LOCUS       NM_024249               4592 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 38, member 10 (Slc38a10),
            transcript variant 1, mRNA.
ACCESSION   NM_024249
VERSION     NM_024249.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4592)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4592)
  AUTHORS   Lindberg,F.A., Nordenankar,K., Forsberg,E.C. and Fredriksson,R.
  TITLE     SLC38A10 Deficiency in Mice Affects Plasma Levels of Threonine and
            Histidine in Males but Not in Females: A Preliminary
            Characterization Study of SLC38A10-/- Mice
  JOURNAL   Genes (Basel) 14 (4), 835 (2023)
   PUBMED   37107593
  REMARK    GeneRIF: SLC38A10 Deficiency in Mice Affects Plasma Levels of
            Threonine and Histidine in Males but Not in Females: A Preliminary
            Characterization Study of SLC38A10[-/-] Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4592)
  AUTHORS   Lindberg,F.A., Roman,E. and Fredriksson,R.
  TITLE     Behavioral profiling of SLC38A10 knockout mice using the
            multivariate concentric square fieldTM test
  JOURNAL   Front Behav Neurosci 16, 987037 (2022)
   PUBMED   36620864
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4592)
  AUTHORS   Lindberg,F.A., Nordenankar,K. and Fredriksson,R.
  TITLE     SLC38A10 Knockout Mice Display a Decreased Body Weight and an
            Increased Risk-Taking Behavior in the Open Field Test
  JOURNAL   Front Behav Neurosci 16, 840987 (2022)
   PUBMED   35677577
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4592)
  AUTHORS   Tripathi,R., Aggarwal,T., Lindberg,F.A., Klemm,A.H. and
            Fredriksson,R.
  TITLE     SLC38A10 Regulate Glutamate Homeostasis and Modulate the
            AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells
  JOURNAL   Front Cell Dev Biol 10, 854397 (2022)
   PUBMED   35450293
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4592)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4592)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   8  (bases 1 to 4592)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
REFERENCE   9  (bases 1 to 4592)
  AUTHORS   Bassett,J.H., Gogakos,A., White,J.K., Evans,H., Jacques,R.M., van
            der Spek,A.H., Ramirez-Solis,R., Ryder,E., Sunter,D., Boyde,A.,
            Campbell,M.J., Croucher,P.I. and Williams,G.R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Rapid-throughput skeletal phenotyping of 100 knockout mice
            identifies 9 new genes that determine bone strength
  JOURNAL   PLoS Genet 8 (8), e1002858 (2012)
   PUBMED   22876197
REFERENCE   10 (bases 1 to 4592)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY308707.1, BC088811.1, AK032245.1 and BY630861.1.
            
            On Sep 18, 2009 this sequence version replaced NM_024249.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032245.1, SRR1660821.191605.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                BY308707.1         2-65
            65-1156             BC088811.1         1-1092
            1157-4572           AK032245.1         1081-4496
            4573-4592           BY630861.1         407-426
FEATURES             Location/Qualifiers
     source          1..4592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.96 cM"
     gene            1..4592
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /note="solute carrier family 38, member 10"
                     /db_xref="GeneID:72055"
                     /db_xref="MGI:MGI:1919305"
     exon            1..372
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..3546
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative sodium-coupled neutral amino acid transporter 10;
                     novel amino acid transporter protein; amino acid
                     transporter SLC38A10"
                     /codon_start=1
                     /product="solute carrier family 38 member 10 isoform 1"
                     /protein_id="NP_077211.4"
                     /db_xref="CCDS:CCDS25728.1"
                     /db_xref="GeneID:72055"
                     /db_xref="MGI:MGI:1919305"
                     /translation="MTAASTSKWGLITNVVNSIVGVSVLTMPFCFKQCGIVLGALLLV
                     FCSWMTHQSCMFLVKSASLSKRRTYAGLAFHAYGKAGKMLVETSMIGLMLGSCITFYV
                     VIGDLGSNFFAPLLGLQVTRTVRVFLLFAVSLFIVLPLSLQRNMMASIQSFSAMALLF
                     YTVFMFVIVLSSLKHGLFSGQWLRQVSYIRWEGVFRCVPIFGMSFACQSQVLPTYDSL
                     DEPSVKTMSSIFASSLNVVTAFYVMVGFFGYVSFTDATTGNVLIHFPSNPVTEMIRVG
                     FVMSVAVGFPMMILPCRQALNTLLFEQQQKDGTFAAGGYMPPLRFKVLTLSVVFGTMV
                     GGVMIPNVETILGFTGATMGSLICFICPALIYKKAHKNAPSAQVVLWVGLGILVVSTL
                     TTLSVTEEAPLDLTQEARSGHRGDAEGAMKVEAARLSVQDPVVVVAEDSQEKLKPAED
                     KEVLEQAQIKGPVDVPGGEAPKEKQEAAQLDRPGQGIAVPMGEAHRHEPPIPHDKVVV
                     DEGQDQEGPEEKKPPPRLPDEGDPAGRGQGAPPLPESEKEKQEPERGGEGKRPGQVLA
                     VGETEHPQKVPEANGQPPVQPRKEDSRPGNRDPQPAAQARDSVELKALAADDGREPAQ
                     KAGGALWKPVESAAESDAGGKAGLPVQRPEAAEQREKKEAEQQGGDQAGSKLEAEIKK
                     LVAEAGRAEMLDHAVLLQVIQEQQVQQKRLLDQQEKLLAVIEEQHKEIRQQRQEGEED
                     KPKPADVQPEPGVAVLRGQEEEAEHAGETLGDDPSQPLQPVLGAPRGRPAPSQDMGQH
                     LPGEVKVLPGRDLADLPAGGSETEPQGAPIDLREDPKAAIKAAGAGKELVPGDLEAVH
                     KAAPPEVPKSPEKQVAKAVAGQRQDVFGEGSEERKETGKEAMAPGADTQKEAVQPLVG
                     AEAKDTKSRQSGPTKAPVQTQAKFHPEPQAIFDTGQGSHPEVRSEAPRAVHIPPEEQH
                     KGKGGAAIQEAKQRPDPNSGPKLAVPAGQKPENAKPNRDLKVQAGSDLRRRRRDLASH
                     PEQELAPKDGVIISFNSLPNVQVNDLRSALDTQLRQAAGAALQVVHSRQIKQLSGDLE
                     EA"
     exon            373..490
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            491..536
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            537..630
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            631..774
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            775..899
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1002
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1185
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1297
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1404
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1561
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1729
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..2200
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2305
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2329
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2506
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..4592
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4075..4080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4093
                     /gene="Slc38a10"
                     /gene_synonym="1810073N04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcacttcct ggtagagtag gctccgaagg cggaagtttg ggtgccggag gcagcgaagc
       61 ggagctgagg tgttgctagc gttgcctgcg gcgcttccgg gttcccgctt cactctgggg
      121 aggcggaggc gggaacctgg aaccatggct atgaggctgc tgcggagcct ggcagggtct
      181 ggaggctgac ctcgcgacgc ctgtccgcgg ccccccctgc ttcaggttta gggttatcta
      241 gggtcgctct gtcctggtcc ctagaccctc aaaatgacgg ccgcctccac ctccaagtgg
      301 gggctgatca cgaacgtggt gaacagcatc gtgggcgtca gcgtgctcac catgcctttc
      361 tgcttcaagc agtgtggcat tgtcctgggg gccctgctcc tggtcttctg ctcctggatg
      421 acacaccagt cttgcatgtt cttggtgaag tcggccagcc tgagcaagag gaggacctat
      481 gctggcctgg cgttccacgc ctacggcaag gccgggaaga tgctggtgga gaccagcatg
      541 attgggctga tgctgggatc ctgcattacc ttctatgtcg tgatcggtga cttggggtcc
      601 aacttctttg ctccgctgct tggattacag gtgaccagga ctgtccgtgt gttcctgctc
      661 ttcgcagtgt ccctgttcat tgtgctcccg ctcagcctgc agagaaacat gatggcctct
      721 atccagtcct tcagtgccat ggcgctcctc ttctacaccg tcttcatgtt cgtgattgtg
      781 ctgtcctccc ttaaacatgg cctctttagt gggcagtggc tgcgacaggt cagctacatt
      841 cgctgggaag gtgttttccg ctgtgtcccc atctttggca tgtcctttgc ctgtcagtcc
      901 caggtcctgc ccacctatga cagcctggac gagccatcag tgaagaccat gagctccatc
      961 tttgcctcct ccctcaacgt ggtcaccgcc ttctatgtca tggtggggtt ttttggttac
     1021 gtcagcttca ctgatgccac cacaggcaat gtgctgatcc acttcccctc caacccggtg
     1081 acagagatga tccgagtggg cttcgtgatg tctgtggctg tgggcttccc catgatgatt
     1141 ctgccgtgca ggcaggcctt gaacacactg ctgtttgagc agcagcaaaa agatggaacc
     1201 tttgctgcag gaggctacat gcccccactc cggtttaaag tcctcaccct ctcggtggtg
     1261 tttggaacca tggttggtgg ggtcatgatc cccaatgtgg aaaccatcct tggcttcaca
     1321 ggagcaacga tggggagcct catctgcttt atctgcccgg ctctgatcta taagaaagcc
     1381 cacaagaatg ccccctcagc ccaggtggtg ctctgggtcg gcctgggcat cctcgtggtc
     1441 agcacactca ccaccctctc tgtgaccgaa gaagctcctc tggacttgac gcaagaagct
     1501 cgcagcggcc accgaggaga tgctgagggc gcaatgaagg tggaggcagc tcggctatca
     1561 gtccaggatc ccgttgtagt tgttgctgag gatagccaag agaagctaaa gccagcagag
     1621 gacaaagagg tactggagca ggcccagatc aagggtcctg tagatgtgcc tggcggggaa
     1681 gctcccaagg agaagcagga agccgcacag ctggatcgcc ccggccaagg tattgctgtc
     1741 cctatgggtg aggcccatcg ccatgagcct cccatccctc atgataaagt ggtggtggat
     1801 gaaggccagg accaagaagg gccagaggag aaaaagccac ctcccaggct cccagatgaa
     1861 ggagaccctg caggcagggg tcaaggggca ccacctctgc ctgagtcaga gaaggagaag
     1921 caggaacctg agagaggagg ggaaggaaag agacccgggc aagtcctggc agtaggagaa
     1981 actgaacatc ctcagaaggt tccagaagca aatggccagc cacctgtgca gcccaggaag
     2041 gaagattcca ggccaggaaa tagggatccg cagccagctg cccaggccag ggactctgtg
     2101 gagctgaagg ctctggcagc agatgacggc agggagcctg cacagaaggc tggaggcgcc
     2161 ctgtggaagc ccgtggagag tgctgctgag agcgatgctg gtgggaaggc gggcctccct
     2221 gtgcaaaggc cggaggctgc agagcagagg gagaagaagg aggctgagca acagggtgga
     2281 gaccaggcgg ggagcaagct ggaagctgaa attaaaaagc tagtagcaga agctgggagg
     2341 gcagagatgc tggaccatgc cgtgctgcta caggtgatcc aagagcagca ggtgcagcag
     2401 aagcgcctcc tggaccagca ggaaaagctg ctcgcagtga ttgaggagca gcacaaggag
     2461 atccggcagc agcgacagga gggcgaggaa gacaagccta agcctgcaga cgtgcagcca
     2521 gagcctgggg tggctgtact ccgaggacag gaggaggagg ctgagcacgc tggggagaca
     2581 ctgggagatg acccttcaca gcctttgcaa cccgtgcttg gagctcctag gggtcgcccc
     2641 gctccatccc aagacatggg ccagcacctc ccaggggaag tcaaggtgct gccaggcaga
     2701 gaccttgctg accttcctgc tggtggctct gaaacagagc cccagggggc cccgattgat
     2761 ctgagagaag acccgaaagc tgccatcaag gcggctggag ctgggaagga gctggtccca
     2821 ggggacttgg aagcagtgca caaggcagcc cctcctgagg tacccaagag tccagagaag
     2881 caggttgcca aggcagttgc cgggcagcgc caagatgtct ttggtgaagg ctccgaagaa
     2941 aggaaagaaa ctggaaagga agcaatggcc cctggtgctg atactcagaa agaggctgtc
     3001 cagcccttgg taggagcaga agctaaggac acaaaatcca ggcagtcggg acccaccaag
     3061 gccccagttc agacccaagc caagtttcac ccagaacccc aggccatctt tgacacaggt
     3121 cagggttctc acccagaggt gagaagtgag gccccccgag cggttcacat acctcctgag
     3181 gagcagcaca aaggaaaagg gggtgccgcc atccaggagg caaagcagag accagatcct
     3241 aactctgggc ccaaactagc tgtgcctgcg ggtcagaagc cagagaatgc caaacccaac
     3301 cgagacctaa aagtgcaggc tggctctgac ctgcggagga gacggcggga tctggcctct
     3361 catccagagc aggagctggc tccaaaggat ggcgtcatca ttagctttaa ctccctccct
     3421 aatgttcagg tgaacgacct ccgcagtgct ctggacaccc agctccgcca ggctgcaggg
     3481 gctgcgttgc aagtggtaca cagccgacag attaaacagt tgtctggaga tctggaggaa
     3541 gcctgagggc ctggtcaggg aaaggctgcc actagacatt ggacggcagc tggtgttctc
     3601 tggtgccacc ctgattggag gccacgttct tatgttccca gggactggta tctaagtccc
     3661 tcatgatgag ttgtgaaagt ctaacctgcc accccacccc agacatcact tgctccaagg
     3721 ctacaccaaa gcactcacta gcccgattat ggtttgggtt ttgaggcagc ccaggaaaga
     3781 cagtgctaag gttcagctcc gacgcttgtc tgttcagact cacggtctgg ccagaagcag
     3841 tgctgacagc atggcaggca actttgaagt tgccagtctt cctctaactt gcaacctgtg
     3901 acagccagat ttcactgact ccataaggtg ggaaacctac aacaggcatg tctgtctgcc
     3961 ctggggtggc cggggggtgg ggggtatgac ttgacttggg ctggggaaag aggcacacag
     4021 ctcccctggt ttttatcacc cacattcttc tgaaggctga ttatgaaaca aaaaaataaa
     4081 acgccactga caagtctcga gtcgagttgg tttacctgca ggaaaacaca ttcagggtcc
     4141 tggacgacac cagacaggct ggaggtcacg gggacacgtg ccccggccga gtgcagctgg
     4201 gagaccaaca ggctcccatg ctgatccctg ttgtagggag gaggttgcac ggtgagtaca
     4261 ggcttgccac cagcaagccc tgggatgtct catttgctgt tctgtatctg tgtggcctca
     4321 gacccagtcg agctgccctt tgtcagccag tactgctgcc agggcatgcc cctgttgtct
     4381 ttgagcagag aacaaggtta tgttttgtca ctcttttgtc cagtaaggag attgagggac
     4441 aataacctgg tttgtcccca agccctggaa cgaagggcct gaaggaccag gagcctcagt
     4501 ggggtcctgt ttggaccagg ccatgcccta gttagtgtgc acgttctgca cctcttgaaa
     4561 tatatttatt acaattaaat tttagactca tg
//
