LOCUS       NM_144893               2009 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus solute carrier family 35, member C2 (Slc35c2),
            transcript variant 2, mRNA.
ACCESSION   NM_144893
VERSION     NM_144893.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2009)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2009)
  AUTHORS   Lu,L., Varshney,S., Yuan,Y., Wei,H.X., Tanwar,A., Sundaram,S.,
            Nauman,M., Haltiwanger,R.S. and Stanley,P.
  TITLE     In vivo evidence for GDP-fucose transport in the absence of
            transporter SLC35C1 and putative transporter SLC35C2
  JOURNAL   J Biol Chem 299 (12), 105406 (2023)
   PUBMED   38270391
REFERENCE   3  (bases 1 to 2009)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2009)
  AUTHORS   Lu,L., Hou,X., Shi,S., Korner,C. and Stanley,P.
  TITLE     Slc35c2 promotes Notch1 fucosylation and is required for optimal
            Notch signaling in mammalian cells
  JOURNAL   J Biol Chem 285 (46), 36245-36254 (2010)
   PUBMED   20837470
  REMARK    GeneRIF: Data show that Slc35c2 enhances fucosylation of Notch1.
REFERENCE   5  (bases 1 to 2009)
  AUTHORS   Leach,R.E., Duniec-Dmuchowski,Z.M., Pesole,G., Tanaka,T.S.,
            Ko,M.S., Armant,D.R. and Krawetz,S.A.
  TITLE     Identification, molecular characterization, and tissue expression
            of OVCOV1
  JOURNAL   Mamm Genome 13 (11), 619-624 (2002)
   PUBMED   12461647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB849961.1, AK160899.1, BE952356.1 and BB772752.1.
            
            On Nov 19, 2011 this sequence version replaced NM_144893.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same
            isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160899.1, BC094025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BB849961.1         2-15
            15-1479             AK160899.1         1-1465
            1480-1980           BE952356.1         17-517              c
            1981-2009           BB772752.1         521-549
FEATURES             Location/Qualifiers
     source          1..2009
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.53 cM"
     gene            1..2009
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /note="solute carrier family 35, member C2"
                     /db_xref="GeneID:228875"
                     /db_xref="MGI:MGI:2385166"
     exon            1..55
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /inference="alignment:Splign:2.1.0"
     exon            56..410
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1385
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     ovarian cancer overexpressed gene 1 protein"
                     /codon_start=1
                     /product="solute carrier family 35 member C2 isoform 1"
                     /protein_id="NP_659142.1"
                     /db_xref="CCDS:CCDS17074.1"
                     /db_xref="GeneID:228875"
                     /db_xref="MGI:MGI:2385166"
                     /translation="MGRWALDVAFVWKAALTLGLVLLYYCFSIGITFYNKWLTKSFHF
                     PLFMTMLHLAVIFLFSALSRALVQCSSHKARVVLSWTDYLRRVAPTALATALDVGLSN
                     WSFLYITVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQ
                     FNVEGFALVLGASFIGGIRWTLTQILLQKADLGLQNPIDTMFHLQPLMFLGLFPLFAI
                     FEGLHLSTSEKIFRFQDTGLLLWVLGSLLLGGILAFGLGFSEFLLVSRTSSLTLSIAG
                     IFKEVCTLLLAAHLLGDQISLLNWLGFALCLSGISLHVALKALHSRGDGGPKPLKSLG
                     SSADLELLLRSSQQEEEDGEEEYFVTQGQQ"
     exon            411..561
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..625
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..698
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..867
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..951
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1127
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1257
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..2009
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1955..1960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /note="hexamer: AATAAA"
     polyA_site      1977
                     /gene="Slc35c2"
                     /gene_synonym="CGI-15; D2Wsu58e; Ovcov1"
                     /note="major polyA site"
ORIGIN      
        1 acagtgccca cctcgagctt ccggcaggag gctcccggcg agagcctggg cggagcagta
       61 gcgctgggga cctgtgaccg ctgcatccag ctaaccatgg gaccgtttgg ctctggccac
      121 cagcccctta ggtgaggact ccatcaaggg cccactgccc attccccatc atggaggccg
      181 agaggatcct tccagccagg ggagctgccc tttgaaaacc gtggtcgagt cctgctggtt
      241 ctccctgcca gccaccttca agagaggctc ctgttcctgc tggcccacgg atggggaggt
      301 gggccctgga cgtcgccttt gtgtggaagg cagctctgac cctgggcctg gtccttctat
      361 actactgctt ctccataggc atcacgttct acaacaaatg gctgacaaag agcttccact
      421 ttccgctctt catgaccatg ctgcacctgg ccgtcatctt cctcttctcc gccctgtcca
      481 gggcactggt tcaatgctcc agccacaagg cccgggtggt gctgagctgg acggactacc
      541 tcagaagagt ggcccccaca gcactggcaa cagcacttga cgtgggcctg tccaactgga
      601 gcttcctcta catcactgtg tccctgtaca cgatgaccaa atcctctgct gtgctcttta
      661 tcctgatttt ctctctcatc ttcaagctgg aggaactgcg tgcagccctg gtcctggtgg
      721 tcctgctcat tgctgggggc ctcttcatgt ttacctataa gtccacgcag ttcaatgtgg
      781 agggctttgc cttggtgctg ggggcttcgt tcatcggtgg catccgctgg acccttacac
      841 aaatactcct gcagaaagcc gatcttggcc tccagaatcc cattgacacc atgttccacc
      901 tgcagccact catgtttctg ggcctcttcc ctctctttgc catattcgaa ggtctccact
      961 tgtccacctc tgagaagatc ttccgcttcc aggacacagg gctgctcctg tgggtgcttg
     1021 ggagcctcct cctcggtggg attctggcct tcggtttggg cttctccgag ttcctcctgg
     1081 tctccagaac gtcaagcctc acactctcca tcgctggcat ctttaaggaa gtctgcaccc
     1141 tgctgttggc agctcacctg ctgggcgacc agatcagcct cctgaactgg ctgggctttg
     1201 ccctctgcct ctctggcatc tccctgcatg tggccctcaa ggctctacat tccagaggtg
     1261 atggtggccc caagcccctg aagagcctgg gctccagcgc tgacctggaa ctgctgctcc
     1321 ggagtagcca gcaggaggaa gaggacgggg aagaggaata ttttgtgacc cagggacaac
     1381 agtgaccagc ccaggagcag caaagcaggc cactctgtgg tcatccctgc tggcagatct
     1441 tggccaggtc cagcagccca gccggtttct cagagccgct gcaagtggtg gcctcagagc
     1501 ttcctgcaag gactctgagc ctccggctct tccctgtgga gcttggtccc aaaaagcgaa
     1561 tgccaggctc acataggacc tgagctgtca gtgaagggag ccagtggcct gtctccacca
     1621 ttgttctggt tctgagagcc aaggtgaacg tgagagatga ggtagtctct cagattcgga
     1681 ctgtggggta tcaggaaagg agtcatggag agactaggcc tcatcacctg gactgcagct
     1741 tcctcagaga gtagatttat ttatagttga aataatgatt tcctctccac agcccagtgt
     1801 tgcctaaggc atgagagcag ggagagccct ggggcctggc ctctcctccg ttccctgcct
     1861 ggggccttgt cctccgctcc gccttctgta gcccatgctc ctgtttgtgc cccaggcccc
     1921 atccttgggg ccacaccatg gacccaccgc aggaaataaa tgagtgtttg ctcagtacca
     1981 gcctctggag actaccagtg cctcagccc
//
