LOCUS       NM_211358               3154 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus solute carrier family 35, member C1 (Slc35c1),
            transcript variant 1, mRNA.
ACCESSION   NM_211358
VERSION     NM_211358.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3154)
  AUTHORS   Lu,L., Varshney,S., Yuan,Y., Wei,H.X., Tanwar,A., Sundaram,S.,
            Nauman,M., Haltiwanger,R.S. and Stanley,P.
  TITLE     In vivo evidence for GDP-fucose transport in the absence of
            transporter SLC35C1 and putative transporter SLC35C2
  JOURNAL   J Biol Chem 299 (12), 105406 (2023)
   PUBMED   38270391
REFERENCE   2  (bases 1 to 3154)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   3  (bases 1 to 3154)
  AUTHORS   Lu,L., Hou,X., Shi,S., Korner,C. and Stanley,P.
  TITLE     Slc35c2 promotes Notch1 fucosylation and is required for optimal
            Notch signaling in mammalian cells
  JOURNAL   J Biol Chem 285 (46), 36245-36254 (2010)
   PUBMED   20837470
REFERENCE   4  (bases 1 to 3154)
  AUTHORS   Yakubenia,S., Frommhold,D., Scholch,D., Hellbusch,C.C., Korner,C.,
            Petri,B., Jones,C., Ipe,U., Bixel,M.G., Krempien,R., Sperandio,M.
            and Wild,M.K.
  TITLE     Leukocyte trafficking in a mouse model for leukocyte adhesion
            deficiency II/congenital disorder of glycosylation IIc
  JOURNAL   Blood 112 (4), 1472-1481 (2008)
   PUBMED   18541720
  REMARK    GeneRIF: Slc35c1(-/-) mice show strongly defective leukocyte
            trafficking but normal lymphocyte homing to the spleen, which may
            explain normal lymphocyte functions in LAD II.
REFERENCE   5  (bases 1 to 3154)
  AUTHORS   Rabionet,M., van der Spoel,A.C., Chuang,C.C., von
            Tumpling-Radosta,B., Litjens,M., Bouwmeester,D., Hellbusch,C.C.,
            Korner,C., Wiegandt,H., Gorgas,K., Platt,F.M., Grone,H.J. and
            Sandhoff,R.
  TITLE     Male germ cells require polyenoic sphingolipids with complex
            glycosylation for completion of meiosis: a link to ceramide
            synthase-3
  JOURNAL   J Biol Chem 283 (19), 13357-13369 (2008)
   PUBMED   18308723
REFERENCE   6  (bases 1 to 3154)
  AUTHORS   Hellbusch,C.C., Sperandio,M., Frommhold,D., Yakubenia,S.,
            Wild,M.K., Popovici,D., Vestweber,D., Grone,H.J., von Figura,K.,
            Lubke,T. and Korner,C.
  TITLE     Golgi GDP-fucose transporter-deficient mice mimic congenital
            disorder of glycosylation IIc/leukocyte adhesion deficiency II
  JOURNAL   J Biol Chem 282 (14), 10762-10772 (2007)
   PUBMED   17276979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY347468.1, AK040986.1, AK033295.1 and BG094697.1.
            
            On Apr 1, 2006 this sequence version replaced NM_211358.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031814.1, AK151154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               BY347468.1         1-253
            254-1678            AK040986.1         1-1425
            1679-3130           AK033295.1         768-2219
            3131-3154           BG094697.1         335-358
FEATURES             Location/Qualifiers
     source          1..3154
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 51.05 cM"
     gene            1..3154
                     /gene="Slc35c1"
                     /gene_synonym="E430007K15Rik; fuct1"
                     /note="solute carrier family 35, member C1"
                     /db_xref="GeneID:228368"
                     /db_xref="MGI:MGI:2443301"
     exon            1..1128
                     /gene="Slc35c1"
                     /gene_synonym="E430007K15Rik; fuct1"
                     /inference="alignment:Splign:2.1.0"
     CDS             597..1688
                     /gene="Slc35c1"
                     /gene_synonym="E430007K15Rik; fuct1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     multispan transmembrane protein fuct1; GDP-fucose
                     transporter 1"
                     /codon_start=1
                     /product="GDP-fucose transporter 1 isoform 1"
                     /protein_id="NP_997597.1"
                     /db_xref="CCDS:CCDS16448.1"
                     /db_xref="GeneID:228368"
                     /db_xref="MGI:MGI:2443301"
                     /translation="MNRAPLKRSRILRMALTGVSAVSEESESGNKPFLLRALQIALVV
                     SLYWVTSISMVFLNKYLLDSPSLQLDTPIFVTFYQCLVTSLLCKGLSTLATCCPGMVD
                     FPTLNLDLKVARSVLPLSVVFIGMITFNNLCLKYVGVPFYNVGRSLTTVFNVLLSYLL
                     LKQTTSFYALLTCGVIIGGFWLGIDQEGAEGTLSLTGTIFGVLASLCVSLNAIYTKKV
                     LPAVDHSIWRLTFYNNVNACVLFLPLMIVLGELRALLAFTHLSSAHFWLMMTLGGLFG
                     FAIGYVTGLQIKFTSPLTHNVSGTAKACAQTVLAVLYYEEIKSFLWWTSNLMVLGGSS
                     AYTWVRGWEMQKTQEDPSSKDGEKSAIRV"
     exon            1129..3139
                     /gene="Slc35c1"
                     /gene_synonym="E430007K15Rik; fuct1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3111..3116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc35c1"
                     /gene_synonym="E430007K15Rik; fuct1"
                     /note="hexamer: AATAAA"
     polyA_site      3139
                     /gene="Slc35c1"
                     /gene_synonym="E430007K15Rik; fuct1"
                     /note="major polyA site"
ORIGIN      
        1 gaaatgcgcg cagggcccgc cctgctcggt aagtggcccg ggacccgcgt cgctgagccg
       61 gaacttgaat tcggctcgtg gcaaccgcag ggccttgctc cggtcaggcc cctgtccgtg
      121 tccctcgaga cgccttcctg agcctcggtg atctccctgc agcacgccct cctttcggct
      181 ctgcgggtgc ttccgggggt tcccgcagcc catgcttccc acgcggtccg cgtccagtta
      241 tttcctcctc cgctccgtcc ttccttcgct ctctcgcttc ctttctccct gcgactcacg
      301 tgtcccctgt cctcaaactg gccatggctg tcaaagccca catccttagt taggcccctt
      361 ctcccttccc tgggtcttgt ttcgtgacac cacctccctc ccccgccccg ggagcgagca
      421 agatgaggag cggtgcacct cggcaaatcc ggaagcagaa cttcatccaa gaaggagggg
      481 accgataggt catcccatgt gacagttgaa ggctgcagcc acagacccta gctgcttgaa
      541 gccctgtagt ccagggactg cttctggccg taaggtgacc cagctcttct gccaccatga
      601 acagggcgcc tctgaagcgg tccaggatcc tgcgcatggc gctgactgga gtctctgctg
      661 tctccgagga gtcagagagc gggaacaagc catttctgct ccgggctctg cagatcgcgc
      721 tggtggtctc tctctactgg gtcacctcca tttccatggt attcctcaac aagtacctgc
      781 tggacagccc ctccctgcag ctggataccc ccatttttgt caccttctac caatgcctgg
      841 tgacctcact gctgtgcaag ggcctcagca ctctggccac ctgctgcccc ggcatggtag
      901 acttccccac cctaaacctg gacctcaagg tggcccgaag tgtgctgccg ctgtcagtgg
      961 tctttatcgg catgataacc ttcaataacc tctgcctcaa gtacgtaggg gtgcccttct
     1021 acaacgtggg acgctcgctc accaccgtgt tcaacgttct tctctcctac ctgctgctca
     1081 aacagaccac ttccttctat gccctgctca cctgcggcgt catcattggt ggtttctggc
     1141 tgggtataga ccaagaagga gctgagggaa ccttgtccct gacgggcacc atcttcgggg
     1201 tgctggccag cctctgcgtc tccctcaatg ccatctatac caagaaggtg ctccctgcag
     1261 tagaccacag tatctggcgc ctaaccttct ataacaatgt caatgcctgc gtgctcttct
     1321 tgcccctgat gatagtgctg ggcgagctcc gtgccctcct ggccttcact catctgagca
     1381 gtgcccactt ctggctcatg atgacgctgg gtggcctgtt tggctttgcc atcggctatg
     1441 tgacaggact gcagatcaaa ttcaccagtc ccctgaccca taacgtgtca ggcacggcca
     1501 aggcctgtgc acagacagtg ctggccgtgc tctactacga agagattaag agcttcctgt
     1561 ggtggacaag caacctgatg gtgctgggtg gctcctccgc ctacacctgg gtcaggggct
     1621 gggagatgca gaagacccag gaggacccca gctccaaaga tggtgagaag agtgctatca
     1681 gggtgtgagc tccttcaggg agccagggct gagctcgggt ggggcctgcc cagcacggaa
     1741 ggcttcccat agagcctact gggtatggcc ctgagcaata atgtttacat ccttctcaga
     1801 agaccatcta agaagagcca ggttctttcc tgataatgtc agaaagctgc caaatctcct
     1861 gcctgcccca tcttctagtc ttgggaaagc cctaccagga gtggcaccct tcctgcctcc
     1921 tcctggggcc tgtctacctc catatggtct ctggggttgg ggccagctgc actctttggg
     1981 cactggactg atgaagtgat gtcttacttt ctacacaagg gagatgggtt gtgaccctac
     2041 tatagctagt tgaagggagc tgtgtaaccc cacatctctg gggccctggg caggtagcat
     2101 aatagctagg tgctattaac atcaataaca cttcagacta cctttggagg cagttgggag
     2161 ctgagccgag agagagagat ggccattctg ccctcttctg tgtggatggg tatgacagac
     2221 caactgtcca tggggtgact gacacctcca cacttcatat tttcaacttt agaaaagggg
     2281 gagccacacg ttttacagat taagtggagt gatgaatgcc tctacagccc ctaaccccac
     2341 tttccctgcc tggcttctct tggcccagaa gggccaccat cctgttctcc aacacctgac
     2401 ccagctatct ggctatactc tctttctgta ctcccttccc cttccccccc ccattagcct
     2461 cctccccaac acctccatct tcaggcagga agtggggtcc actcagcctc tgttcccatc
     2521 tgcttggacc cctgagcctc tcatgaaggt aggcttatgt tctctgaggc tggggccgga
     2581 ggagcgcact gattctcgga gttatcccat caggctcctg tcacaaaata gcctaggccg
     2641 tgtgtctaag aacagtggag gttggcttat aactgttctg ggggcagcga agcccacatc
     2701 aaggtactca tagacccagt atttctgagg aaacccctgt ccacatcctc acttggtaaa
     2761 ggcacagata atctccctca ggcctcttgt ataggagcac tagccctggg agggctccgc
     2821 cccatgacct gatcacccca aagccttcaa cagaaggatt ccaacatgaa tttggggaca
     2881 gaagcactca gaccacgatg cccagcacca caccctccta tcctcagggt agctgtcact
     2941 gtcctagtcc cttctgtttg gccttttgta ccctcatttc cttggcgtca tgtttgatgt
     3001 ctttgtctct ttcgtgagaa gatggggaaa ccatgtcagc ctctgcttcc gacttcccat
     3061 gggttctaat gaagttggtg gggcctgatg ccctgagttg tatgtgattt aataaaaaaa
     3121 aaattttttt aaaaacaaaa aaaaaaaaaa aaaa
//
