LOCUS       NM_027052               3932 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus solute carrier family 38, member 4 (Slc38a4),
            transcript variant 4, mRNA.
ACCESSION   NM_027052
VERSION     NM_027052.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3932)
  AUTHORS   Kim,H.S., Na,M.J., Son,K.H., Yang,H.D., Kim,S.Y., Shin,E., Ha,J.W.,
            Jeon,S., Kang,K., Moon,K., Park,W.S. and Nam,S.W.
  TITLE     ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2
            expression and suppresses SLC38A4 expression in liver cancer
  JOURNAL   Exp Mol Med 55 (1), 95-107 (2023)
   PUBMED   36599932
  REMARK    GeneRIF: ADAR1-dependent miR-3144-3p editing simultaneously induces
            MSI2 expression and suppresses SLC38A4 expression in liver cancer.
REFERENCE   2  (bases 1 to 3932)
  AUTHORS   Matoba,S., Kozuka,C., Miura,K., Inoue,K., Kumon,M., Hayashi,R.,
            Ohhata,T., Ogura,A. and Inoue,A.
  TITLE     Noncanonical imprinting sustains embryonic development and
            restrains placental overgrowth
  JOURNAL   Genes Dev 36 (7-8), 483-494 (2022)
   PUBMED   35483741
REFERENCE   3  (bases 1 to 3932)
  AUTHORS   Xie,Z., Zhang,W. and Zhang,Y.
  TITLE     Loss of Slc38a4 imprinting is a major cause of mouse placenta
            hyperplasia in somatic cell nuclear transferred embryos at late
            gestation
  JOURNAL   Cell Rep 38 (8), 110407 (2022)
   PUBMED   35196486
REFERENCE   4  (bases 1 to 3932)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3932)
  AUTHORS   Jiang,W., Shi,J., Zhao,J., Wang,Q., Cong,D., Chen,F., Zhang,Y.,
            Liu,Y., Zhao,J., Chen,Q., Gu,L., Zhou,W., Wang,C., Fang,Z.,
            Geng,S., Xie,W., Chen,L.N., Yang,Y., Bai,Y., Lin,H. and Li,X.
  TITLE     ZFP57 dictates allelic expression switch of target imprinted genes
  JOURNAL   Proc Natl Acad Sci U S A 118 (5) (2021)
   PUBMED   33500348
REFERENCE   6  (bases 1 to 3932)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 3932)
  AUTHORS   Gu,S., Langlais,P., Liu,F. and Jiang,J.X.
  TITLE     Mouse system-N amino acid transporter, mNAT3, expressed in
            hepatocytes and regulated by insulin-activated and phosphoinositide
            3-kinase-dependent signalling
  JOURNAL   Biochem J 371 (Pt 3), 721-731 (2003)
   PUBMED   12537539
REFERENCE   8  (bases 1 to 3932)
  AUTHORS   Smith,R.J., Dean,W., Konfortova,G. and Kelsey,G.
  TITLE     Identification of novel imprinted genes in a genome-wide screen for
            maternal methylation
  JOURNAL   Genome Res 13 (4), 558-569 (2003)
   PUBMED   12670997
REFERENCE   9  (bases 1 to 3932)
  AUTHORS   Mizuno,Y., Sotomaru,Y., Katsuzawa,Y., Kono,T., Meguro,M.,
            Oshimura,M., Kawai,J., Tomaru,Y., Kiyosawa,H., Nikaido,I.,
            Amanuma,H., Hayashizaki,Y. and Okazaki,Y.
  TITLE     Asb4, Ata3, and Dcn are novel imprinted genes identified by
            high-throughput screening using RIKEN cDNA microarray
  JOURNAL   Biochem Biophys Res Commun 290 (5), 1499-1505 (2002)
   PUBMED   11820791
  REMARK    GeneRIF: Ata3 has been identified as an imprinted gene by
            high-throughput screening using RIKEN cDNA microarray.
REFERENCE   10 (bases 1 to 3932)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051023.1.
            
            On Apr 6, 2007 this sequence version replaced NM_027052.2.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051023.1, AK167539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3932              AK051023.1         2-3933
FEATURES             Location/Qualifiers
     source          1..3932
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 52.77 cM"
     gene            1..3932
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /note="solute carrier family 38, member 4"
                     /db_xref="GeneID:69354"
                     /db_xref="MGI:MGI:1916604"
     exon            1..102
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            103..240
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1765
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /note="system-N amino acid transporter 3; system A amino
                     acid transporter 3; amino acid transporter A3;
                     Na(+)-coupled neutral amino acid transporter 4"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid transporter 4"
                     /protein_id="NP_081328.2"
                     /db_xref="CCDS:CCDS27779.1"
                     /db_xref="GeneID:69354"
                     /db_xref="MGI:MGI:1916604"
                     /translation="MDPMELNNVSIEPDGDSCSGDSIQDSYTGMENSDKDAMNSQFAN
                     EDAESQKFLTNGFLGKKKLADYADEHHPGMTSFGMSSFNLSNAIMGSGILGLSYAMAN
                     TGIILFIIMLLTVAILSLYSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFISITM
                     QNIGAMSSYLFIIKYELPEVIRAFMGLEENTGEWYLNGNYLVLFVSVGIILPLSLLKN
                     LGYLGYTSGFSLSCMVFFVSVVIYKKFQIPCPLPALDHNNGNLTFNNTLPIHMISLPN
                     DSESSGVNFMMDYAHHNPAGLDEKQVAGPLHSNGVEYEAQGAEKCQPKYFVFNSRTAY
                     AIPILAFAFVCHPEVLPIYSELKDRSRRKMQTVSNISISGMLVMYLLAALFGYLSFYG
                     DVEDELLHAYSKVYTFDTALLMVRLAVLVAVTLTVPIVLFPIRTSVITLLFPRKPFSW
                     LKHFGIAAIIIALNNILVILVPTIKYIFGFIGASSATMLIFILPAAFYLKLVKKEPLR
                     SPQKIGALVFLVTGIIFMMGSMALIILDWIYNPPNPNHH"
     exon            241..331
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            332..447
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            448..521
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            522..614
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            615..696
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            697..779
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            780..838
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1114
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1194
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1295
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1420
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1565
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1663
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..3932
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /note="hexamer: ATTAAA"
     polyA_site      1987
                     /gene="Slc38a4"
                     /gene_synonym="1110012E16Rik; 1700012A18Rik; Ata3; mATA3;
                     mNAT3; SNAT4"
                     /note="major polyA site"
ORIGIN      
        1 actctttggg aagccaatag agaagacgga agggtctccc ggtctaaccc ttgccgccac
       61 atccattgga ttccaacccg aagagggtag acagaaaggc gggaaagggc tgtgaggtca
      121 aatggacccc atggaactga acaacgtcag catcgaaccc gacggagaca gctgcagcgg
      181 ggacagtatt caggacagct acaccggcat ggaaaactcc gacaaggacg ccatgaacag
      241 ccaatttgct aatgaagatg ccgaaagtca gaagttcctg acaaatgggt ttttagggaa
      301 gaagaagcta gccgattacg cggatgagca tcaccctgga atgacttcct ttggaatgtc
      361 ctcatttaac ctgagcaacg ccatcatggg cagtgggatc ttaggcttgt cctatgccat
      421 ggccaacacc gggatcatcc tttttataat catgctgctt actgtggcaa tactctcgct
      481 ctactcggtt caccttttgc tgaagacagc caaggaagga gggtctctaa tctatgaaaa
      541 attgggcgag aaagcatttg gatggcctgg gaaaattgga gccttcatct ctattacaat
      601 gcagaacatt ggagccatgt caagctacct cttcatcatt aagtacgaac tgcctgaagt
      661 aatcagagca ttcatgggac ttgaagaaaa cactggggaa tggtacctca acggcaacta
      721 cctcgtctta tttgtgtccg tggggatcat cctcccgctc tctctcctta aaaatttagg
      781 ctaccttggc tacaccagtg gattttctct ctcctgcatg gtgtttttcg tcagtgtggt
      841 gatttacaaa aaattccaaa ttccctgccc tctgcctgct ctggatcaca acaacggaaa
      901 tctgacgttc aacaacacac ttccgattca catgatctcg ctgcctaatg actcggagag
      961 ctcgggtgtg aacttcatga tggattacgc tcaccacaac ccagctgggc tggatgagaa
     1021 gcaggtcgca ggccctcttc acagcaatgg cgtggagtac gaagcccagg gtgctgagaa
     1081 atgccaacca aaatactttg tgttcaattc ccggacggcc tatgcaatcc caatcctggc
     1141 ttttgctttt gtctgccacc ctgaggtcct tcccatctac agcgagctta aagatcgatc
     1201 ccgcagaaag atgcagacgg tgtccaacat ttccatctca ggcatgctcg tcatgtacct
     1261 tcttgcggcc ctctttggtt atctgagctt ctacggggac gttgaagacg agctgctgca
     1321 tgcttacagc aaggtctaca catttgatac ggctcttctc atggtgcgcc tggcagtcct
     1381 ggtggcagtg acactgaccg tgcccatcgt gctgttcccg atccgtactt cggtgatcac
     1441 actgctgttt ccaaggaaac ccttcagctg gctgaagcat ttcgggatcg ctgcaatcat
     1501 catcgcactc aacaacatcc tggtcatcct cgtgcctacc atcaaataca tctttggatt
     1561 cataggggct tcttctgcca ctatgctgat tttcattctt ccggctgcgt tttatctcaa
     1621 gctcgtcaag aaagaacctc taagatcacc ccagaagatt ggggctttgg tcttccttgt
     1681 gactggaatt attttcatga tgggaagcat ggcgctcatt atactcgact ggatctacaa
     1741 cccgccgaat cccaatcacc actaatcccg gggagacgcg tctccactgg aaacagctga
     1801 aattgtctga aggacatttt agttgtcttg attgggatgt tagtctgagg aattagcaag
     1861 attccaaaga cgtttttcta gctctatcat gggatacttg tggaagagaa aattatgggt
     1921 tttgttggga atggttttgt tgggaatggt gaaggatgca ttaaaaattc tgtggcacac
     1981 attttaaccc aggccgtgca gtgcagtgtg tgatgcccga gttgtgtttg cagcagctgt
     2041 gcaagctgaa gcctgttggc tgcgtgtgtt ggtcagcaga caatagcctg tccccccatg
     2101 gtcactccac ttctctccac ccccagatta acaggtaatt ctactctcag aacatcagac
     2161 aaagacctcc tggttggcga agctatcatc agttacggcc atctctcact ctacaccaac
     2221 actaagggtc ggttgactag ctgaggcagg gggatatctt gggagctgtc cctgtgagga
     2281 tcatgaatga cggttgccag tatagagtac ttcatttcaa tactcaagga atagtttgcc
     2341 caacctgctt attacaccga gttagtgaat tttcattctt tttatttttt ggtatggcaa
     2401 atgttcaaac atctcactaa acatagaggg gggttattta gtttatcatg aaacaactac
     2461 caaaaagtaa tggtttttaa catctgcctt ttcatgttgt ttctgatatc tttgttccac
     2521 tttgtctttg aacaaggctt cccctctcgt cttccgttct cactcttcgt aattttcaga
     2581 agaccacagt ccgtgtggag acacactacc cagtattgtt tgatacatct ctatttgata
     2641 aacattcagt gcaggaaact gtgattttgc tatatgtttg tgtacataat ctcattctgc
     2701 agttatcaga acgttgacat atgggacatt ggatttttat tttttacata tgtaggtttt
     2761 tttttcttca cagacaaaat gtttatatca tcagggtggg gcagggaatt aagctggtgg
     2821 gctcaaaaat ccatgggtac ttatctgtcc attggagaca tctaaaaatt aaagtcaaag
     2881 ttgtgcatag ttcagtaatg ctcttcactg tttacaagac tataatcatc tcagcaaagt
     2941 agcgaaggaa gggtttgtaa ataattttca gtgctaacaa tggtctttga atttaacatg
     3001 tctagaatag ggtttagttc attttagttt acatcggaac ttggtgacat tcatttgcca
     3061 ttaatagaac atcgtgtggt taggaataaa tgcaccaaca tgacccaaaa ccacattgct
     3121 cacatccatg gacgcttaca cgggatggag ttcagactcc gcccactgcc tagaatctct
     3181 ggcattgact tctttttttc aattactggt tgtatatttt acatttcagt aaaaagccaa
     3241 gtctgaaatg caagtatcct acaggtagtg atagtactgt cacaccaaag cagtttttca
     3301 acagtgtgcc taagaaacat atatttgttt actgtgtcat tttctggacc ttaagactat
     3361 acaatggtgt gctttgtgat agaaattgag cattactaga aactaccata acttcggagt
     3421 tattatcatt tgggagggaa aaaaatcacc aaataggatc tttaagatgt ctttctattt
     3481 tcattcatcc aagaaataaa tcaagataga aagcagaaag ggtgtgctgc aaatattaaa
     3541 tatattttat ctgaacatat taaatgtgaa tataaaagat taatccaaaa atattggaaa
     3601 cctgtgaaat ctgtacgtat ttcgaatctt tacacttaga gcagctaacc tggaagtatc
     3661 cacttgtgta gttagatatt caagagcaat atcacagtgc caaagacttc attcacacag
     3721 caccgatcat ttgtgtggcc gttttcagga ttagagttca cacagactcc agggcagata
     3781 ctcagaatac cgttttctgg taaatttaac ccatttgtaa acagatacaa attttatttt
     3841 cttacatcat ttataagacg gttcaatgta ctggggggat tttttttatt acagactgtg
     3901 tattggtata taataaataa acttttcaaa tg
//
