LOCUS       NM_001037717            2959 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 38, member 6 (Slc38a6), mRNA.
ACCESSION   NM_001037717 XM_889626
VERSION     NM_001037717.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2959)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2959)
  AUTHORS   Peng,Y., Chen,W., Huang,F., Geng,M., Li,X., Zhang,F., Zhu,W.,
            Meng,L., Holmdahl,R., Xu,J. and Lu,S.
  TITLE     SLC38A6 expression in macrophages exacerbates pulmonary
            inflammation
  JOURNAL   Respir Res 24 (1), 33 (2023)
   PUBMED   36707853
  REMARK    GeneRIF: SLC38A6 expression in macrophages exacerbates pulmonary
            inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2959)
  AUTHORS   Gandasi,N.R., Arapi,V., Mickael,M.E., Belekar,P.A., Granlund,L.,
            Kothegala,L., Fredriksson,R. and Bagchi,S.
  TITLE     Glutamine Uptake via SNAT6 and Caveolin Regulates
            Glutamine-Glutamate Cycle
  JOURNAL   Int J Mol Sci 22 (3), 1167 (2021)
   PUBMED   33503881
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2959)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2959)
  AUTHORS   Bagchi,S., Baomar,H.A., Al-Walai,S., Al-Sadi,S. and Fredriksson,R.
  TITLE     Histological analysis of SLC38A6 (SNAT6) expression in mouse brain
            shows selective expression in excitatory neurons with high
            expression in the synapses
  JOURNAL   PLoS One 9 (4), e95438 (2014)
   PUBMED   24752331
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2959)
  AUTHORS   Sundberg,B.E., Waag,E., Jacobsson,J.A., Stephansson,O., Rumaks,J.,
            Svirskis,S., Alsio,J., Roman,E., Ebendal,T., Klusa,V. and
            Fredriksson,R.
  TITLE     The evolutionary history and tissue mapping of amino acid
            transporters belonging to solute carrier families SLC32, SLC36, and
            SLC38
  JOURNAL   J Mol Neurosci 35 (2), 179-193 (2008)
   PUBMED   18418736
REFERENCE   7  (bases 1 to 2959)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159813.2.
            
            On Aug 16, 2011 this sequence version replaced NM_001037717.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC157928.1, SRR11927934.4178730.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC159813.2         192365-192549       c
            186-316             AC159813.2         190874-191004       c
            317-390             AC159813.2         187164-187237       c
            391-443             AC159813.2         169200-169252       c
            444-483             AC159813.2         160381-160420       c
            484-562             AC159813.2         149339-149417       c
            563-645             AC159813.2         142293-142375       c
            646-704             AC159813.2         141829-141887       c
            705-770             AC159813.2         137924-137989       c
            771-824             AC159813.2         137637-137690       c
            825-904             AC159813.2         135649-135728       c
            905-1005            AC159813.2         134504-134604       c
            1006-1130           AC159813.2         128759-128883       c
            1131-1275           AC159813.2         127502-127646       c
            1276-1370           AC159813.2         127224-127318       c
            1371-2959           AC159813.2         125352-126940       c
FEATURES             Location/Qualifiers
     source          1..2959
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 30.42 cM"
     gene            1..2959
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /note="solute carrier family 38, member 6"
                     /db_xref="GeneID:625098"
                     /db_xref="MGI:MGI:3648156"
     exon            1..185
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1451
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /note="Na(+)-coupled neutral amino acid transporter 6;
                     probable sodium-coupled neutral amino acid transporter 6;
                     amino acid transporter SLC38A6"
                     /codon_start=1
                     /product="solute carrier family 38 member 6"
                     /protein_id="NP_001032806.2"
                     /db_xref="CCDS:CCDS49088.1"
                     /db_xref="GeneID:625098"
                     /db_xref="MGI:MGI:3648156"
                     /translation="MQASRHSIQAEPGWYVSAQQPEEAVAADEWSPLLSNEPHRQGSS
                     GASFGLSVFNVMNAIMGSGILGLAYVMANTGILGFSFLLLFVALLASYSVHLLLAMCI
                     HTAVTSYEDLGLFAFGLPGKVVVAGTIIIQNIGAMSSYLLIIKTELPAAISEFLPSDH
                     SGSWYLDGQMLLIIICVGIVFPLSLLPKIGFLGYTSSLSFFFMVFFALVVVIKKWAVP
                     CPVTLDCINEVFQISNATDDCKPKLFHFSKESVYAIPTMAFSFLCHTSVLPIYCELQS
                     PSKKRMQNVTNTAIALSFLVYFVSALFGYLTFYDKVESELLQGYSKYLPHDVIVMAVK
                     LCILFAVLLTAPLIHFPARKALMMILFSNYPFSWIRHSLTTAALNAIIVVLAIYVPDI
                     RNVFGVVGASTSTCLIFVFPGLFYLKLSREDFLSWKKLGALFLLLTGAVVGSFSLVLI
                     IFDWVNK"
     exon            186..316
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            317..390
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            391..443
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            444..483
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            484..562
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            563..645
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            646..704
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            705..770
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            771..824
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            825..904
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1005
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1130
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1275
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1370
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..2959
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2940..2945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /note="hexamer: AATAAA"
     polyA_site      2959
                     /gene="Slc38a6"
                     /gene_synonym="EG625098"
                     /note="major polyA site"
ORIGIN      
        1 tgaagccgct cagccggggc gcttggggtt aggggaagcg gctccgtgat ttacttagca
       61 gtcggtcgcg gagcaccatg caggcgtccc ggcacagcat ccaagcggag ccaggctggt
      121 acgtctctgc ccagcagcca gaggaggcgg tggctgcaga cgagtggagt ccgttgctaa
      181 gcaacgaacc tcacaggcag ggatcctccg gtgcttcctt tggtctctcc gtctttaacg
      241 tgatgaacgc catcatggga agcggcatcc ttggtttggc gtatgtgatg gctaacacgg
      301 gtatccttgg atttagtttc ctgctgctgt ttgttgctct cctggcttct tactcagtcc
      361 atctcctgct tgccatgtgc atccacaccg ccgtgacgtc ttacgaagat ctgggactct
      421 tcgcttttgg attacctgga aaggtggtgg tggcaggcac cataataatt cagaatattg
      481 gagctatgtc atcttatctt ttaattatta aaacagagct tcctgctgct atttcagaat
      541 ttttacctag tgaccacagt gggtcttggt atcttgatgg acagatgttg ctgatcatca
      601 tctgtgtagg catcgtgttt cctctctcac tgcttcccaa gataggcttt cttggctaca
      661 caagcagtct atcatttttc tttatggtgt tctttgctct tgtggtagta attaaaaaat
      721 gggccgttcc ttgtcctgtg accttagatt gcatcaatga agtctttcag atttcaaacg
      781 caacagatga ctgtaaacca aagctctttc atttctccaa agagagcgtt tacgccatac
      841 caaccatggc tttttccttt ctctgccata cctcagtatt gcccatatac tgtgagcttc
      901 aaagcccttc aaagaaaagg atgcagaatg tgaccaacac agcgattgcg ttgagctttc
      961 tggtttactt tgtgtctgca ctctttggct acctcacttt ttatgacaaa gtggagtcag
     1021 aattgctaca aggttatagt aaatacttgc cacatgatgt tattgtcatg gctgtgaagt
     1081 tgtgcatact attcgccgtg cttctgacag cccctctaat ccacttccct gccaggaaag
     1141 ctttaatgat gatcctgttc tccaattacc cgttctcctg gatccgacat tccctgacca
     1201 cagcagcgct caacgccatc atcgtggtgc tcgccatcta tgtcccggac attagaaatg
     1261 tatttggtgt ggttggcgcc agcacatcga catgcttgat ttttgtgttc ccagggttat
     1321 tttatcttaa actcagccga gaggacttcc tctcctggaa aaagcttggg gctttgttcc
     1381 tgctcctcac aggcgctgtg gtcggaagct tcagtttagt gctcatcatt tttgactggg
     1441 tcaacaaatg aaaaagtttt tattatgaag actaacttac ctctctataa acaagaaggg
     1501 atcattgtgg aaggtgccat atatgaaaat tacactcagg aaaactgtta atagggaagc
     1561 cggacagagc agcaatagga atttagccat tttaatttta accaaaatta gaaatactca
     1621 aaatacttga aatgttctta aatgtgcaga gtcactcttt tgtttggaag tttcattttc
     1681 tgtgttttgt tctgtgtctg aagcaggacc tagctgtgta gaccaagctg gccttgaact
     1741 cacagcagtc tgctattggg atttggttct aagacaaagg tcttaatttg gttcccaaag
     1801 cctggcttcc aggcctgagg gtccctgtcc tcagctggct tcaattgata atttacaaaa
     1861 aaaaaaaaaa ttgccaatgg ctggacagaa aaatggaggt gggactttta gattgtacgg
     1921 gcaagggaca gagaggggga gagaagaatc gccatgattg agggggaaag ggatcagatt
     1981 taagagctgc aggagaaagt tatccagcaa tgtaggttga aagggaaagc agccctgggg
     2041 gttgggggtg gggtgggtgg ggctgctgcc caataagtaa ctgggcagca ctcgggaggc
     2101 agaggcaggc ggatttctga gttcgaggcc agcctggtct acaaagtgag ttccaggaca
     2161 gccagggcta tacagagaaa ccctgtctcg aaaaacaaaa acaaacaaac aaacaaaaca
     2221 cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca aaataaaaca
     2281 aaaaacccat agatttagaa ggtgttaagc caggaatacc agagggaaat gtatgctagc
     2341 ctcggagagg actagaagtg cccagccatt gagctagtta aggcatgtca gaatcagctg
     2401 gaatgtagac tcatttgaga atccagatag ctcctgggca ggcgcagctt gagtgggact
     2461 tgccaggagc caaagcgggt taaccaatca ccgctacaga ctgcctgctg ctgctcctgc
     2521 caagtgctgg ggttaggaac tctgccacca tcctggcaca tgcctggcat ctgtgactta
     2581 aaaaaaaaag tagcctttat tttttttaga gtagttgtgc atttccatac gtattgagca
     2641 aatgaactga aagattctat gtgacttctt actccaactc tgtagctttc ctgctatgaa
     2701 tgaatgcctt gtgtcagtgt agcacgtgtt acacccaggg atgctaaagt ccaaggttga
     2761 cattaaagtt tctcttggcc accactgatt ttcctaccag aatgtcatga ttgggatcat
     2821 gtaggactga gtgtcatgtc cagtcctgag tgatgcccca ttatatggct gtatcatgtt
     2881 tgttgatcca ctcacctcat ggaagacctt tctactactt ccaggttttg ccagccatca
     2941 ataaaagcac taaaaatgc
//
