGASVVPFMKKTFYKRLLLYFIALAIGTLYSNALFQLIPEAFGFNPQDNYV
                     SKSAVVFGGFYLFFFTEKILKMLLKQKNEHHHGHNHFTSETLPSKKDQEEGVTEKLQN
                     GDLDHMIPQHCNSELDGKAPGTDEKVIVNSMSVQDLQASQSACYWLKGVRYSDIGTLA
                     WMITLSDGLHNFIDGLAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNAGMSI
                     QQALFFNFLSACCCYLGLAFGILAGSHFSANWIFALAGGMFLYIALADMFPEMNEVCQ
                     EDEKNDSFLVPFVIQNLGLLTGFSIMLVLTMYSGQIQIG"
     exon            523..709
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /inference="alignment:Splign:2.1.0"
     exon            710..879
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /inference="alignment:Splign:2.1.0"
     exon            880..999
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1188
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1396
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1581
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..4927
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4908..4913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /note="hexamer: AATAAA"
     polyA_site      4927
                     /gene="Slc39a14"
                     /gene_synonym="FAD-123; fad123; ZIP-14; Zip14"
                     /note="major polyA site"
ORIGIN      
        1 atgcggcggg ggccggacgt agagaggggg cgcgtggctg ttggcgggga cgcacccact
       61 cagtagctgt gtcgcccgct gccttggggg gggggccctg gatagtgagg ctgcgtgggc
      121 ccgactgccg gctggaggac ttcagtgtgt ctccaggcta cttaatatcc agagtggaaa
      181 ctgttggctc agtttgacca ggtaaacctt gagctgcaca ttagccttgg cctcaccatc
      241 ctggtatccg tggtcaccat gaagcggctg cacccagccc ttccaagctg cctcctgttg
      301 gtgctgtttg gtatatggag aactgccccc cagactcatg cctcgtctgc tggcctgccg
      361 cccctcagtg ccacctcctt cctggaagat ctcatggacc gctatggaaa gaatgacagc
      421 cttaccctga cacagctgaa gtccctgctc gaccacctgc atgtgggagt gggccgggat
      481 aatgtttccc agcccaagga aggacccagg aacctctcca cgtgctttag ctctggagac
      541 ctctttgcgg cgcacaactt gagcgagcga tctcagatcg gggcgagtga gttccaggag
      601 ttctgcccca ccattctcca gcagctggat tcccaggcct gcacctcaga aaaccagaag
      661 tctgaggaga atgaacagac agaggagggg aagccaagcg ccattgaagt atgggggtac
      721 ggtttcctct gcgttaccgt catctccctc tgctccctca tgggggccag cgtggtgccc
      781 ttcatgaaga agacttttta caagaggctc ctgctctact tcatagcctt ggcgattgga
      841 accctctact ccaacgccct cttccagctc atcccagagg cttttggctt caaccctcag
      901 gacaattacg tctccaagtc tgcagtggtg tttgggggtt tctacctttt ctttttcaca
      961 gaaaagatcc tgaagatgct cttgaagcag aaaaacgagc accatcacgg gcataaccat
     1021 tttacctccg agacacttcc ttccaagaag gaccaggagg agggtgtgac cgagaagcta
     1081 cagaacgggg acctggatca catgatccct cagcactgca acagcgagct ggatggcaag
     1141 gcgcctggca cggacgagaa ggtcattgtc aactccatgt ctgtgcagga cctgcaggca
     1201 tcccagagtg cttgctactg gctcaagggg gtccgctact ctgatatcgg gaccttggcc
     1261 tggatgatca ccctgagcga tgggctccac aatttcatcg atggcctggc tattggtgcc
     1321 tccttcactg tgtctgtctt ccaaggcatc agcacgtcag tggccattct ctgtgaggaa
     1381 ttccctcatg agctgggaga cttcgtcatc ctgctcaatg ctggcatgag catccagcag
     1441 gctctcttct tcaacttcct ctctgcctgc tgctgctatt tgggtctggc ctttggcatc
     1501 ctggctggca gccacttctc tgcaaactgg atttttgcac tggctggagg aatgttcttg
     1561 tatattgccc tagccgatat gttccctgag atgaatgaag tctgccagga ggatgagaag
     1621 aacgacagct ttctggtccc ctttgtcatc cagaatcttg gcctcctaac cggcttctcc
     1681 attatgctgg tcctcacaat gtattcaggg cagattcaga tcgggtagga ccctgccatt
     1741 ggggagccag tggcattgga catcgggctc tgggccccca tctggtcccc ggcccgagga
     1801 ctcagcatcc acgaagcatc atggaaaagg cagctcttta aaaactggca cagacttgtc
     1861 tgcctgcatt cagatgtcat ctgtttcaaa tgctctgtcc taggaagaag ctgccctggg
     1921 aatctctagg tagtgcctcg aaccgttgtc tcccgaccct ttccactgat gattctggag
     1981 ctgaaacgcc acatgtagga cacgcctccc ttttccttct ggccaccctc ctccctttct
     2041 cttggaagaa gcactgagag atgtggaatc ttttacaatg taaaaatgaa gccagtggtc
     2101 atggtttggt tagaagtatc agtgtggctt ccagctttgg ggcctgtgat tctaaatgtg
     2161 tgtacccagg atttcaggtc ggtccatttt ggcatgggtt ctcatgtttt tacagagaag
     2221 agggcagaag acaagactcc tgtgtttttc agtctgttaa ctgttctctg aaaaggctga
     2281 ctttccgatg agtatggcag gcagaggggc aggggattgc ctgagtgagg agggggtaga
     2341 actagtgatg gatgtcctgt ctccttggtg ctcggtttcc accaggatgc tgcgtgcagg
     2401 ttgcttgcag catctggagt cacataatca tccaggcgag ccactgtggg cattctctgg
     2461 cgtggcaaga ggtctgctaa atcagttgtt tttgccctga tcctcacgcc ttcctattgc
     2521 tttctttttc tagttaactt tgtagatgcc tcacggggag cacggtcaga gcacatttaa
     2581 aggtttttgc ataggaggga aactgcacaa atcagtctcc cctggtcaag acctctgcca
     2641 gtagaacctg actcatagaa tcaggacaca gttgtttatg cctttttgtg accaaggtga
     2701 ttgggaatgg agtcattgca ggccagactt aggacttgct aattgcagaa ataatagttg
     2761 aataccatgg gactctggac cttgaggtca attcttgagg tcaggactgc agacgtcatt
     2821 gctgccaatg ggttttaaag gacaccatct agctaccact tcctccccgg tcccagacaa
     2881 caagattgaa tactgaattg aatcgagtgt aaattgcttt catttggtcc aggaaaacaa
     2941 aacaaaacaa aaccagatgc ttgacatttc acaccacaag ccagcctcag gcgctgtgca
     3001 gccccctcct cagaactctg gcttccaggg gagctaatct ccaggttcac taagtgaatt
     3061 aatttattat tatcatattg atacatggat tccttagcca ctttggagag ccagtctctc
     3121 ccgaagcctt tcttagtggt gcccacagtc acagtccagg agccattgtt cgcatgactt
     3181 acagtactga atcattgcca atccctgagt ctttctgttc ttaccacagg aaaactgtcc
     3241 attaaaagca gtgtgcatat atatatatat atatatatat atatatatat atatatatat
     3301 acatatatat atatgcactc acatgtattc atatatatat atatatatat atatatatat
     3361 atatatacac acacacacac acacacacat gtatgtgtgt gtgtgtgtgt gtgtgtgttc
     3421 attcttgttc ttcttgggga aacatgcttg aaaccaggaa tcctgaaatc ctgagaacac
     3481 aactggggaa acagaaattt gctcagtttc tctccctgct cttgcctctt gcctttgaga
     3541 caaggcagca ggaagaggaa agttcagcaa tcaaggtact agattggatg tcaggaccag
     3601 gtcctggtag gcttagggtc cagttttacc aaagaaccag ttccttcaat gttagaagct
     3661 aagctttatg ttaccgtcat ggttgttggt gtttgaaggc gagtctcatc tctcctgttc
     3721 tatttctcct acaaatgctt taggaggtag cagaaattga cactcaaagt gtaagactga
     3781 gcaggctgtg tgactcgtac ctgtaatctc agcccctagg gaggcagagt cagcaggctc
     3841 aagttttata ccagcctggg cttcatagtg aatagcaggc cagtctgggc tacatagcaa
     3901 gctcctgtgt cagcaagaca aaatgaagat aaaaaaccgt aaaatttaag attgtaggtc
     3961 tgagggtgtg gctcagtggt agcacgtttt ttgtccagtg tgtatgtgac accctgaatg
     4021 tcattcccag caccaccaca gccccccccc caaaggttga aagattccac tttacctagc
     4081 tcatgcatta tatttttaac tttaggagtt cccctagctc ctgtccttta aatgccctta
     4141 tgctggaatc ggatggtggc ttggtttgtt taaaagagct taaaaagagt cttaaacatg
     4201 agatagactg tctgccatgc acccttcctg tgaactcaag aactttgagg aaatcctggg
     4261 gcttcttcag ggcggagggc tggcatcagt cagacacagg tggggcgtgg gagccaactg
     4321 ataatccatt gctattggca acagattcgc cccatgagtt gaaaatgtgg ccgttgacct
     4381 tcttttgact tttaaatgtt gaacttgctg ttttaagcat ctgtacatat aagaggctga
     4441 aggggctacg ggctgcttag cggacacttc tcccctggcc ttactgccca tagcttctgt
     4501 tccctgttaa cactagcaag gaaagtgctt gtcacacaga ggagccctca gccaggcctt
     4561 ggattctgtc attggaggac ctcatttctg acctcacctt cagtcctcca tccccgccct
     4621 ccaatactta gggtcaccag ggggagcact ctccggtacc cttcacctgg gttttaaatg
     4681 gcttctctct gtctggatca cctaggatcc agttttagtg aaccctcttc caaagagata
     4741 cagataagct ggatgatttt ttgcataaag aaagaggatt ttactcatag ttccctttac
     4801 agttccatca cagtattttt tttaaataac tcaggtgtta tgagaattag aaaataaaat
     4861 aatttatgtc atgtgaactg taaatgtttt atttgtaaga ttctataaat aaagctatat
     4921 tctgtaa
//
