LOCUS       NM_001199217            2454 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 38, member 3 (Slc38a3),
            transcript variant 2, mRNA.
ACCESSION   NM_001199217
VERSION     NM_001199217.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2454)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2454)
  AUTHORS   Dolgodilina,E., Camargo,S.M., Roth,E., Herzog,B., Nunes,V.,
            Palacin,M. and Verrey,F.
  TITLE     Choroid plexus LAT2 and SNAT3 as partners in CSF amino acid
            homeostasis maintenance
  JOURNAL   Fluids Barriers CNS 17 (1), 17 (2020)
   PUBMED   32046769
  REMARK    GeneRIF: Choroid plexus LAT2 and SNAT3 as partners in CSF amino
            acid homeostasis maintenance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2454)
  AUTHORS   Dabrowska,K. and Zielinska,M.
  TITLE     Silencing of Transcription Factor Sp1 Promotes SN1 Transporter
            Regulation by Ammonia in Mouse Cortical Astrocytes
  JOURNAL   Int J Mol Sci 20 (2), 234 (2019)
   PUBMED   30634395
  REMARK    GeneRIF: the results demonstrate the regulatory role of Sp1 in
            regulation of SN1 expression and activity in ammonia-treated
            astrocytes and implicate altered Sp1 phosphorylation status in this
            capacity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2454)
  AUTHORS   Dong,W., Todd,A.C., Broer,A., Hulme,S.R., Broer,S. and Billups,B.
  TITLE     PKC-Mediated Modulation of Astrocyte SNAT3 Glutamine Transporter
            Function at Synapses in Situ
  JOURNAL   Int J Mol Sci 19 (4), 924 (2018)
   PUBMED   29561757
  REMARK    GeneRIF: This indicates a role for PKC in dynamically controlling
            the trafficking of SNAT3 transporters in astrocytes in situ.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2454)
  AUTHORS   Chan,K., Busque,S.M., Sailer,M., Stoeger,C., Broer,S., Daniel,H.,
            Rubio-Aliaga,I. and Wagner,C.A.
  TITLE     Loss of function mutation of the Slc38a3 glutamine transporter
            reveals its critical role for amino acid metabolism in the liver,
            brain, and kidney
  JOURNAL   Pflugers Arch 468 (2), 213-227 (2016)
   PUBMED   26490457
  REMARK    GeneRIF: SNAT3 is required for amino acid homeostasis and
            determines critical functions in various organs. Loss of Snat3
            cannot be compensated.
REFERENCE   6  (bases 1 to 2454)
  AUTHORS   Gu,S., Roderick,H.L., Camacho,P. and Jiang,J.X.
  TITLE     Identification and characterization of an amino acid transporter
            expressed differentially in liver
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3230-3235 (2000)
   PUBMED   10716701
REFERENCE   7  (bases 1 to 2454)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   8  (bases 1 to 2454)
  AUTHORS   Xia,Y., Welch,C.L., Warden,C.H., Lange,E., Fukao,T., Lusis,A.J. and
            Gatti,R.A.
  TITLE     Assignment of the mouse ataxia-telangiectasia gene (Atm) to mouse
            chromosome 9
  JOURNAL   Mamm Genome 7 (7), 554-555 (1996)
   PUBMED   8672141
REFERENCE   9  (bases 1 to 2454)
  AUTHORS   Mehdizadeh,S., Warden,C.H., Wen,P.Z., Xia,Y.R., Mehrabian,M. and
            Lusis,A.J.
  TITLE     The glutathione peroxidase gene, Gpx1, maps to mouse chromosome 9
  JOURNAL   Mamm Genome 7 (6), 465-466 (1996)
   PUBMED   8662233
REFERENCE   10 (bases 1 to 2454)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ183778.1, AK002607.1 and BC054846.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010678.1, SRR1660821.171194.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CJ183778.1         28-42
            16-1807             AK002607.1         2-1793
            1808-2454           BC054846.1         1951-2597
FEATURES             Location/Qualifiers
     source          1..2454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.69 cM"
     gene            1..2454
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /note="solute carrier family 38, member 3"
                     /db_xref="GeneID:76257"
                     /db_xref="MGI:MGI:1923507"
     exon            1..96
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            97..246
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1663
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /note="N system amino acids transporter NAT-1; N-system
                     amino acid transporter 1; system N amino acid transporter
                     1; Na(+)-coupled neutral amino acid transporter 3"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid transporter 3"
                     /protein_id="NP_001186146.1"
                     /db_xref="CCDS:CCDS23503.1"
                     /db_xref="GeneID:76257"
                     /db_xref="MGI:MGI:1923507"
                     /translation="MEIPRQTEMVELVPNGKHLEGLLPVGVPTTDTQRTEDTQHCGEG
                     KGFLQKSPSKEPHFTDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLL
                     TAVALLSSYSIHLLLKSSGIVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYL
                     YIIKSELPLVIQTFLNLEKPASVWYMDGNYLVILVSVTIILPLALMRQLGYLGYSSGF
                     SLSCMVFFLIAVIYKKFQVPCPLAHNLANATGNFSHMVVAEEKAQLQGEPDTAAEAFC
                     TPSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKRKMQHISNLSIAVMYVMY
                     FLAALFGYLTFYDGVESELLHTYSKVDPFDVLILCVRVAVLIAVTLTVPIVLFPVRRA
                     IQQMLFQNQEFSWLRHVLIATGLLTCINLLVIFAPNILGIFGIIGATSAPCLIFIFPA
                     IFYFRIMPTDKEPARSTPKILALCFAAVGFLLMTMSLSFIIIDWVSGTSQHGGNH"
     exon            247..325
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            326..441
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            442..515
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            516..608
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            609..690
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..773
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            774..832
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1003
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1083
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1184
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1309
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1454
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1558
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..2442
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1808
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
     regulatory      2423..2428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /note="hexamer: TATAAA"
     polyA_site      2442
                     /gene="Slc38a3"
                     /gene_synonym="0610012J02Rik; D9Ucla2; mNAT; Nat1;
                     Slc38-3; Sn1; Snat3"
                     /note="major polyA site"
ORIGIN      
        1 gctgcagttg ccgctgcagc cctgcgctca gcctggagca gagcggatct caccctctgg
       61 aacggagtgt gctgaacgtg cccaccacga ggccagatac ctgactgtca gtgtgagagc
      121 agtgttctgg ggtggtctct gagccatgga gataccccga cagacagaga tggtggagct
      181 ggtgcccaat ggcaaacact tggaggggct tctaccagtg ggcgtgccta caacagacac
      241 ccagaggact gaagacaccc aacactgtgg agagggcaag ggcttccttc agaagagtcc
      301 cagcaaggag ccacacttca ccgatttcga ggggaagaca tcatttggga tgtcagtgtt
      361 caatctcagc aacgccatca tgggcagtgg aattctgggg ctcgcctacg ccatggccaa
      421 tacgggcatc atccttttcc tgttcctgct tacagcggtc gccctgttgt ctagctattc
      481 catccacctg ctcctcaagt cttcggggat tgtgggcatc cgtgcctacg agcagttggg
      541 ctaccgtgcc tttgggaccc cggggaagct ggcagcagcc ctggccatta cgcttcagaa
      601 cattggagcc atgtccagct acctatacat catcaagtct gaattgcctc ttgtcataca
      661 gaccttcctg aatctggaga agccggcctc ggtgtggtac atggatggca actaccttgt
      721 gatcctggtt tctgtcacca tcattctgcc cctagcactg atgcgacagc tcggctacct
      781 gggttactcc agtggcttct ctctcagctg catggtgttc ttcttgatcg cagtcatcta
      841 taagaagttc caagttcctt gcccattggc acacaacctg gccaatgcca ccggcaactt
      901 cagccacatg gtggtggcag aggagaaggc acagctgcag ggcgagcctg acactgctgc
      961 tgaggccttc tgtaccccaa gctacttcac cctcaactca cagacagcat acaccatccc
     1021 catcatggct ttcgccttcg tctgccaccc tgaggtgctg cccatatata cagagctcaa
     1081 ggacccctcc aagaggaaga tgcagcacat ctccaacctg tccattgctg tcatgtatgt
     1141 catgtacttc ctggccgccc tcttcggcta cctcaccttc tacgacgggg tggagtcgga
     1201 gctgctgcac acctacagca aggtggaccc gtttgatgtg ctgatcttgt gtgtgcgagt
     1261 ggccgtgctg atagcggtca cacttacagt tccgattgtt ctgttcccgg tacgacgtgc
     1321 tatccagcag atgctgtttc agaaccagga gttcagctgg ttgcggcacg tgctcattgc
     1381 cactggcctg cttacgtgca tcaatctgct ggttatcttc gcccccaaca tcttgggcat
     1441 atttgggatc attggtgcca catctgctcc gtgcctcatc ttcatcttcc ctgccatctt
     1501 ctacttccga atcatgccca ctgacaagga gcctgcaaga tccaccccta aaatcctggc
     1561 cctttgtttc gctgcggttg gcttcctgct gatgaccatg agcctgagtt tcatcatcat
     1621 tgactgggtc tctgggacca gccagcatgg aggaaaccat taggatgacc tccatcttgt
     1681 cctgtctatt catcctagca cctcctgccc tctctctctc cagcccctgc tcccagccag
     1741 gggctaagta aggggagaga gaccggggag aaagactctg taaatactat ggcctctggc
     1801 tccacccata tcctctccgt tggaaggttt ttgttgaaga gccaggacca aggcccatgg
     1861 accacccctg ctgggctcca gagctgcagg ggcttcctgc actaggaaca gggtggggct
     1921 gtcatcgcct tagatcccat gaaaccctcc atcctcctcc agcagctgtg cacactgagg
     1981 cctagcggcc acctcctgag gtcacacagg cagtaggggc acacagagcc agaaaaccca
     2041 ggcctgaaga catcccctag tcctgctgag agaccacagt ctaaacccaa gggctcatcc
     2101 ctgatctcca gccccgtttc caacacttgg gccccaaatc ttgggtactc ttgtcttctt
     2161 ccctctcctc cataggggac cctatcccat cccatatttg gggtcagcag gttctgctga
     2221 ggatggggct ggtatgcacc ccaaaagatc cctgctgtgg gccttcacag ttcaggggag
     2281 gctgggactc ccacacctca cgcctgggcc atgacttaca ttccactgct gggagaaggg
     2341 aggccaggcc cagagtagcc tgcccttggg agtcaaagac cctagaagcc aggctggcac
     2401 aggaatgggg aggcttgcct tttataaata ttatacacaa gaaaaaaaaa aaaa
//
