LOCUS       NM_001409652            2768 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus solute carrier family 39 (zinc transporter), member 12
            (Slc39a12), transcript variant 2, mRNA.
ACCESSION   NM_001409652
VERSION     NM_001409652.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2768)
  AUTHORS   Zhu,X., Yu,C., Wu,W., Shi,L., Jiang,C., Wang,L., Ding,Z. and Liu,Y.
  TITLE     Zinc transporter ZIP12 maintains zinc homeostasis and protects
            spermatogonia from oxidative stress during spermatogenesis
  JOURNAL   Reprod Biol Endocrinol 20 (1), 17 (2022)
   PUBMED   35065654
  REMARK    GeneRIF: Zinc transporter ZIP12 maintains zinc homeostasis and
            protects spermatogonia from oxidative stress during
            spermatogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2768)
  AUTHORS   Bin,B.H., Bhin,J., Takaishi,M., Toyoshima,K.E., Kawamata,S.,
            Ito,K., Hara,T., Watanabe,T., Irie,T., Takagishi,T., Lee,S.H.,
            Jung,H.S., Rho,S., Seo,J., Choi,D.H., Hwang,D., Koseki,H.,
            Ohara,O., Sano,S., Tsuji,T., Mishima,K. and Fukada,T.
  TITLE     Requirement of zinc transporter ZIP10 for epidermal development:
            Implication of the ZIP10-p63 axis in epithelial homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 114 (46), 12243-12248 (2017)
   PUBMED   29078349
REFERENCE   3  (bases 1 to 2768)
  AUTHORS   Chowanadisai,W., Graham,D.M., Keen,C.L., Rucker,R.B. and
            Messerli,M.A.
  TITLE     Neurulation and neurite extension require the zinc transporter
            ZIP12 (slc39a12)
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9903-9908 (2013)
   PUBMED   23716681
  REMARK    GeneRIF: Data indicate that ZIP12 (slc39a12) is a Zn(2+) uptake
            transporter with a conserved pattern of high expression in the
            mouse and Xenopus nervous system.
REFERENCE   4  (bases 1 to 2768)
  AUTHORS   Dike,S., Balija,V.S., Nascimento,L.U., Xuan,Z., Ou,J., Zutavern,T.,
            Palmer,L.E., Hannon,G., Zhang,M.Q. and McCombie,W.R.
  TITLE     The mouse genome: experimental examination of gene predictions and
            transcriptional start sites
  JOURNAL   Genome Res 14 (12), 2424-2429 (2004)
   PUBMED   15574821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845290.7 and AL844558.6.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AL845290.7         102839-102948
            111-445             AL844558.6         141418-141752       c
            446-727             AL844558.6         134643-134924       c
            728-935             AL844558.6         130650-130857       c
            936-1108            AL844558.6         125881-126053       c
            1109-1283           AL844558.6         123382-123556       c
            1284-1456           AL844558.6         110768-110940       c
            1457-1606           AL844558.6         96641-96790         c
            1607-1714           AL844558.6         95230-95337         c
            1715-1781           AL844558.6         86918-86984         c
            1782-1940           AL844558.6         81071-81229         c
            1941-2128           AL844558.6         78853-79040         c
            2129-2212           AL844558.6         50435-50518         c
            2213-2768           AL844558.6         36020-36575         c
FEATURES             Location/Qualifiers
     source          1..2768
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 10.56 cM"
     gene            1..2768
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /note="solute carrier family 39 (zinc transporter), member
                     12"
                     /db_xref="GeneID:277468"
                     /db_xref="MGI:MGI:2139274"
     exon            1..110
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            111..445
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2341
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; zinc transporter ZIP12; ZIP-12; zrt- and
                     Irt-like protein 12; solute carrier family 39 member 12"
                     /codon_start=1
                     /product="zinc transporter ZIP12 isoform 2 precursor"
                     /protein_id="NP_001396581.1"
                     /db_xref="GeneID:277468"
                     /db_xref="MGI:MGI:2139274"
                     /translation="MCFWTNLSVWMILLSHSLSLVSSTETGKTLTQNNSRAGSQGLLE
                     VLRVLSAGDHWSLNHPQSLIKILLERTGCPQRTDWTQGDCKLCLEADALLLTAGGNLE
                     DELREEVVQRVSLLLLYYIIHQEEICSSKLNMSNREYEFYLHSLLGLRQDEDSYFLSE
                     KETDDILAFTRKYFGTSSSQCMETKILQRESGIQGSNGADEKTLPQLAATIIALSLQG
                     VCLGRKALPSPDDFTEYIFSFLNSTNTLHLSEIEQLLNMLTTRRTCAKEDKYLHQYQR
                     KQNTEEHSLRDPKTSTAMDKESDDHSPSWDQACFSARQLVEIFLQNHSSLSISKEDFK
                     QLSPGIIQQLLSCSCQMPKDQQAKPPPTTLEKYGYSTVAVTLLTLGSMLGTALVLFHS
                     CEENYSLILQLFVGLAVGTLSGDALLHLIPQVLGLHKQEAEFGHFHESQSPIWKLLGL
                     LGGIHGFFLIEKCFILLVSPNTKGLPLVNEHVGHTHHLGLNPELNDQSSGGKSISTIQ
                     LKGPEDSQTTVLPIGNVPASNRNGKTISLLAIMILVGDSLHNFADGLVIGTAFSSSLE
                     SGVTTTIAILCHEIPHEMGDFAVLLSSGLSVRTAILMNFLSALTAFAGLYIGLSVSAD
                     PRVQDWILTVTAGMFLYLSLVGMADENFQAPFVEEAIFVPMCGFGIFVENYLPEMTHV
                     QTQRPWMTFLLQNVGLVLGWFSLLLLAVYEQNIKI"
     exon            446..727
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            728..935
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1108
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1283
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1456
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1606
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1714
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1781
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1940
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2128
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2212
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2768
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2330..2335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /note="hexamer: ATTAAA"
     regulatory      2335..2340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /note="hexamer: AATATA"
     polyA_site      2353
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /note="major polyA site"
     polyA_site      2356
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /note="major polyA site"
     regulatory      2729..2734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /note="hexamer: AATATA"
     regulatory      2748..2753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
                     /note="hexamer: AATAAA"
     polyA_site      2749
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
     polyA_site      2768
                     /gene="Slc39a12"
                     /gene_synonym="Gm731"
ORIGIN      
        1 tttttttttt ttttttaagg cagaagtaga aaccacaaca gcttcttaag agaacagcaa
       61 tgcatatttt gaaggaaatt ctggctcttt tttcccctca aatgttgaag gaaaccctct
      121 ggttgtaaat ttgtcctgca tgaagcctcc cattcacccc caacacaacc caagcccaag
      181 agtggacatg tgcttctgga ccaatctttc agtgtggatg atcctactgt cccactccct
      241 cagcctcgtt tcctctactg agaccggcaa aaccctcact cagaataaca gcagagctgg
      301 gagccaaggc ctgctagaag ttctgagggt cctctctgct ggtgaccact ggtccctcaa
      361 ccatccacaa agcctcatca aaattctgtt ggagaggact gggtgtccac agagaacaga
      421 ttggacacaa ggagactgca agctgtgttt ggaagcagat gcactgttac tcacagctgg
      481 gggaaatttg gaggatgagc taagagagga ggtagtccag agagtttctc ttcttctcct
      541 ctactacata attcatcagg aagagatctg ttcttccaag ctcaacatga gcaacagaga
      601 atatgagttt tacctgcaca gcctactcgg ccttaggcag gatgaagact cctatttcct
      661 ttcagagaag gagactgatg acatcttggc tttcaccagg aagtactttg gcacttccag
      721 tagccagtgt atggaaacta agattctgca gagggaatct ggcattcagg gcagcaatgg
      781 tgctgatgaa aagacacttc ctcagctggc agcaaccatc atcgctctgt cactccaagg
      841 agtttgtctg ggaagaaaag ccttgccttc tccagatgat tttacagagt atattttcag
      901 tttcctgaat agtaccaata ccctccacct atctgaaata gagcaacttc tgaacatgct
      961 cacgaccaga aggacctgtg ctaaagagga taaatacctc catcaatacc aaaggaaaca
     1021 aaacacagag gaacacagtt tgagagaccc caagacatct acagcaatgg acaaagagtc
     1081 tgatgatcat tctccttcct gggatcaggc ttgcttctct gctaggcagt tggtggagat
     1141 atttctacag aatcatagca gtctgtccat ttctaaggag gactttaagc agctaagtcc
     1201 agggatcatc cagcaacttc tcagctgctc ttgtcagatg cccaaggacc agcaagcaaa
     1261 gcccccaccc accactctgg agaaatatgg ctacagtaca gtggcagtga cactcctaac
     1321 cttgggctcc atgcttggga cagcgctggt ccttttccac agctgtgagg agaactacag
     1381 tcttatttta cagctgttcg tgggtttggc tgtggggacg ctctctgggg atgccctgct
     1441 ccatctcata cctcaggttc ttggtttaca taagcaggaa gcagagtttg ggcatttcca
     1501 tgaaagccaa agtcctattt ggaagctgtt gggactactt ggaggcatcc atggattttt
     1561 cttgatagaa aaatgtttta tccttcttgt atcaccaaat accaagggtc tgccattagt
     1621 taatgaacat gtgggacata cacaccatct tggactcaat ccagaattaa atgaccagtc
     1681 aagtggaggc aagtctatct caaccatcca actgaaaggc ccagaagatt cacagacaac
     1741 tgtgctaccc ataggcaatg tgccagcctc caacagaaat ggcaaaacca tcagcttatt
     1801 ggccattatg atcctggttg gagatagcct gcacaatttt gcagatggcc tagtaatagg
     1861 cacagccttc tcctcttcat tggagtcagg agtgaccaca acaattgcta tcttgtgtca
     1921 tgaaattcca catgaaatgg gagactttgc agtgctctta agctcaggac tctctgtcag
     1981 gactgccatc ctgatgaatt ttctaagtgc cctgacggcc ttcgcaggac tgtacattgg
     2041 tctctcagta tctgctgacc cacgtgtcca agactggatt ttaacagtga ctgctgggat
     2101 gttcttatat ttatctttgg tggggatggc ggatgaaaat ttccaggcac catttgttga
     2161 agaagctatc tttgttccaa tgtgtggttt tggaatcttt gttgaaaatt atcttcctga
     2221 aatgactcat gttcagacac aacgaccctg gatgacgttt ctcctgcaga atgtcggatt
     2281 ggtccttggc tggttttctc ttttgctctt agctgtatat gaacagaata ttaaaatata
     2341 agttaagaat ctctaatggc ttccaaaatg taattatctg ctcatatctc gtatcttcca
     2401 tgttctctat gccaatcact aatttggtat ttatattcga ggcaaagaat ttgtcattta
     2461 tcttaactta ttaattctgt attataaatt tttagaaata tatatatgtg agtctggctt
     2521 ggattaaaat ctttattttt gtttctgaca ctgtgattgg ccacaataat gtttagtgtt
     2581 agaaaattct taattctagt cagctgcaaa aatattattt ccctacaaaa gaatgtttat
     2641 tccttatatt tgaagcagac atttttgtcg ttgtttttta aattgttaat aatatattgt
     2701 tttctatgtg attagtaaag cataagcaaa tataattgta gaaatgtaat aaaggctagt
     2761 ttcaatta
//
