LOCUS       NM_021435               3633 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 35, member B4 (Slc35b4),
            transcript variant 1, mRNA.
ACCESSION   NM_021435
VERSION     NM_021435.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3633)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3633)
  AUTHORS   Wex,B., Safi,R.M., Antonios,G., Zgheib,P.Z., Awad,D.B.,
            Kobeissy,F.H., Mahfouz,R.A., El-Sabban,M.M. and Yazbek,S.N.
  TITLE     SLC35B4, an Inhibitor of Gluconeogenesis, Responds to Glucose
            Stimulation and Downregulates Hsp60 among Other Proteins in HepG2
            Liver Cell Lines
  JOURNAL   Molecules 23 (6), 1350 (2018)
   PUBMED   29867058
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3633)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3633)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   5  (bases 1 to 3633)
  AUTHORS   Yazbek,S.N., Buchner,D.A., Geisinger,J.M., Burrage,L.C.,
            Spiezio,S.H., Zentner,G.E., Hsieh,C.W., Scacheri,P.C.,
            Croniger,C.M. and Nadeau,J.H.
  TITLE     Deep congenic analysis identifies many strong, context-dependent
            QTLs, one of which, Slc35b4, regulates obesity and glucose
            homeostasis
  JOURNAL   Genome Res 21 (7), 1065-1073 (2011)
   PUBMED   21507882
  REMARK    GeneRIF: Decreased SLC35B4 expression led to increased
            gluconeogenesis in H2.35 cells.
REFERENCE   6  (bases 1 to 3633)
  AUTHORS   Pereira,J.D., Sansom,S.N., Smith,J., Dobenecker,M.W.,
            Tarakhovsky,A. and Livesey,F.J.
  TITLE     Ezh2, the histone methyltransferase of PRC2, regulates the balance
            between self-renewal and differentiation in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15957-15962 (2010)
   PUBMED   20798045
REFERENCE   7  (bases 1 to 3633)
  AUTHORS   Ashikov,A., Routier,F., Fuhlrott,J., Helmus,Y., Wild,M.,
            Gerardy-Schahn,R. and Bakker,H.
  TITLE     The human solute carrier gene SLC35B4 encodes a bifunctional
            nucleotide sugar transporter with specificity for UDP-xylose and
            UDP-N-acetylglucosamine
  JOURNAL   J Biol Chem 280 (29), 27230-27235 (2005)
   PUBMED   15911612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153817.6.
            
            On Mar 7, 2023 this sequence version replaced NM_021435.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138591.1, AB041549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC153817.6         232085-232293       c
            210-323             AC153817.6         225768-225881       c
            324-426             AC153817.6         222932-223034       c
            427-476             AC153817.6         221681-221730       c
            477-558             AC153817.6         218896-218977       c
            559-619             AC153817.6         218636-218696       c
            620-729             AC153817.6         216983-217092       c
            730-805             AC153817.6         215780-215855       c
            806-881             AC153817.6         214740-214815       c
            882-3633            AC153817.6         211182-213933       c
FEATURES             Location/Qualifiers
     source          1..3633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 14.75 cM"
     gene            1..3633
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /note="solute carrier family 35, member B4"
                     /db_xref="GeneID:58246"
                     /db_xref="MGI:MGI:1931249"
     exon            1..209
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1128
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /note="UDP-xylose and UDP-N-acetylglucosamine transporter"
                     /codon_start=1
                     /product="nucleotide sugar transporter SLC35B4"
                     /protein_id="NP_067410.1"
                     /db_xref="CCDS:CCDS19989.1"
                     /db_xref="GeneID:58246"
                     /db_xref="MGI:MGI:1931249"
                     /translation="MRPAFAVGLVFAGCCSNVIFLELLARTHPGCGNIVTFAQFLFIA
                     VEGFLFEANLGRKPPAIPIRYYAIMVTMFFTVSVVNNYALNLNIAMPLHMIFRSGSLI
                     ANMILGIIILKKRYSMFKYTSIALVSAGIFICTFMSAKQVTVQTGLSDKDGFQAFAWW
                     LLGIAALTFALLMSARMGIFQETLYRQFGKHSKEALFYNHALPLPGFIFLASDIYDHV
                     VLFNKSELYQVPVIGVTMPVMWFYLLMNVVTQYVCIRGVFILTTECTSLTVTLVVTLR
                     KFVSLIFSILYFQNQFTMWHWLGTSFVFIGTLMYTEVWKNLGTTKSELQKDDKKD"
     exon            210..323
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            324..426
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            427..476
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            477..558
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            559..619
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            620..729
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            730..805
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            806..881
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            882..3633
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3610..3615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /note="hexamer: TATAAA"
     polyA_site      3633
                     /gene="Slc35b4"
                     /gene_synonym="4930474D06Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggaagagtt gatcaagacg gccctcaggg agggaaccgc tggcggtggt gatgttgcgc
       61 gcggattttc tagggtagcg aactgaaagg gcgctttttc tgcgcgctgg ctccccgtgc
      121 cccgcaccgg ccatgcgccc ggccttcgcg gtgggcctgg tgttcgcagg ctgctgcagt
      181 aatgtgatct tcctagagct gctggcccgg acacatccag gatgcgggaa catcgtcacg
      241 tttgcgcagt tcttatttat tgctgtggaa ggcttccttt ttgaagctaa cttgggaagg
      301 aagccaccag ctatcccaat aaggtactat gccatcatgg taaccatgtt cttcactgtc
      361 agcgtggtga acaactatgc cctgaacctg aacatcgcca tgccgctgca tatgatattc
      421 agatcaggct ctctgattgc caacatgatt ctaggaatta tcattttgaa gaaaagatac
      481 agtatgttca agtatacctc cattgccctg gtgtctgcag ggatatttat ttgcactttc
      541 atgtcagcaa agcaggtgac tgtccagacc ggcttgagtg acaaggatgg attccaggcc
      601 tttgcatggt ggttactagg tattgcggca ctgaccttcg ctctgctgat gtcggcaaga
      661 atgggcatct tccaagagac tctgtacaga cagtttggga agcactccaa ggaggcgtta
      721 ttttataatc acgcccttcc acttcccggg ttcatcttct tggcctctga tatttatgac
      781 cacgttgtcc tgttcaataa gtctgaactc tatcaagttc cagtcatcgg tgtgacgatg
      841 cccgtcatgt ggttctacct cctcatgaat gtcgtgactc aatatgtgtg catccggggt
      901 gtgttcatcc ttacaacaga gtgtacctcc ctcaccgtca cactggttgt gactctgcgc
      961 aagtttgtga gcctcatctt ttctatcttg tacttccaga accagttcac tatgtggcac
     1021 tggctgggca cctcgtttgt cttcattgga accttaatgt acacagaggt gtggaaaaac
     1081 ctcgggacca caaaaagtga gctgcaaaag gatgacaaga aggactgagg tctgcctggg
     1141 acagacagac agacggtgtt atgtgagagc ggcctctgct gcaggtctgg ccaccatttc
     1201 actttagctg atgccaaatt accagagtat tgaagcagaa aggctccaga gcttcctcca
     1261 aaaggatggg actcatctgc tctcacgagt ctgcatttgt agattccaca taggcatccc
     1321 tgagatagaa taaacaaaac aagcaaggct accaggcaga ccgtcgggca gcctctgcat
     1381 ttgcttttct atttctttgc cagaacatca gaaccatatt tgttgaattc caagtctcag
     1441 agcttctagt tttctacctg tgtcgcactt gttgctaccg atgccttttt gctatgtacc
     1501 tctttcctcc cgtcacccct gcacacttaa gcactttgca gcacagccaa cattccaggc
     1561 acaatcaggc actgagtgat ccagtggaca tgcgaaaaat tagaccccag gagtgatgag
     1621 gccggactcc ctccagcgtg ttggtgttgg gagagaagca gttgtcccca tgagcagatc
     1681 tgtgagctgg atgccggtga tgctggagta gacggctgga tcccaccacg cacatttcac
     1741 gttatttgat tagtcaatgc aaagatcaca cacttctttc acctgttgct ttctgtagtt
     1801 agagcagtcc tgcagcgctc attgcacatt agaaaggaag aaaacttgaa agtggatcga
     1861 gaagagggag acctttcctt ccatctccca cgtgaagccc cttggcctgt ttacggagat
     1921 ggagaaggaa gtgtggccca atacagctca ctctttcagc accctgagag actgttgccc
     1981 ctgtgaaccc agccacacac ttccatggga ctcctgtggg tttcaaatat gtgtctgtga
     2041 gaggcgttaa gacctggtag ccagaagata cttctgagaa ttgtcacctg tcaagtcatc
     2101 gatgatgatt gattgataca caggcgtgag tgtgctcaaa ccccagctgc ggcagggtga
     2161 agtcttcttg ttccatagat atgggactgc ttttgggtgt gcctgggagg tggcatgaca
     2221 cagcatgttt acatacagaa acaggcctgg ctcttttccg ctgatcactc tgaaggtctg
     2281 attgtcctct cttggatccc cttgaggaag agtaaccctg tcacacagca tgtggcgctt
     2341 gtgtgccctt agctggattg tatgtgattg aagaacaaga acattgtgtt gctttctttc
     2401 ctcgtcccca cttagggcca gaccctcatt accctcacct agccatctgc tcctctgcaa
     2461 acagctacac acaatgtttc tctcgcacag acgacagcct tccattcttc cactatgtgc
     2521 tgactgtgct cagactgagg agtggctctc catctcctcg gctcactgta gctctttgtt
     2581 gcaccctctg aagatgctct ttgatgggtc tgaacagcag cagcaaagag aactatccca
     2641 atcctctggg tcccctggga aggcaaagag aactgtccta atcctctggg tcccctggga
     2701 aggcagttaa gacttttttc tgttacatta aatgcagata ctgtttctcc acctaagtcc
     2761 ccaggtttgc agactgattg tcattctggc cattgacagc ttcccagtgc tggtaatggt
     2821 ctgttctcaa agacctgaat tagatgtgaa cccattcaca gtcccagaag ctctgtagct
     2881 actttgaaat atgtggggtt gcctggacca atgttgctat aaataccaag tgttaaaagc
     2941 ccccttaaaa agacagtaat aaaaagtact tttttcttcc agtttaacag aagaatctgt
     3001 ccctcggggc tcttgaggct ccattctgat tactcctaac aggctataac cttcagttac
     3061 ctagagcttc cctttttatg ttgggagaag tagcacacag cttgtagttc cctgagactg
     3121 gctgatacaa tctaactgga ccggttaggg tttcagaatg tgtatccctt tgtgggtttt
     3181 gttgaaggag atgtaagaac agataagagt gcgggctctg ctggctcaag ctagcaagtg
     3241 ccccagctgc ttcctgccgt gcagtagaca gaagaaaatg taaccggcac tagttacagt
     3301 tttgtaaaat tgcccttcta aaggttctgt tttccttctc attgtgtatg cttgttgcac
     3361 agggccctgt ggttggacac ttccctgcag ttgagtactt cccccaagct ctcctctccc
     3421 cgtgttaggt cctgctgttc ccctgaacag ttttgccttc taccttcaga tcgcatacac
     3481 accgtggttt catgtctctc tacaaagctc aggagctaca aataagagca cacatatgct
     3541 gtttgtcctc cctacaccag ctaacccctt aataggacca tctctggata catccataaa
     3601 atcactcttt ataaaagtca tttctctttg cca
//
