LOCUS       NM_001290765            2315 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Mus musculus solute carrier family 39 (metal ion transporter),
            member 13 (Slc39a13), transcript variant 1, mRNA.
ACCESSION   NM_001290765 XM_006500098
VERSION     NM_001290765.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2315)
  AUTHORS   Shoji,M., Ohashi,T., Nagase,S., Yuri,H., Ichihashi,K.,
            Takagishi,T., Nagata,Y., Nomura,Y., Fukunaka,A., Kenjou,S.,
            Miyake,H., Hara,T., Yoshigai,E., Fujitani,Y., Sakurai,H., Dos
            Santos,H.G., Fukada,T. and Kuzuhara,T.
  TITLE     Possible involvement of zinc transporter ZIP13 in myogenic
            differentiation
  JOURNAL   Sci Rep 14 (1), 8052 (2024)
   PUBMED   38609428
  REMARK    GeneRIF: Possible involvement of zinc transporter ZIP13 in myogenic
            differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2315)
  AUTHORS   Hara,T., Yamada,I., Ohashi,T., Tamura,M., Hijikata,A., Watanabe,T.,
            Gao,M., Ito,K., Kawamata,S., Azuma,S., Yoshigai,E., Sumiyoshi,Y.,
            Yasuhiro,N., Ohara,O., Santos,H.G.D. and Fukada,T.
  TITLE     Role of Scl39a13/ZIP13 in cardiovascular homeostasis
  JOURNAL   PLoS One 17 (10), e0276452 (2022)
   PUBMED   36269775
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2315)
  AUTHORS   Wang,J., Cheng,X., Zhao,H., Yang,Q. and Xu,Z.
  TITLE     Downregulation of the zinc transporter SLC39A13 (ZIP13) is
            responsible for the activation of CaMKII at reperfusion and leads
            to myocardial ischemia/reperfusion injury in mouse hearts
  JOURNAL   J Mol Cell Cardiol 152, 69-79 (2021)
   PUBMED   33307093
  REMARK    GeneRIF: Downregulation of the zinc transporter SLC39A13 (ZIP13) is
            responsible for the activation of CaMKII at reperfusion and leads
            to myocardial ischemia/reperfusion injury in mouse hearts.
REFERENCE   4  (bases 1 to 2315)
  AUTHORS   Jin,L., Chen,Y., Crossman,D.K., Datta,A., Vu,T., Mobley,J.A.,
            Basu,M.K., Scarduzio,M., Wang,H., Chang,C. and Datta,P.K.
  TITLE     STRAP regulates alternative splicing fidelity during lineage
            commitment of mouse embryonic stem cells
  JOURNAL   Nat Commun 11 (1), 5941 (2020)
   PUBMED   33230114
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2315)
  AUTHORS   Lee,M.G., Choi,M.A., Chae,S., Kang,M.A., Jo,H., Baek,J.M., In,K.R.,
            Park,H., Heo,H., Jang,D., Brito,S., Kim,S.T., Kim,D.O., Lee,J.S.,
            Kim,J.R. and Bin,B.H.
  TITLE     Loss of the dermis zinc transporter ZIP13 promotes the mildness of
            fibrosarcoma by inhibiting autophagy
  JOURNAL   Sci Rep 9 (1), 15042 (2019)
   PUBMED   31636298
  REMARK    GeneRIF: Loss of the dermis zinc transporter ZIP13 promotes the
            mildness of fibrosarcoma by inhibiting autophagy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2315)
  AUTHORS   Yamauchi,T., Hirose,T., Sato,K., Iwai,K., Takahashi,N.,
            Minaguchi,J., Ueno,T., Tangkawattana,P. and Takehana,K.
  TITLE     Changes in skin structure of the Zip13-KO mouse by Makomo (Zizania
            latifolia) feeding
  JOURNAL   J Vet Med Sci 79 (9), 1563-1568 (2017)
   PUBMED   28781296
REFERENCE   7  (bases 1 to 2315)
  AUTHORS   Hirose,T., Ogura,T., Tanaka,K., Minaguchi,J., Yamauchi,T.,
            Fukada,T., Koyama,Y. and Takehana,K.
  TITLE     Comparative study of dermal components and plasma TGF-beta1 levels
            in Slc39a13/Zip13-KO mice
  JOURNAL   J Vet Med Sci 77 (11), 1385-1389 (2015)
   PUBMED   26050750
  REMARK    GeneRIF: This study concluded that skin fragility due to defective
            ZIP13 protein may be attributable to impaired extracellular matrix
            synthesis accompanied by abnormal peripheral TGF-beta homeostasis.
REFERENCE   8  (bases 1 to 2315)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   9  (bases 1 to 2315)
  AUTHORS   Brommage,R., Liu,J., Hansen,G.M., Kirkpatrick,L.L., Potter,D.G.,
            Sands,A.T., Zambrowicz,B., Powell,D.R. and Vogel,P.
  TITLE     High-throughput screening of mouse gene knockouts identifies
            established and novel skeletal phenotypes
  JOURNAL   Bone Res 2, 14034 (2014)
   PUBMED   26273529
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2315)
  AUTHORS   Fukada,T., Civic,N., Furuichi,T., Shimoda,S., Mishima,K.,
            Higashiyama,H., Idaira,Y., Asada,Y., Kitamura,H., Yamasaki,S.,
            Hojyo,S., Nakayama,M., Ohara,O., Koseki,H., Dos Santos,H.G.,
            Bonafe,L., Ha-Vinh,R., Zankl,A., Unger,S., Kraenzlin,M.E.,
            Beckmann,J.S., Saito,I., Rivolta,C., Ikegawa,S., Superti-Furga,A.
            and Hirano,T.
  TITLE     The zinc transporter SLC39A13/ZIP13 is required for connective
            tissue development; its involvement in BMP/TGF-beta signaling
            pathways
  JOURNAL   PLoS One 3 (11), e3642 (2008)
   PUBMED   18985159
  REMARK    GeneRIF: The Slc39a13-KO mouse represents a novel animal model
            linking zinc metabolism, BMP/TGF-beta signaling and connective
            tissue dysfunction.
            Erratum:[PLoS One. 2008;3(11). doi:
            10.1371/annotation/a6c35a12-e8eb-43a0-9d00-5078fa6da1bb]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL691439.8.
            
            On Jan 5, 2022 this sequence version replaced NM_001290765.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.195333.1,
                                           SRR17253011.151909.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AL691439.8         21770-21839         c
            71-379              AL691439.8         20046-20354         c
            380-493             AL691439.8         17628-17741         c
            494-651             AL691439.8         17197-17354         c
            652-753             AL691439.8         16521-16622         c
            754-843             AL691439.8         16330-16419         c
            844-894             AL691439.8         15271-15321         c
            895-1027            AL691439.8         14935-15067         c
            1028-1127           AL691439.8         14679-14778         c
            1128-2315           AL691439.8         13406-14593         c
FEATURES             Location/Qualifiers
     source          1..2315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.44 cM"
     gene            1..2315
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /note="solute carrier family 39 (metal ion transporter),
                     member 13"
                     /db_xref="GeneID:68427"
                     /db_xref="MGI:MGI:1915677"
     exon            1..70
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            71..379
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1203
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; zinc transporter ZIP13; zrt- and Irt-like
                     protein 13; solute carrier family 39 member 13"
                     /codon_start=1
                     /product="zinc transporter ZIP13 isoform a precursor"
                     /protein_id="NP_001277694.1"
                     /db_xref="CCDS:CCDS71095.1"
                     /db_xref="GeneID:68427"
                     /db_xref="MGI:MGI:1915677"
                     /translation="MPGCPCPGCGMAGQRLLFLTVLALELLERAGGSQPALRSLGAAA
                     ACRLDNKESESWGALLSGERLDTWICSLLGSLMVGLSGVFPLLVIPLEMGTLLQSEAG
                     AWRLRQLLSFALGGLLGNVFLHLLPEAWAYTCNITPATGLAWPVSAPPAGGEGQSLQR
                     QQQLGLWVIAGFLTFLALEKMFLNSKEDPSQAPSKDPTAAALNGGHCLAQPAAEPGLR
                     AVVRNLKVSGYLNLLANTIDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDF
                     AILLRAGFDRWTAAKLQFSTALGGLLGACFAICTQSPKGVEETVVWILPFTSGGFLYI
                     ALVNVLPDLLEEDDPWHSLQQVLLLCSGVLVMVLLSLFVE"
     exon            380..493
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            494..651
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            652..753
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            754..843
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            844..894
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1027
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1127
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..2315
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2296..2301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /note="hexamer: AATAAA"
     polyA_site      2315
                     /gene="Slc39a13"
                     /gene_synonym="1100001L14Rik; ZIP-13; ZIP13"
                     /note="major polyA site"
ORIGIN      
        1 actgcagctg gatggccggg cccgcccgga gcgctgcatc tgctgccgct gccacctctg
       61 ccactgcgcg cgcccggcat gcctggatgt ccctgccctg gctgtggtat ggcaggccaa
      121 aggctcctct tcctcactgt ccttgccctg gagctcctgg aaagggctgg aggttcccag
      181 ccagccctcc ggagcctggg ggctgcagct gcctgtcgcc tggataataa agaaagcgag
      241 tcctgggggg ctttgctgag tggggagcga ctggacacct ggatctgctc cctcttgggc
      301 tctctcatgg ttgggctcag tggggttttc cccttgctgg tcattcccct ggagatgggg
      361 accctgttac agtcagaagc cggagcctgg cgactgaggc agctgctcag ctttgcctta
      421 ggtggactcc tgggcaacgt gtttctgcac ctgctgccgg aggcgtgggc ctacacctgt
      481 aacatcaccc ccgccactgg cttggcatgg cctgttagtg ctccccctgc aggtggtgaa
      541 gggcagagtc tgcagcgaca gcaacaactg gggctatggg tcatcgctgg cttcctgacc
      601 ttcctggcgt tggagaagat gttcctcaac agcaaggagg accccagcca ggcccccagc
      661 aaagacccca ctgctgccgc gctcaatgga ggccactgtc tggcccagcc ggctgcagag
      721 cccggcctga gagccgtggt ccggaacctc aaagtcagtg gctatctcaa cctgcttgcc
      781 aacaccatag acaacttcac tcatgggctg gctgtggctg ccagcttcct tgtgagcaaa
      841 aagatcgggc ttctgaccac catggccatc ctcctgcatg agatccccca tgaggtgggt
      901 gactttgcta tcctgctccg ggctggcttt gaccgatgga cggcagctaa gctacagttt
      961 tctacagccc tgggaggcct tctgggggcc tgctttgcca tctgtacaca gtcccccaaa
     1021 ggagtagagg agacggtggt ctggatcctg cccttcacct cgggaggctt tctctatatc
     1081 gccctggtga atgtgttacc tgacctcttg gaagaagacg acccgtggca ctccctgcaa
     1141 caggtgctgc tgctctgctc cggtgttctg gtgatggtgc tgctttcatt gtttgttgaa
     1201 taaccactgc tcacagccca ctctgcacag cgagcaatga gactccagtc tgttctgtga
     1261 ccaagtgtga gaggcagagg gtgaatgcta gagaggagcc tctcactgca cagagggtgt
     1321 gtggtgtgca cacgcagcca gagtgggaga gagaccgaca ctgtgacccc tgggtgcaga
     1381 gcccagagcc caacgtagca cctgcccaga caccccactg tcacctagca gcaaggaatg
     1441 acagcaccgg tgccagcaca ggcctcactt ctcattgaca aagaaaccag cccaaggagc
     1501 ccagggctac agcccaaaga gagggacaga gcccaaagtt gttcctcctt ggggctctag
     1561 cccaagagag aaaagaaaaa aacaaaccct ctgcttacac atctaggccc caagcactgt
     1621 agaggcagag gcaacacagc ttttccctgc tgtccatttt ccttaccctt cctacttacc
     1681 ccctctacag ccaaagaaat gggaggtggg tgctgtgtag ccccagcccc gactcagcac
     1741 tgatgtccta cccctcccca acgctgagca ggcagctgct ccaagacctc tctctagggg
     1801 cagccagcct ggctagcacg tttccccaac aaatattccc tggccacacg ggcagctctc
     1861 accacctcca gctgccaaac agcagcctgc aagtcagcaa gtagtccagg ctagccgtct
     1921 ctcagcacag ctctccggga tgctcctgcc agcacagggt ccagcaggca tgcatgcccc
     1981 aggcagagac agtgagcctt gctgccctct ccagctcagg ggcccttgtc ctttgggtta
     2041 agagtaagat gggggtggtg agggctccac attgtcagtg ctcaggaatg tgaactggaa
     2101 gaatgctgaa gccataatcc ccaactattt cccttggctg acacccaggt actcagctgg
     2161 cccaatctac agccagactc cagccctgct gctcaactgt ggatgttaga gatgtggcca
     2221 ctgaagagtc tgactgatcc acagcagtta tgctgtggct catctttatc tgtaaatact
     2281 tgttctgtag atataaataa attacttaga ccggc
//
