LOCUS       NM_029529               2629 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 35, member D3 (Slc35d3), mRNA.
ACCESSION   NM_029529 XM_125515
VERSION     NM_029529.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2629)
  AUTHORS   Wang,H., Yu,L., Wang,J., Zhang,Y., Xu,M., Lv,C., Cui,B., Yuan,M.,
            Zhang,Y., Yan,Y., Hui,R. and Wang,Y.
  TITLE     SLC35D3 promotes white adipose tissue browning to ameliorate
            obesity by NOTCH signaling
  JOURNAL   Nat Commun 14 (1), 7643 (2023)
   PUBMED   37996411
  REMARK    GeneRIF: SLC35D3 promotes white adipose tissue browning to
            ameliorate obesity by NOTCH signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2629)
  AUTHORS   Qian,C., Wu,Z., Sun,R., Yu,H., Zeng,J., Rao,Y. and Li,Y.
  TITLE     Localization, proteomics, and metabolite profiling reveal a
            putative vesicular transporter for UDP-glucose
  JOURNAL   Elife 10, e65417 (2021)
   PUBMED   34269178
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2629)
  AUTHORS   Chen,S.Y., Lu,K.M., Ko,H.A., Huang,T.H., Hao,J.H., Yan,Y.T.,
            Chang,S.L., Evans,S.M. and Liu,F.C.
  TITLE     Parcellation of the striatal complex into dorsal and ventral
            districts
  JOURNAL   Proc Natl Acad Sci U S A 117 (13), 7418-7429 (2020)
   PUBMED   32170006
REFERENCE   4  (bases 1 to 2629)
  AUTHORS   Wei,Z.B., Yuan,Y.F., Jaouen,F., Ma,M.S., Hao,C.J., Zhang,Z.,
            Chen,Q., Yuan,Z., Yu,L., Beurrier,C. and Li,W.
  TITLE     SLC35D3 increases autophagic activity in midbrain dopaminergic
            neurons by enhancing BECN1-ATG14-PIK3C3 complex formation
  JOURNAL   Autophagy 12 (7), 1168-1179 (2016)
   PUBMED   27171858
  REMARK    GeneRIF: that SLC35D3 enhanced the formation of the
            BECN1-ATG14-PIK3C3 complex to induce autophagy
REFERENCE   5  (bases 1 to 2629)
  AUTHORS   Zhang,Z., Hao,C.J., Li,C.G., Zang,D.J., Zhao,J., Li,X.N., Wei,A.H.,
            Wei,Z.B., Yang,L., He,X., Zhen,X.C., Gao,X., Speakman,J.R. and
            Li,W.
  TITLE     Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine
            signaling in striatal D1 neurons
  JOURNAL   PLoS Genet 10 (2), e1004124 (2014)
   PUBMED   24550737
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2629)
  AUTHORS   Lu,K.M., Evans,S.M., Hirano,S. and Liu,F.C.
  TITLE     Dual role for Islet-1 in promoting striatonigral and repressing
            striatopallidal genetic programs to specify striatonigral cell
            identity
  JOURNAL   Proc Natl Acad Sci U S A 111 (1), E168-E177 (2014)
   PUBMED   24351932
REFERENCE   7  (bases 1 to 2629)
  AUTHORS   Meng,R., Wang,Y., Yao,Y., Zhang,Z., Harper,D.C., Heijnen,H.F.,
            Sitaram,A., Li,W., Raposo,G., Weiss,M.J., Poncz,M. and Marks,M.S.
  TITLE     SLC35D3 delivery from megakaryocyte early endosomes is required for
            platelet dense granule biogenesis and is differentially defective
            in Hermansky-Pudlak syndrome models
  JOURNAL   Blood 120 (2), 404-414 (2012)
   PUBMED   22611153
  REMARK    GeneRIF: SLC35D3 is depleted in platelets from 2 of 3
            Hermansky-Pudlak syndrome models and, when expressed ectopically in
            melanocytes, SLC35D3 localizes to melanosomes in a manner requiring
            a HPS-associated protein complex
REFERENCE   8  (bases 1 to 2629)
  AUTHORS   Chintala,S., Tan,J., Gautam,R., Rusiniak,M.E., Guo,X., Li,W.,
            Gahl,W.A., Huizing,M., Spritz,R.A., Hutton,S., Novak,E.K. and
            Swank,R.T.
  TITLE     The Slc35d3 gene, encoding an orphan nucleotide sugar transporter,
            regulates platelet-dense granules
  JOURNAL   Blood 109 (4), 1533-1540 (2007)
   PUBMED   17062724
  REMARK    GeneRIF: Slc35d3 specifically regulates the contents of
            platelet-dense granules. Unlike HPS or CHS genes, it has no
            apparent effect on other lysosome-related organelles such as
            melanosomes or lysosomes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171277.9.
            
            On Apr 30, 2007 this sequence version replaced NM_029529.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047610.1, AK042761.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-876               AC171277.9         62814-63689         c
            877-2629            AC171277.9         60147-61899         c
FEATURES             Location/Qualifiers
     source          1..2629
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 9.12 cM"
     gene            1..2629
                     /gene="Slc35d3"
                     /gene_synonym="6230421J19Rik; Frcl1"
                     /note="solute carrier family 35, member D3"
                     /db_xref="GeneID:76157"
                     /db_xref="MGI:MGI:1923407"
     exon            1..876
                     /gene="Slc35d3"
                     /gene_synonym="6230421J19Rik; Frcl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..1706
                     /gene="Slc35d3"
                     /gene_synonym="6230421J19Rik; Frcl1"
                     /note="fringe connection-like protein 1; frc, fringe-like
                     1"
                     /codon_start=1
                     /product="solute carrier family 35 member D3"
                     /protein_id="NP_083805.1"
                     /db_xref="CCDS:CCDS23719.1"
                     /db_xref="GeneID:76157"
                     /db_xref="MGI:MGI:1923407"
                     /translation="MRQLCRGRVLGISVAIAHGVFSGSLNILLKFLISRYQFSFLTLV
                     QCLTSSTAALSLELLRRLGLIAVPPFGLSLARSFAGVAVLSTLQSSLTLWSLRGLSLP
                     MYVVFKRCLPLVTMLIGVLVLKNGAPSPGVLAAVLITTCGAALAGAGDLTGDPIGYVT
                     GVLAVLVHAAYLVLIQKASADTEHGPLTAQYVIAVSATPLLVICSFASTDSIHAWTFP
                     GWKDPAMVSIFVACILIGCAMNFTTLHCTYINSAVTTSFVGVVKSIATITVGMVAFSD
                     VEPTSLFIAGVVVNTLGSIIYCVAKFLETRRQSNYEDLESQAEGEERQPSGDQLPFVM
                     EELPAKSGNSEPESAEGAGDSVQQGGQESRGSIRGISLAARSSRAEGHSDEVGRRSLK
                     DTYLEVWRLVRGTKYMKKDYLMENEALPSP"
     exon            877..2629
                     /gene="Slc35d3"
                     /gene_synonym="6230421J19Rik; Frcl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2604..2609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc35d3"
                     /gene_synonym="6230421J19Rik; Frcl1"
                     /note="hexamer: AATAAA"
     polyA_site      2628
                     /gene="Slc35d3"
                     /gene_synonym="6230421J19Rik; Frcl1"
                     /note="major polyA site"
ORIGIN      
        1 ggtgggcgct ggatgcccca gggaagcagg ctccacccgc cccgcggcag ccgcctcagc
       61 aggtccagtc cgcactccgc agagcatcct tctgacccag gaaccacacg ggacacagct
      121 catcagggat cctcacctac ttccaagtcg cggtctctag gattcccgcc actcctctca
      181 cacccgtccc ccacccctgc cacttttcgg agtcccccgc ccccgcctcc cggcatctgc
      241 ggggcagtcg cacgcggagc tgctgagccg ggaggacgcc cggctggagc tgccctccgc
      301 agcccagccc gcactccctg cccttcgctt cgtcccgccg cccggcccgc gcccccgctg
      361 ccctcgctct gcgcctcccc gccgacctcc tgcgagtctc gagctccgcc acggcggggt
      421 acggcggggc cggcgcgatg cggcagctgt gccggggccg cgtgctgggc atctcggtgg
      481 cgatcgcgca cggggtcttt tctggctccc tcaacatcct gctcaagttc ctcatcagcc
      541 gctaccagtt ctccttcctg accctggtgc agtgcctgac cagctccacc gccgcgctga
      601 gcctggagct gctgcggcgc ctggggctca ttgccgtgcc ccccttcggc ctgagcctag
      661 ctcgctcctt cgctggggtt gccgtgctct ccacgctgca gtccagtctc actctctggt
      721 cgctgcgcgg cctcagcctg cccatgtacg tagtcttcaa gcgctgcctg cccctagtca
      781 ccatgctcat cggtgtgctg gtgctcaaga acggcgcgcc ctcgcccgga gtgctagcgg
      841 ccgtgctcat caccacctgc ggcgccgccc tggcaggagc tggcgacctg acgggcgacc
      901 ccattgggta cgtaacgggc gtgctggctg tattggtgca cgcagcctac ctggtgctga
      961 tccagaaggc gagcgcggac acggagcacg ggcctctcac cgcacagtat gtgatcgccg
     1021 tctccgccac ccctctgctg gtcatctgct ctttcgccag caccgactcc atccacgcct
     1081 ggacctttcc aggctggaag gacccggcca tggtttccat attcgtggcc tgtatcctga
     1141 tcggctgtgc catgaacttc accacactgc actgtaccta catcaactct gctgtgacca
     1201 ccagcttcgt gggcgtggtg aagagcatcg ccactatcac ggtgggcatg gtggcgttca
     1261 gcgacgtgga gcccacctct ctattcattg ctggcgttgt ggtgaacacc ctgggctcca
     1321 tcatttattg tgtggccaaa ttcttggaga ccagaaggca aagcaactat gaagatctgg
     1381 aatcgcaggc agagggagag gagcgacagc caagtgggga ccagttgcct ttcgttatgg
     1441 aggagctgcc cgccaagagc ggaaatagcg agccagagag tgcggagggg gcaggtgact
     1501 ccgtgcagca aggtgggcaa gagtcaaggg gcagcatcag agggatttca ctggcggcta
     1561 ggagttcaag agcagaaggg cattctgatg aggtgggaag gaggtcctta aaggacactt
     1621 acttagaagt gtggagacta gttaggggaa ctaagtacat gaagaaggat tatttgatgg
     1681 aaaacgaggc attacccagt ccttgaaaaa gacatgcatg tatgtacata ttacatacag
     1741 ccgttttatg tggcagaaat aacgtctaag gaagggcctc cagttttatt ctgaggggtg
     1801 ggggttagag atgcaagagc tgaaagggac cgacagagac aaattagcac ctatttatta
     1861 tttattaata atagtgggac tttgcctgag gtgccacaga aagaagagac ctgtgcaggt
     1921 gcttaaccaa atcaaaagcg acttcagctt cagactcctg gacattcatt tttttttttg
     1981 tctttataat cataaccaaa tatctgcatg taccaagagt ccctcagcca ccccttccaa
     2041 agatggcttg tagtaatgat ggtatcactt agtaagttca aaggtcacat tcaggggcac
     2101 atttctgatg acagaactag tttttattgc ctgttaggca aagagtatat tgttgaaatg
     2161 acgtttataa atacactgaa ttgtttactc ttcgggtcat ctgcaatatt gtgtttactc
     2221 gtatttttct tccttctttt ttaaaaaatg ggtattctat tatatattga taggaaatgt
     2281 tgaagctatt ttgaagacat gggttcctag ctttgattat gaagtctaaa gtttgttctt
     2341 tgtaattata tatgttaaag gctgtttggg tcccttgctt tataatattt attactgaat
     2401 gctataacct ttaaaaaacc cattttccca tgtaatactc tttcgaggaa atgcagtgac
     2461 tggattatat ttagtgttga ctgtaaaaca gccagaggga aacagaccac cttggtctgc
     2521 actgcacacc ccaaaactct gttacaaaaa gagccactgc tatattcgca ttacgatatt
     2581 tttctatctt atatttgtca aaaaataaag tgtgagtcta tctgtaaag
//
