LOCUS       NM_001411505            2349 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus solute carrier family 39 (zinc transporter), member 1
            (Slc39a1), transcript variant 2, mRNA.
ACCESSION   NM_001411505 XM_006501560
VERSION     NM_001411505.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Elgheznawy,A., Oftering,P., Englert,M., Mott,K., Kaiser,F.,
            Kusch,C., Gbureck,U., Bosl,M.R., Schulze,H., Nieswandt,B.,
            Vogtle,T. and Hermanns,H.M.
  TITLE     Loss of zinc transporters ZIP1 and ZIP3 augments platelet
            reactivity in response to thrombin and accelerates thrombus
            formation in vivo
  JOURNAL   Front Immunol 14, 1197894 (2023)
   PUBMED   37359521
  REMARK    GeneRIF: Loss of zinc transporters ZIP1 and ZIP3 augments platelet
            reactivity in response to thrombin and accelerates thrombus
            formation in vivo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Bhutia,Y.D., Babu,E., Ramachandran,S., Yang,S., Thangaraju,M. and
            Ganapathy,V.
  TITLE     SLC transporters as a novel class of tumour suppressors: identity,
            function and molecular mechanisms
  JOURNAL   Biochem J 473 (9), 1113-1124 (2016)
   PUBMED   27118869
  REMARK    Review article
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Furuta,T., Ohshima,C., Matsumura,M., Takebayashi,N., Hirota,E.,
            Mawaribuchi,T., Nishida,K. and Nagasawa,K.
  TITLE     Oxidative stress upregulates zinc uptake activity via Zrt/Irt-like
            protein 1 (ZIP1) in cultured mouse astrocytes
  JOURNAL   Life Sci 151, 305-312 (2016)
   PUBMED   26979775
  REMARK    GeneRIF: under oxidative stress-loaded conditions, astrocytes
            exhibit increased zinc clearance activity and this is due, at least
            in part, to increased ZIP1 expression.
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Brommage,R., Liu,J., Hansen,G.M., Kirkpatrick,L.L., Potter,D.G.,
            Sands,A.T., Zambrowicz,B., Powell,D.R. and Vogel,P.
  TITLE     High-throughput screening of mouse gene knockouts identifies
            established and novel skeletal phenotypes
  JOURNAL   Bone Res 2, 14034 (2014)
   PUBMED   26273529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Segawa,S., Shibamoto,M., Ogawa,M., Miyake,S., Mizumoto,K.,
            Ohishi,A., Nishida,K. and Nagasawa,K.
  TITLE     The effect of divalent metal cations on zinc uptake by mouse
            Zrt/Irt-like protein 1 (ZIP1)
  JOURNAL   Life Sci 113 (1-2), 40-44 (2014)
   PUBMED   25089007
  REMARK    GeneRIF: mouse Zrt/Irt-like protein 1 (ZIP1) uptake of zinc is
            affected by divalent metal cations
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Wang,F., Dufner-Beattie,J., Kim,B.E., Petris,M.J., Andrews,G. and
            Eide,D.J.
  TITLE     Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and
            ZIP3 zinc uptake transporters
  JOURNAL   J Biol Chem 279 (23), 24631-24639 (2004)
   PUBMED   15054103
  REMARK    GeneRIF: ZIP1 and ZIP3 zinc uptake transporter activity is
            controlled by zinc-stimulated endocytosis
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   Kambe,T., Yamaguchi-Iwai,Y., Sasaki,R. and Nagao,M.
  TITLE     Overview of mammalian zinc transporters
  JOURNAL   Cell Mol Life Sci 61 (1), 49-68 (2004)
   PUBMED   14704853
  REMARK    Review article
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Dufner-Beattie,J., Langmade,S.J., Wang,F., Eide,D. and Andrews,G.K.
  TITLE     Structure, function, and regulation of a subfamily of mouse zinc
            transporter genes
  JOURNAL   J Biol Chem 278 (50), 50142-50150 (2003)
   PUBMED   14525987
  REMARK    GeneRIF: ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc
            homeostasis rather than primary roles in the acquisition of dietary
            zinc
REFERENCE   9  (bases 1 to 2349)
  AUTHORS   Lioumi,M., Ferguson,C.A., Sharpe,P.T., Freeman,T., Marenholz,I.,
            Mischke,D., Heizmann,C. and Ragoussis,J.
  TITLE     Isolation and characterization of human and mouse ZIRTL, a member
            of the IRT1 family of transporters, mapping within the epidermal
            differentiation complex
  JOURNAL   Genomics 62 (2), 272-280 (1999)
   PUBMED   10610721
REFERENCE   10 (bases 1 to 2349)
  AUTHORS   Crozet,F., el Amraoui,A., Blanchard,S., Lenoir,M., Ripoll,C.,
            Vago,P., Hamel,C., Fizames,C., Levi-Acobas,F., Depetris,D.,
            Mattei,M.G., Weil,D., Pujol,R. and Petit,C.
  TITLE     Cloning of the genes encoding two murine and human cochlear
            unconventional type I myosins
  JOURNAL   Genomics 40 (2), 332-341 (1997)
   PUBMED   9119401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119825.11.
            
            On Aug 26, 2022 this sequence version replaced XM_006501560.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4106253.1,
                                           SRR17253011.8006926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC119825.11        143648-143702
            56-287              AC119825.11        144375-144606
            288-418             AC119825.11        144769-144899
            419-2349            AC119825.11        147129-149059
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.21 cM"
     gene            1..2349
                     /gene="Slc39a1"
                     /gene_synonym="Zip1; Zirtl"
                     /note="solute carrier family 39 (zinc transporter), member
                     1"
                     /db_xref="GeneID:30791"
                     /db_xref="MGI:MGI:1353474"
     exon            1..55
                     /gene="Slc39a1"
                     /gene_synonym="Zip1; Zirtl"
                     /inference="alignment:Splign:2.1.0"
     exon            56..287
                     /gene="Slc39a1"
                     /gene_synonym="Zip1; Zirtl"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1075
                     /gene="Slc39a1"
                     /gene_synonym="Zip1; Zirtl"
                     /note="Zrt/Irt-like protein 1; ZIP-1; mZIP1; zrt- and
                     Irt-like protein 1; solute carrier family 39 member 1"
                     /codon_start=1
                     /product="zinc transporter ZIP1"
                     /protein_id="NP_001398434.1"
                     /db_xref="GeneID:30791"
                     /db_xref="MGI:MGI:1353474"
                     /translation="MGPWGEPELLVWRPEAVASEPSVPVGLEVKLGALVLLLLLTLIC
                     SLVPVCVLRRSGANHEASASGQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEALEA
                     LHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQTSPPHPEETRALLGTVNGGPQHWH
                     DGPGIPQAGGTPAAPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLLHK
                     GILAVSLSLRLLQSHLRVQVVAGCGILFSCMTPLGIGLGAALAESAGPLHQLAQSVLE
                     GMAAGTFLYITFLEILPQELATSEQRILKVILLLAGFALLTGLLFVQI"
     exon            288..418
                     /gene="Slc39a1"
                     /gene_synonym="Zip1; Zirtl"
                     /inference="alignment:Splign:2.1.0"
     exon            419..2349
                     /gene="Slc39a1"
                     /gene_synonym="Zip1; Zirtl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2325..2330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc39a1"
                     /gene_synonym="Zip1; Zirtl"
                     /note="hexamer: AATAAA"
     polyA_site      2349
                     /gene="Slc39a1"
                     /gene_synonym="Zip1; Zirtl"
                     /note="major polyA site"
ORIGIN      
        1 attcccgacg cgaggccgga accgagcgac agcaatggag tgagaccctc gggagttttc
       61 tctgtatagg tccaagagtc accgagttat cacagccacc atggggccct ggggggagcc
      121 agagctcctg gtgtggcgcc cagaagcagt cgcatcggag ccctcggtgc cagtagggct
      181 ggaagtgaag ctgggggccc tggtgctgct gctgctgctg acactcatct gcagcctggt
      241 acctgtctgt gtgcttcgaa ggtcaggtgc taaccatgaa gcttcagcct cgggccagaa
      301 agccctgagc ctcgtcagct gcttcgcagg aggagtcttt ttggctacat gtcttctgga
      361 cctgctgcct gactacctgg ctgccataga tgaggccttg gaggccctgc atgtgacgct
      421 tcagttcccc ttgcaagagt tcatcttggc catgggtttc ttcctggtcc tggtgatgga
      481 gcagatcacg ctggcttaca aggaacagac cagtccaccc cacccggaag agacaagggc
      541 tctactgggc acagtgaatg gtgggcctca gcactggcac gatggaccag ggatccccca
      601 ggccggcgga actccagcag ctccctcagc cctgcgtgct tgtgtcctgg tcttctcctt
      661 agccttgcac tcagtatttg agggcctggc tgtagggttg cagcgagaca gggctcgggc
      721 aatggagctg tgcctagctc tgctgcttca caaaggcatt ctggcagtca gcctgtccct
      781 gcggctgcta cagagccacc tacgtgtgca ggtggtggct ggctgcggga tcctcttctc
      841 atgtatgaca cctctgggca tcgggttggg tgcagctctg gcagagtcag ctgggcctct
      901 gcaccagctg gcccaatctg ttctagaggg catggcagct ggcaccttcc tctatatcac
      961 cttcctggaa attctacccc aggaactggc cacttctgag cagaggatcc tcaaggtcat
     1021 tctgctccta gcaggctttg ccctgctcac tggccttctc tttgtccaaa tctaaggtgc
     1081 ttcaagagaa agggcagggg aggttggcta tcaggtgccc ctgtcctccc tccctaccct
     1141 tctcaattgg tgggaaatag aaagaagtgg agaagggaag tagtgaggac caaagagttc
     1201 tcttagatat agggatggga catttggact atgaataatg agatggaagt gggcagagaa
     1261 gaggctagcc ccagacccaa agaataagag atagcgaagt tactacagac gtggtcaggg
     1321 acattagaag gaggcagact gctacagtca gaggccaggc agtacatctc agagacaagc
     1381 tgacagaaga actgagagtt aggcatccag cctctttgcg ataaagatac agaggctgta
     1441 agtcaaagcc agtatcctgt tggttctagc ccatctcacc actctgatgg ctgaaatggt
     1501 tcctcctcct ttcttccctc ctactcttat atttctctct tgtcttccac taagggacta
     1561 gtgccaaatg gtctctctgc cagttttcgt aatttatctg gcctctcctg tcctcacctt
     1621 tttgggttgc tctgtgtagc cttggctgtc ctggaactca ctcttgtaaa ccaggctggg
     1681 cttgagttta cagagctcca cctgtctctg cctctgcctc cttaatgctg ggactaaagg
     1741 ggtgccatgc caccactgcc tagctcacta gtctgttgtt aaagtgccaa atacccaccc
     1801 acccaccctt taggtttgtt tgcttttttt tttttttttt tttttttttt tttttgacag
     1861 ggtttctctg tataaccctg gttgtcctgg cctcaaactc agagctcagt ctgcctctgc
     1921 ctcctgagca ctgggattaa aggtgtgtag cacatgtatt gctcacctgc cccctttttg
     1981 aaagcacagt gctgaggtgc tggggcctgc ctagcacctc agtggagacc tatttgctct
     2041 tttatttagg ccccatagtt tggggtgggg aagaaatatt tgctgaactg gtctggagtg
     2101 agagaaaagt aggtactgac accagacact acagaaagtg gacatggtgg tccataccta
     2161 gaaaaaaacc aataacctgc caaaacttta tatctgagga gtccggggtg gagggagaca
     2221 gactccctcc cccaggatta tttttgggga gggagggctg tgcataggtc tgtactctgt
     2281 agaatctatt ttactaactg acctgttttg ggatatgtta cccaaataaa agatgtttct
     2341 atacacttc
//
