LOCUS       NM_153139               5280 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 36 (proton/amino acid
            symporter), member 1 (Slc36a1), mRNA.
ACCESSION   NM_153139
VERSION     NM_153139.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5280)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5280)
  AUTHORS   Wang,D., Wan,X., Du,X., Zhong,Z., Peng,J., Xiong,Q., Chai,J. and
            Jiang,S.
  TITLE     Insights into the Interaction of Lysosomal Amino Acid Transporters
            SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells
  JOURNAL   Biomolecules 11 (9), 1314 (2021)
   PUBMED   34572527
  REMARK    GeneRIF: Insights into the Interaction of Lysosomal Amino Acid
            Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in
            C2C12 Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5280)
  AUTHORS   Do,T.T., Hindlet,P., Waligora-Dupriet,A.J., Kapel,N., Neveux,N.,
            Mignon,V., Delomenie,C., Farinotti,R., Feve,B. and Buyse,M.
  TITLE     Disturbed intestinal nitrogen homeostasis in a mouse model of
            high-fat diet-induced obesity and glucose intolerance
  JOURNAL   Am J Physiol Endocrinol Metab 306 (6), E668-E680 (2014)
   PUBMED   24425764
  REMARK    GeneRIF: Data suggest that a high-fat diet induces expression of
            two amino acid transporters (Slc36a1, Slc6a20a) in intestinal
            mucosa pointing to a specific and adaptive absorption of some amino
            acids in high-fat diet-induced obesity and glucose intolerance.
REFERENCE   4  (bases 1 to 5280)
  AUTHORS   Singh,A.K., Amlal,H., Haas,P.J., Dringenberg,U., Fussell,S.,
            Barone,S.L., Engelhardt,R., Zuo,J., Seidler,U. and Soleimani,M.
  TITLE     Fructose-induced hypertension: essential role of chloride and
            fructose absorbing transporters PAT1 and Glut5
  JOURNAL   Kidney Int 74 (4), 438-447 (2008)
   PUBMED   18496516
  REMARK    GeneRIF: The essential role of chloride and fructose absorbing
            Slc36a1 is reported.
REFERENCE   5  (bases 1 to 5280)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 5280)
  AUTHORS   Foltz,M., Mertl,M., Dietz,V., Boll,M., Kottra,G. and Daniel,H.
  TITLE     Kinetics of bidirectional H+ and substrate transport by the
            proton-dependent amino acid symporter PAT1
  JOURNAL   Biochem J 386 (Pt 3), 607-616 (2005)
   PUBMED   15504109
  REMARK    GeneRIF: detailed analysis of the transport mode of the murine PAT1
            in oocytes; PAT1 is an electrogenic H+-coupled amino acid symporter
            with the capability for bidirectional amino acid transport
REFERENCE   7  (bases 1 to 5280)
  AUTHORS   Bermingham,J.R. Jr. and Pennington,J.
  TITLE     Organization and expression of the SLC36 cluster of amino acid
            transporter genes
  JOURNAL   Mamm Genome 15 (2), 114-125 (2004)
   PUBMED   15058382
REFERENCE   8  (bases 1 to 5280)
  AUTHORS   Boll,M., Foltz,M., Rubio-Aliaga,I., Kottra,G. and Daniel,H.
  TITLE     Functional characterization of two novel mammalian electrogenic
            proton-dependent amino acid cotransporters
  JOURNAL   J Biol Chem 277 (25), 22966-22973 (2002)
   PUBMED   11959859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ105223.1, AY211262.1, AL713870.26 and BE132784.1.
            
            On Apr 13, 2007 this sequence version replaced NM_153139.3.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY211262.1, AF453743.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-828               CJ105223.1         2-829
            829-1650            AY211262.1         799-1620
            1651-4860           AL713870.26        108674-111883
            4861-5280           BE132784.1         1-420               c
FEATURES             Location/Qualifiers
     source          1..5280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.33 cM"
     gene            1..5280
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /note="solute carrier family 36 (proton/amino acid
                     symporter), member 1"
                     /db_xref="GeneID:215335"
                     /db_xref="MGI:MGI:2445299"
     exon            1..149
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            150..294
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1582
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /note="proton/amino acid transporter 1; solute carrier
                     family 36 member 1"
                     /codon_start=1
                     /product="proton-coupled amino acid transporter 1"
                     /protein_id="NP_694779.3"
                     /db_xref="CCDS:CCDS36156.1"
                     /db_xref="GeneID:215335"
                     /db_xref="MGI:MGI:2445299"
                     /translation="MSTQRLRNEDYHDYSSTDVSPEESPSEGLGSFSPGSYQRLGENS
                     SMTWFQTLIHLLKGNIGTGLLGLPLAVKNAGLLLGPLSLLVIGIVAVHCMGILVKCAH
                     HLCRRLNKPFLDYGDTVMYGLECSPSTWVRNHSHWGRRIVDFFLIVTQLGFCCVYFVF
                     LADNFKQVIEAANGTTTNCNNNVTVIPTPTMDSRLYMLSFLPFLVLLSFIRNLRVLSI
                     FSLLANISMFVSLIMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFAFEGIGVVLP
                     LENKMKDSQKFPLILYLGMAIITVLYISLGSLGYLQFGANIKGSITLNLPNCWLYQSV
                     KLLYSIGIFFTYALQFYVAAEIIIPAIVSRVPEHFELMVDLCVRTAMVCVTCVLAILI
                     PRLDLVISLVGSVSSSALALIIPPLLEVVTYYGEGISPLTVTKDALISILGFVGFVVG
                     TYESLCELIQPSHSDSSTNSTSAFI"
     exon            295..385
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..474
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..570
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..655
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..874
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..973
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1140
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1310
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..5274
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5246..5251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /note="hexamer: AATAAA"
     polyA_site      5274
                     /gene="Slc36a1"
                     /gene_synonym="5830411H19Rik; Pat1"
                     /note="major polyA site"
ORIGIN      
        1 gtgacagggc ccggaagcgg ctgtccagga ggctagaaaa ccatggctag gggtcggcgc
       61 tgaggctacg cgaggtgggc tgagcaggag cgggagccag agccggagcc ggagccggag
      121 cgggagcccg ggccgggcag ggccgaccgc taccatgtcc acacagaggc ttcggaacga
      181 agactatcat gactacagtt ccacagacgt gagccccgag gagagcccat ctgaaggcct
      241 tggcagcttc tcccccggct cctaccaacg cttaggagag aacagtagca tgacatggtt
      301 ccagaccctg atccacctgc tgaaaggcaa cattggcacc ggactgctgg ggctgcctct
      361 ggcagtgaag aacgcaggcc tcctgttggg tcctctcagc ctgctggtga ttggtatcgt
      421 ggccgtgcac tgcatgggta tcctggtgaa gtgtgctcat cacttatgtc gtagactgaa
      481 caaacccttt ttggactatg gggacacggt gatgtatgga ctagaatgca gccccagcac
      541 ctgggtccgg aaccactccc actggggaag gcgcatcgtg gacttcttcc tcatcgtcac
      601 tcagctggga ttctgctgtg tctacttcgt gtttctggcg gacaacttta agcaggtgat
      661 agaggcagcc aatgggacca ccaccaactg caacaacaat gtgaccgtga tcccgacgcc
      721 caccatggac tctcgactct acatgctctc cttcctgccc ttcctggtgt tgctgtcttt
      781 catcaggaac ctgcgtgtgt tgtccatctt ctccctgctg gccaacatca gcatgttcgt
      841 cagcctgatc atgatatacc agttcattgt ccagaggatc ccagacccca gccacctccc
      901 cttggtggct ccatggaaga cctaccctct gttctttggc acagcgattt ttgcttttga
      961 aggcattgga gtggttctac cccttgagaa caaaatgaag gactcacaga aatttccatt
     1021 gattctgtat ttggggatgg ctatcatcac tgtactctac atcagcctgg ggagcctggg
     1081 gtacctgcaa tttggagcta atatcaaggg cagcatcacc ctcaacctgc ccaactgctg
     1141 gttgtaccag tcggtgaagc tgctgtactc cataggcatc ttcttcacct atgccctcca
     1201 gttctatgtc gcagctgaga tcatcatccc ggccattgtg tcccgagtgc ctgagcattt
     1261 cgagctgatg gtggaccttt gtgtgcgcac cgccatggtc tgtgtgacat gtgtgctggc
     1321 catcctcatc ccacgcctgg acctggtcat ctccctggtg ggctctgtga gcagcagcgc
     1381 cctggccctc atcatcccgc ccctgctgga ggtggtcacc tactatggag agggcattag
     1441 ccccctgacc gtcaccaagg atgccctcat cagcatcctg ggcttcgtgg gcttcgtggt
     1501 ggggacctac gagtctctgt gtgagctgat ccagccaagc catagcgact cctctaccaa
     1561 ttccaccagt gccttcatat aaggatctgg gtgtgctccc tccaccagcc tcaccctgtg
     1621 tgtctcccag tagtgtcccc acatcctcag gtatagtcca gcctctggaa aaaggcaggg
     1681 ttgctgcctg ggcactgctc tatctggcat tggacccttg ggtaacctgg gctagatgag
     1741 actgagactg ggggagggcg gggagcagcc cctccacttg tgatggtgcc gtcgctgctc
     1801 tccttcatca cgcctcctcc ctcggcactg ccccccccgc cacccccccg cccccccccc
     1861 ccccccccgt ctgaccagcc acgcctaaat tattcccatt gcacagctca ctttatttaa
     1921 aaggtagtct ctggctcccg acattttctc ctttcctggg ccaggcctag attaaataag
     1981 tggggactct catgttttac aaagccaggc ctctttctca tcaggctccc aaatgctgta
     2041 cctcactgtt ccacccagct gagtcctgag agggttctgg atgccccccc acccccaata
     2101 gtttacagcc agccctgaat gctgaaggtt tccatctgct gtctgacttg gggaacccac
     2161 aggccacgtc acctcttctc gtttcctctg tgtaggtcac agtgctgccc cttgatttct
     2221 ttaaagacaa tgagacactg ctcaggctgg aggtatttac ggtgtattta agcttagggt
     2281 tcaggctctt gacttcagac ctggcatcac agcttcagca gcttggcact tggcttctcc
     2341 ttccactaag acacctgctc caggggacct tggatatgcc ctccgccctg ccctcttggc
     2401 cattttgttg tttgtttgtc tgttttgttt ttgttttgtt tccagacagg gtctcatgtc
     2461 accagagttg gctttgaact tgcttgctgt gtagtcaagg atgacgatgg gctctcagtt
     2521 ctcctaccgt tgcctcaagt atggaggtta ctagcatgag ctgccactcc cagctggctc
     2581 agagacctca agcagatcat gtgagcatgc accgcctctg gaagccccat gcttctgtgg
     2641 acttccattc atgagactga ctccatatgg gcactcggaa gtactcgtgt atacaaggct
     2701 aaggacgggg cgcagttcct cttcatagac actacgcaca agggtcattg tttacagttc
     2761 ctggggagag agcagaatcc ctgccttgcc ccaagctgcc tctgtatcct gggcttccaa
     2821 ggaaccacta aacactaact gtggcccata cctgccccta ttatgcctct cacagagtca
     2881 cctggcttct aggtcagtca tcttagggtg tgcctttaga ggccactgag agtccatgac
     2941 ttgccactgc tcccctgttg atgtcaggat tcccaaagga cagctgttgg ctctccatct
     3001 ctgggttatg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgatag
     3061 tgaacacgtg tgcatgcaca catatgcaca ctacagagcg gtttgtgtct cctctctggt
     3121 taccaggctc ttaactacag ataggatttg ccttgaaact cgagttagag aaagaagcaa
     3181 gaatttatca gagtgctgct tttgtgtttg acagaagcta gtggcccaac cttgcagcca
     3241 agccccttct cgctgttctg tccagagcct gctgcgtgac ttctaggtca caggatggga
     3301 aggatggttt ctggctacag cagccactgt ccttagcagc gttgctagga gtagccattg
     3361 ctgtcttggc cccgaggaga gcaatgcttt tttccctttc tggcatcagc atccccacag
     3421 gtgcttatgt ggcctggttc cagctgggac tcacagacgc cttgctttct gaagtctcag
     3481 gctggaaagt gaccaaagta ggtttagacg ctggccagca acccaactgt gggccaggct
     3541 ctctcttaga agccacctga gcttggcttc ctgggtggga agaaagtcta ttctgaactt
     3601 ttacaggcgc tcctacccag gtctagaccc attgtccaag gccagctact cttcagggcc
     3661 cctggcctga cacggtgtgg tgtgccttct gtagcatttg gctgagggca gcttccttgg
     3721 taccttggta tggcccacat cttttgacct cttgctatac tcctgaggta ctgtcagttt
     3781 ggtgacctga ctctttgagc aaggtcaggg cctttctgga tggacaccag gaagctgcta
     3841 agcacatagt gccaggcgcc acacacagcc caggcgccca caggagccct gagtcagagc
     3901 cctcctgacc cctcccactg tcagtttgga gccagatggc ccccggtggg aaaacagata
     3961 aatgggagct tgggcagaac aatatagaca aggcttgtgg aaactaagcc tgaatccaga
     4021 tgccccagag gcagacatgc cccatccttg ccagcccatt ccttgtctgt acccaaagtc
     4081 agaggccagt tatcgaaaac ttgaatgtga gcacttgctg ggaagcatgt gatctagccc
     4141 gagcaaccca ccgtgccctt agctgtggca tcacttgtgc tgctgtctgg gtcgggagag
     4201 gtagaggtta gcttaggccc acctgtctca cctcactagc cacacctatg ggcaggtgct
     4261 cctgtctgct ctcttcccct ggaagtcttg tgctaagtgt gatcagtggt ctgaagctag
     4321 atcccagagc ctgtccttag gctgtctcat cctcagattt ctccctcccg tcagtgtctg
     4381 ctctttggat tccattgttt cacttgatcc ttccaggaag tgcagagctc agatcatgtt
     4441 tacagcactc actaccccct tctaatgccc gcccgcccac ctgcctgccc gacaagggct
     4501 ctggacaagg gtttgctttc cctgctagcc agccccagcc accattccca ctggcacact
     4561 gaggctttct ggggcctgat atgggaacca gacagagtgg tcggacgtgg caatcaggag
     4621 ggtggcgcca agctggcttg agaatttaat tttccaaagt acattacaaa tcagatacca
     4681 ttaggggaaa gcgggccatg tggctcatct ttgaaactgt ggtcaatact tgaaggcact
     4741 ttagtcctgc tggccgcgcc agcttccgtc tggccggtgt cttctttttc tgtgtgtccc
     4801 gagccattca ctggtcagag acattaaacc gtgctcataa gcagttatca aaaaaaagca
     4861 gcagaaaatg aggctggaag gagcctggtg tttaccctgt tctttggttt aaatcaagcc
     4921 gatgttgaag aagctggaat ttttttttta tgaataataa aatcccacgt ctatatcgta
     4981 aagctgtcag tatatgttga aatcaaggaa cgagagaact gccctacaga gagtcttaac
     5041 agccagacag taccgtgtgc tggcgcctac ctggatgtgc attgcgtaca cgcgtggggc
     5101 atgtcagagc ttcagatgtg cattgcgaac atgcatgggt catgtcatag cttcagatgt
     5161 gcattgtgta catgtgtggg tcatgtcaga gcttctaggt ctcatttggg ttgcacatat
     5221 ggatcttgtg ttaaatttcc acttcaataa atgaatttta ttttttattt ttgaaaaaaa
//
