LOCUS       NM_011895               2039 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus solute carrier family 35 (CMP-sialic acid
            transporter), member 1 (Slc35a1), mRNA.
ACCESSION   NM_011895 XM_911593
VERSION     NM_011895.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2039)
  AUTHORS   Ury B, Potelle S, Caligiore F, Whorton MR and Bommer GT.
  TITLE     The promiscuous binding pocket of SLC35A1 ensures redundant
            transport of CDP-ribitol to the Golgi
  JOURNAL   J Biol Chem 296, 100789 (2021)
   PUBMED   34015330
REFERENCE   2  (bases 1 to 2039)
  AUTHORS   Urbanek K, Sutherland DM, Orchard RC, Wilen CB, Knowlton JJ,
            Aravamudhan P, Taylor GM, Virgin HW and Dermody TS.
  TITLE     Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase and
            Solute Carrier Family 35 Member A1 Are Required for Reovirus
            Binding and Infection
  JOURNAL   J Virol 95 (2), e01571-20 (2020)
   PUBMED   33087464
  REMARK    GeneRIF: Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase
            and Solute Carrier Family 35 Member A1 Are Required for Reovirus
            Binding and Infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2039)
  AUTHORS   Ahuja S and Whorton MR.
  TITLE     Structural basis for mammalian nucleotide sugar transport
  JOURNAL   Elife 8, e45221 (2019)
   PUBMED   30985278
  REMARK    GeneRIF: Detailed visualization of extensive protein-substrate
            interactions explains the mechanisms governing substrate
            selectivity. Further structural analysis of mCST's unique
            lumen-facing partially-occluded conformation, coupled with the
            characterization of substrate-induced quenching of mCST's intrinsic
            tryptophan fluorescence, reveals the concerted conformational
            transitions that occur during substrate transport.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2039)
  AUTHORS   Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S,
            Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA and
            Xu S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   5  (bases 1 to 2039)
  AUTHORS   Maggioni A, von Itzstein M, Gerardy-Schahn R and Tiralongo J.
  TITLE     Targeting the expression of functional murine CMP-sialic acid
            transporter to the E. coli inner membrane
  JOURNAL   Biochem Biophys Res Commun 362 (3), 779-784 (2007)
   PUBMED   17764658
  REMARK    GeneRIF: analysis of the functional murine CMP-sialic acid
            transporter expressed in the E. coli inner membrane
REFERENCE   6  (bases 1 to 2039)
  AUTHORS   Zhao W, Chen TL, Vertel BM and Colley KJ.
  TITLE     The CMP-sialic acid transporter is localized in the medial-trans
            Golgi and possesses two specific endoplasmic reticulum export
            motifs in its carboxyl-terminal cytoplasmic tail
  JOURNAL   J Biol Chem 281 (41), 31106-31118 (2006)
   PUBMED   16923816
  REMARK    GeneRIF: CMP-sialic acid transporter is localized in the
            medial-trans Golgi
REFERENCE   7  (bases 1 to 2039)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2039)
  AUTHORS   Ishida N, Yoshioka S, Iida M, Sudo K, Miura N, Aoki K and Kawakita
            M.
  TITLE     Indispensability of transmembrane domains of Golgi UDP-galactose
            transporter as revealed by analysis of genetic defects in
            UDP-galactose transporter-deficient murine had-1 mutant cell lines
            and construction of deletion mutants
  JOURNAL   J Biochem 126 (6), 1107-1117 (1999)
   PUBMED   10578063
REFERENCE   9  (bases 1 to 2039)
  AUTHORS   Eckhardt M, Gotza B and Gerardy-Schahn R.
  TITLE     Membrane topology of the mammalian CMP-sialic acid transporter
  JOURNAL   J Biol Chem 274 (13), 8779-8787 (1999)
   PUBMED   10085119
REFERENCE   10 (bases 1 to 2039)
  AUTHORS   Eckhardt M, Muhlenhoff M, Bethe A and Gerardy-Schahn R.
  TITLE     Expression cloning of the Golgi CMP-sialic acid transporter
  JOURNAL   Proc Natl Acad Sci U S A 93 (15), 7572-7576 (1996)
   PUBMED   8755516
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY324392.1, CF172178.1, Z71268.1 and AL928738.8.
            
            [WARNING] On Oct 17, 2023 this sequence was replaced by
            NM_011895.4.
            
            On Mar 21, 2009 this sequence version replaced NM_011895.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012252.1, AK144170.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               BY324392.1         1-195
            196-825             CF172178.1         2-631
            826-1348            Z71268.1           647-1169
            1349-2039           AL928738.8         58759-59449         c
FEATURES             Location/Qualifiers
     source          1..2039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 16.86 cM"
     gene            1..2039
                     /gene="Slc35a1"
                     /gene_synonym="CST"
                     /note="solute carrier family 35 (CMP-sialic acid
                     transporter), member 1"
                     /db_xref="GeneID:24060"
                     /db_xref="MGI:MGI:1345622"
     exon            1..195
                     /gene="Slc35a1"
                     /gene_synonym="CST"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1190
                     /gene="Slc35a1"
                     /gene_synonym="CST"
                     /note="CMP-SA-Tr; CMP-Sia-Tr; solute carrier family 35
                     member A1"
                     /codon_start=1
                     /product="CMP-sialic acid transporter"
                     /protein_id="NP_036025.2"
                     /db_xref="CCDS:CCDS18030.1"
                     /db_xref="GeneID:24060"
                     /db_xref="MGI:MGI:1345622"
                     /translation="MAPARENVSLFFKLYCLTVMTLVAAAYTVALRYTRTTAEELYFS
                     TTAVCITEVIKLLISVGLLAKETGSLGRFKASLSENVLGSPKELAKLSVPSLVYAVQN
                     NMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWISVFMLCGGVTLVQW
                     KPAQATKVVVAQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGI
                     VVTLAGTYLSDGAEIQEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSA
                     AAAIVLSTIASVLLFGLQITLSFALGALLVCVSIYLYGLPRQDTTSIQQEATSKERII
                     GV"
     exon            196..373
                     /gene="Slc35a1"
                     /gene_synonym="CST"
                     /inference="alignment:Splign:2.1.0"
     exon            374..533
                     /gene="Slc35a1"
                     /gene_synonym="CST"
                     /inference="alignment:Splign:2.1.0"
     exon            534..686
                     /gene="Slc35a1"
                     /gene_synonym="CST"
                     /inference="alignment:Splign:2.1.0"
     exon            687..753
                     /gene="Slc35a1"
                     /gene_synonym="CST"
                     /inference="alignment:Splign:2.1.0"
     exon            754..930
                     /gene="Slc35a1"
                     /gene_synonym="CST"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1065
                     /gene="Slc35a1"
                     /gene_synonym="CST"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..2039
                     /gene="Slc35a1"
                     /gene_synonym="CST"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagctgcg gttttccgag cccccgcagg accgagtctc ccagacttgt cgctccgcac
       61 gccgcgcggc ttccgccgta gcccccgctt cctcctcgcg cgtgtggtgc ggcgggctct
      121 ctaggccggt gcgtctctat ggccgcaggg gcgtcagttc cgcagactct ctcggcacca
      181 tggctccggc gagagaaaat gtcagtttat tcttcaagct gtactgcttg acggtgatga
      241 ctctggtggc tgccgcttac accgtagctt taagatacac aaggacaaca gctgaagaac
      301 tctacttctc aaccactgcc gtgtgtatca cagaagtgat aaagttactg ataagtgttg
      361 gcctgttagc taaggaaact ggcagtttgg gtagatttaa agcctcatta agtgaaaatg
      421 tcttggggag ccccaaggaa ctggcgaagt tgagtgtgcc atcactagtg tatgctgtgc
      481 agaacaacat ggccttcctg gctctcagta atctggatgc agcagtgtac caggtgacct
      541 atcaactgaa gatcccctgc actgctttat gtactgtttt aatgttaaat cgaacactca
      601 gcaaattaca gtggatttcc gtcttcatgc tgtgtggtgg ggtcacactc gtacagtgga
      661 aaccagccca agctacaaaa gtcgtggtag cgcagaatcc attgttaggc tttggtgcta
      721 tagctattgc tgtattgtgc tctggatttg caggagttta ttttgaaaaa gtcttaaaga
      781 gttccgacac ttccctttgg gtgagaaaca ttcagatgta tctgtcaggg atcgttgtga
      841 cgttagctgg tacctacttg tcagatggag ctgaaattca agaaaaagga ttcttctatg
      901 gctacacgta ttatgtctgg tttgttatct tccttgctag tgtgggaggc ctctacacgt
      961 cagtggtggt gaagtataca gacaacatca tgaaaggctt ctctgctgcc gcagccattg
     1021 ttctttctac cattgcttca gtcctactgt ttggattaca gataacactt tcatttgcac
     1081 tgggagctct tcttgtgtgt gtttccatat atctctatgg gttacccaga caagatacta
     1141 catccattca acaagaagca acttcaaaag agagaatcat tggtgtgtga tttgaatctc
     1201 aagagattcc tataaggact taaactgttg ataataaatt agagccttaa gtcaacccca
     1261 gatggtaggt taaataatgt caacaaaata attgtatgac ataagaatca agaagaaaac
     1321 tctgaatgaa atgctaaaac agatttaatt tgggtgtgtt tggtgtcaag ttatattatt
     1381 tcaaaatgaa ggactttata tatatgagag agagagagag agagagagag agaaagagag
     1441 agagagatct tgtacacaga gcatggaggt gccatggtat ttttgtgtgt gtgtgtgtgt
     1501 gtgtgtgtgt gtgatgtaca cagagcacgg aggcaatgat gcaggaccag agagcatcag
     1561 gtgaaactat aatattcaag caacgaggtt taagaccgtg tctgagggtt acagtgccaa
     1621 agccatttct gtacacactg ttctcttgtt caggtacctg gagaggaagg ctagccttct
     1681 tctccagtcc atggatagta ctttgtcccc atagcagtga ggatctagct tctcttctca
     1741 gagtgaggaa ggagtaagac agttgaacac acctcagggt gaatctactt cgtagctcag
     1801 acactgactt ctgggtgaag actgagaact ctagtgatgc atttgtgcca tttactgtct
     1861 ggttcctatt tctttgctgt cagctgatat acttttcaga aaattttata agctgctttt
     1921 atactttctt ttttataaag tatggttacc tgttgggctc tcaatttgtg actttcagtg
     1981 attttaaaat atttctataa tgttaatggg gaaatccagc aataaactta tttctacca
//
