LOCUS       NM_011402               4185 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus solute carrier family 34 (sodium phosphate), member 2
            (Slc34a2), mRNA.
ACCESSION   NM_011402
VERSION     NM_011402.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4185)
  AUTHORS   Uehara,Y., Tanaka,Y., Zhao,S., Nikolaidis,N.M., Pitstick,L.B.,
            Wu,H., Yu,J.J., Zhang,E., Hasegawa,Y., Noel,J.G., Gardner,J.C.,
            Kopras,E.J., Haffey,W.D., Greis,K.D., Guo,J., Woods,J.C.,
            Wikenheiser-Brokamp,K.A., Kyle,J.E., Ansong,C., Teitelbaum,S.L.,
            Inoue,Y., Altinisik,G., Xu,Y. and McCormack,F.X.
  TITLE     Insights into pulmonary phosphate homeostasis and
            osteoclastogenesis emerge from the study of pulmonary alveolar
            microlithiasis
  JOURNAL   Nat Commun 14 (1), 1205 (2023)
   PUBMED   36864068
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4185)
  AUTHORS   Knopfel,T., Himmerkus,N., Gunzel,D., Bleich,M., Hernando,N. and
            Wagner,C.A.
  TITLE     Paracellular transport of phosphate along the intestine
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 317 (2), G233-G241 (2019)
   PUBMED   31169994
REFERENCE   3  (bases 1 to 4185)
  AUTHORS   King,A.J., Siegel,M., He,Y., Nie,B., Wang,J., Koo-McCoy,S.,
            Minassian,N.A., Jafri,Q., Pan,D., Kohler,J., Kumaraswamy,P.,
            Kozuka,K., Lewis,J.G., Dragoli,D., Rosenbaum,D.P., O'Neill,D.,
            Plain,A., Greasley,P.J., Jonsson-Rylander,A.C., Karlsson,D.,
            Behrendt,M., Stromstedt,M., Ryden-Bergsten,T., Knopfel,T., Pastor
            Arroyo,E.M., Hernando,N., Marks,J., Donowitz,M., Wagner,C.A.,
            Alexander,R.T. and Caldwell,J.S.
  TITLE     Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal
            tract by tenapanor reduces paracellular phosphate permeability
  JOURNAL   Sci Transl Med 10 (456) (2018)
   PUBMED   30158152
REFERENCE   4  (bases 1 to 4185)
  AUTHORS   Miyagawa,A., Tatsumi,S., Takahama,W., Fujii,O., Nagamoto,K.,
            Kinoshita,E., Nomura,K., Ikuta,K., Fujii,T., Hanazaki,A.,
            Kaneko,I., Segawa,H. and Miyamoto,K.I.
  TITLE     The sodium phosphate cotransporter family and nicotinamide
            phosphoribosyltransferase contribute to the daily oscillation of
            plasma inorganic phosphate concentration
  JOURNAL   Kidney Int 93 (5), 1073-1085 (2018)
   PUBMED   29398136
  REMARK    GeneRIF: Nampt/NAD(+) system for Npt2 regulation and cellular
            shifts to tissues such as the liver play an important role in
            generating daily oscillation of plasma inorganic phosphate levels.
REFERENCE   5  (bases 1 to 4185)
  AUTHORS   Zhang,L., Guo,X., Zhang,L., Yang,F., Qin,L., Zhang,D. and Qin,Y.
  TITLE     SLC34A2 regulates miR-25-Gsk3beta signaling pathway to affect tumor
            progression in gastric cancer stem cell-like cells
  JOURNAL   Mol Carcinog 57 (3), 440-450 (2018)
   PUBMED   29178392
  REMARK    GeneRIF: SLC34A2 regulated sphere formation and self-renewal
            properties of CD44(+) gastric cancer stem cell-like cells (GCSCs),
            in vitro and in vivo. Mechanistic investigations revealed that
            Gsk3beta was the most strikingly up-regulated gene in response to
            SLC34A2 knockdown in GCSCs and Wnt/beta-cantenin signaling was
            required for SLC34A2-mediated sphere formation.
REFERENCE   6  (bases 1 to 4185)
  AUTHORS   Xu,Y., Yeung,C.H., Setiawan,I., Avram,C., Biber,J., Wagenfeld,A.,
            Lang,F. and Cooper,T.G.
  TITLE     Sodium-inorganic phosphate cotransporter NaPi-IIb in the epididymis
            and its potential role in male fertility studied in a transgenic
            mouse model
  JOURNAL   Biol Reprod 69 (4), 1135-1141 (2003)
   PUBMED   12773415
  REMARK    GeneRIF: NaPi-IIb was the predominantly expressed epithelial
            isoform of the sodium-inorganic phosphate cotransporter and was
            markedly overexpressed in the proximal region in the infertile
            knockout compared to the fertile heterozygous c-ros transgenic
            mouse
REFERENCE   7  (bases 1 to 4185)
  AUTHORS   Arima,K., Hines,E.R., Kiela,P.R., Drees,J.B., Collins,J.F. and
            Ghishan,F.K.
  TITLE     Glucocorticoid regulation and glycosylation of mouse intestinal
            type IIb Na-P(i) cotransporter during ontogeny
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 283 (2), G426-G434 (2002)
   PUBMED   12121891
REFERENCE   8  (bases 1 to 4185)
  AUTHORS   Miyoshi,K., Shillingford,J.M., Smith,G.H., Grimm,S.L., Wagner,K.U.,
            Oka,T., Rosen,J.M., Robinson,G.W. and Hennighausen,L.
  TITLE     Signal transducer and activator of transcription (Stat) 5 controls
            the proliferation and differentiation of mammary alveolar
            epithelium
  JOURNAL   J Cell Biol 155 (4), 531-542 (2001)
   PUBMED   11706048
REFERENCE   9  (bases 1 to 4185)
  AUTHORS   Xu,H., Bai,L., Collins,J.F. and Ghishan,F.K.
  TITLE     Molecular cloning, functional characterization, tissue
            distribution, and chromosomal localization of a human, small
            intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)
  JOURNAL   Genomics 62 (2), 281-284 (1999)
   PUBMED   10610722
REFERENCE   10 (bases 1 to 4185)
  AUTHORS   Hilfiker,H., Hattenhauer,O., Traebert,M., Forster,I., Murer,H. and
            Biber,J.
  TITLE     Characterization of a murine type II sodium-phosphate cotransporter
            expressed in mammalian small intestine
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14564-14569 (1998)
   PUBMED   9826740
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB873139.1, AK004832.1, CJ097638.1, AK145599.1 and CJ205572.1.
            
            On Apr 16, 2010 this sequence version replaced NM_011402.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096369.1, AK145599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BB873139.1         2-3
            3-2487              AK004832.1         2-2486
            2488-3035           CJ097638.1         47-594
            3036-4171           AK145599.1         3033-4168
            4172-4185           CJ205572.1         373-386
FEATURES             Location/Qualifiers
     source          1..4185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 28.92 cM"
     gene            1..4185
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /note="solute carrier family 34 (sodium phosphate), member
                     2"
                     /db_xref="GeneID:20531"
                     /db_xref="MGI:MGI:1342284"
     exon            1..44
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            45..159
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2141
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /note="sodium/phosphate cotransporter 2B; solute carrier
                     family 34 member 2; sodium-phosphate transport protein 2B;
                     Na(+)/Pi cotransporter 2B; Na(+)-dependent phosphate
                     cotransporter 2B; type IIb Na/Picotransporter"
                     /codon_start=1
                     /product="sodium-dependent phosphate transport protein 2B"
                     /protein_id="NP_035532.2"
                     /db_xref="CCDS:CCDS19291.1"
                     /db_xref="GeneID:20531"
                     /db_xref="MGI:MGI:1342284"
                     /translation="MAPWPELENAQPNPGKFIEGASGPQSSIPAKDKEASKTNDNGTP
                     VAKTELLPSYSALVLIEEHPEGTDPWDLPELQDTGIKWSERDTKGKTLCIFQGVGKFI
                     LLLGFLYLFVCSLDVLSSAFQLVGGKVAGQFFSNNSIMSNPVAGLVIGVLVTVMVQSS
                     STSSSIIVSMVASSLLTVRAAIPIIMGANIGTSITNTIVALMQAGDRNEFRRAFAGAT
                     VHDFFNWLSVFVLLPLEAATHYLEILTNLVLETFKFQNGEDAPDILKVITDPFTKLII
                     QLDKKVIQQIAMGDSAAQNKSLIKIWCKSITNVTEMNVTVPSTDNCTSPSYCWTDGIQ
                     TWTIQNVTQKENIAKCQHIFVNFSLPDLAVGIILLTVSLVVLCGCLIMIVKLLGSVLR
                     GQVATVIKKTLNTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSAMTPLIGIGVIS
                     IERAYPLTLGSNIGTTTTAILAALASPGNTLRSSLQIALCHFFFNISGILLWYPIPFT
                     RLPIRLAKGLGNISAKYRWFAVFYLIFFFFVTPLTVFGLSLAGWPVLVGVGVPIILLL
                     LLVLCLRMLQFRCPRILPLKLRDWNFLPLWMHSLKPWDNVISLATTCFQRRCCCCCRV
                     CCRVCCMVCGCKCCRCSKCCRDQGEEEEEKEQDIPVKASGAFDNAAMSKECQDEGKGQ
                     VEVLSMKALSNTTVF"
     exon            160..297
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            298..426
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            427..570
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            571..682
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            683..878
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            879..974
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1095
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1263
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1380
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1505
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..4175
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4145..4150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /note="hexamer: AATAAA"
     regulatory      4151..4156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /note="hexamer: AACAAA"
     polyA_site      4165
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
     polyA_site      4175
                     /gene="Slc34a2"
                     /gene_synonym="D5Ertd227e; NaPi-2b; Npt2b"
                     /note="major polyA site"
ORIGIN      
        1 acctgggtgc ctcctgctgt cccttacctg cgaagggagc gctgatcatg gctccttggc
       61 ccgagttgga aaatgcccag cccaaccccg gtaaattcat cgagggggcc tctggaccac
      121 aatcgagcat acctgccaaa gacaaggagg ccagcaaaac aaatgacaac gggactcctg
      181 tagccaagac tgaactgcta ccctcctatt ccgccctggt tctcatagag gagcatcccg
      241 aggggacgga cccctgggac ctgcctgaac tccaggacac tgggatcaaa tggtcagaga
      301 gagacaccaa agggaagacg ctctgcattt tccagggggt tgggaagttc attcttctcc
      361 tggggtttct ctacttgttc gtgtgctccc tggatgtact gagcagcgcc ttccagcttg
      421 ttggaggcaa agtggccgga cagttcttca gcaacaactc catcatgtct aatcctgtgg
      481 ctggactggt gataggggtt ctggtgacag tcatggttca aagctccagc acctcttcct
      541 ccatcatcgt cagcatggtt gcttcttcat tgctgacggt tcgggctgcc atccccatca
      601 tcatgggcgc taacattgga acctccatca ccaacacgat cgtggcgctt atgcaggcag
      661 gagacagaaa tgagttcaga agggcatttg caggagccac tgttcatgac ttcttcaact
      721 ggctctctgt gttcgtgctc ttgcctctgg aggctgccac ccattacctg gagatcctga
      781 ccaaccttgt gttagaaacc ttcaagttcc agaatggaga agatgcccca gacattctga
      841 aagtcatcac agaccccttc acaaagctca tcatccagct ggataaaaag gtcatccaac
      901 aaatcgcaat gggtgactca gcggcccaga acaagagcct gatcaagatc tggtgtaaaa
      961 gtataaccaa tgtgactgag atgaatgtca ccgtcccctc gactgataac tgcacctctc
     1021 cttcatattg ctggactgat ggcatacaga cctggaccat ccagaacgtt acccaaaagg
     1081 agaacattgc taaatgtcag cacatcttcg tgaacttcag tctcccagac cttgctgtgg
     1141 gcatcatctt gcttactgtc tccctggtgg tcctctgtgg ctgtctgatc atgatagtca
     1201 agctgttggg ttctgtgctc aggggacaag tcgctactgt catcaagaag accctgaata
     1261 ctgatttccc ctttcccttt gcttggctga ctggctacct ggccatcctt gtgggggcag
     1321 gcatgacctt catcgtgcaa agcagctctg tgttcacgtc tgccatgact ccactcatcg
     1381 gtattggggt gatcagcatt gagagggcat atccactcac gttgggctcc aacattggca
     1441 ccaccaccac cgccattctg gctgctttag ccagcccagg caacaccttg aggagttctc
     1501 tccagattgc cctgtgccat ttcttcttca acatctctgg aatattgctt tggtacccaa
     1561 tcccattcac ccgtctgccc atccgtctgg ctaaaggcct aggcaacatc tctgccaagt
     1621 atcgctggtt cgcagtcttc tatctcatct tcttcttctt tgtgaccccg ctgacagtgt
     1681 ttggcctgtc tctggcaggc tggccagtgc tggtgggcgt gggcgtaccc atcatcctgc
     1741 tgctgctcct ggttctgtgc ctccggatgc tgcagttccg ctgccctcgc atcttgcccc
     1801 tgaagctccg ggactggaat ttcctaccct tgtggatgca ctctctgaaa ccctgggaca
     1861 acgtcatctc cctggccacc acctgcttcc agaggcgttg ctgctgctgt tgccgcgtgt
     1921 gctgccgtgt ctgctgcatg gtgtgcggct gcaagtgctg tcgctgcagc aagtgctgca
     1981 gggaccaggg agaggaagag gaggagaagg agcaggatat cccggtcaag gcttctgggg
     2041 cctttgacaa tgcagctatg agcaaagagt gccaagatga gggcaagggc caagtggaag
     2101 ttctgagcat gaaggccctg tccaacacta cagtgttcta ggggcaccta ggagtcaggg
     2161 gtgaggagga cctcaggtcc catgggatcc accccttccg taagcgtctc cagctacctc
     2221 gctaggattt ctgatgagga agaataacac caactctagc tctcctacca ccagagtaac
     2281 agtctgtagt tgaattggac ttatcttctc tgcttctcaa gtgcctccct cttagaagac
     2341 aatacagaga ggcctcagat gacttcatcc acctctggct ttcaaagcca atcctcaccc
     2401 aaaggtcaag tcttaaggga ggcattaggg aaggttctgg aaagacccaa tgtaaagagt
     2461 atttgtaaat atatgtacaa agcagtcatt tcttggtatg aaacctcagc cacatctttt
     2521 ttttttttta tcaaagtcta ctccccctac tcaatagctc ctcctcctat tcgtccctgc
     2581 cccagagcag ccaagtccaa acagtgaagt aatggcttgg agcccataga tgtaagcctc
     2641 catagcttac attgcaggag atgttctcta tggaggaggc ttcatctggg tatagtcaga
     2701 tcaagcagtt gaccccagtg tcctcagctt cagcttccta ggatggagag acacatggtt
     2761 ggggttcata tttggtttct gtacgtaggg ctctggatta atctagaata ggaggcattg
     2821 gtgttcttgg tcagagtaat attgctgatg gaacctgtaa gacctgtgtc ccaagccctc
     2881 tccgttgcta ccactcggga ccatctgctt gtgaagggtc tgtttatctt gttttgtgca
     2941 aggagacttg ctgggccagc ctttagtggt ctgtttccat ccacccactc accctcttgc
     3001 tcatgaaaca tgttcccatc ttccataggt gagctttgtc ctgccccttt ccatgcctac
     3061 aaagctccaa gggaattctt aggagggagg agataggaaa tggctagatg ctcttaagag
     3121 tcaagatgaa gccagtaggg tttggagtga ctgcaggtaa agggtgggat cctattcata
     3181 caggatacct gtgcctttta gagcccacgt gtaataccca caatggctct gcaaccatcc
     3241 ccataactcc ccccacctcc cataagaaca agcctcagct tgacttaggg caggtgtggc
     3301 tccataggac catgtcctct ccatcctctc ccatcatgct cttcgccata ggaagaggtg
     3361 gagatgccaa actgagcccc tctgtagata aaagttccca aagagccatt tatgtggcat
     3421 atttatagct atgcatctgt acagaatact tcataactta tacatagtaa atagtgattt
     3481 gttttatagt gtctcatttg gaaatgaggc agggttcttt tatgtactgt gaaaagagca
     3541 cctttgtata ttttgtaata ctgcctttaa acacaactct ctgaggccac gctatacctc
     3601 cctgtaaata tgtaagttac accccaggag gtggctttgc cctctgttga ttatatatat
     3661 tttttctttt taaaaaaatg ggatccttgt tcccatgtta attgtatttt tttaaactgg
     3721 ttgaggaaag ggggaaataa aaatcacacc ccaagccccc cgccccccgc aagtgtgctg
     3781 cttccaattg cagggtgaca ggaggtatct ttccctactc aaacctcacc atgcatcacc
     3841 acgggaagct atgtagtttc tggtgacact ttgggacaca gaggacttag tcccaccttc
     3901 agttttctct tttccaagtc atggggataa gctactgaga gctatgctaa gcaaagcata
     3961 acattttgta gttaatgaat gttaccaggt ttggaagcaa agactcgggt ggaatctttg
     4021 aaatcacaca gttgatgttt tgaaactatg tgcaggccat cttctgtctt gtttttaaaa
     4081 tttctacatt agagggggaa gggggcagtg agtgggatgt aaattgaata agtaaaaatt
     4141 taaaaataaa aacaaattaa ttccagtact gtaaaaaaaa aaaaa
//
