LOCUS       NM_172479               1878 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 38, member 5 (Slc38a5), mRNA.
ACCESSION   NM_172479
VERSION     NM_172479.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Radzishevsky,I., Odeh,M., Bodner,O., Zubedat,S., Shaulov,L.,
            Litvak,M., Esaki,K., Yoshikawa,T., Agranovich,B., Li,W.H.,
            Radzishevsky,A., Gottlieb,E., Avital,A. and Wolosker,H.
  TITLE     Impairment of serine transport across the blood-brain barrier by
            deletion of Slc38a5 causes developmental delay and motor
            dysfunction
  JOURNAL   Proc Natl Acad Sci U S A 120 (42), e2302780120 (2023)
   PUBMED   37812701
  REMARK    GeneRIF: Impairment of serine transport across the blood-brain
            barrier by deletion of Slc38a5 causes developmental delay and motor
            dysfunction.
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Sniegowski,T., Rajasekaran,D., Sennoune,S.R., Sunitha,S., Chen,F.,
            Fokar,M., Kshirsagar,S., Reddy,P.H., Korac,K., Mahmud Syed,M.,
            Sharker,T., Ganapathy,V. and Bhutia,Y.D.
  TITLE     Amino acid transporter SLC38A5 is a tumor promoter and a novel
            therapeutic target for pancreatic cancer
  JOURNAL   Sci Rep 13 (1), 16863 (2023)
   PUBMED   37803043
  REMARK    GeneRIF: Amino acid transporter SLC38A5 is a tumor promoter and a
            novel therapeutic target for pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Zhu,L., Xia,X., Li,G., Zhu,C., Li,Q., Wang,B., Shi,N.X., Lei,Z.,
            Yang,S., Zhang,Z., Li,H., Tan,J., Liu,Z., Wen,Q., Zhong,H.,
            Lin,X.J., Sun,G., Bao,X., Wang,Q., Deng,L., Bin,L., Cao,G. and
            Yin,Z.
  TITLE     SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via
            potentiating lysosomal acidification
  JOURNAL   Cell Rep 42 (8), 112910 (2023)
   PUBMED   37531255
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Wang,Z., Yemanyi,F., Blomfield,A.K., Bora,K., Huang,S., Liu,C.H.,
            Britton,W.R., Cho,S.S., Tomita,Y., Fu,Z., Ma,J.X., Li,W.H. and
            Chen,J.
  TITLE     Amino acid transporter SLC38A5 regulates developmental and
            pathological retinal angiogenesis
  JOURNAL   Elife 11, e73105 (2022)
   PUBMED   36454214
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1878)
  AUTHORS   Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von
            Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S.,
            Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A.,
            Bastidas-Ponce,A., Collden,G., Irmler,M., Beckers,J.,
            Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R.,
            Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U. and
            Lickert,H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. doi:
            10.1038/s41586-021-03347-z.. PMID: 33712809]
REFERENCE   6  (bases 1 to 1878)
  AUTHORS   Liu,H., Shafey,D., Moores,J.N. and Kothary,R.
  TITLE     Neurodevelopmental consequences of Smn depletion in a mouse model
            of spinal muscular atrophy
  JOURNAL   J Neurosci Res 88 (1), 111-122 (2010)
   PUBMED   19642194
REFERENCE   7  (bases 1 to 1878)
  AUTHORS   Umapathy,N.S., Dun,Y., Martin,P.M., Duplantier,J.N., Roon,P.,
            Prasad,P., Smith,S.B. and Ganapathy,V.
  TITLE     Expression and function of system N glutamine transporters (SN1/SN2
            or SNAT3/SNAT5) in retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 49 (11), 5151-5160 (2008)
   PUBMED   18689705
  REMARK    GeneRIF: ISH and IF revealed SN1 and SN2 expression in the
            ganglion, inner nuclear, and photoreceptor cell layers.
REFERENCE   8  (bases 1 to 1878)
  AUTHORS   O'Shaughnessy,P.J., Abel,M., Charlton,H.M., Hu,B., Johnston,H. and
            Baker,P.J.
  TITLE     Altered expression of genes involved in regulation of vitamin A
            metabolism, solute transportation, and cytoskeletal function in the
            androgen-insensitive tfm mouse testis
  JOURNAL   Endocrinology 148 (6), 2914-2924 (2007)
   PUBMED   17332066
REFERENCE   9  (bases 1 to 1878)
  AUTHORS   Petri,A., Ahnfelt-Ronne,J., Frederiksen,K.S., Edwards,D.G.,
            Madsen,D., Serup,P., Fleckner,J. and Heller,R.S.
  TITLE     The effect of neurogenin3 deficiency on pancreatic gene expression
            in embryonic mice
  JOURNAL   J Mol Endocrinol 37 (2), 301-316 (2006)
   PUBMED   17032746
REFERENCE   10 (bases 1 to 1878)
  AUTHORS   Umapathy,N.S., Li,W., Mysona,B.A., Smith,S.B. and Ganapathy,V.
  TITLE     Expression and function of glutamine transporters SN1 (SNAT3) and
            SN2 (SNAT5) in retinal Muller cells
  JOURNAL   Invest Ophthalmol Vis Sci 46 (11), 3980-3987 (2005)
   PUBMED   16249471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805902.5, AK054485.1, AK158125.1 and BX523289.1.
            
            On Mar 19, 2014 this sequence version replaced NM_172479.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077667.1, AK054485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL805902.5         62758-62770
            14-726              AK054485.1         1-713
            727-1749            AK158125.1         848-1870
            1750-1861           AK054485.1         1737-1848
            1862-1863           AK158125.1         1984-1985
            1864-1878           BX523289.1         511-525
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.74 cM"
     gene            1..1878
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /note="solute carrier family 38, member 5"
                     /db_xref="GeneID:209837"
                     /db_xref="MGI:MGI:2148066"
     exon            1..125
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1542
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /note="system N transporter 2"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid transporter 5"
                     /protein_id="NP_766067.2"
                     /db_xref="CCDS:CCDS52990.1"
                     /db_xref="GeneID:209837"
                     /db_xref="MGI:MGI:2148066"
                     /translation="MAISCAVGMEMQEPKMNGTLSAGAAAGYRQEREGFLPTTRNPAT
                     GRKPVQFLDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLS
                     SYSIHLLLTCASVVGIRAYEQLGQRAFGPAGKVVVAIIICLHNVGAMSSYLFIIKSEL
                     PLVIGTFLHMDPEGDWFLKGNLLIILVSLLIILPLALMKHLGYLGYTSSLSLTCMLFF
                     LISVIYKKFQIGCDVSHNDTVVEAEQAPLQAFNSSCEAELFTVDSQMSYTVPIMAFAF
                     VCHPEVLPIYTELCRPTQRRMQAVANMSIGAMFIMYGLTATFGYLTFYSTVKAEMLEM
                     YTQEDMLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPSKAFSWLRHVAIALILLI
                     LVNILVICVPTIRDIFGFIGSTSAPSLIFILPSVFYLRIVPTEVEPLFSWPKIQALCF
                     GVLGVLFMAISLGFMFANWATGQSRMSGH"
     exon            126..182
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            183..261
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            262..377
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..451
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            452..544
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..623
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            624..706
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..765
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..894
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..974
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1075
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1191
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1336
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1440
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1868
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1847..1852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /note="hexamer: AATAAA"
     polyA_site      1868
                     /gene="Slc38a5"
                     /gene_synonym="E330031E14; JM24; SN2"
                     /note="major polyA site"
ORIGIN      
        1 gaggtggggg cgggagatag ggactgaaag agacagaaaa gggcagacgg cgcgggagac
       61 agagtctgcc ctgtgggagg aaagttctat ttcccacttc aaatggccat ttcatgcgct
      121 gtggggatgg aaatgcagga accaaagatg aatggaaccc tctctgcggg tgctgctgcg
      181 ggctacaggc aggaacgcga aggcttcctg cccaccaccc gtaaccctgc tactgggagg
      241 aaacctgtcc agttcttgga tttcgagggg aagacatcat tcggaatgtc agtgttcaac
      301 ctcagcaacg ctatcatggg gagtggcatc ctgggactgg cttatgccat ggcacacact
      361 ggagtcatct tctttttggc cctgctgctg tgcattgctc tcctgtcttc ttactccatt
      421 cacctcctgc tgacctgtgc cagtgttgta ggcatccgtg cctatgagca gctgggacag
      481 agggcatttg gacctgccgg gaaagtagtc gtggccatca tcatctgtct gcacaacgtt
      541 ggggctatgt ccagttacct gttcatcatc aaatctgaac tcccccttgt tattggcacc
      601 ttcctgcaca tggaccctga gggagactgg ttcttgaagg ggaatctcct tatcatcctg
      661 gtcagcttgt taatcatctt gcccctggct ctcatgaaac acctgggcta cctggggtac
      721 acaagcagcc tctccctgac ctgcatgctg ttttttctca tttcggtcat ctataagaag
      781 ttccagattg gctgtgatgt gagccacaat gacacagtag tggaggctga acaagctcct
      841 ttgcaggcgt ttaacagcag ctgcgaggcc gagctcttca ccgttgactc gcagatgtct
      901 tacacagtgc ctattatggc ttttgcgttt gtctgccacc ctgaggtgct gcccatctac
      961 acagaacttt gccgccccac ccagcgcagg atgcaagctg tggccaacat gtccatcgga
     1021 gctatgttca tcatgtatgg actcacagcg acctttggat acctcacctt ctacagcact
     1081 gtgaaggcag agatgctgga aatgtacacc caggaggaca tgcttatcct ttgtgtgcgt
     1141 ctggccgtac tgcttgcagt aaccctcact gtgcctgttg tgcttttccc tatccgccga
     1201 gccctccagc agctgctctt tccaagcaag gccttcagct ggctacgcca tgtggccatt
     1261 gccttgattc tgcttattct ggtcaatatc ctcgtcatct gtgtgccaac catccgcgat
     1321 atctttgggt ttattgggtc cacttcagcc cctagcctca tcttcatcct tcccagtgtc
     1381 ttctacctcc gtattgtacc tactgaggtg gaacctttgt tttcctggcc caagatccag
     1441 gccctgtgct ttggtgtcct gggagtcctc ttcatggcca tcagcctggg cttcatgttt
     1501 gccaactggg ccacaggcca gagccgtatg tctggccact gagctggcct ggtttgcctc
     1561 actcagcccc tatgctcacg cgtgtatacg agggaatcca agtcactttc ctgagtcctt
     1621 cctgcctggg acatggaggt gtctggtctc taataacatt gctgtgggaa atggggacag
     1681 ttgaggaggc atagtaagta gtttatcccc ttccccttag agttgcctca ctgccaacct
     1741 catgagagga ggtatgggag gccaggtcct tagaagagtt cttagcccac atagttctca
     1801 cttcctagat gaagctgtta gggttaccct ggcgctaaaa gggaagaata aagatgctga
     1861 atgaaaaaaa aaaaaaaa
//
