LOCUS       NM_001145960            4111 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus solute carrier family 37 (glycerol-3-phosphate
            transporter), member 2 (Slc37a2), transcript variant 1, mRNA.
ACCESSION   NM_001145960
VERSION     NM_001145960.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4111)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4111)
  AUTHORS   Ng,P.Y., Ribet,A.B.P., Guo,Q., Mullin,B.H., Tan,J.W.Y.,
            Landao-Bassonga,E., Stephens,S., Chen,K., Yuan,J., Abudulai,L.,
            Bollen,M., Nguyen,E.T.T.T., Kular,J., Papadimitriou,J.M., Soe,K.,
            Teasdale,R.D., Xu,J., Parton,R.G., Takayanagi,H. and Pavlos,N.J.
  TITLE     Sugar transporter Slc37a2 regulates bone metabolism in mice via a
            tubular lysosomal network in osteoclasts
  JOURNAL   Nat Commun 14 (1), 906 (2023)
   PUBMED   36810735
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4111)
  AUTHORS   Iskarpatyoti,J.A., Shi,J., Abraham,M.A., Rathore,A.P.S., Miao,Y.
            and Abraham,S.N.
  TITLE     Mast cell regranulation requires a metabolic switch involving
            mTORC1 and a glucose-6-phosphate transporter
  JOURNAL   Cell Rep 40 (13), 111346 (2022)
   PUBMED   36170813
  REMARK    GeneRIF: Mast cell regranulation requires a metabolic switch
            involving mTORC1 and a glucose-6-phosphate transporter.
REFERENCE   4  (bases 1 to 4111)
  AUTHORS   Zhao,Q., Wang,Z., Meyers,A.K., Madenspacher,J., Zabalawi,M.,
            Zhang,Q., Boudyguina,E., Hsu,F.C., McCall,C.E., Furdui,C.M.,
            Parks,J.S., Fessler,M.B. and Zhu,X.
  TITLE     Hematopoietic Cell-Specific SLC37A2 Deficiency Accelerates
            Atherosclerosis in LDL Receptor-Deficient Mice
  JOURNAL   Front Cardiovasc Med 8, 777098 (2021)
   PUBMED   34957260
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4111)
  AUTHORS   Wang,Z., Zhao,Q., Nie,Y., Yu,Y., Misra,B.B., Zabalawi,M.,
            Chou,J.W., Key,C.C., Molina,A.J., Quinn,M.A., Fessler,M.B.,
            Parks,J.S., McCall,C.E. and Zhu,X.
  TITLE     Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates
            Murine Macrophage Inflammation by Controlling Glycolysis
  JOURNAL   iScience 23 (5), 101125 (2020)
   PUBMED   32428862
REFERENCE   6  (bases 1 to 4111)
  AUTHORS   Kim,J.Y., Tillison,K., Zhou,S., Wu,Y. and Smas,C.M.
  TITLE     The major facilitator superfamily member Slc37a2 is a novel
            macrophage- specific gene selectively expressed in obese white
            adipose tissue
  JOURNAL   Am J Physiol Endocrinol Metab 293 (1), E110-E120 (2007)
   PUBMED   17356011
  REMARK    GeneRIF: The function of this macrophage-specific putative sugar
            transporter is central to the metabolism of the macrophage
            population specifically present in obese white adipose tissue.
REFERENCE   7  (bases 1 to 4111)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   8  (bases 1 to 4111)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 4111)
  AUTHORS   Bartoloni,L., Wattenhofer,M., Kudoh,J., Berry,A., Shibuya,K.,
            Kawasaki,K., Wang,J., Asakawa,S., Talior,I., Bonne-Tamir,B.,
            Rossier,C., Michaud,J., McCabe,E.R., Minoshima,S., Shimizu,N.,
            Scott,H.S. and Antonarakis,S.E.
  TITLE     Cloning and characterization of a putative human glycerol
            3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation
            analysis in two candidate phenotypes, DFNB10 and a glycerol kinase
            deficiency
  JOURNAL   Genomics 70 (2), 190-200 (2000)
   PUBMED   11112347
REFERENCE   10 (bases 1 to 4111)
  AUTHORS   Takahashi,Y., Miyata,M., Zheng,P., Imazato,T., Horwitz,A. and
            Smith,J.D.
  TITLE     Identification of cAMP analogue inducible genes in RAW264
            macrophages
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 385-394 (2000)
   PUBMED   11004510
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138284.9 and AC154434.2.
            
            On Oct 3, 2022 this sequence version replaced NM_001145960.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028984.1, BC038000.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC138284.9         41060-41174         c
            116-197             AC154434.2         10431-10512
            198-291             AC154434.2         11009-11102
            292-370             AC154434.2         11221-11299
            371-506             AC154434.2         12637-12772
            507-583             AC154434.2         13184-13260
            584-750             AC154434.2         14009-14175
            751-788             AC154434.2         14617-14654
            789-941             AC154434.2         14939-15091
            942-1032            AC154434.2         15422-15512
            1033-1095           AC154434.2         16848-16910
            1096-1181           AC154434.2         17221-17306
            1182-1230           AC154434.2         17950-17998
            1231-1304           AC154434.2         18160-18233
            1305-1383           AC154434.2         18471-18549
            1384-1481           AC154434.2         18674-18771
            1482-1546           AC154434.2         19017-19081
            1547-1603           AC154434.2         19282-19338
            1604-4111           AC154434.2         20735-23242
FEATURES             Location/Qualifiers
     source          1..4111
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.74 cM"
     gene            1..4111
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /note="solute carrier family 37 (glycerol-3-phosphate
                     transporter), member 2"
                     /db_xref="GeneID:56857"
                     /db_xref="MGI:MGI:1929693"
     exon            1..115
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1577
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /note="isoform 1 is encoded by transcript variant 1; cAMP
                     inducible 2 protein; sugar phosphate exchanger 2;
                     cAMP-inducible protein 2; solute carrier family 37 member
                     2; cAMP inducible gene 2; solute carrier family 37
                     (glycerol-3-phosphate transporter), member 1;
                     glucose-6-phosphate exchanger SLC37A2"
                     /codon_start=1
                     /product="glucose-6-phosphate exchanger SLC37A2 isoform 1"
                     /protein_id="NP_001139432.1"
                     /db_xref="CCDS:CCDS52769.1"
                     /db_xref="GeneID:56857"
                     /db_xref="MGI:MGI:1929693"
                     /translation="MRSSLAPGVWFLRAFSRDSWFRGFILLLTFLIYACYHMSRKPIS
                     IVKSRLHQNCSEMVRPVNDTHDLNDTTWCSWSPFDKDDYKELLGAVDNAFLVAYAIGM
                     FISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWNIHMLWYFVLIQICNGLVQTTG
                     WPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQHWGLSFIVPGIIT
                     AIMGVITFLFLIEYPEDVDCTPPRHHDDPEKEQDNPEDPVNSPYSSRESNVDIAASSS
                     KEQGPEPEAISFLGALRIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHFSAKEAG
                     DLSTLFDVGGIIGGIMAGLISDYTNSRATTCCIMLILAAPMMFLYNYIGQNGITSSIV
                     MLIICGVLVNGPYALITTAVSADLGTHESLKGNAKALSTVTAIIDGTGSIGAALGPLL
                     AGLISPTGWNNVFYMLISADVLACLLLCRLVYKEILAWKTACGRSSGSSLALTHPR"
     exon            116..197
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..291
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..370
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..506
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..583
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..750
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..788
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..941
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1032
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1095
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1181
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1230
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1304
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1383
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1481
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1546
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1603
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..4111
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2649..2654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /note="hexamer: AATACA"
     polyA_site      2669
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /note="major polyA site"
     regulatory      2733..2738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /note="hexamer: AGTAAA"
     polyA_site      2753
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
     regulatory      2930..2935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /note="hexamer: AATAAA"
     polyA_site      2947
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
     regulatory      4092..4097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
                     /note="hexamer: ATTAAA"
     polyA_site      4111
                     /gene="Slc37a2"
                     /gene_synonym="cI-2; ci2; G3PP; Slc37a1"
ORIGIN      
        1 acgcgcgccg gctctgcacc ctccatagtc tcagcttcga gtgccggcgc ctcaagatgc
       61 ggtcctccct ggctcctggt gtctggttcc ttcgcgcctt ctctagggac agctggttcc
      121 gtggcttcat cctgctgctc accttcctca tttatgcctg ttatcacatg tccagaaagc
      181 ccatcagcat cgtcaagagc cgcctgcacc agaactgctc agagatggtc agacctgtta
      241 atgacaccca cgatctcaat gataccacct ggtgcagctg gagtccattc gacaaagatg
      301 actacaagga gttactagga gctgtggaca atgccttcct agtggcttat gccattggca
      361 tgtttattag tggaatcttt ggggagcggc tgcccctgcg ttactacctc tcggctggaa
      421 tggtgctaag tggcctattc acctccctct ttggcctggg gtacttctgg aatatccaca
      481 tgctctggta ctttgtgctc atccagatct gcaacgggct tgtgcagact acaggctggc
      541 catctgtggt gacctgtgtt ggcaactggt ttgggaaggg aaagcgggga ttcatcatgg
      601 gcatctggaa ctctcacaca tctgtgggca acattctggg ctctctgatt gctggagtct
      661 gggtgaacca gcactggggc ctgtcattca tcgtgcctgg cattatcact gctatcatgg
      721 gtgtcatcac cttcctcttt cttattgaat atccagaaga tgtggactgt acccctcctc
      781 ggcatcatga tgacccggag aaggaacagg acaaccctga ggatcctgtg aatagtccct
      841 acagcagcag ggagagtaat gtggacattg cagccagctc ctccaaggag cagggccctg
      901 agcctgaagc catcagtttc ctgggggcac tcagaattcc gggagtgatc gagttctctt
      961 tatgtctgct ctttgccaag ttggtcagct atacctttct ctactggctg cccttgtaca
     1021 tcttcaatgt ggctcacttt agtgccaagg aggctgggga cctatccacg ctttttgatg
     1081 ttggtggcat cataggtggc atcatggcag ggctcatcag cgactacacc aatagcaggg
     1141 ccaccacttg ctgcatcatg ctgatcttgg ctgctcccat gatgttcctg tacaactaca
     1201 ttggccagaa tgggataacc agttccatag tgatgttaat tatctgtggg gtcctggtca
     1261 atggccctta cgcactcatc acgacagcgg tctctgctga cctgggcaca catgagagcc
     1321 tgaagggtaa cgccaaggcc ctctccactg tcacggccat tatcgacggc actggttcca
     1381 taggtgcggc tctggggccc ctactggccg ggctcatttc cccgacaggc tggaacaatg
     1441 tgttctacat gctcatctct gccgacgtct tggcttgctt gctcctctgc aggttggtgt
     1501 acaaagagat cctggcctgg aagacggcct gcggcagaag cagtggctct agtctggccc
     1561 taacccaccc gcgatagtat tttcctcaag tcccatgact tttgtacaaa caaatttgag
     1621 gcctcaattg gaagagcaac atgggccacc cctgctgggt acccaactta tgagcaagag
     1681 aatggaagct tccatcacag ggagaggcaa agcctcctga tctaactggt ctagccccaa
     1741 gctacattgc cactaaggaa gggtacagaa aactctatgg gaaggggctg ctgagcacca
     1801 agcatgggaa catggcagac ttcaaggcct gagctctggg aactgcaatc agaaggaatg
     1861 ggctgaaagc agaaaggaag gacaggttca gactcttgct tgtttggatt ccaaggcctg
     1921 gaaaaggtgc atctctcctt cccatgttaa attataaacc tctgtaatta tcctgtacct
     1981 atgagggatt tcaccttgtt tcaaaggtgc tgggcctctc tctctctctg tttctgtctc
     2041 tgtgtctgtc tctgtctatg aactattctt tctgtatttc tccaagtagg accctgttga
     2101 tctatcctcc actcgatcct gttgataact cagccacttt gaagcattag tgctgccttt
     2161 gcagagtcaa ggcttggatg gggtacggga gctgtcataa gtactaaatg taggggaact
     2221 tgctctcggg ctcttgaccg tgtccaccct cagagcccag taccttcctt gcctcactct
     2281 taagatgcct cagtggatga agacatcagg gtcagtttgg tgaagactaa ggtgttgtat
     2341 acaactgcaa atgccagtgt gaattaagca ctgggtgctc aagtcatgac agctgtcctt
     2401 taagaacaaa caggaagtgg ctatgggaag aacttaaccc tgaacatagg tgccaagttt
     2461 agcaagaaat gaagatacca ctggaaacat ctgcgtaact gctactgagc agttgctagg
     2521 agacaccttg cagccaccct ctgcctggtg ttctgatgcc ccttccttcc gctcttgagt
     2581 cctggttcac gacatgccag gctgactcct ggcatttccg cctgacctct aagctgccca
     2641 tcagcaccaa tacagatttc ctttgccaac tgtgccactg cttatccttg gtagggcctg
     2701 gcatagcagc agccatgggg ctcgtgaggg gcagtaaagc attgtcacat gaacaacaaa
     2761 gattggtgtt ctggggctgc gacagctgtc tttcccagag ggcattgctc atgacattga
     2821 taacactgtg caatccagca ggagcctaga cccccataca agatacatcc attgcattta
     2881 ctaggatgtt gtgtcagtca gtgtgttagc tagatacact ggcctcagca ataaaatata
     2941 aagctcactt gcctggttct cactttagtc ctgcaggaag cagtcagtca ggcacatctt
     3001 atcctcagga cctggtacag ggcaggggct ggcacatggt agtctgctca gtgttcacaa
     3061 atccctcaag accagaaaga ctgaccttat gtggaaagga cagactttaa ggcaaagctg
     3121 tgttacttct gtaggccact agatggtgat agcatcccgt agtagagtcc agggcaggca
     3181 gggttgctat tccttcctct gcagagaagg aagactctgc tttcctgaca cagcctcttg
     3241 agagatcagt gtgggaggag tggttctagg aggtcttctc tatctcagcc tcattactta
     3301 ccacattctt cctgtctcct catctacaca ggggaataac attgctcaag gcatgggact
     3361 ggtgtgaagg gagataagtg ttagtcacac ttgctgctct tgtctccttt gcagagaaga
     3421 cagactatga aaatagaaac aacacaagct acaaagcaat gacctcagtt gagggctaca
     3481 tcattcatta gttcagacct gatgcgacag gactggtggg cagggccagt aggggcgatc
     3541 ctggtggctt cacgtgtgac agtatttgaa ggaagaatcc aagggccttg gatgatcaat
     3601 atgaaaaggc agtgagaagc agaagacaga agaagctaat ataaatcttg tcatgctgtc
     3661 ctatgctggg ataaggacca gagcatggac acacgcacac atgcactcca ggcaggcaag
     3721 agagtcatta gaaagcttca aaagatttgt gagagcccag agccaggctt caaaaatgaa
     3781 ggcttaggct ggaggtgtaa gaagagggtt ggagaaaacc ccaaaggctg aggatcacca
     3841 cccccatgga ccgttctgca ctcgcttgcc aggccaggtt ctctgcaccc tcctcatccc
     3901 cccaacacgc cagctctgcg cacagtttgt tcactagagg cctggtacct gtcttctctc
     3961 aggcctctgc actcacacgg ggctaatgca ggaacattac cttaattagt tattcattta
     4021 atttaacttc acatttggtc tcaattaagc ttaaaatgtt cttccttata gatgctacaa
     4081 tagcacgtgt aattaaaagg caataactct t
//
