LOCUS       NM_153170               2431 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 36 (proton/amino acid
            symporter), member 2 (Slc36a2), mRNA.
ACCESSION   NM_153170 XR_106229
VERSION     NM_153170.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2431)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2431)
  AUTHORS   Ghnaimawi,S., Zhang,S., Baum,J.I. and Huang,Y.
  TITLE     The Effects of Maternal Intake of EPA and DHA Enriched Diet During
            Pregnancy and Lactation on Offspring's Muscle Development and
            Energy Homeostasis
  JOURNAL   Front Physiol 13, 881624 (2022)
   PUBMED   35733999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2431)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   4  (bases 1 to 2431)
  AUTHORS   Ussar,S., Lee,K.Y., Dankel,S.N., Boucher,J., Haering,M.F.,
            Kleinridders,A., Thomou,T., Xue,R., Macotela,Y., Cypess,A.M.,
            Tseng,Y.H., Mellgren,G. and Kahn,C.R.
  TITLE     ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige,
            and brown adipocytes
  JOURNAL   Sci Transl Med 6 (247), 247ra103 (2014)
   PUBMED   25080478
  REMARK    GeneRIF: The amino acid transporter PAT2 and the purinergic
            receptor P2RX5 are cell surface markers expressed in classical
            brown and beige adipocytes.
REFERENCE   5  (bases 1 to 2431)
  AUTHORS   Zebisch,K. and Brandsch,M.
  TITLE     Transport of L-proline by the proton-coupled amino acid transporter
            PAT2 in differentiated 3T3-L1 cells
  JOURNAL   Amino Acids 44 (2), 373-381 (2013)
   PUBMED   22711289
  REMARK    GeneRIF: During the 14 day differentiation period the uptake of the
            prototype PAT2 substrate L-[(3)H]proline increased ~5-fold.
REFERENCE   6  (bases 1 to 2431)
  AUTHORS   Rubio-Aliaga,I., Boll,M., Vogt Weisenhorn,D.M., Foltz,M., Kottra,G.
            and Daniel,H.
  TITLE     The proton/amino acid cotransporter PAT2 is expressed in neurons
            with a different subcellular localization than its paralog PAT1
  JOURNAL   J Biol Chem 279 (4), 2754-2760 (2004)
   PUBMED   14600155
REFERENCE   7  (bases 1 to 2431)
  AUTHORS   Boll,M., Foltz,M., Rubio-Aliaga,I. and Daniel,H.
  TITLE     A cluster of proton/amino acid transporter genes in the human and
            mouse genomes
  JOURNAL   Genomics 82 (1), 47-56 (2003)
   PUBMED   12809675
REFERENCE   8  (bases 1 to 2431)
  AUTHORS   Bermingham,J.R. Jr., Shumas,S., Whisenhunt,T., Sirkowski,E.E.,
            O'Connell,S., Scherer,S.S. and Rosenfeld,M.G.
  TITLE     Identification of genes that are downregulated in the absence of
            the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in
            sciatic nerve
  JOURNAL   J Neurosci 22 (23), 10217-10231 (2002)
   PUBMED   12451123
REFERENCE   9  (bases 1 to 2431)
  AUTHORS   Cannon,J.P., Haire,R.N. and Litman,G.W.
  TITLE     Identification of diversified genes that contain
            immunoglobulin-like variable regions in a protochordate
  JOURNAL   Nat Immunol 3 (12), 1200-1207 (2002)
   PUBMED   12415263
REFERENCE   10 (bases 1 to 2431)
  AUTHORS   Boll,M., Foltz,M., Rubio-Aliaga,I., Kottra,G. and Daniel,H.
  TITLE     Functional characterization of two novel mammalian electrogenic
            proton-dependent amino acid cotransporters
  JOURNAL   J Biol Chem 277 (25), 22966-22973 (2002)
   PUBMED   11959859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK086373.1, AK079053.1 and BB520081.1.
            
            On or before Jan 28, 2012 this sequence version replaced
            XR_106229.1, NM_153170.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044800.1, AK041041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AK086373.1         2-37
            37-2406             AK079053.1         2-2371
            2407-2431           BB520081.1         249-273
FEATURES             Location/Qualifiers
     source          1..2431
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.16 cM"
     gene            1..2431
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /note="solute carrier family 36 (proton/amino acid
                     symporter), member 2"
                     /db_xref="GeneID:246049"
                     /db_xref="MGI:MGI:1891430"
     exon            1..267
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1555
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /note="tramdorin 1 (transmembrane domain rich protein);
                     proton/amino acid transporter 2; tramdorin-1; solute
                     carrier family 36 member 2; transmembrane domain rich
                     protein 1"
                     /codon_start=1
                     /product="proton-coupled amino acid transporter 2"
                     /protein_id="NP_694810.2"
                     /db_xref="CCDS:CCDS24709.1"
                     /db_xref="GeneID:246049"
                     /db_xref="MGI:MGI:1891430"
                     /translation="MSVTKSARSPQVATPLNLDLPESAKKLQSQDPSPANGSSSESSK
                     KTKGITGFQTLVHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGLIACHCMHILVR
                     CAQRFCHRLNKPFMDYGDTVMHGLAFSPNAWLQNHAHWGRRVVSFFLIVTQLGFCCVY
                     IVFLADNLKQVVEAVNSTTISCHKNETVVLTPTMDSRLYMLSFLPVLGLLVFVRNLRV
                     LTIFSLLANISMLVSLVIIAQYIIQEIPDASQLPLVASWKTYPLFFGTAIFSFESIGV
                     VLPLENKMKDARGFPTILSLGMSIITTLYIAIGALGYLRFGDDIKASITLNLPNCWLY
                     QSVKLLYVVGILCTYALQFYVPAEIIIPLAVSQVSKRWALPVDLSIRLALVCLTCMLA
                     ILIPRLDLVLSLVGSVSSSALALIIPPLLEVVTYYGEGISPLTVTKDALISILGFMGF
                     VVGTYQALDELIKSGNSPALSNSTMFIQ"
     exon            268..358
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..447
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..543
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..628
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..847
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..946
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1113
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1283
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..2431
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1753..1758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /note="hexamer: ATTAAA"
     polyA_site      1773
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
     regulatory      2387..2392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /note="hexamer: AGTAAA"
     polyA_site      2414
                     /gene="Slc36a2"
                     /gene_synonym="A530067G19Rik; PAT2; Tramd1"
                     /note="major polyA site"
ORIGIN      
        1 attccagcca ggccagagca agctctccgg tcagatctac tgggcccaac ttgcacctgc
       61 acatacacct ccttgattgc cctctcccta ccttgagctt gccctttctg aagccatcat
      121 gtctgtgacc aagagtgcca ggagtccgca ggtagccacc cctctcaatc tggaccttcc
      181 tgagagtgcc aagaagctgc agagccagga tcccagtcca gcgaatggga gctcttcaga
      241 gtcatcaaag aagaccaagg gcataaccgg gttccagaca ttggttcatc tggtcaaagg
      301 caacatgggc acagggatcc tcggacttcc cctggctgtg aagaatgcgg gcatcttgat
      361 gggcccactc agcttgctgg taatgggcct catcgcctgc cactgtatgc acatcctagt
      421 cagatgtgcc cagcgcttct gtcacagact gaacaagcct ttcatggact atggggacac
      481 agtgatgcac ggactggctt tcagtcccaa tgcctggctg caaaaccacg cccactgggg
      541 gaggcgtgtc gtgagcttct tcctcatcgt cacccagctg ggtttctgct gtgtgtacat
      601 tgtgtttctg gcggacaatt taaaacaggt agtagaagct gttaacagca caaccatcag
      661 ctgccacaag aacgagacgg tagttctgac gcccaccatg gactctcgac tctacatgct
      721 ctccttcctg cccgttctgg ggcttctggt gttcgtcagg aacctgcgtg tcctcaccat
      781 cttctccctg ctggccaaca tcagcatgct ggtcagcctg gtcatcattg cccagtacat
      841 catccaggaa attccagatg ccagccagtt gccactggta gcaagctgga agacctaccc
      901 gctcttcttt ggaacagcca ttttttcatt tgaaagcatc ggtgtggtcc tgcctctgga
      961 aaacaagatg aaggatgccc gcggcttccc aaccattctg tctttgggga tgtccatcat
     1021 caccaccctg tacattgcta tcggggctct gggctacctg cggtttggag atgacatcaa
     1081 agccagcatc actcttaacc tgcccaactg ctggctgtac caatcagtca agctcctgta
     1141 tgtcgtcggt atcctgtgta cctatgccct gcagttctac gtccctgcgg aaatcatcat
     1201 cccccttgct gtctctcagg tgtcaaaacg ctgggcactg cccgtggacc tgtctatccg
     1261 gcttgccctg gtctgcctca catgcatgct ggccatcctc atcccacgcc tggacctggt
     1321 cctctccctg gtgggctctg tgagcagcag cgccctggcc ctcatcatcc cgcccctgct
     1381 ggaggtggtc acctactatg gagagggcat tagccccctg accgtcacca aggatgccct
     1441 catcagcatc ctgggcttca tgggctttgt ggtggggacc taccaggccc tggatgagct
     1501 gatcaagtcc gggaactctc ccgccctgtc caactccacc atgtttattc agtgacagag
     1561 cctctcctcg cccacggtga cttatgttgt ctatgaattt tttcactttg ccttttctct
     1621 ggtccaagac aggaaaaaac aaaacaaaac aaaaaacagg tgtagcatat ccccagtacc
     1681 gtgtgtgtgt gcgcgcgcgc gcaaaggaga tgggggccat ctacaccgca tacaaggtgt
     1741 agatagatgg tcattaaaaa caaaagaaat gttggtcgtt ctctagtttt ccacactgtg
     1801 gagacctcac ctgtggaaac cgccatcttg tttttgtcat ttatctgcta atttcctgcc
     1861 ttgagtggag ctatgcaaaa agcaaccact aggcggcagc aatagccagc ttttggcaga
     1921 aggtagtctc tgcccgctga ggctttggtt atttcctttt cctgaccatg atggggaaca
     1981 ctgtgctcaa ggcagcatca agatggaggg ggccagggcc agtcacaatg ctcagataaa
     2041 atgtcaccat ctatgttaca gataagtgtg ttgaactttc taaaccacta agtcttagcc
     2101 caactcagaa atccagcagt gaacaagaaa aacatagggt catgcctatg ggccaggggc
     2161 agcagacaga gacatcattg gagtcgtttt tttacttctg aattcttgca atgaacatct
     2221 tctgttacct gtcgggcacc aagcataata cagggctctt atataatagt ttgggtaaag
     2281 gtgttataaa aacaagagct tatataacat tgtagctttg tgtacccaac agtagagtct
     2341 acgggtcatc tcctgagtct tgaccttgta acttgccatg gtcaacagta aaagtgttac
     2401 aaatggaaat tcgatgatgg cttccaccct g
//
