LOCUS       NM_175121               4658 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus solute carrier family 38, member 2 (Slc38a2),
            transcript variant 1, mRNA.
ACCESSION   NM_175121
VERSION     NM_175121.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4658)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4658)
  AUTHORS   Zhang,W., Miura,A., Abu Saleh,M.M., Shimizu,K., Mita,Y., Tanida,R.,
            Hirako,S., Shioda,S., Gmyr,V., Kerr-Conte,J., Pattou,F., Jin,C.,
            Kanai,Y., Sasaki,K., Minamino,N., Sakoda,H. and Nakazato,M.
  TITLE     The NERP-4-SNAT2 axis regulates pancreatic beta-cell maintenance
            and function
  JOURNAL   Nat Commun 14 (1), 8158 (2023)
   PUBMED   38071217
  REMARK    GeneRIF: The NERP-4-SNAT2 axis regulates pancreatic beta-cell
            maintenance and function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4658)
  AUTHORS   Guo,C., You,Z., Shi,H., Sun,Y., Du,X., Palacios,G., Guy,C.,
            Yuan,S., Chapman,N.M., Lim,S.A., Sun,X., Saravia,J., Rankin,S.,
            Dhungana,Y. and Chi,H.
  TITLE     SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour
            immunity
  JOURNAL   Nature 620 (7972), 200-208 (2023)
   PUBMED   37407815
REFERENCE   4  (bases 1 to 4658)
  AUTHORS   Du,C., Xu,H., Cao,C., Cao,J., Zhang,Y., Zhang,C., Qiao,R., Ming,W.,
            Li,Y., Ren,H., Cui,X., Luan,Z., Guan,Y. and Zhang,X.
  TITLE     Neutral amino acid transporter SLC38A2 protects renal medulla from
            hyperosmolarity-induced ferroptosis
  JOURNAL   Elife 12, e80647 (2023)
   PUBMED   36722887
  REMARK    GeneRIF: Neutral amino acid transporter SLC38A2 protects renal
            medulla from hyperosmolarity-induced ferroptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4658)
  AUTHORS   Shen,L., Yu,Y. and Karner,C.M.
  TITLE     SLC38A2 provides proline and alanine to regulate postnatal bone
            mass accrual in mice
  JOURNAL   Front Physiol 13, 992679 (2022)
   PUBMED   36213239
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4658)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4658)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4658)
  AUTHORS   Hyde,R., Peyrollier,K. and Hundal,H.S.
  TITLE     Insulin promotes the cell surface recruitment of the SAT2/ATA2
            system A amino acid transporter from an endosomal compartment in
            skeletal muscle cells
  JOURNAL   J Biol Chem 277 (16), 13628-13634 (2002)
   PUBMED   11834730
  REMARK    GeneRIF: Insulin promotes the cell surface recruitment of the
            SAT2/ATA2 system A amino acid transporter from an endosomal
            compartment in skeletal muscle cells.  (ATA2 or SAT2)
REFERENCE   9  (bases 1 to 4658)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4658)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109201.12.
            
            On Sep 22, 2017 this sequence version replaced NM_175121.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048178.1, AK031615.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AC109201.12        86684-87004         c
            322-524             AC109201.12        85891-86093         c
            525-606             AC109201.12        85458-85539         c
            607-722             AC109201.12        85198-85313         c
            723-796             AC109201.12        82712-82785         c
            797-889             AC109201.12        82492-82584         c
            890-971             AC109201.12        82289-82370         c
            972-1054            AC109201.12        80832-80914         c
            1055-1113           AC109201.12        80557-80615         c
            1114-1272           AC109201.12        80293-80451         c
            1273-1352           AC109201.12        79794-79873         c
            1353-1453           AC109201.12        79590-79690         c
            1454-1578           AC109201.12        78955-79079         c
            1579-1723           AC109201.12        78573-78717         c
            1724-1821           AC109201.12        78385-78482         c
            1822-4658           AC109201.12        74668-77504         c
FEATURES             Location/Qualifiers
     source          1..4658
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 52.6 cM"
     gene            1..4658
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /note="solute carrier family 38, member 2"
                     /db_xref="GeneID:67760"
                     /db_xref="MGI:MGI:1915010"
     exon            1..321
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..524
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..1923
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium-coupled neutral amino acid transporter 2; system A
                     transporter 1; amino acid transporter A2; system A amino
                     acid transporter 2; system N amino acid transporter 2;
                     amino acid system A transporter; sodium-coupled neutral
                     amino acid symporter 2"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid symporter 2
                     isoform 1"
                     /protein_id="NP_780330.2"
                     /db_xref="CCDS:CCDS27778.1"
                     /db_xref="GeneID:67760"
                     /db_xref="MGI:MGI:1915010"
                     /translation="MKKTEMGRFNISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADV
                     DPENQNFLLESNLGKKKYETDFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIA
                     LFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGHKAYGLAGKLAASGSITMQNIG
                     AMSSYLFIVKYELPLVIKALMNIEDTNGLWYLNGDYLVLLVSLVLILPLSLLRNLGYL
                     GYTSGLSLLCMIFFLIVVICKKFQIPCPVEAALVANETVNGTFTQAALALAFNSTADD
                     ACRPRYFIFNSQTVYAVPILTFSFVCHPAVLPIYEELKSRSRRRMMNVSKISFFAMFL
                     MYLLAALFGYLTFYGHVESELLHTYSEIVGTDILLLVVRLAVLVAVTLTVPVVIFPIR
                     SSVTHLLCPTKEFSWLRHSIITVTILSFTNLLVIFVPTIRDIFGFIGASAAAMLIFIL
                     PSAFYIKLVKKEPMRSVQKIGALCFLLSGIVVMIGSMGLIVLDWVHDASAAGGH"
     exon            525..606
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            607..722
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            723..796
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..889
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            890..971
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1054
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1113
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1272
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1352
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1453
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1578
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1723
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1821
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..4658
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4642..4647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /note="hexamer: AATACA"
     polyA_site      4658
                     /gene="Slc38a2"
                     /gene_synonym="5033402L14Rik; ATA2; mKIAA1382; SAT2;
                     SNAT2"
                     /note="major polyA site"
ORIGIN      
        1 gcgctcggga agctgctcca caccgcgcca cgccgtcgcc cgcgccgcta cccctcaatc
       61 tccgccggag gatcgtgatc gccattcccc gctctttttt ttcatttttc tttaataatt
      121 aaagaggaaa aaaaaatcca cctcttctgc ctgttgttgg attacgggga aattttaaaa
      181 attttttatt aaaaaaaata aaagaaaagg actccgtcac tgttacattt tttccctcgt
      241 tttacaattc tggtgtgtga ccgagacagc ccacgggaga cgctgccgtg aggtgggcca
      301 gctcgcaggg agagcaccga ggcagcctcg agggccagtg cgccgccaag gacaaaagga
      361 agcccgcgcc gcgagcgagc cgcacaccgt ccgtccctcc cgagcagcat gaagaagacc
      421 gaaatgggaa ggttcaacat ctccccggat gaggacagca gcagttacag ctccaacagt
      481 gacttcaact actcataccc caccaagcag gctgctctga aaagccatta tgccgacgtg
      541 gatcccgaaa accagaactt tttacttgaa tcaaatttgg ggaagaagaa gtacgaaaca
      601 gactttcatc caggtactac ttcctttgga atgtcagtat ttaatctgag caatgcgatt
      661 gtgggcagtg gaatccttgg gctttcttat gccatggcta atactggaat tgctcttttt
      721 ataattctct tgacgttcgt gtcaattttt tcgctatact ccgtccatct cctcctcaag
      781 actgccaacg aaggaggatc tttattgtac gaacagttgg gacataaggc gtatggtctg
      841 gctggaaagc tagcagcctc cggatcgata accatgcaga acattggggc tatgtcaagc
      901 tacctcttca tagtgaaata tgagttacct ttggtgatca aggcattaat gaacattgaa
      961 gatacaaatg ggttgtggta tctgaacggt gactatctgg tccttctggt gtcccttgtc
     1021 ctcattcttc cattgtcact gctgagaaat ctaggatact tggggtacac cagcggcctc
     1081 tctctgctct gtatgatatt tttcctgatc gtggtgattt gcaagaagtt tcagatccct
     1141 tgccccgtgg aagctgcttt ggtggccaac gaaactgtga acggcacctt tacccaggca
     1201 gcgttggcgt tggcattcaa tagcaccgca gacgatgctt gcaggccacg ctatttcatc
     1261 ttcaactcgc agactgtgta tgcagtaccc atcctgacgt tttcctttgt ctgccatccc
     1321 gctgttcttc ccatctacga agagctaaag agccgcagcc ggagacggat gatgaacgtg
     1381 tccaagattt ccttcttcgc catgtttctg atgtacttgc tcgctgctct ctttggatac
     1441 ctgacctttt acggacacgt ggaatcggaa ttgctgcata cctactccga gatcgtgggg
     1501 actgacattc ttctccttgt tgtccgattg gctgtgctgg tggctgtcac cctcacggtc
     1561 ccagtagtta ttttccctat ccggagttcc gtcactcact tactgtgtcc cacaaaagag
     1621 ttcagctggc tccggcacag catcatcacc gtgaccatct tgtccttcac caatttgctc
     1681 gtcatctttg tccccactat tagggacatc ttcgggttca ttggggcgtc ggcggctgcc
     1741 atgctgatct ttatcctccc gtctgccttc tacatcaagt tagtgaagaa ggaaccaatg
     1801 agatccgtgc aaaagattgg ggctctgtgt tttctcctga gtggcatagt ggtgatgatt
     1861 ggaagcatgg gcttgattgt gctggattgg gtccacgatg cctccgctgc aggtgggcac
     1921 taacagctcc cctcacgctg gatggtccat ccgcctgcct accgtgttga gtcgactcag
     1981 cctgctcagt ctcacctgat gcgtcccggt cacttccttt tgaagtgcag tctactcgct
     2041 ggttcttctg gattcagaat aagtgaactt ttctttctct ttggtttttt gtttttgttt
     2101 ttgttttttt tttttaagaa gctatctgtg tgttagggaa tggatagtac gacaaaacca
     2161 cgagccttgg gttaagggaa gtgacaagtt tattccattc cagagaatgg acgaactttt
     2221 aactttttat caaagccaca tgtttggctg tctcattgtt taacttggat attttatgat
     2281 tttacttgaa tgtgcctaac ggaaccattc gatgtgagaa acacttctta atttacagca
     2341 aagtattgaa ataagcattg agaaaataca cttatttttt gtaccaaaaa atactttaaa
     2401 agacctcaga agcactattt tactttgaag aaattgcatt tttgaacttt actcagaacc
     2461 agttgtcaat aaactccatc aaacaatttc attgatattt aaaaatgaat attagtatta
     2521 tgaaattatt tgcctttttt gtgggcatta taagccaaat acttttttac ccaaaaatca
     2581 ttttcgggaa aaatgttaca aaaaattgca ccatggatta gcatggtttt gtttttgttc
     2641 attcagattc atttgaagga tagttggtcg ttgctgcacc aagtcaggtg aactccgttc
     2701 atcgctttct ttgcctccaa ataattggtt cattacaact aaaatgttta tgtcttcaat
     2761 tagtctggga aacagtgccg agatttctgt aggaaatgaa ataactgatt ttgaggtacc
     2821 aaatagtgca attgggtaag acagggttta ttcagttgca tcggtctcca gagttacagt
     2881 gtcagctctg ggtcgtgctt tttgggccca tcctttaaaa ccttgcttcc aaaagtgaaa
     2941 acgggcgttt gatggcaata ggccaaaact gtccaataga gagcagaact tccaaaggct
     3001 catctactgg aagcgtggtt tacttgacaa cacgcagctc agtggtgctc ctgctgtgtt
     3061 ggcagtccag gctgcaccat gcaggtacac tgcaggccct cctcagaaag gtttctcatg
     3121 cagcaagctt cctaaaaact cgaactggat catcatctca ttgaatgaga tgcagaatca
     3181 atttgtttac atcgaacaaa tgatcagcta ggggaggcgg gacaagctgc ctgtcctcgg
     3241 tgtctggtcc agccgcatgc ttacctttcc atttcaattc cagttaaacg tgaagacatt
     3301 acttggaagc ttggctttaa gagcacattt actgtctgtt aacggtgtat ggtgaacata
     3361 tttttaaata atgaggtact ttgctcatca agcgtattgt ctaaggtcta attaatatac
     3421 ataattccat taagtggtgg agggaagcaa gtagaatcgt caattggtta tctggctctt
     3481 gaaactacat gttttgagtt tgaggcaggg gccagaagaa atgtgacaca catggttttt
     3541 gttacagtct tgtattgtat atgtgactga attcataggc aaggtatgtc tgccattaaa
     3601 gactcttgca gactggaaga cgtctggtag tgctacatac attgggtaca accaatggtc
     3661 agttctgtcc caagatgaaa cccctgggga ctgtgtagac gcaaaggcag tgagaagaca
     3721 ctcccccatg ctgcttactt gtcatcaagt ccagaacctc acctgctcgt caaagactct
     3781 gcacctccgc ttgaagtcct ggaaagagtc ctggctacca tatgccaggg gatgctgaga
     3841 ggcaggcatc ctgagaggtg ccatgacaac caggatcctg ttcacagccg atcagtgtgg
     3901 agagacttcc caaacctcct gtgagggagc aaggttccaa atgaatttca ggccaaattc
     3961 caaagcttgg ggctgtttta cccgccttga ggttcctgaa ctgaattctc agccttgagc
     4021 agtcttcagt attaaaacca ctgtcccgtc acctcaattc acatcgctgt cttccatgga
     4081 acgtttcaat aactgtactg ttatttatag agcagcatta atccattaaa gctaacctat
     4141 ttttcaatat ttatgataaa ctgtacatat attgtccata tgtatttgta aatagattgt
     4201 atatactgtt ggaattgggt tcaagtgtat atattcccct aagtttctta actgcatttt
     4261 gatgaattca cattatatat gtctccaaat tacttgtaca gagaattcaa tcttaagaaa
     4321 ttgacattgt gtataatact aaaattgaaa ataacttgtt taaattgtat ttgcaataaa
     4381 ctggttggac atcaacttaa gttcagataa tctaaagctt taaatgaggt ctaaattttc
     4441 aaaatgcagt agctaccaca tggctatctg gtaacatgtc aagtgtgatc tcaatgaaag
     4501 aggactcctt gtatgtatat agtgtaaatg tcccagctgt actgttagag gccaacatgc
     4561 ctctgtggcc tgttggcaga gagtaaatgc tacaccggtt tcaatgaaac aatgtatgtt
     4621 tgttttaact gaactaaaat aaatacatga ttaatcaa
//
