LOCUS       NM_080854               2054 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus solute carrier family 34 (sodium phosphate), member 3
            (Slc34a3), transcript variant 1, mRNA.
ACCESSION   NM_080854
VERSION     NM_080854.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Sasaki,S., Shiozaki,Y., Hanazaki,A., Koike,M., Tanifuji,K., Uga,M.,
            Kawahara,K., Kaneko,I., Kawamoto,Y., Wiriyasermkul,P., Hasegawa,T.,
            Amizuka,N., Miyamoto,K.I., Nagamori,S., Kanai,Y. and Segawa,H.
  TITLE     Tmem174, a regulator of phosphate transporter prevents
            hyperphosphatemia
  JOURNAL   Sci Rep 12 (1), 6353 (2022)
   PUBMED   35428804
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Clerin,V., Saito,H., Filipski,K.J., Nguyen,A.H., Garren,J.,
            Kisucka,J., Reyes,M. and Juppner,H.
  TITLE     Selective pharmacological inhibition of the sodium-dependent
            phosphate cotransporter NPT2a promotes phosphate excretion
  JOURNAL   J Clin Invest 130 (12), 6510-6522 (2020)
   PUBMED   32853180
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Hanazaki,A., Ikuta,K., Sasaki,S., Sasaki,S., Koike,M., Tanifuji,K.,
            Arima,Y., Kaneko,I., Shiozaki,Y., Tatsumi,S., Hasegawa,T.,
            Amizuka,N., Miyamoto,K.I. and Segawa,H.
  TITLE     Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in
            klotho knockout mice different properties between juvenile and
            adult stages
  JOURNAL   Physiol Rep 8 (3), e14324 (2020)
   PUBMED   32026654
  REMARK    GeneRIF: Role of sodium-dependent Pi transporter/Npt2c on Pi
            homeostasis in klotho knockout mice different properties between
            juvenile and adult stages.
REFERENCE   4  (bases 1 to 2054)
  AUTHORS   Fujii,T., Segawa,H., Hanazaki,A., Nishiguchi,S., Minoshima,S.,
            Ohi,A., Tominaga,R., Sasaki,S., Tanifuji,K., Koike,M., Arima,Y.,
            Shiozaki,Y., Kaneko,I., Ito,M., Tatsumi,S. and Miyamoto,K.I.
  TITLE     Role of the putative PKC phosphorylation sites of the type IIc
            sodium-dependent phosphate transporter in parathyroid hormone
            regulation
  JOURNAL   Clin Exp Nephrol 23 (7), 898-907 (2019)
   PUBMED   30895530
  REMARK    GeneRIF: Acute regulation of NaPi-IIc protein by parathyroid
            hormone is involved in the inactivation of Na(+)-dependent Pi
            cotransporter activity and that phosphorylation of the transporter
            is involved in the rapid modification.
REFERENCE   5  (bases 1 to 2054)
  AUTHORS   Miyagawa,A., Tatsumi,S., Takahama,W., Fujii,O., Nagamoto,K.,
            Kinoshita,E., Nomura,K., Ikuta,K., Fujii,T., Hanazaki,A.,
            Kaneko,I., Segawa,H. and Miyamoto,K.I.
  TITLE     The sodium phosphate cotransporter family and nicotinamide
            phosphoribosyltransferase contribute to the daily oscillation of
            plasma inorganic phosphate concentration
  JOURNAL   Kidney Int 93 (5), 1073-1085 (2018)
   PUBMED   29398136
  REMARK    GeneRIF: Nampt/NAD(+) system for Npt2 regulation and cellular
            shifts to tissues such as the liver play an important role in
            generating daily oscillation of plasma inorganic phosphate levels.
REFERENCE   6  (bases 1 to 2054)
  AUTHORS   Shibasaki,Y., Etoh,N., Hayasaka,M., Takahashi,M.O., Kakitani,M.,
            Yamashita,T., Tomizuka,K. and Hanaoka,K.
  TITLE     Targeted deletion of the tybe IIb Na(+)-dependent
            Pi-co-transporter, NaPi-IIb, results in early embryonic lethality
  JOURNAL   Biochem Biophys Res Commun 381 (4), 482-486 (2009)
   PUBMED   19233126
REFERENCE   7  (bases 1 to 2054)
  AUTHORS   Segawa,H., Onitsuka,A., Kuwahata,M., Hanabusa,E., Furutani,J.,
            Kaneko,I., Tomoe,Y., Aranami,F., Matsumoto,N., Ito,M.,
            Matsumoto,M., Li,M., Amizuka,N. and Miyamoto,K.
  TITLE     Type IIc sodium-dependent phosphate transporter regulates calcium
            metabolism
  JOURNAL   J Am Soc Nephrol 20 (1), 104-113 (2009)
   PUBMED   19056871
  REMARK    GeneRIF: Npt2c maintains normal Ca metabolism, in part by
            modulating the vitamin D/fibroblast growth factor 23 axis.
REFERENCE   8  (bases 1 to 2054)
  AUTHORS   Bacconi,A., Virkki,L.V., Biber,J., Murer,H. and Forster,I.C.
  TITLE     Renouncing electroneutrality is not free of charge: switching on
            electrogenicity in a Na+-coupled phosphate cotransporter
  JOURNAL   Proc Natl Acad Sci U S A 102 (35), 12606-12611 (2005)
   PUBMED   16113079
REFERENCE   9  (bases 1 to 2054)
  AUTHORS   Madjdpour,C., Bacic,D., Kaissling,B., Murer,H. and Biber,J.
  TITLE     Segment-specific expression of sodium-phosphate cotransporters
            NaPi-IIa and -IIc and interacting proteins in mouse renal proximal
            tubules
  JOURNAL   Pflugers Arch 448 (4), 402-410 (2004)
   PUBMED   15007650
  REMARK    GeneRIF: NaPi-IIc mRNA and protein was up-regulated by the low-Pi
            diet in all nephron generations analysed
REFERENCE   10 (bases 1 to 2054)
  AUTHORS   Ohkido,I., Segawa,H., Yanagida,R., Nakamura,M. and Miyamoto,K.
  TITLE     Cloning, gene structure and dietary regulation of the type-IIc
            Na/Pi cotransporter in the mouse kidney
  JOURNAL   Pflugers Arch 446 (1), 106-115 (2003)
   PUBMED   12690469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732309.9 and BC125326.1.
            
            On Nov 19, 2011 this sequence version replaced NM_080854.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB054999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AL732309.9         126812-126866       c
            56-67               AL732309.9         126047-126058       c
            68-2007             BC125326.1         1-1940
            2008-2054           AL732309.9         121529-121575       c
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.09 cM"
     gene            1..2054
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /note="solute carrier family 34 (sodium phosphate), member
                     3"
                     /db_xref="GeneID:142681"
                     /db_xref="MGI:MGI:2159410"
     exon            1..55
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            56..179
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            180..266
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            267..395
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            396..539
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            540..651
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            652..847
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            848..937
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1025
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1193
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1310
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1435
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..2054
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2034..2039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /note="hexamer: AATAAA"
     polyA_site      2054
                     /gene="Slc34a3"
                     /gene_synonym="naPi-2c; Npt2c; Npt2c-v1; NptIIc"
                     /note="major polyA site"
ORIGIN      
        1 gcagctgttc cctctgtgcc tcctccctgc tggtgccccc tcaccataca tgcagagcta
       61 ggattgggcc tgggtcttcc ccttcttgaa atccatgccg aattccctcg ccggtggcca
      121 ggtccccaac cctactctgg atgcctttga cctggtggac cggagtctga gaaatgcagg
      181 aatctccggt tccattccag gcttggaaga gggaggtaca gatccctgga ccttctctcc
      241 gctgaagaac gctgaccaac tgaaagaggt tggcatggcc agcaggcttc gccgggtggt
      301 cagcagcttt ctcaaggcat gtggactcct gggaagcctc tactttttca tctgctccct
      361 ggacatcctc agctctgctt tccagctact aggcagcaaa atggctggag acattttcaa
      421 ggacaatgtg gtgctgtcca accctgtggc gggcttggtc attggtgtgc tggtcacagt
      481 ccttgtccag agctccagca catcttcctc tatcgtggtc agcatggtgg cctctaagtt
      541 gctgactgtc caggtgtctg tgcctatcat catgggcgtc aatgtgggta cttcgatcac
      601 cagcaccctg gtctcaatgg cgcagtcagg ggaccgggat gaatttcaga gggccttcag
      661 cggctcggcc gtgcatggca tcttcaactg gctcacagta ttggtattgc tgccgctgga
      721 gagtgccacc gcagcattag agagactgag tgagctggcc ctgggtgctg ctagcctgca
      781 gccagggcag caggcccccg acatcctcaa ggcactgact cggcctttca cacacctcat
      841 catccagctg gatagcagtg tgataaccag cggtattacc agcaacacca ctaacagcag
      901 cctgattaag cattggtgtg gcttcagggg ggagacgccc cagggaagca gtgagggatg
      961 tggcctcttc agctcttgca cagagaggaa cagctcagca tctccagagg aggacagatt
     1021 gctctgccat cacctgtttg ccggctcaaa actcacagac ttggctgtgg gcttcatcct
     1081 gctggcgggc tcgctgctgg tgctctgtgt ctgtctggtc ctcatcgtta aactgctcaa
     1141 ctctgtgttg aagggccgca tcgcacaggc tgtgaagact gttatcaatg cagattttcc
     1201 cttccccttt ggctggctca gcggctactt ggctatcctc gttggcgcag gcctaacctt
     1261 cttgcttcag agcagtagtg tcttcacagc agccatcgtg cctctcatgg gggttggggt
     1321 gattgacctg gaacgggcct accccctctt cttgggttcc aacatcggca ccaccaccac
     1381 agccctgctg gctgccttag ccagccctgc agacatgtta atcttcgcag ttcaggttgc
     1441 tctcatccac ttcttcttca acctggctgg catactgctg tggtacctgg tgcctgtctt
     1501 gagactgcca attccactgg ccaagcgctt tggaaacctg actgcccagt atcgctgggt
     1561 ggccattgtc tacctactat taaccttcct gctgctaccc ctagcagcct ttggactttc
     1621 cctggcaggg ggcacagtgc tggctgcagt agggggtcct ctggtggggc tggtgctcct
     1681 tatcatcctg gttaatgtcc tgcaacaaca ccgaccatct tggctgcccc gctgtcttca
     1741 atcctgggcc tggctgccac tctggctcca ttctctggag ccctgggacc gcctggtgac
     1801 tgcttgttgc ccctgcaggg cctgcagcaa ctctcctatg accagcaaag tggctcactg
     1861 ctatgagaac ccacaagtca tagcttctca gcagttgtga aaagtgggta ccatagccag
     1921 ctccactagc ttcagggcat tggaggcggg agagaccgcc tgccagtcct cgctaagaca
     1981 gaggagcagg gctccacacg gatgttttag tctcttatat cctctccttt tcaaataaac
     2041 gaggttacta ttga
//
