LOCUS       NM_001404697            5353 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus solute carrier family 35 (UDP-N-acetylglucosamine
            (UDP-GlcNAc) transporter), member 3 (Slc35a3), transcript variant
            5, mRNA.
ACCESSION   NM_001404697 XM_006501425
VERSION     NM_001404697.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5353)
  AUTHORS   Saito,S., Mizumoto,S., Yonekura,T., Yamashita,R., Nakano,K.,
            Okubo,T., Yamada,S., Okamura,T. and Furuichi,T.
  TITLE     Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal
            chondrodysplasia with vertebral anomalies and impaired
            glycosaminoglycan biosynthesis
  JOURNAL   PLoS One 18 (4), e0284292 (2023)
   PUBMED   37053259
  REMARK    GeneRIF: Mice lacking nucleotide sugar transporter SLC35A3 exhibit
            lethal chondrodysplasia with vertebral anomalies and impaired
            glycosaminoglycan biosynthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5353)
  AUTHORS   Toscanini,M.A., Favarolo,M.B., Gonzalez Flecha,F.L., Ebert,B.,
            Rautengarten,C. and Bredeston,L.M.
  TITLE     Conserved Glu-47 and Lys-50 residues are critical for
            UDP-N-acetylglucosamine/UMP antiport activity of the mouse
            Golgi-associated transporter Slc35a3
  JOURNAL   J Biol Chem 294 (26), 10042-10054 (2019)
   PUBMED   31118275
  REMARK    GeneRIF: cells expressing E47C or K50C mSlc35a3 variants had lower
            levels of GlcNAc-containing glycoconjugates than WT cells
REFERENCE   3  (bases 1 to 5353)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5353)
  AUTHORS   O'Shaughnessy,P.J., Abel,M., Charlton,H.M., Hu,B., Johnston,H. and
            Baker,P.J.
  TITLE     Altered expression of genes involved in regulation of vitamin A
            metabolism, solute transportation, and cytoskeletal function in the
            androgen-insensitive tfm mouse testis
  JOURNAL   Endocrinology 148 (6), 2914-2924 (2007)
   PUBMED   17332066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147242.4 and AC131038.6.
            
            On Apr 13, 2022 this sequence version replaced XM_006501425.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.45084.1,
                                           SRR17253011.2536789.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC147242.4         125678-125872
            196-400             AC131038.6         147280-147484       c
            401-555             AC131038.6         140121-140275       c
            556-678             AC131038.6         139912-140034       c
            679-850             AC131038.6         133955-134126       c
            851-969             AC131038.6         130713-130831       c
            970-1103            AC131038.6         128021-128154       c
            1104-5353           AC131038.6         122319-126568       c
FEATURES             Location/Qualifiers
     source          1..5353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 50.44 cM"
     gene            1..5353
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /note="solute carrier family 35 (UDP-N-acetylglucosamine
                     (UDP-GlcNAc) transporter), member 3"
                     /db_xref="GeneID:229782"
                     /db_xref="MGI:MGI:1917648"
     exon            1..195
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1194
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /note="isoform 2 is encoded by transcript variant 5;
                     UDP-N-acetylglucosamine transporter; golgi UDP-GlcNAc
                     transporter"
                     /codon_start=1
                     /product="UDP-N-acetylglucosamine transporter isoform 2"
                     /protein_id="NP_001391626.1"
                     /db_xref="GeneID:229782"
                     /db_xref="MGI:MGI:1917648"
                     /translation="MERVPVTNEEKTMSANLKYLSLGILVFQTTSLVLTMRYSRTLKE
                     EGPRYLSSTAVVVAEFLKIMACIFLVYKDSKCSVRALNRVLHDEILNKPMETLKLAIP
                     SGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLGKKLGVYQWLSLVILM
                     AGVAFVQWPSDSQELNSKDLSTGSQFVGLMAVLTACFSSGFAGVYFEKILKETKQSVW
                     IRNIQLGFFGSIFGLMGVYVYDGELVSKNGFFQGYNQLTWIVVALQALGGLVIAAVIK
                     YADNILKGFATSLSIILSTIISYFWLQDFVPTSVFFLGAILVIAATFLYGYDPKPAGN
                     PTKA"
     exon            196..400
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            401..555
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            556..678
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            679..850
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            851..969
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1103
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..5353
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4029
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /note="major polyA site"
     polyA_site      4882
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /note="major polyA site"
     regulatory      5019..5024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /note="hexamer: GATAAA"
     polyA_site      5037
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
     regulatory      5090..5095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /note="hexamer: CATAAA"
     polyA_site      5103
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
     regulatory      5328..5333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5353
                     /gene="Slc35a3"
                     /gene_synonym="2310050P13Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggcagtgtg cctgcaagct ccagactggc gggccaagtg ccttgggggc caggctggcg
       61 gcctgtcctt ccgcggtcat ttcgggagct ccggctcagc ctgtgacccc gggctaggga
      121 cgagtctgct cggtgagaaa ggacggtgta gtcaagaagc tgcagggact tggagagatg
      181 gaaagggtgc ccgtgacaaa tgaagagaaa acaatgtctg ccaacctaaa atatctttcc
      241 ttgggaattt tggtgtttca gactaccagt ctggttctaa cgatgcggta ttctaggact
      301 ttaaaagagg aggggcctcg ttatctgtct tctacagcag tggttgtggc tgaatttttg
      361 aagataatgg cctgcatctt tttagtctac aaagacagta agtgtagtgt gagagcactg
      421 aatagagtac tgcatgatga aattcttaat aagcccatgg aaaccctgaa gctcgctatc
      481 ccgtcaggga tatatactct tcagaacaac ttactctatg tggcactgtc aaacctagat
      541 gcagccactt accaggttac atatcagttg aaaatactta caacagcatt attttctgtg
      601 tctatgcttg gtaaaaaatt aggtgtgtac cagtggctct ccctagtaat tctgatggca
      661 ggagttgctt ttgtacagtg gccttcagat tctcaagagc tgaactctaa ggacctttca
      721 acaggctcac agtttgtagg cctcatggca gttctcacag cctgtttttc aagtggcttt
      781 gctggagttt attttgagaa aatcttaaaa gaaacaaaac agtcagtatg gataaggaac
      841 attcaacttg gtttctttgg aagtatattt ggattaatgg gtgtatacgt ttatgatgga
      901 gaattggtct caaagaatgg attttttcag ggatataatc aactgacgtg gatagttgtt
      961 gctctgcagg cacttggagg ccttgtaata gctgctgtca tcaaatatgc agataacatt
     1021 ttaaaaggat ttgcgacctc cttatccata atattgtcaa caataatatc ttatttttgg
     1081 ttgcaagatt ttgtgccaac cagtgtcttt ttccttggag ccatccttgt aatagcagct
     1141 actttcttgt acggttacga tcccaaacct gcaggaaatc ccactaaagc atagtcatgt
     1201 cctgtcctta actggattct cacagtggtg ccctaggaac ctcaacatta atcttgcaca
     1261 gaggacttct gcagattcta tgaagaaatc atcaggctaa atctgatcgt tctgttcaaa
     1321 tggtttgaaa acgtgtagcc ttcaggatga agtgtgtccg tcatctgcaa cccaagcttg
     1381 gaagagtgtc caggaagtag gcttagaggg gatactggga ggaggcctta cgtctgagct
     1441 cctagtgact tcagcctttt agttgctgta gcactgtcca gtgcagcctt tgcaagagca
     1501 cacacatgca aagaaagagc aaggtttgca aggtagatct gcctacactt atcccatgtt
     1561 cttaacctta ccctttctgt acagatgtat caagctacat gatctattta aatggaaatt
     1621 tataattgcc tatcaagctg tgaacaaaca aatataattt aaaaccattt tcatgtatcc
     1681 agggttttat atctatacag aggattccta aggaaaggat tgacaagttt tacttgttta
     1741 attccatacg atttgattaa gtgatctggg tttgaatcat atttaaattt agtgtagaat
     1801 caatctctct ctctgtctct ctctgtctct ctctgtctgt gtgtgtgtgt atgtgtgtct
     1861 gaccatttac tgctttgagg cagctgaatg cagtttggtt cttcccgtgc tagagtggca
     1921 gagactggcc ctagtggagc ttactcatca tttcccaggt ctgtctcttt tctcattatt
     1981 ctcatcatta cattaaattg aatttgtgtg tcctgccatt aaaaatttta agtgaattta
     2041 aagggattaa gtactcattt aataattgaa aataaaataa tgattactgt ctaggctcca
     2101 ttttgagaaa tctaaactat gaagcatata ttgaatgtag ttttgaaatg gagaattttc
     2161 ttgttaatct gcagtagcaa tttcttttaa tctttgacag aaacaacaat caaaagagtg
     2221 ttagttctct cagtggacca tgattaaact gatttcctta cagacattcc ctactgccat
     2281 atgctacttt cttttttctt tttcttaaag catattgtaa cttgtttttt tgtttttctt
     2341 aaggcagatt ttcattatgt agacccaact ggccttgaac tcacaaatat ctatctggca
     2401 gcctctgcct ggtgagtgat gggattaaag gtgtgggcca ctctgcccac ctcactacat
     2461 tgttttaagg gagttgcatt atattttaag ttctaaggct atttagaagt ttttatgtct
     2521 taaagcccac tctccccacc tgatcatgtg tctggcagat gtgactgcct tcagggtttc
     2581 ctctctggtg ttcctgtgag tccttctggg aaggagcaac catttgcttt agaatagtag
     2641 attttctttc tttttaacac tggagttgag gatacaaatt atgagttatt taataataaa
     2701 ttcaaaggag agagaatata ttagaaatag taaagtaaac cgggaggcaa aaatacgttc
     2761 tatatttgga atataagtta tttaattatt gtccatatgc agaattacct attgaagatc
     2821 tattttattc tttcatttat attgtatata ttttaaaact ttgttcaaat agatacaaac
     2881 ctgtaaaaag gtaattattt tttatgtagt tctaatagat tttgttaaat ggaatttgac
     2941 tcaaaagcac tgttgttaag aactgtaagg ttcccttggc aaccttggat tggctatttg
     3001 atcttatcag agcaaatgta ctttcaacag tggacatgac taaccaattc cattcagagt
     3061 ttcaaagtac ttaaaatgat agaatattta acatcattgc accgatgagg ataaagtgat
     3121 agcaggcttt ctgaatgcct ggtttatggt tttcagtgac tgccttttag agcttgacta
     3181 ttttgagcat ggtgtgaggc caccacagca ttcaagcata tgtcctagga cctataacca
     3241 agtacaaccc agatcctgca aatgcacaaa gttcaagagg acagattcat ggtctgctca
     3301 tattaaagca ttgtgtgggc aagtgtgtta atacagtgtg gattcaaaat gattggttat
     3361 ttagatatgg tctaccctgt cttaacccta cagaaatata gacaaagaag cagttggata
     3421 gtaaggttgt tcaagttata atacatttta ggtgtctgaa aatcttttat gcatcattta
     3481 tatttttcct ttctagtcag ttaaaaagta attgggctga atgtatagtc taaaaattta
     3541 taaggaaata ataatatgtg ggggaaatgg gcttgtaacc tagattgtgt catatatatt
     3601 gatgctgaaa ttttgtgtaa tgtggtttgt gttttgatga cattcaaagg tgttattgtg
     3661 tcatgcttcc ataactcttc gattatttaa aagttatgct tttaaaggtg tacttgttat
     3721 ttctcagcta ctttcactaa aggcacgtgt gagttcatgg agaagaagcc tgccagctga
     3781 gagctgtagt aaggttaggt acagcacact gggagaaagc ttcatgtccc gggcaggccc
     3841 ttagtgcagc aacagcagct ccttactgga cgcttttcag gttgtaagtt acctgtgcag
     3901 tagagcatag aggttggagg ttcagaactg acatgtttac atcagtttct atggaatgac
     3961 acagaagttc atatgagaaa aaggcagctt gatatttaaa ccacagtcta tattaagaaa
     4021 ttccaaaaag aaattagtcg acatcctgct ctgaaccata aaatagaata ctgttcttac
     4081 aaatccggtt actagacttt aaaaatgtca ttatactgtc attcaatgaa gtgtttttgt
     4141 ttccttgtct ttttgaggca gcatcttaac tgtgccaccc tggctgcctg gggtttactg
     4201 tgtagaccag gctggcctgg aaatcacgga gatccgcctg cctctgcctt cagagtgctg
     4261 ggattaaagg tgtaggccac cacccccatt tgagttttgt tttgttttac ttagttttta
     4321 aagaaaggct ttagtgtcac tcattctatt taaacattca ttgtagaata ttttattact
     4381 atatattttt acccgggatt tataaaaagt aattatgtta tactgaaagt catctcaagg
     4441 atctccagga taattaaagt aatcgaatag ggccaatgaa aatgcacctt tatcacagtc
     4501 tggtcctatg tgccttgcct taccaaataa atacctgact tttatggaga atatactgta
     4561 atttacaact gtagacacat acttgaaagt gggatttttt ttcaagaata actataattc
     4621 tagcttttgg ttgtttcaac attttccctt taaatctatt gtcaaaccac ctgatactga
     4681 gtatcctatt aaagtatcta agtatcctat taaagtatct atgagcagca cttgcctaag
     4741 tgagttgtga tatctgcacc atgattcagg tttgatactt taccatttgt atataattgt
     4801 ttgtttgttg ttgttttttt ttcttgtaag acatgatttg ttgtgattta aaacaatatt
     4861 tttaaatgat tttgacccta aattgatata tgtctgtatt tcatttatat agttattttt
     4921 tgagatttgg gaatatgatt tgttgtatgt ttaaattttt atggatatat aattcaaagg
     4981 aatgtataaa ctgtctttta ttaagtggat ttttagatga taaatttctc atgtcaattt
     5041 ttggtaccat tattatctat atttaataga taagagaaat agataatttc ataaataact
     5101 acatatagtt ttctatattt ccattttcta tttttacctg tgtctgattt aatctgggga
     5161 ttggttgctt atttttatat tttaggaatg agttgcttat cttcatctct tggaaacttt
     5221 ttatcacaag taatttgctt tgttttagcc agaaactagc ttttatttca agtggttaga
     5281 atttctctgc ctatataata atcacagccg aaaagtattt tgtttgaaat aaaatacttc
     5341 tttgctgctg gca
//
